Induction of heme oxygenase-1 protects against podocyte apoptosis under diabetic conditions

Lee, Sang Choel,Han, Seung Hyeok,Li, Jin Ji,Lee, Sun Ha,Jung, Dong-Sub,Kwak, Seung-Jae,Kim, Seung Hye,Kim, Dong Ki,Yoo, Tae-Hyun,Kim, Jin Hyun,Chang, Se-Ho,Han, Dae Suk,Kang, Shin-Wook International Society of Nephrology 2009 Kidney international Vol.76 No.8

Heme oxygenase-1 (HO-1) is an anti-oxidant enzyme normally upregulated in response to oxidant injury. Here we determined the role of HO-1 in podocyte apoptosis in glomeruli of streptozotocin-treated rats and in immortalized mouse podocytes cultured in media containing normal or high glucose. HO-1 expression, its activity, the ratio of Bax/Bcl-2 protein, and active caspase-3 fragments were all significantly higher in isolated glomeruli of diabetic rats and in high glucose–treated podocytes. These increases were inhibited by zinc protoporphyrin treatment of the rats or by HO-1 siRNA treatment of the podocytes in culture. The number of apoptotic cells was also significantly increased in the glomeruli of diabetic rats and in high glucose–treated podocytes. Inhibition of HO-1 accentuated the increase in apoptotic cells both in vivo and in vitro. Our findings suggest that HO-1 expression protects against podocyte apoptosis under diabetic conditions.

안면신경 마비 환자에 있어서의 측두근 및 근막피판을 이용한 안면근 기능 회복 증례보고

정창주,권혁도,엄인웅,우승철,민승기,정호용 大韓顎顔面成形再建外科學會 1994 Maxillofacial Plastic Reconstructive Surgery Vol.16 No.1

Generally, the totally paralyzed face can never be made normal by any of the current methods of reconstruction. Careful selection of patients based on sound judgment of what can and cannot be achieved by the proposed surgical technique is paramount to a successful operation and a satisfied patient. The results are related to time of delayed between injury and repair : the shorter the delay the better are the results. The objectives in correcting facial paralysis are to achieve normal appearance at rest ; symmetry with voluntary motion ; control of the ocular, oral, and nasal sphincter; symmetry with involuntary emotion and controlled balance when expressing when expressing emotion ; and no significant functional deficit secondary to the reconstructive surgery. It must be employed a number of concepts, for treatment of the paralyzed face by surgeon, depending on the cause, time interval, and wound characteristics, as well as the availability of and necessity for neuromuscular substitution. Nerve grafts, crossovers, muscle transfers, free muscle and nerve-muscle grafts, micronuerovascular muscle transfers, and regional muscle transpostion are the principal methods being developed. We applied the tmporal musle transposition for reanimation of unilatrally paralyzed faces for long times on two patients. The results of muscle transposition can be enhanced by the patient's learning to activate the transposed muscle by voluntary effort, and are best in patients who are motivated to learn the necessary motor-sensory coordination techniques.

크론병에 대한 CoPPLX의 방어효과에 대한 연구

이호학,김유림,문창기,이재일,양병윤,김종수,이정민,정재혁,안석진,박상준,김윤권,김소연,김영중,조민구,최영자,장성조 圓光大學校 醫科學硏究所 2005 圓光醫科學 Vol.20 No.1

외측 미칩 갑상선에서 발생하여 다발성 전이로 발현된 유두상 갑상선암 1예

천남일,이창훈,홍세인,정진욱,윤인석,조동혁,강호철,정동진,정민영 대한내분비학회 2001 Endocrinology and metabolism Vol.16 No.4-5

마이크로파 여기 플라즈마광 생성을 위한 도파관 시스템 설계에 관한 연구

전상재,전후동,송창현,하석영,이승혁,이태호,박의준 금오공과대학교 2005 論文集 Vol.26 No.-

In this paper, the plasma lighting system(PLS) excited by the commercial high power magnetron is developed. The design concepts are based on maximizing the huninous efficacy in conjunction with the miniaturization of waveguide system Furthermore the fine tuning is simplified by using only one stub, and the impedance matching is maximized by introducing the tapering technique. The experimental results show that the luminous efficacy can be dramatically improved by the proposed design method.

