류마치스성 심장판막질환 환자에서 심방세동의 F파와 좌심방크기 및 조직소견에 관한 연구

신길자,이우형,김광호,박영식,한운섭 대한순환기학회 1988 Korean Circulation Journal Vol.18 No.2

본태성 고혈압 환자에 있어서 혈장 Renin 활성도와 혈청 칼슘 및 마그네슘에 관한 연구

신길자,이우형 梨花女子大學校 醫科大學 醫科學硏究所 1985 EMJ (Ewha medical journal) Vol.8 No.1

Serum calcium, magnesium and plasma renin activity were studied in the gro-ups of 20 controls and 20 hypertensives. All patients were admitted to Ewha Womans University Hospital between Ma-rch 1984 and August 1984. The following results were obtained : 1) The plasma renin activity in normal controls were 1.40±1.48mg/ml/hr, and 1.59±1.97 ng/ml/hr in hypertensives. Most of the hypertensives were normal re-nin hypetension. 2) The serum calcium in normal controls were 8.85±0.84㎎/dl and 9.14±0.49㎎/dl in hypertensives and had no correlationship between plasma renin activity and serum ca-lcium in controls, byt had positive correlationship in hypertensives (P<0.025). 4) The serum magnesium in normal controls were 2.85±0.82㎎/dl and 2.63±0.34㎎/dl in hypertensives and had no correlationship to mean blood pressure. 5) There were no correlationship between plasma renin activity and serum magnesium in both controls and hypertensives.

원발성 확장성 심근증의 임상적 연구

신길자 梨花女子大學校 醫科大學 醫科學硏究所 1991 EMJ (Ewha medical journal) Vol.14 No.1

In order to observe the clinical characteristics of the primary dilated cardiomyopathy. I reviewed 39 patients examined in the Cardiology Department of the Ewha Womans University Hospital from January. 1986 to in June. 1990. The findings were as follows ; 1) Among whom 27 patients were male and 17 were female with a male to female ratio of 2.3:1. 2) An age distribution was diverse from 17 years to 79 years old with a mean age 58.2±15.6 year. The peak age incidence was the 6th decade. 3) The most frequent chief complaints were exertional dyspnea(82.1%) and orthopnea(20.5%). 4) The duration of symptoms was relatively short. mainly less than 1 month. suggesting an abrupt onset of symptoms. 5) Among various arrhythmias. atrial fibrillation was most common(30.8%) and premature ventricular contraction(23.1%) and premature atrial contraction(10.3%) were frequently found. 6) By M-Mode echocardiography. left ventricular enddiastolic dimension(LVEDD) was 65.7±9.3mm. left ventricular endsystolic dimension(LVEDS) was 57.8±8.1mm and ejection fraction was 31.1±5.9%. 7) After treatment, most of the patients(82.0%) were improved to New York Heart Association Function Class Ⅱ. Before treatment. 71.7% of the patients were belongs to New York Heart Association Functional Class Ⅲ and Ⅳ.

호흡기질환에 있어서 Ambroxol의 임상효과에 대한 연구

신길자,경난호,민태희 梨花女子大學校 醫科大學 醫科學硏究所 1985 EMJ (Ewha medical journal) Vol.8 No.4

The expectorant effect of Ambroxol was observed in 13 cases of respiratory diseases(5 cases with bronchial asthma, 2 cases with acute bronchitis, 2 cases with lung ca, 2 cases with pneumonia, 1 case with chronic bronchitis and 1 cases with pulmonary tuberculosis) between Nov. '83 and Mar. '84. The folliwing results were obtained; 1) Clinical improvement of % of cases after treatment with Ambroxol was 78% of cough, 62% of frequency of sputum expectoration, 59% of amount of sputum vloume, 80% of expectoration and 75% of color of sputum. 2) Clinical improvement of pulmonary function test was as follows;(1) Improvement of less than 10% of FVC was 9 cases(69.2%) improvement between 10% and 20% of FVC was 3 cases(23.1%), and improvement of more than 20% of FVC was 1 case(7.7%). (2) Improvement of less than 10% of FEV_1/FVC was 11 cases(84.6%), improvement between 10% and 20% of FEV_1/FVC was 2 cases(15.4%)3) No remarkable side effects was observed.

