족과관절염좌 환자에 대한 동씨침법과 일반침법의 효과에 대한 비교 연구

안호진,정동화,황규선,윤기붕,김태우,문장혁,백종엽,이상무,Ahn, Ho-jin,Jeong, Dong-hwa,Hwang, Kyu-seon,Yoon, Ki-bung,Kim, Tae-woo,Moon, Jang-huyk,Baek, Jong-yeob,Lee, Sang-moo 대한침구의학회 2003 대한침구의학회지 Vol.20 No.1

Objective: The purpose of this study is to compare the effects of Dong-si acupuncture therapy and General acupuncture therapy for the patients with acute ankle sprain. Methods : This study has been carried out for 60 cases of ankle sprain patients who have visited Dong-Seo Oriental medical Hospital from May 1, 2002 to September 30, 2002. We have treated 30 cases of them by Dong-si acupuncture therapy and the other 30 cases by General acupuncture therapy. And we have compared those two group. Results : 1. There was no significant difference at the treatment period and the number of treatment times in comparing two groups. 2. The number of treatment times for good effect is that : Dong-si took $1.57{\pm}0.85$ times and General acupuncture therapy took $2.15{\pm}0.96$ times. And we have found that the effect of Dong-si acupuncture therapy is faster than the other.

NGS_SNPAnalyzer: a desktop software supporting genome projects by identifying and visualizing sequence variations from next-generation sequencing data

Dong‑Jun Lee,Taesoo Kwon,Chang‑Kug Kim,Young‑Joo Seol,Dong‑Suk Park,Tae‑Ho Lee,Byung‑Ohg Ahn 한국유전학회 2020 Genes & Genomics Vol.42 No.11

Background Sequence variations such as single nucleotide polymorphisms are markers for genetic diseases and breeding. Therefore, identifying sequence variations is one of the main objectives of several genome projects. Although most genomeproject consortiums provide standard operation procedures for sequence variation detection methods, there may be differencesin the results because of human selection or error. Objective To standardize the procedure for sequence variation detection and help researchers who are not formally trainedin bioinformatics, we developed the NGS_SNPAnalyzer, a desktop software and fully automated graphical pipeline. Methods The NGS_SNPAnalyzer is implemented using JavaFX (version 1.8); therefore, it is not limited to any operatingsystem (OS). The tools employed in the NGS_SNPAnalyzer were compiled on Microsoft Windows (version 7, 10) andUbuntu Linux (version 16.04, 17.0.4). Results The NGS_SNPAnalyzer not only includes the functionalities for variant calling and annotation but also providesquality control, mapping, and filtering details to support all procedures from next-generation sequencing (NGS) data to variantvisualization. It can be executed using pre-set pipelines and options and customized via user-specified options. Additionally,the NGS_SNPAnalyzer provides a user-friendly graphical interface and can be installed on any OS that supports JAVA. Conclusions Although there are several pipelines and visualization tools available for NGS data analysis, we developedthe NGS_SNPAnalyzer to provide the user with an easy-to-use interface. The benchmark test results indicate that theNGS_SNPAnayzer achieves better performance than other open source tools.

실험연구 : 마우스에서 Procaine 투여에 의한 Cisplatin 신독성의 완화 기전

안도환 ( Do Whan Ahn ),김상래 ( Sang Rae Kim ),하동호 ( Dong Ho Ha ),김세환 ( Se Hwan Kim ) 대한마취과학회 2007 Korean Journal of Anesthesiology Vol.52 No.3

Background: Procaine binds to DNA and reduces cisplatin nephrotoxicity, but the mechanism is poorly understood. We explored whether procaine amelioration of cisplatin nephrotoxicity was related to down-and/or up-regulation of inflammatory response gene tumor necrosis factor-α (TNF-α), oxidative stress indicator gene heme oxygenase-1 (HO-1) or cell cycle inhibitor gene p21. Methods: Cisplatin and procaine were intraperitoneally injected to mice at a single dosage of 16 and 80 mg/kg, respectively. Renal evaluation was performed 72 hours after cisplatin administration. The expression of transcripts and proteins was analyzed using real time RT-PCR and Western blot, respectively. Results: Procaine treatment moderately attenuated necrotic changes of renal proximal tubules and increases in BUN and creatinine concentration by cisplatin administration. Kidney platinum level between the cisplatin (cis) group and the cisplatin + procaine (CisPro) group was not different. Although the level of TNF-α mRNA increased 4-fold higher in the Cis group than in the control, this increase was not attenuated by procaine treatment. Gene expression of p21 and HO-1 was elevated 175 and 4-times higher in the Cis group than in the control, respectively. But their expression was no further elevated, rather significantly reduced in the CisPro group compared to the Cis group. Protein abundance of p21 and HO-1 was paralleled by their respective mRNA expression. Conclusions: Procaine amelioration of cisplatin nephrotoxicity is likely to be achieved through processes other than the regulation of TNF-α, HO-1 or p21 gene expression. (Korean J Anesthesiol 2007; 52: 318~27)

정신분열병 및 정신분열형 장애에 대한 올란자핀의 효과와 안전성

안용민,강대엽,권준수,김창윤,김철응,반건호,신영민,이기철,이동우,이중서,조현상,채정호,김용식 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.4

