서울 서남부지역 노인 인구에서 비만증 유병률과 고지혈증과의 상관성

최경묵,조영직,김경오,김동림,김난희,백세현,안정천,서홍석,오동주,최동섭 대한노인병학회 2000 Annals of geriatric medicine and research Vol.4 No.3

기존의 치료에 반응하지 않는 다발성 간전이 대장암 환자에서 방사선조사와 병합한 수지상세포 면역치료의 1, 2상 임상시험

최영민(Youngmin Choi),이형식(Hyung-Sik Lee),권혁찬(Hyuk-Chan Kwon),한상영(Sang-Young Han),최종철(Jong-Cheol Choi),정주섭(Ju-Seop Chung),김창원(Chang-Won Kim),김동원(Dong-Won Kim),강치덕(Chi-Duk Kang) 대한방사선종양학회 2008 Radiation Oncology Journal Vol.26 No.2

목 적: 기존치료에 반응하지 않는 다발성 간전이를 동반한 대장암 환자에서 방사선치료와 병합한 수지상세포 면역 치료의 독성과 반응도를 조사하였다. 대상 및 방법: 2004년 5월부터 2006년 11월까지 다발성 간전이가 동반된 대장암 환자들 중에서 항암화학 요법에 반응하지 않은 환자 중 지원자를 대상으로 연구를 시행하였다. 본 임상 시험에 대하여 동아대학교병원과 부산대학교병원의 임상윤리심의위원회의 허가를 획득하였고, 동의서에 서명한 환자들을 임상 시험의 대상으로 등록하였다. 환자의 말초 혈액으로부터 수지상세포를 추출하여 배양하였다. 임상시험 일자에 맞추어서 6×106개의 수지상세포를 바이알(0.5 ml)에 넣어서 디씨백/아이알 주사를 만들었다. 수지상세포 면역치료는 2주 간격으로 간전이암조직에 3회 주사하고, 5주에 내약성 평가를 하였다. 내약성 평가를 통과한 환자에게는 8주에 4번째 수지상세포 면 역치료를 하였다. 병의 악화가 없거나 임상시험에 대한 환자의 동의 철회가 없는 경우에는 5, 6번째 수지상세포면역치료를 각각 12, 16주에 시행하였다. 방사선치료는 수지상세포 면역치료를 주사할 간전이암 부위에 주사하기 전일 및 당일에 4 Gy씩을 조사하였다. 내약성 평가는 3×106개의 수지상세포로부터 시작하여, 12×106개의 수지상세포까지 시행하였다. 내약성 평가의 최대 내성 용량으로 추가 임상시험을 하였다. 수지상세포 면역치료 주사를 맞은 모든 환자들에서 안전성 평가를 하였다. 4회 이상 주사를 맞은 환자들을 대상으로 10주에 치료 반응을 평가하여 유효성을 조사하였다. 결 과: 임상시험에 등록한 24명 중 22명에서 수지상세포 면역치료를 시행하였다. 내성약 평가에는 14명이 등록하여 11명에서 평가를 완료하였다. 시험약과의 관련성이 있을 것으로 생각되는 grade 3 이상의 약물반응으로 인한 이상반응은 없었다. 12×106개의 수지상세포를 내성용량으로 확인하였고, 내성용량인 12×106개 수지상세포 면역치료를 이용하여 8명에서 추가로 시험을 하였다. 치료에 대한 환자들의 내성은 양호하였고, grade 3을 초과하는 치명적인 부작용은 발생되지 않았다. 4회 이상의 수지상세포 면역치료 주사를 받은 환자가 17명이었고, 이 중의15명에서는 종양의 반응도 평가가 이루어졌다. 본 연구의 목적은 안전성 평가이지만, 면역치료의 유효성 평가를 위해, 방사선치료와 수지상세포 면역치료 주사가 시행된 부위 외의 간전이암에서 반응도를 조사 하였다. 면역치료의 반응은 평가가 이루어진 환자들에서 정지성 병변이 4명, 진행성 병변이 11명 이었다. 결 론: 수지상세포 면역치료와 병행한 방사선치료는 이론적으로 국소 및 전신 제어에 상승효과가 있을 것으로 기대할 수 있다. 하지만 기존 치료에 반응하지 않는 매우 진행된 직장암 환자들을 대상으로 한 본 연구에서는 방사선 치료와 병합한 수지상세포 면역치료로 인한 심각한 부작용의 발생은 없었다는 결과와 4예에서의 정지성 병변의 관찰을 보고한다. 수지상세포의 최대 투여 용량, 적절한 투여 방법, 적절한 방사선의 양, 방사선과 수지상 세포의적절한 투여 간격 등에 관한 추가 연구를 통하여, 향후 제 2상, 3상 시험으로서의 진행 여부에 긍정적인 결과를얻을 수 있다고 판단한다. Purpose: To assess the toxicity and tumor response induced by DCVac/IRⓇ dendritic cell (DC) immunotherapy combined with irradiation for refractory colorectal cancer patients with multiple liver metastases. Materials and Methods: Between May 2004 and November 2006, applicants from a pool of refractory colorectal cancer patients with multiple liver metastases were enrolled. The patients were registered after having signed the informed consent form, which had been approved by the Institutional Review Board from the Dong-A University and Busan National University Hospital. DCs were obtained from peripheral blood of each patient, and then cultured in vitro. A total of 6×106 DCs were packed into a vial (DCVac/IRⓇ, 0.5 ml) at the convenience of each patient’s schedule. On the day before and on the day of each vaccination, each patient received a 4 Gy radiation dose to the target tumor. On the day of vaccination, the indicated dose of autologous DCs was injected into the irradiated tumor using ultrasound-guided needle injection procedures. A total of four vaccinations were scheduled at three 2-week intervals and one 4 week interval at the Dong-A University and Busan National University Hospital. If the tumor status was deemed to be stable or responding to therapy, an additional vaccination dose or two was approved at 4 week intervals beyond the fourth immunization. A tolerance test for DCs was conducted by injecting a range of doses (3×106 to 12×106 DCs) after the 3rd injection. Moreover, the maximal tolerable dose was applied to additional patients. Treatment safety was evaluated in all patients who had at least one injection. Treatment feasibility was evaluated by the 10th week by assessing the response of patients having at least 4 injections. For systemic toxicities, the evaluation was performed using the National Cancer Institute Common Toxicity Criteria, whereas adverse effects were recorded using common WHO toxicity criteria. Results: Of the 24 registered patients, 22 received the DCs injections. Moreover, of the 14 patients that applied for the tolerance test, only 11 patients completed it because 3 patients withdrew their testing agreement. A grade 3 or more side effect, which was possibly related to the DC injection, did not occur in additional patients. The 12×106 DC injection was identified as the maximum tolerable dose, and was then injected in an additional 8 patients. Patients tolerated the injection fairly well, with no fatal side effects. In order to assess the feasibility of DC immunotherapy, the response was evaluated in other hepatic lesions outside of the targeted hepatic lesion. The response evaluation was performed in 15 of the 17 patients who received at least 4 injections. Stable and progressive disease was found in 4 and 11 patients, respectively. Conclusion: The DC-based immunotherapy and radiotherapy is theoretically synergistic for the local control and systemic control. The DCVac/IRⓇ immunotherapy combined with irradiation was tolerable and safe in the evaluated cases of refractory colorectal cancer with multiple liver metastases. Future work should include well designed a phase II clinical trials