인슐린비의존성 당뇨병에 있어서 고지혈증에 대한 Lovastatin(Mevacor^�)의 임상효과

신길자,경난호 梨花女子大學校 醫科大學 醫科學硏究所 1991 EMJ (Ewha medical journal) Vol.14 No.3

Patient with noninsulin dependent diabetes mellitus(NIDDM) have a major risk factor of the coronary herat disease which is important cause of death in NIDDM patients. In addition, they have relatively high levels of plasma cholesterol. In order to assess the hypolipidemic effect and adverse effect of lovastatin, we studied in 30 NIDDM with mild to moderate elevations of serum cholesterol. Lovastatin, HMG-CoA reductase inhibitor(20㎎ once daily in the evening) was given for 12 wks, during which blood glucose concentration remained controlled. The following results were obtained: 1) Lovastatin reduced totol cholesterol by 26.4%, low-density lipoprotein(LDL) by 26.9%, and triglyceride(TG) by 26.7%. 2) During the study period, one patient complained nausea and vomiting, the other patient complained itching. No abnormalities in serum values were noted. In conclusion, lovastatin was effective agent in NIDDM with hypercholeste rolemia without siginificant side effect.

본태성 고혈압환자의 좌심실 비대 평가에 있어서 심전도와 심초음파도의 비교에 대한 연구 : 표준 12극 심전도 총QRS 전위를 중심으로

신길자,박시훈,이우형 梨花女子大學校 醫科大學 醫科學硏究所 1995 EMJ (Ewha medical journal) Vol.18 No.1

연구배경 : 본태성 고혈압환자에 있어서 좌심실 비대는 환자의 예후에 중요한 영향을 미친다. 그러나 종전의 심전도에 의한 좌심실 비대의 진단은 비교적 정확하지 못하며, 심초음파도 개발된 이후 좌심실질량의 측정이 가능하게 되었다. 이에 저자들은 심전도와 심초음파도로 진단된 좌심실 비대를 비교 관찰함으로써 정확도를 평가하였다. 방법 : 좌심실 비대를 진단하기 위하여 본태성 고혈압환자 50예와 정상인 50예에 대하여 심전도 및 심초음파검사를 시행하였다. 결과 : 심전도로 측정한 좌심실비대의 평가에 있어서 총 QRS 전위는 고혈압환자군에서 205.6±51.3mm, 정상대조군에서 149.6±42.4mm였고(p<0.01), SV_1+RV_5 or V_6는 고혈압환자군에서 0.86+0.47, 정상대조군에서 0.83±0.20(p>0.05)였다. 심초음파도로 측정한 좌심실 질량지수는 고혈압환자군에서 209±60gm/m^2, 정상대조군에서 117±30gm/m^2(p<0.01)이었다. 심전도상의 좌심실비대의 진단기준은 심에코도와 비교해 볼 때, 총 QRS 전위의 합은 민감도와 특이도가 65.0%, 78%였고, 정확도는 61.4%였으며, SV_1+RV_5 or V_6는 45.0%, 85.0%로써 정확도는 68.8% 였으며, RV_6 : RV_5는 10.0%, 78,2% 였고 정확도는 85.6%였다. 결론 : 이상의 결과 좌심실비대 평가에 있어서 심전도상 좌심실비대 평가는 총 QRS 전위의 합을 이용하는 것이 SV_1+RV-5 or RV_6 : RV_5를 이용하는 것보다 민감도 및 정확도가 높았다. Background : Left ventricular hypertrophy(LVH) is an important prognostic factor in essential hypertersion. But the method of diagnosis of LVH by electrocardiography has limitations. In this study, we compared the sensitivity of the total 12-lead QRS amplitude with the sensitivity of certain standard electrocardiographic criteria for left ventriculart hyterthophy in patients with essential hypertension. Materials & Method : Atotal of 50 hypertrophy patients and 50 normal adults were studied. For diagnosis fo left ventricular hypertrophy by electrocardiography, we use Sokoliw and Lyon index, the ratio of RV_6 : RV_5 and a method using the total QRS complex voltage of standard 12-lwads. By echocardiography, we calculated left ventricular mass index. Results : The total QRS voltage ranged from 127mm to 332mm(mean : 205±51mm) in hypertensives, 86mm to 308mm(mean : 149±42mm) in nonmal group. Using 175mm as the upper limit of normal, this method gave a sensitivity of 80% show reasonable sensitivity of any criteria tested. The Sokolow-Lyon index gave a sensitivity of 45%, the RV_6/RV_5 ratio gave only 10% of sensitivity. Conclusion : Total 12-lead QRS voltage more than 175mm is a useful indicator of left ventriculat hypertrophy in patients with essential hypertension.

