지중내 공동 탐지를 위한 비파괴 검사 기법에 대한 실험적 연구

유정동(Jund Dong?Yoo),양학모(Hak Mo?Yang),장기창(Ki Chang?Jang),강승민(Seung Min?Kang),조소현(So Hyun?Cho),김현기(Hyun-Ki?Kim),Seung Soo?Kim,Da Bin?Jin 대한토목학회 2018 대한토목학회 학술대회 Vol.2018 No.10

조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성

김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.

韓國河川의 流出率과 流出指標로서의 洪水直前 流量

金熙鍾,柳又秀,金佳鉉,申東守,韓健模,全裕燦 東亞大學校 大學院 1984 大學院論文集 Vol.9 No.-

This paper is a study on relation between run-off ratio and antecedent discharge, run-off ratio and antecedent discharge per unit area, antecedent discharge and antecedent precipitation, by the data from the five major river basins in Korea and the small river basins in Pusan. The Nak-Dong rivers(An-Dong upper stream) f=0.4780+0.0124 ln qA r=0.99 qA=0.3368e0.1101R r=0.99 f=0.5793+0.0146 ln(qA/A) r=0.99 The Nak-Dong rivers except Ga-song station f=0.2017-0.0840 ln qA r=0.75 f=0.7012+0.0750 ln(aA/A) r=0.71 The Han rivers f=-0.0035+01267 on qA r=0.75 f=1.1311+0.1263 ln(qA/A) r=0.71 L=302.9064-43.8490 ln qA r=0.84 The Geun rivers(Mu-sin Cheon) f=0.295+0.1823 ln qA r=0.93 f=0.8417+0.1823 ln(qA/A) r=0.93 L=40.0456+62.0346 ln qA r=0.94 The Yeong-san rivers f=0.3766+0.0598 ln qA r=0.79 f=0.8084+0.0599 ln(qA/A) r=0.79 The Seom-jin rivers f=-1.3875+0.6505 ln qA r=0.92 f=2.1633+0.3465 ln(qA/A) r=0.76 Small river basin in Pusan f=0.3635+0.1120 ln qA r=0.87

조혈모세포이식 환자에서 발생한 Cytomegalovirus 질환의 특징 : 일개 대학변원에서 최근 10년간의 경험

최수미,이동건,박선희,김시현,김유진,민창기,김희제,이석,최정현,유진홍,김동욱,이종욱,민우성,신완식,김춘추 대한감염학회 2009 감염과 화학요법 Vol.41 No.1

Background : Studies on cytomegalovirus (CMV) diseases in Korean hematopoietic stem cell transplant (HSCT) recipients are lacking and do not reflect the recent trends of advances and changes. Therefore, we tried to analyze the clinical features of CMV diseases in HSCT recipients over the past 10 years at a tertiary university hospital in Korea. Methods : Retrospective review of medical records was done for all adult HSCT patients who received transplant at the Catholic HSCT Center from January 1998 to January 2008. Results : Forty-four cases (2.2%) of CMV diseases were identified. CMV pneumonia was diagnosed in 17 patients, retinitis in 16 patients, enterocolitis in 7 patients, esophagitis 1 patient, gastritis in 1 patient, duodenitis in 1 patient, and hepatitis in 1 patient. The median onset of symptom was 90 days after transplantation. Late CMV diseases accounted for 47.7%. CMV related death varied from 0 to 58.8% according to the involved organ. CMV retinitis was diagnosed relatively later in the course of transplantation mostly in patients who had chronic graft versus host disease (GVHD). On the contrary, CMV enterocolitis mainly occurred in patients who suffered from acute GVHD. The overall concurrent CMV reactivation was documented to be 63.6%: the concurrent CMV reactivation was observed only in 37.5% of patients with retinitis. Conclusions : We observed some differences in the pattern of CMV disease manifestation according to the involved organ and reconfirmed the fact that CMV pneumonia is the most common and fatal disease in HSCT recipients. Additionally, CMV retinitis was not uncommon in HSCT recipients. Since specific marker does not exist in predicting retinitis, regular ocular examination should be done thoroughly, especially in patients with chronic GVHD.

