결장 직장암 환자에서 근치적 절제술 후 혈청 CEA치의 변화에 대한 임상적 의의

김영훈,배병노,김기환,한세환,김홍주,김영덕,김홍용 대한대장항문학회 2003 Annals of Coloproctolgy Vol.19 No.6

수출입 컨테이너 장치장 배정을 위한 소프트웨어의 개발

김갑환,김홍배,홍봉희,김기영,배종욱,최진오,김두열,이영기,박영만,박강태,손행대 한국경영과학회 1995 經營 科學 Vol.12 No.3

The Pusan Container Terminal faces a rapid increase in berthing time of container ships as well as in waiting time of external trucks, which is due to an absolute lack of yard space. This research is focused on the development of a decision support system for the planning of the container terminal yard assignment so that the yard space would be utilized most effectively. Efforts should be given to the reasonable assignment of the yard storage and the dynamic adaptation to the ever changing environment. The software introduced here is based o the know-how of the field exports and its framework takes the approach of the hierarchical decision making.

Alcaligenes sp. GB-77에 의한 Polyhydroxyalkanoic Acid의 생산

김근배,손홍주,이상준 부산대학교 유전공학연구소 1995 분자생물학 연구보 Vol.11 No.-

Polyhydroxyalkanoic acid(PHA)를 생산하는 세균들을 하수처리장의 활성오니로부터 존화배양에 의하여 분리하였다. 이들 중 단일기질로부터 PHA를 생산하는 균주의 생리학적 성질을 검토한 결과 Alcaligenes 속으로 동정되었다. 균체 생육에 최적인 배양온도, pH는 각각 36℃, pH6.8로 나타났으며, 탄소원으로 과당 10g/l, 질소원으로 polypeptone 5g/l, Na_2HPO_4 1×10^-2 M, KH_2PO_4 1.3×10^2 M이었다. PHA 합성을 위한 최적조건을 조사하기 위하여 2단계 배양법을 이용한 결과, 배양온도 36℃, pH6.8, C/N 비 50이 PHA 합성에 최적인 것으로 나타났다. 탄소원을 간헐적으로 첨가하는 유가배양에 의하여 배양 60시간만에 건조균체량 17.4g/l, PHA 9.1g/l를 얻을 수 있었다. 추출, 정제된 PHA는 NMR에 의하여 분석한 결과 PHA/HV copolymer 임을 확인할 수 있었다. For polyhydroxyalkanoci acid (PHA) production, several microorganisms were isolated from sewage sludge. One of them, GB-77 strain, was chosen from its PHA/HV copolymer production on only fructose without cosubstrate. The isolated strain GB-77 was identified as the genus Alcaligenes. Optimal temperature and pH for cell growth were 36℃ and 6.8. Optimal medium composition was 10 g/l of fructose and 5 g/l of polypeptone, 1×10^-2 M Na_2HPO_4, 1.3×10^-2 M KH_2PO_4. To investigate the optimal condition for polyhydroxyalkanoic acid production two-stage culture technique was used; first stage for cell grown and second stage for PHA production on unbalanced growth conditions. Optimal conditions for high PHA production were C/N ratio 50, temperature 36℃ and pH 6.8. To overcome frutose inhibition on cell growth, intermittent feeding fed-batch culture technique was used. Total cell concentration was 17.4 g/l with 9.1 g/l of PHA. The purified PHA was identified PHA/HV copolymer by NMR analysis.

불안정한 지지면에서의 평형 훈련이 편마비 환자의 균형 능력에 미치는 영향

배수찬,김근조,윤홍일 대한정형물리치료학회 2001 대한정형도수물리치료학회지 Vol.7 No.2

The purpose of this study was to investigate the balancing training effect on weight bearing ratio and postural sway on the unstable surface for the CVA patients with balance disability. The inclusion criteria were walking independently 20m distances. Eighteen subjects, 4 with right and 14 with left hemiplegic patients were participated in this study. The range of age was from 35 to 75 and the duration from onset time was from 1 to 38 months. The intervention program including balancing training that they were introduced for 10 minutes every other day during 12 weeks to experimental group, and general therapeutic exercise to control group. The result of this study were as following: 1. The balancing training on the unstable surface showed that the postural sway of left/right distribution would appear more effective on sitting with eyes opened. 2. The balancing training on the unstable surface showed that the postural sway of forward/rear distribution, left/right distribution and distance would appear more effective on standing with eyes opened. 3. The balancing training on unstable surface would increase more effective on the weight-bearing ratio of left/right difference and frequency. 4. The balancing training on unstable surface was statistical significant on the postural sway of left/right distribution and area in experimental group, and it was statistical significant on the postural sway of forward/rear distribution, left/right distribution and distance in control group, too.