Single-Walled Carbon Nanotubes/Polymer Composite Electrodes Patterned Directly from Solution

Chang, Jingbo,Najeeb, Choolakadavil Khalid,Lee, Jae-Hyeok,Kim, Jae-Ho American Chemical Society 2011 Langmuir Vol.27 No.11

<P>This work describes a simple technique for direct patterning of single-walled carbon nanotube (SWNT)/poly(3,4-ethylenedioxythiophene)–poly(styrenesulfonate) (PEDOT–PSS) composite electrodes in a large area on a substrate based on the solution transfer process by microcontact printing using poly(dimethylsiloxane) (PDMS) stamps. Various shapes of SWNT/PEDOT–PSS composite patterns, such as line, circle, and square, can be easily fabricated with high pattern fidelity and structural integrity. The single parallel line pattern device exhibits high electrical conductivity (0.75 × 10<SUP>5</SUP> S/m) and electronic stability because of alignment of nanotubes and big-size SWNT bundles (∼5 nm). The electromechanical study reveals that the composite patterns show ∼1% resistance change along SWNT alignment direction and ∼5% resistance change along vertical alignment direction after 200 bend cycles. Our approach provides a facile, low-cost method to pattern transparent conductive SWNT/polymer composite electrodes and demonstrates a novel platform for future integration of conducting SWNT/polymer composite patterns for optoelectronic applications.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/langd5/2011/langd5.2011.27.issue-11/la2009573/production/images/medium/la-2011-009573_0008.gif'></P>

A Study on the New Education and Training Scheme for Developing Seafarers in Seafarer 4.0 - Focusing on the MASS -

Chang-Hee Lee,Gwi-ho Yun,Jung-Hyeok Hong 해양환경안전학회 2019 해양환경안전학회지 Vol.25 No.6

4차 산업 혁명으로 해양산업은 해사 관련 기술 및 시스템, 특히 선원의 역할에 상당한 변화가 생길 것으로 예상됩니다. 특히, 자율운항선박(MASS)은 인적과실에 의한 안전사고의 예방과 해상 작업 환경의 개선을 위하여 개발되고 있습니다. IMO는 교육 및 훈련 분야를 포함한 모든 분야에서 MASS의 도입에 대한 준비작업을 하고 있습니다. 이에 반해 국내지정교육기관은 아직 MASS에 탑승할 선원을 육성하기 위한 자격기준이나 교육훈련에 대한 계획을 수립하지 못하고 있는 상황입니다. 따라서 본 논문은 MASS의 특성과 적용기술을 검토하고, AI, 빅 데이터, 사이버 보안 등 급변하는 기술 환경에 최적화될 수 있는 스마트 선원의 능력 및 교육 훈련에 대한 필요성을 제시하고자 한다. The current maritime industry is expected to have a significant impact on the role of maritime-related technologies and systems, especially seafarers, in the rapidly changing Fourth Industrial Revolution. The Maritime Autonomous Surface Ship (MASS) aims to reduce the number of safety accidents and improve seafarers’ working environment. With regard to MASS, the International Maritime Organization has been trying to minimize unexpected impact in the maritime education and training sector by establishing international conventions such as the Standards of Training, Certification and Watchkeeping for Seafarers. However, domestic designated educational institutions have not yet established an education and training scheme to develop seafarers who will be on board for MASS. Therefore, this paper reviews the technology of MASS, analyzes the changes in education and training in order to upgrade the qualifications, and suggests the competencies of smart seafarers equipped with the integrated management ability required for Artificial Intelligence, Big Data, Cybersecurity, and the Digital System Revolution through education and training. In addition, this study provides basic information for the education and training of seafarers who are optimized for the rapidly changing technological environment.

부비동염에서 기원한 진균성 동맥류의 치료과정 중 발생한 코일의 이동

장혁(Hyeok Chang),김도희(Do Hee Kim),김정희(Jung Hee Kim),이호진(Ho Jin Lee),홍상덕(Sang Duk Hong),홍창기(Chang Ki Hong) 대한두개저학회 2020 대한두개저학회지 Vol.15 No.1

Invasive sphenoid fungal sinusitis sometimes invades the adjacent structures such as the optic nerve or cavernous sinus. Here, we present the treatment for a primarily embolized mycotic aneurysm that ruptured during endoscopic sinus surgery. This report describes the case of a 72-year-old man with a mycotic aneurysm. Although the patient’s mycotic aneurysm was controlled by coil embolization, the subsequent endoscopic surgery resulted in massive bleeding and dislocation of the embolic coil. The ruptured vessel was stably controlled by internal carotid artery occlusion. This case emphasizes the need for careful consideration when performing endoscopic surgery for sphenoid sinusitis in patients especially with a mycotic aneurysm.