Characterization of a Constitutive β-Lactamase from a Pseudomonas aeruginosa

유진홍,허동호,최정현,김양리,신원식,강문원 대한화학요법학회 1996 대한화학요법학회지 Vol.14 No.2

Objective : We analyzed some physicochermical chracteristics of a constitutive β-lactamase from a clinical isolate of a Pseudomonas aeruginosa which resistant to various β-lactams except imipenem and susceptible to aminoglycosides the proportion of its contribution to such resistance profile. Method : 1. Antimicrobial susceptibility test was done by the broth dilution method. 2. In hibition profile was done using EDTA, HgCl₂ and p-chloromercuribenzoate (pCMB). We also measured 50% inhibitory concentration(IC??) using β-lactamase inhibitors, such as clavulanic acid, sulbactam. 3. Kinetics study for substrate profile was performed by spectrophotometric assay using crude extracts and various antimicrobial agents. Relative hydropysis rates were determined. 4. The isoelectric point(pI) was determined by isoelectric focusing. The molecular weight was estimated by SDS-polycrylamide gel electrophoresis. Results : 1. The strain was resistant to ceftriaxone, sulperazon, piperacillin, ceftazidime, and aztreonam, while it was susceptible to gontamicin, tobramycin, amikacin and imipenem. 2. The β-lactamase was not inhibited by EDTA, and pCMB, whereas it was inhibited by HgCI₂. The IC?? of clavulanic acid was over 100μM and that of sulbactam was 22μM. 3. The relative maximal hydrolysis rate was calculated by setting V_(max) for cephaloridine at 100. The enzyme hydrolyzed cephalosporins more rapidly than penicillins. 4. The pI was 9.3 by isoelectric focusing. The molecular weight was estimated to be 40kDa. Conclusion : According to its substrate profile, pI and molecular weight, the β-lactamase from a clinical isolate of P. aeruginosa was a cephalosporinase belonging to group 1 in the Bush-Jacoby-Medeiros classification scheme.

Microarray 의 Hybridization 최적화에 대한 연구

유동현,정인숙,이용성 漢陽大學校 精神健康硏究 2000 精神健康硏究 Vol.19 No.-

중학교 과학 분야(과)에 대한 7차 교육 과정 중 화학 단원의 비교 분석에 관한 연구

유광식,이동현 울산대학교 2003 자연과학논문집 Vol.13 No.1

제7차 교육 과정에 대한 중학교 과학과의 교육 목표와 과학 교과서 및 교사용 지도서의 화학 단원에 대한 학습 목표를 Klopfer의 과학 교육 목표 분류 체계를 이용하여 비교 분석하였고, 본 과정의 개선 및 시행에 필요한 자료를 얻고자 하였다. 분석 결과는 다음과 같았다. 1. 제7차 교육 과정의 중학교 과학과 교육 목표는 Klopfer의 과학 교육 목표 분류 체계의 범주에서 G.0을 제외한 전 범주에 걸쳐 그 목표를 설정하고 있으며, 범주 A.0~E.0과 F.0, H.0, I.0의 비중 등은 높게 나타났다. 2. 제7차 교육 과정의 중학교 과학 교과서는 1, 2학년 모두 과학적 태도 및 흥미(H.0)에 관한 요소나 목표가 전혀 언급되고 있지 않기 때문에 과학에 대한 흥미를 잃게 하지 않을까 우려 된다. 과학에 대한 경향성(I.0)의 목표 역시 언급되어 있지 않아서 정의적 영역의 목표가 소외되어 있음을 알 수 있었다. 지식과 이해(A.0)에 관한 목표는 84.8%로 지나치게 편중되어 있는 반면에 과학 지식과 과학적 방법의 적용(F.0)에 관한 목표는 5.9%로서 낮았으므로 중학교 과학 교과서의 화학 단원이 실생활과 관련이 적은 내용으로 구성되어 있음을 알 수 있었다. 3. 제7차 교육 과정의 중학교 과학과 교사용 지도서의 지식과 이해에 관한 목표 비율은 83.0%로서 47% 정도를 제안하고 있는 미국 NSTA(National Science Teachers Association, 1982)의 권장 비율보다 월등 높은 것을 알 수 있었다. 과학적 탐구 과정(B.0~E.0)에 관한 목표 비율은 11.0%로서 NSTA(1982)의 권장 비율 30%에 비해 낮음을 알 수 있었다. The educational objectives of science on the 7th curriculum and the learning objectives for the chemistry domain of the middle school science textbooks and teacher's guides on the 7th curriculum were comparatively analyzed by use of Klopfer's Taxonomic system. This study tries to obtain data for improving and operating of the 7th curriculum. The analytical results are as follows. 1. The educational objectives of middle school science on the 7th curriculum include all of the categories of Klopfer's Taxonomic system except G.O. A.0~E.0, F.0, H.0, and I.0 were shown in high level. 2. Attitudes and interests(H.0) wasn't described at all in the middle school science textbooks on the 7th curriculum for 1 and 2 year course of middle school and it showed responsible for losing the interest of science. Orientation(I.0) wasn't also described. It showed that the affective domain was alienated. It seems to be overemphasized that knowledge and comprehension (A.0) are 84.8%. Scientific knowledge and methods(F.0) was contained only 5.9% in the textbook. This fact showed that the chemistry domain of the middle school science textbooks consists of some irrelevant contents to the actual life. 3. Knowledge and comprehension of the middle school science teacher's guides on the 7th curriculum was described 83.0% which is higher than 47% of NSTA(National Science Teachers Association, 1982). Processes of scientific inquiry(B.0~E.0) was only 11.0% which is lower than 30% of NSTA.