자속 분포학습에 의한 영구자석 동기전동기의 토오크 리플 저감

이동희,송달섭,원태현 동의공업대학 2001 論文集 Vol.27 No.1

PMSM drives are widely used in the industrial and residential applications because of high efficiency, high power density and high performance. For better performance of PMSM, however, torque ripples should be reduced. This paper investigates a reduction of torque ripple due to the unsinusoidal flux linkage produced by the shapes of stator slot and magnetic pole. To minimize torque ripple, a simple flux estimator is proposed. This method interactively compensates the distributed flux linkage from an error between the measured and estimated currents. The proposed algorithm is verified through simulation.

프로축구팀에 대한 지역주민들의 사회문화적 인식

최동순,이창섭,이종호 충남대학교 체육과학연구소 2006 體育科學硏究誌 Vol.24 No.1

This study is on sociocultural recognition of regional residents for professional football dub, Daejeon Citizen FC. For this 348 persons were participated in survey. Two Analyses were performed : 1) One-way analysis of varience that investigates the significant differences of sociocultural recognition among sex, age, school career, income, and social class, participation degree for soccer activities and interest degree for soccer; 2) multiple regression analysis that investigates the sociocultural cognitions(regional identity, social interaction, cultural life) of regional residents for Daejeon Citizen FC(existence, game, relevance with residents). The result of above analyses gained following conclusions : 1) There are significant differences on sociocultural recognition among sex, social class, participation degree for soccer activities and interest degree for soccer. 2) Game, relevance between residents and Daejeon Citizen FC contribute to reinforcement of regional identity, social interaction and cultural life of residents; existence of Daejeon Citizen FC do not contribute to them instead.