폭풍파랑에 따른 해빈과 호형 사주 지형변화 현장 관측 및 XBeach 모델 민감도 분석

진혁(Hyeok Jin),도기덕(Kideok Do),장성열(Sungyeol Chang),김인호(In Ho Kim) 한국해안해양공학회 2020 한국해안해양공학회 논문집 Vol.32 No.6

호형 사주는 동해안에서 흔히 분포하는 지형특징으로 고파랑시를 제외하고 리드미컬한 형상을 지속적으로 유지한다. 하지만, 2019년 9, 10월에 동해안에 직 간접적 영향을 미친 연속적인 4개의 태풍으로 인해 해안선과 평행한 연안사주가 형성되었고 해안선 부근에 침식과 퇴적이 반복되는 패턴을 보였지만 전반적인 해안선 후퇴가 발생하였다(약 2m). 이와 같은 연속적인 폭풍파랑으로 인한 지형변화와 각 폭풍(NE-E 입사파) 이벤트의 영향을 모의하기 위해 폭풍 사상시 해빈의 침식 모의에 널리 사용되는 XBeach를 사용하였다. 개선된 XBeach 수치모의를 위해 최신 계수보정 연구 동향에 따라 계수보정이 실시되었으며, 이로부터 도출된 최적의 계수 값을 수치 모의에 적용하였다. 모델의 입력값으로 사용된 파랑, 조석 및 폭풍 사상 전후 수심 자료와 최적의 계수 값을 활용한 결과, 해안선 부근의 침식 및 퇴적 반복패턴(BSS = 0.77(침식 단면), 0.87(퇴적단면))과 해안선과 평행한 연안 사주의 형성을 성공적으로 모의하였다. 각 태풍의 최대 입사파고 도달 시 수치 모의된 전체 퇴적물 이동 벡터 및 지형변화 분석결과, 입사파향이 호형 사주의 거동에 상당한 영향을 미치는 것으로 나타났다. 또한, 유의파고 크기뿐만 아니라 고파랑의 지속시간 또한 퇴적물 이동량의 중요한 요인으로 판단 된다. 하지만 모델링 결과, 내측 쇄파대(inner surfzone)의 지형변화 및 연안 사주의 마루의 정확한 위치 예측을 위해서는 추가적인 보정과정이 필요함을 시사한다. Crescentic sand bar in the coastal zone of eastern Korea is a common morphological feature and the rhythmic patterns exist constantly except for high wave energy events. However, four consecutive typhoons that directly and indirectly affected the East Sea of Korea from September to October in 2019 impacted the formation of longshore uniform sand bar and overall shoreline retreats (approx. 2 m) although repetitive erosion and accretion patterns exist near the shoreline. Widely used XBeach to predict storm erosions in the beach is utilized to investigate the morphological response to a series of storms and each storm impact (NE-E wave incidence). Several calibration processes for improved XBeach modeling are conducted by recently reported calibration methods and the optimal calibration set obtained is applied to the numerical simulation. Using observed wave, tide, and pre & post-storm bathymetries data with optimal calibration set for XBeach input, XBeach successfully reproduces erosion and accretion patterns near MSL (BSS = 0.77 (Erosion profile), 0.87 (Accretion profile)) and observed the formation of the longshore uniform sandbar. As a result of analysis of simulated total sediment transport vectors and bed level changes at each storm peak Hs, the incident wave direction contributes considerable impact to the behavior of crescentic sandbar. Moreover, not only the wave height but also storm duration affects the magnitude of the sediment transport. However, model results suggest that additional calibration processes are needed to predict the exact crest position of bar and bed level changes across the inner surfzone.

Breakdown characteristics of SF₆ and Imitation Air in Temperature Decline

Lim, Chang-Ho,Choi, Eun-Hyeok,Kim, Do-Seok,Kim, Young-Su,Park, Won-Zoo,Lee, Kwang-Sik The Korean Institute of IIIuminating and Electrica 2007 조명·전기설비학회논문지 Vol.21 No.4

This paper describes experiments of the breakdown characteristics by temperature change of $SF_6$ gas and Imitation Air(I-Air) in model GIS(Gas Insulated Switchgear). From the results of the experiments, the breakdown characteristics classify the vapor stage of $SF_6$ according to Paschen's law, in which the stage of coexistence for gas & liquid of the voltage value increases. This results in large deviation and the breakdown of the voltage(VB) low stage as the interior of the chamber is filled with a mixture of $SF_6$ that is not liquefacted and remaining air that can not be ventilated. The ability of $SF_6$ liquid($LSF_6$) insulation is higher than high-pressurize $SF_6$ gas. The VB of the I-Air decreases as the temperature drops and the VB also drops. It is considered that the results of this paper are fundamental data for the electric insulation design of superconductor and cryogenic equipment that will be studied and developed in the future.