전자상거래의 비용우위 효과에 관한 소비자 지각 : 인터넷 쇼핑몰 이용자를 중심으로 Concentrated on Consumers' Perceptions on the Internet Shopping Mall

유동근,서영호,조임현 한국경영과학회 1999 한국경영과학회지 Vol.24 No.4

Since the Internet was applied for commercial purpose, many companies have been making use of the internet in electronic commerce and the internet has brought many changes on consumer and supplier behaviors. It seems that consumers and suppliers can obtain more accurate information rapidly and pay less for the same product/service than in traditional commerce. This study tries to investigate the difference in the cost factors perceived by consumers between traditional commerce and the Internet commerce. Empirical results show that there is no significant difference in consumers' perception of cost factors between traditional commerce and the internet commerce Contrary to general perception, a large number of consumers do no, believe that the internet commerce is generally more economical than traditional commerce. The factors where the consumers think Internet commerce has cost advantages are search cost and purchasing cost. However, consumers are understanding the benefits of the internet commerce and are expecting that internet commerce bring about economic advantages in consumer markets in the near future.

연약지반 위에 시공되는 교대의 측방유동에 대한 안정성 평가

유남재,김동건,전상현 江原大學校 産業技術硏究所 2010 産業技術硏究 Vol.30 No.B

In this paper stability about lateral soil movement of bridge abutment constructed on the soft ground, reinforced with the sand compaction pile (SCP) and the preconsolidaton methods, was evaluated by using the centrifuge testing facility which stress conditions in field could be reconstructed in the laboratory. The layouts of model such as ground condition, sand compaction piles and abutment was determined on the basis of similitude law with the reduced scale of 1/200. Construction sequences of installing SCP, preparing reclaimed ground, preconsolidating ground and building the piled bridge abutment were reconstructed during centrifuge modelling and measurements of movement were followed in each sequence. From analyzing the results of measuring movements of the model abutment and the ground, measured lateral movement of model abutment was found to be within the allowable value so that stability of abutment against lateral sliding was secured.

내시경적 절제로 진단된 폴립 형태의 심재성 낭종성 위염 2예

허종현,조영화,성용완,유재훈,구동영,김갑식,노지훈,문원 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2

Gastritis cystica profunda (GCP) is a disease characterized by hyperplastic and significant extension of cystic dilatation of the gastric mucous glands, which results in a cystic lesion in gastric submucosa. It often occurs on the part of gastroenterostomy, but can be found in the stomach without any previous surgery. GCP has variable gross finding including solitary polyps, diffuse ones, submucosal tumors, and rare giant gastric mucosal fold. It is difficult to tell GCP from a cancerous lesion by gross finding that the disease demands a necessary tissue biopsy, though GCP is commonly showed as a benign in the progress. We report a case of GCP in polypoid types diagnosed by endoscopic polypectomy.