오토폼 소프트웨어를 사용한 원통형상의 드로잉 공정해석

정동원,고형훈,문원섭 제주대학교 공과대학 첨단기술연구소 2005 尖端技術硏究所論文集 Vol.16 No.1

Drawing process at the household goods until industrial site is used in the various filed. This study are drawing process analysis using Auto-Form software which used a Static-implicit time integration method. Analysis simulation result, it was possible to know that choice of a bead and blank size choice can be optimized through a forming analysis. By making apply this to an industrial site the productivity improvement and cost reduction etc. effect able was predicted.

신세대 대학생의 도덕의식 조사 연구

김동섭 公州大學校 産業開發硏究所 1998 産業開發硏究 Vol.6 No.-

Undergraduates who were born in Korea in 1970's have different moral consciousness comparing to one their parent's generation because of the rapid growth of economy and introduction of various kinds of foreign culture. This study is based on a survey from 500 of undergraduates, who are from all over the country and attending the Kongju National University, and a statistical analysis with significance level of 5% was performed. According to the survey, the undergraduates showed healthy moral consciousness on contrary to what had been expected and it can be summarized as follows; 1)the spirit of filial piety and respect should not be changed. 2)the degree of respect toward elderly people is still very high. 3)deep concering about supporing elderly parents was observed, 4)the most popular desired number of children is two. 4)to promote public welfare for popular desired number of children is two. 5) to promote public welfare for elderly people, enhancing the public welfare system and promoting nationwide attention toward respecting elderly ones were chosen as major concerns, and 6) as issues need to be stressed for moral education for the youngsters, manners related to respecting elderly ones, respecting others and selecting polite terms and keeping promises and time were chosen. Based on the study, in order to promote the moral consciousness of the undergraduates with changes of the times, establishing solid policies and showing concerns and guidance from the older generation are desired.