2,6-Dimethylphenyl-3-methylamidinourea Hydrochloride(Lidamidine HCl)의 지사효과에 대한 임상적 연구

신길자,경난호 梨花女子大學校 醫科大學 醫科學硏究所 1985 EMJ (Ewha medical journal) Vol.8 No.2

The antidiarrheal effects of Lidamidine was observed in 30 cases of acute and chronic diarrhea between Mar. '85 and May '85. The following results were ob-tained. 1) Overall evaluation of therapy was rated by physician and patient at the end of the study revealed excellant control in 50%, good control in 30%, fair con-trol in 15% and poor in 5% of the cases and in placebe 10 of 10 cases all re-vealed no effect. 2) Vital signs were stable and all laboratory findings including CBC, urinaly-sis, liver function test revealed no significant change during the treatment. 3) Mean daily dose were 32.3±29.4mg. 4) There was no side effect of Lidamidine Hydrochloride. 5) Mean duration of treatment were 4.5±1.5 days.

심실중격결손증환자에서 이면성 Doppler 심초음파도와 심도자로 측정한 폐혈류량, 체혈류량 및 폐혈류량과 체혈류량 비율의 비교에 대한 연구

신길자,이우형,김광호,박영식 대한순환기학회 1988 Korean Circulation Journal Vol.18 No.3

혈심증과 동반된 관상동맥-폐동맥누공 1예 보고

신길자,이웅구,조승연,심원흠 대한순환기학회 1985 Korean Circulation Journal Vol.15 No.3

한국인 본태성 고혈압환자의 계절변화에 따르는 혈압변동에 대한 연구

신길자(Gil Ja Shin),조홍근(Hon Keun Cho) 대한내과학회 1997 대한내과학회지 Vol.53 No.6

Objectives: The mortality rate due to stroke and myocardial infarction by the complication of the hypertension were the major causes of death among the Korean followed by the cancer. There are many factors to affect the blood pressure variability such as physical activity, sleeping, activation of the autonomic nervous system, climate, cold exposure and seasonal variation. The blood pressure was increased by cold exposure. In general, blood pressure was increased in winter and the cardiovascualr mortality is also increased at winter. In Korea, we have distinct seasonal variation of the climate, we have no clinical data on the seasonal variation of the blood pressure. Methods: To investigate the seasonal variation of blood pressure of Korean essential hypertensives and make effort to reduce the cardiovascualr mortality, we studied 63 hypertensive men and women hypertensives. Results: 1) The mean age was 60±10 years with 19men and 44 women. The mean systolic blood pressure was 146±22mmHg, mean diastolic blood pressure was 91 ±11mmHg. 2) The mean systolic and diastolic blood pressure during the 12 months was 137±18mmHg, 86±10mmHg in men respectively. In women, the mean systolic blood pressure was 137±16mmHg and the mean diastolic blood pressure was 86±8mmHg. 3) The biochemical findings including hemoglobin, hematocrit and creatinine levels were significantly lower in women(P<0.05). 4) The systolic and diastolic blood pressure were significantly increased during the winter as January and February, 5) There was also significant increase of systolic blood pressure at the transitional zone to the sum- mer to autumn(P=0.0004). Conclusion: There was significant increase in systolic and diastolic blood pressure in winter in Korean hypertensives. This phenomenon was also observed the transitional zone to summer to autumn. So, during these period, more strict blood pressure control by frequent measurement and increase the room temperature may be recommended to reduce the cardiovascular mortality during winter.