다이아몬드 터닝머신을 이용한 알루미늄반사경의 절삭특성

김건희,고준빈,김홍배,원종호 한국공작기계학회 2002 한국생산제조학회지 Vol.11 No.4

A 110 mm diameter aspheric metal secondary mirror for a test model of an earth observation satellite camera was fabricated by ultra-precision single point diamond turning(SPDT). Aluminum alloy for mirror substrates is known to be easily machinable, but not polishable due to its ductility. A harder material, Ni, is usually electrolessly coated on an Al substrate to increase the surface hardness for optical polishing. Aspheric metal secondary mirror without a conventional polishing process, the surface roughness of Ra=10nm, and the form error of Ra=λ/12(λ=632.8nm) has been required. The purpose of this research is to find the optimum machining conditions for reflector cutting of electroless-Ni coated Al alloy and apply the SPDT technique to the manufacturing of ultra precision optical components of metal aspheric reflector.

생산량을 고려한 부품-기계 셀 형성에서의 퍼지이론 이용

김홍배,김재한 慶星大學校 1994 論文集 Vol.15 No.2

This paper deals with Machine-Part Group Formation in Group Technology. In order to consider uncertainty and impreciseness in Machine-Part Group Formation, this paper introduces Fuzzy Theory. In this paper we consider production volume in determination of fuzzy similarity coefficient. Although there is no proper performance measure, Fuzzy similarity coefficient proposed in this paper consider production volume and the result of this study can applicable to real life cell formation.

자동차용 핀-관 열교환기의 제작 및 열성능 향상에 관한 연구

김영완,김홍배,이상윤 여수대학교 1998 論文集 Vol.13 No.2

Naphthalene sublimation technique is employed to investigate the heat transfer enhancement of fin-tube heat exchangers using vortex generators. Experiments are performed for the fin-circular tube heat exchanger with and without vortex generators, and fin-flat tube heat exchanger with and without vortex generators. Local and spanwise averaged heat transfer coefficients are measured on the surface of fin, and compared with those obtained without vortex generator. Average heat transfer coefficients of fin-flat tube heat exchanger are much lower than those of fin-circular tube heater exchanger. On the other hand, fin-flat tube heat exchanger with vortex generators has a little higher heat transfer value than fin-circular tube with vortex generators. Friction loss for four types of heat exchanger are also measured and compared.

디버터의 열유동 및 열응력 해석

김영완,이상윤,김홍배 여수대학교 1998 論文集 Vol.13 No.2

For the optimal design of plasma facing components of a fusion reactor, the thorough understanding of thermal behavior of high heat flux components are required. The purpose of this research is to investigate the characteristics of heat flow and thermal stress in divertors which are exposed to high heat load varying with time and space. Numerical simulations of heat flow and thermal stress for three types of divertor are performed using finite volume method and finite element method. Respectively, commercial FLUENT code are used in the heat flow simulation, and maximum surface temperature, temperature distribution and cooling rate are calculated. Commercial ABAQUS code are used for calculating temperature distribution, thermal stress, strain and displacement. Through this computer simulation, design data for cooling system and structural are provided.

비정규 공정능력의 평가

김홍준,이우언,김종배 대구산업정보대학 2002 논문집 Vol.16 No.-

The main objective of this study are to propose two measure that would be process capability indices and percentage nonconforming for evaluation of non-normal process capability. In this paper we propose an example, a distribution generated from the Johnson family of distributions, to demonstrate how a new process capability index C_(psk) perform in terms of sensitivity to departure of the process median from the target value in comparison with normal process, the Pearson system and the Wright method. Second method show using the percentage nonconforming by the Pearson, Johnson and Burr functions. This example shows a little difference between the Pearson system and Johnson system, but Burr system overestimated than the two systems for process capability. The percentage nonconforming can be related to an equivalent capability indices for a process having a normal distribution. Thus, considering only process capability indices or percentage nonconforming separately is not a valid assessment of process capability, both criteria must be evaluated jointly.

