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B형 간염 동반 원발성 간암 환자에서의 CYP2D6와 NAT2 다형현상에 관한 연구
신동일,이광수,최연남,황기은,조율희 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.2
The CYP2D6 and N-acetyltransferase (NAT2) are polymorphic enzymes which are expressed in the hepatocyte in a genotype-determined manner. CYP2D6 and NAT2 are known to be involved in the inactivation and activation of various mutagens and carcinogens, respectively. The activities of the two enzyme systems are associated with the genetic susceptibility of many human cancers. This study was performed to determine the genotype frequencies of the two enzyme systems in primary hepatocellular carcinoma patients and healthy controls. One hundred healthy controls and 55 liver cancer patients were analyzed by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP). The results are as followings:1. In the healthy controls, CYP2D6 wild type allele frequency was 0.985 and CYP2D6^*4 frequency was 0.015, and no CYP2D6 poor-metabolizer was detected. No significant differences were found in hepatocellular carcinoma patient group. 2. Frequencies of F, S1, S2 and S3 alleles of NAT2 system were 0.725, 0.01, 0.14 and 0.125 in controls, respectively. The genotype frequencies were found to be 0.91 of rapid acetylator and 0.09 of slow acetylator. No significant differences were found in hepatocellular carcinoma patient group. 3. These results suggest that the distribution of CYP2D6 and NAT2 polymorphisms is very unique in Korean populations characterized by extremely low frequency of CYP2D6 poor-metabolizer and NAT2 slow acetylator. CYP2D6 and NAT2 polymorphisms seemed not to play an important role in the hepatic carcinogenesis in Korean population.
(Shin Taek Oh),(In Gang Jang),(Sung Wook Kim),(Baik Kee Cho),(Seung Dong Lee) 대한피부과학회 2002 Annals of Dermatology Vol.14 No.1
N/A Hobnail hemangioma(HH)is a benign acquired vascular tumor of endothelial origin which should be differentiated from other malignant vascular neoplasm such as Kaposi`s sarcoma or angiosarcoma.We report a case of hobnail hemangioma in a 21-year-old woman who had a dusky-red patch on her left shin.Histologically,ectatic vascular channels with a single layer of plumped endothelial cells were seen and the vascular channels seemed to dissect the collagen bundles.She underwent treatment with surgical excision with primary closure. (Ann Dermatol 14(1)45-47, 2002).
김동출,신은택,이동명,이윤경,기근홍 조선대학교 부설 의학연구소 1998 The Medical Journal of Chosun University Vol.23 No.2
Bilateral renal agenesis is an uniformly lethal malformation occurring in 1-2/10000 birth. This condition is associated with severe oligo-hydroamnios, intrauterine growth retardation, pulmonary hypoplasia and extrarenal anomalies. We experience a case of bilateral renal agenesis associated with agenesis of both ureters and bladder, and single umbilical artery. But the infant had normal pulmonary development. Specific IgM for herpes virus in maternal serum was detected.
인터넷을 통한 동기화 된 캡션 및 동영상 데이터베이스에 관한 설계 및 구현
홍동권,박기현,신승봉 계명대학교 산업기술연구소 1998 産業技術硏究所 論文報告集 Vol.21 No.1
Current information society requires effective ways to process multimedia data like image, audio, video and so on, Many public of private information providers gather, store multimedia information and supply a different kind of multimedia data to users in everywhere. Most of users nowadays access multimedia data via internet. Audio and video data are usually transmitted to users by using streaming technology for instant replay. In this paper, we investigate database design techniques for effective retrieval of video segment and replay method of retrieved videos, Especially we shows the design and implementation technique for closed captioning of streaming file.
換氣窓이 설치된 中庭形 아트리움의 여름철 熱環境에 관한 測定硏究
김영철,신기식,박상동,최무혁 대한건축학회 2004 대한건축학회논문집 Vol.20 No.6
The atrium in a building is a popular design skill due to its aesthetic, open appearance. It is relatively inexpensive to build and maintain atrium, and also we can expect energy saving effect. But its indoor space is thermally different from typical space because of its tall and large shape with top light. The upper part of atrium has the thermal problem of overheating during summer season. As one of the measures to solve this problem, the ventilation windows near the top light can be used. In this study, the vertical temperatures in the atrium were measured and analysed to understand the thermal environment in the atrium and the effect of ventilation window to reduce the overheating at the upper part of atrium. The ventilation windows were proved to have the effect to lower the temperature of the upper part of atrium as 3.8℃ at the condition of outdoor air temperature of 28℃.