초기계태에서 valproic acid에 의한 신경관 기형 : 입체현미경적 관찰

김동호,조무연,정유남,최영주,이종선,민경수,이무섭 충북대학교 의학연구소 2000 忠北醫大學術誌 Vol.10 No.1

연구목적 ' 항경련제인 valproic acid가 초기계태의 신경관 형성에 영향을 주는 기형유발에 대해 입체현미경하에서 관찰하였다 연구재 료 및 방법 : 백색의 Leghorn의 신선한 수정란을 30-35시간 동안 배양하여 Hamburger & Hamilton 기 5-10기의 초기 계태를 천공 필터를 이용하여 분리하여 6-30시간 동안 CO2 세포 배양기에서 배양하였고 무작위로 대조군과 실험군을 분류하였다. 실험군은 valproic acid 의 RPMI culture media 의 농도에 따라 100 ㎍/㎖, 200 ㎍/㎖, 500 ㎍/㎖, 1000 ㎍/㎖ 네가지 군으로 분리하였다. 각각의 대조군과 valproic acid를 처치한 실험군에서 입체 현미경하에서 초기계태의 신경관 형성의 형태학적인 특징과 기형형성의 빈도를 비교하였다. 결과: valproic acid가 없는 RPMI media에서 배양된 대조군은 24개의 계태는 22(91.7%)개는 정상으로 자랐으며 2(8.3%)개는 비정상으로 자랐다 이에 반하여 valproic acid가 처치된 RPMI media에서 배양된 72개의 계태는 42(58.3%)개가 비정상으로 자랐다. 주로 확인된 이상 형태는 신경주름의 변형. 신경관 폐쇄부전, 체절의 장애 및 발육 정지 등 이었다. 계태의 기형 형성은 valproic acid의 농도에 비례하여 증가하였다. valproic acrid 의 농도가 100 ㎍/㎖인 경우 18개 계태 중 2(11.1%)개에서 경미한 신경관 기형이 나타났으며 200 ㎍/㎖인 경우 18개 계태 중 11(61,1%)개는 정상, 7(38.9%)개는 명백한 신경관 기형이 나타났으며 500 ㎍/㎖인 경우 18개의 계태 중 5(27.8%)개는 정상. 13(72.2%)개는 명백한 신경관 기형을 나타냈다. 1000 ㎍/㎖인 경우 18(100%)개 모두 심한 신경관 기형이 나타났다. 결론: valproic acid는 초기계태에서 신경관 기형을 유발 했는데 저농도에서는 일부 경미한 신경관 이상을 보였고 고농도에서는 대부분 심한 신경관 손상을 동반하고 성장 속도가 둔화되어 약 용량의 증가에 따라 기형이 증가되는 dose-dependent manner 로 그 영향이 나타났다. Purpose : The teratogeruc effects of valproic acid widely used as anticonvulsant on the neurulation of the explanted eraly chick embryos were observed by the stereoscope. Materials and Methods: Fresh fertilized white leghorn hen eggs were incubated for 30-35 hours in an e99 incubator. The Hamburger and Hamilton stage 5-10 chick embryos were explanted using the punched-out filter paper explantation technique and cultured in the CO2 cell culture incubator for 6-30 hours. They were randomly divided into a control group and an experimental group. The experimental group was divided into four subgroups according to the valproic acid concentrations of 100 ㎍/㎖, 200 ㎍/㎖, 500 ㎍/㎖, 1000 ㎍/㎖ with which the RPMI culture media were treated. The morphological characteristics and the incidences of teratogenic effects on the neurulation of early chick embryos in the control and experimental groups were compared with each other using the stereomicroscope. Results : Of the 24 chick embryos cultured in the RPMI media without valproic acrid, 22 embryos(91.7%) developed normally, and 2 embryos (8.3%) developed abnormally, in contrast, among 72 embryos cultured in the valproic acrid-treated media, 42 embryos(58.3%) developed abnormally. The frequent anomalous features were deformities of the neural folds, failure of neural tube closure, derangement of somites, and developmental arrest. Of 18 embryos cultured in the media treated each with 100㎍/㎖ of valproic acid, 2 embryos(11.1%) showed mild abnormality of neural tube defect on stereoscopic examination. Of 18 embryos cultured 7l the media treated each with 200㎍/㎖ of valproic acid, 11 embryos(61.1%) developed normally for 20 hours and 7 embryos (38.9%) showed definite neural tube defect. Of 18 embryos cultured in the media 7reated each with 500㎍/㎖ of vaIprolc acid, 5 embryos(27.8%) developed normally (or 20 hours and 13 embryos (72.2% ) showed definite neural tube defect. Of 18 embryos cultured in the media treated each with 1000㎍/㎖ of valproic acid, 1 embryo developed normally for 4 hours but all embryos (100%) showed severe neural tube defect on whole brain after 8 hours of culture. Conclusion : Valproic acid induced mild neural tube defects in low concentration and in high concentration of valproic acid, most chick embryos developed slowly and showed severe neral tube defects. The frequency and severity of abnormal embryos ulcreased in dose-dependent manner.

KC80196을 이용한 Profibus Interface Card 구현

송동섭,신동렬 成均館大學校 科學技術硏究所 1999 論文集 Vol.50 No.1

Due to the advances in data communication and hardware technology, many centralized control systems have been replaced by distributed digital systems. Fieldbuses are low level industrial networks and are currently undergoing enormous revolution. Industries have recently observed lots of applications using fieldbus networks. Profibus is one of fieldbus currently available. In this paper we describe the interface between the applications and the Profibus network and then implement an interface card on DIN 19 245 Profibus Standard. We show that this implementation is a useful technique of converting serial communication to intelligent polling network as well as the efficient and simple design.

PMSM의 저속운전 및 기동성능 개선을 위한 선형 엔코더

이동희,송달섭,원태현 동의공업대학 2001 論文集 Vol.27 No.1

PMSM(Permanent Magnet Synchronous Motor) drives are widely used in the industrial applications and home appliances because of high torque ratio, high efficiency and precise control performance. In recent years there has been a significant development of PMSM motors of various kinds. Improvements in the properties of permanent magnet materials have increased the viability of related types of motors. However, precise speed and position information is essential for the good control performance. In order to produce correct torque, the rotor flux position information from position sensor has to be identified. In this paper, a low cost position sensor is proposed for improving of starting and low speed performance of PMSM. The proposed position sensor produces a linear analog signal that is proportional to the electrical rotor position. The information of initial rotor position at the starting instance and accurate position in the low speed can be obtained with the proposed encoder. The performance of the proposed encoder is verified with experimental results.

TCP/IP 상의 국제생산메시지규격(MMS)을 이용한 공장 통신망 시스템의 설계 및 구현

김동성,김윤섭 금오공과대학교 2008 論文集 Vol.29 No.-

This paper consider a design and implementation of a factory communication systems using the manufacturing message specification (MMS) on TCP/IP protocol suite. The proposed method provides a common factory communication system for networked automation equipments. The implemented overall system can be used for a design framework of factory communication systems using .MMS on TCP/IP.