Lipoprotein(a)와 대동맥판막과 승모판막 경화증 및 복부 대동맥 두께의 상관관계에 대한 연구

김민수,유근배,이상운,임양희,신길자,조홍근 梨花女子大學校 醫科大學 醫科學硏究所 1998 EMJ (Ewha medical journal) Vol.21 No.3

연구배경 : Lipoprotein(a)의 농도와 대동맥판막의 두께, 승모판막의 두께 및 복부 대동맥의 두께와의 관계에 대하여 조사하고, 다른 관상동맥질환의 위험인자와의 관계를 규명해 보고자 하였다. 대상 및 연구방법 : 1995년 6월부터 1996년 5월까지 이화여자대학교 의과대학 부속 동대문병원에서 심초음파검사를 시행하였던 환자 116명을 대상으로 하였으며 이중 급성심근경색증, 갑상선질환 및 혈청 지질치에 영향을 미치는 약제를 복용중인 환자를 제외하였다. 성별, 나이, 고혈압의 유무, 흡연유무 및 혈청 콜레스테롤, 고밀도지단백콜레스테롤, 중성지방, 저밀도지단백콜레스테롤, lipoprotein(a)치를 측정하였고, 미국 휼레트 패커드사의 Sono 1000 을 이용하여 대동맥판막의 두께, 승모판막의 두께 및 대동맥의 두께를 측정하였다. 결과 : 1) Lipoprotein(a)는 남자가 34.6±34.3mg/dl, 여자가 25.6±23.4mg/dl 이었으며, 총 콜레스테롤, 저밀도 지단백콜레스테롤 및 고밀도지단백콜레스테롤, 중성지방에는 남녀간에 유의한 차이가 없었다(p>0.05). 2) Lipoprotein(a) 농도와는 대동맥판막의 두께만이 의의있는 양의 상관관계를 보였으며, 승모판막의 두께, 복부대동맥 두께 및 상행 대동맥의 내경과는 관계가 없었다. 3) Lipoprotein(a)와 일반 특성 및 생화학적인 특성과의 관계에서 Lipoprotein의 농도는 오직 흡연과 관계가 있었으며(p<0.01), 혈압, 연령, 총콜레스테롤, 중성지방, 고밀도지단백콜레스테롤 및 저밀도지단백콜레스테롤과는 무관하였다. 4) 18명의 환자에서 관상동맥조영술을 실시하여 관상동맥질환의 유무 및 정도와 대동맥 판막두께와의 관계를 분석한 결과 대동맥 판막이 두꺼울수록 관상동맥질환의 정도가 심했다(p<0.01). 결론 : 본 연구에서 lipoprotein(a)농도와 대동맥 판막의 두께가 의의있는 양의 상관관계를 보였으며, lipoprote-in(a)의 농도는 흡연력만 관계가 있었다. 또한, 대동맥 판막이 두꺼울수록 관상동맥 질환의 정도가 심한 것을 볼 때, lipoprotein(a)의 농도 및 대동맥판막의 두께가 관상동맥 질환의 위험인자가 될 것으로 생각된다. Background : An elevated serum lipoprotein(a) level is an independent risk factor for athe-rosclerotic diseases, and the lipoprotein(a) level is correlated to preclinical atherosclerosis. To evaluate the association between lipoprotein(a) and aortic selerosis, ,itral sclerosis, and abdominal aorta thickness, we measured the aortic valve thickness, mitral valve thickness and abdominal aorta thickness. Also, we assessed the relationship between the aortic valve sclerosis, mitral valve sclerosis, abdominal aorta thickness and other coronary risk factors. Method : We measured serum lipoprotein(a) in 116 patients(52 men, 64 women) with mean age of 58.7±13.9 years. Aortic valve thickness was assessed by parasternal long and short axis two dimensional echocardiography, mitral valve thickness was measured by apical 4 chamber view. The abdominal aorta thickness was measured by the subcostal view. Result : The level of lipoprotein(a) was significantly correlated with the aortic valve thickness, but not with the miral valve thickness and the abdominal aorta thickness. lipoprotein(a) level was higher in smoking patients(p<0.05), and not related to other ariables such as blood pressure, age, total cholesterol, triglyceride, high density lipoprotein and low density lipoprotein. Coronary angiography was performed in 18 paitents, and there was a tendency of the coronary artery disease with high level of the lipoprotein(a)(p<0.005). There was no significant difference in the thickness of aortic valve in terms of sex, blood pressure, total cholesterol, high density lipoprotein, triglyceride or blodo sugar. Conclusion : We conclude that increased serum levels of lipoprotein(a) are closely related to aortic valve sclerosis and may be a risk factor for coronary artery disease.