연구목적 : 본 다기관 공동임상연구는 국내 환자를 대상으로 새로운 항정신병약물인 올라자핀의 치료 효과와 안전성을 확인하고자 시행되었다. 방 법 : 1999년 7월부터 2000년 3월까지 국내 10개 병원에 방문한 정신분열병 및 정신분열형 장애 105명을 대상으로 비대조 개방 임상연구를 시행하였다. 중등도 이상의 정신병 증상을 지니거나, 부작용으로 약물교체가 필요한 경우 또는 기분장애 증상의 치료가 필요한 환자를 대상으로 하였다. 2∼7일간의 약물 배설기간 후에 1일 10mg의 올란자핀을 투여하였고, 이후로 3∼7일 간격으로 용량을 조절하여 총 8주간 투여하였다. 치료 효과는 PANSS(Positive and Negative Syndrome Scale), BPRS(Brief Psychiatric Rating Scale), CGI(Clinical Global Impression-Severity), MADRS(Montgomery-Asberg Depression Rating Scale), HAM-A(Hamilton Rating Scale for Anxiety)로 판정하였다. 안전성 평가는 자발적인 이상반응 보고, 활력징후와 혈액 검사 및 SAS(Simpson-Angus Scale), BARS(Barnes Akathisia Rating Scale), AIMS(Abnormal Involuntary Movement Scale)척도를 이용하였다. 결 과 : 105명중에서 85.7%인 90명이 8주간의 치료를 완료하였다. 평균 최빈 용량은 일일 16.1(±4.7)mg이었고, 종료시점에서의 BPRS전체 점수가 기저 상태에 비해 40%이상 감소된 반응군은 69.5%이었다. PANSS의 양성 증후군과 일반정신병리 뿐만 아니라 음성 증후군 소척도에서도 유의한 감소를 보였으며, 이 감소들은 치료 초기부터 나타나서 8주간 지속되었다. 43.8%의 피험자가 중등도 이상의 우울증상을 같이 지니고 있었으며, 올란자핀에 의해 MADRS와 HAM-A가 유의하게 감소하였다. 치료 기간 동안에 활력징후에는 뚜렷한 변화가 없었으나 체중은 8주간 지속적으로 증가하였다. SAS와 AIMS는 감소하였으며, 정좌불능증을 제외한 나머지 추체외로 증상의 발생비율도 낮았다. 임상적인 증상이나 징후를 동반하지 않는 ALT/SGPT의 상승을 보였지만 프로락틴을 포함하는 대부분의 혈액 검사상 뚜렷한 이상 변화는 없었다. 결 론 ; 비록 본 임상연구가 비대조 개방 임상연구로서 많은 제한점을 가지고 있지만, 올란자핀이 기존 약물에 내약성을 보이거나 기분증상을 동반하는 정신병에 치료 효과가 있었다. 그리고 기존 항정신병약물 치료시에 문제가 되었던 추체외로 증상과 고프르로락틴 혈증을 포함하는 대부분의 부작용면에서 안전성을 보여 주었다. Objective : This multicenter clinical trial was carried out to investigate the efficacy and the safety of olanzpine for the treatment of Korean patients. Mothod : 105 patients with schizophrenia and schizophreniform disorder, visited at 10 mental or university hospitals, had received an open and non-comparative treatment with olanzapine for 8 weeks. Patients had psychotic or depressive symptoms with the severity above moderate degree or intolerable side effects to previous antipsychotics. After a wash-out period of 2-7 days, 10mg olanzapine was prescribed initially to all the patients, and then the dosage could be adjusted within the range of 5-20mg/day of olanzapine by 3-7 days. Results : 90(85.7%) of 105 patients completed the 8-weeks trial and the mean modal dose of olanzapine was 16.1(±4.7%)mg/day. At the end of the trial, 73 patients(69.5%) were classified as responder, which was defined as 40% or more improvement in BPRS(Brief Psychiatric Rating Scale) score comparing to baseline. There was a significant reduction in the scores of PANSS(Positive and Negative Syndrome Scale)and subscales including negative symptom scores and CGI. Also weekly analysis showed that the reductions in scores were kept on for the whole period of the trial. 43.8% of all the patients had depressive symptoms at the baseline and total scores of MADRS(Montgomery-Asberg Depression Rating Scale) and HAM-A(Hamilton Rating Scale for Anxiety) were also reduced after the trials. Vital signs revealed no clinically significant changes but continuous weight gain was observed during the treatment with olanzapine. The scores of SAS(Simpson-Angus Scale) and AIMS(Abnormal Involuntary Movement Scale) for assessing the EPS(extrapyramidal symptoms)and tardive dyskinesia respectively were significantly decreased and only a few patients reported EPS as adverse events. Although mild and clinically non-significant of ALT/SGPT was observed, most laboratory parameters including plasma prolactin level showed to significant changes during the trial. Conclusions : Although this trial had many limitations because it was a non-comparative and open study, olanzapine showed high efficacy on the positive, negative and depressive symptoms in schizophrenia and schizophreniform disorder.In addition to that, olanzapine showed a substantially favorable safety profile, such as low incidence of EPS and hyperprolactinemia.

經口的 Steroid 性 避姙劑의 長期服用이 韓國女性의 血淸中 Lipoprotein 과 High Density Lipoprotein Cholesterol 含量에 미치는 效果

安東皓,郭春植,鄭春浩 慶北大學校 醫科大學 1981 慶北醫大誌 Vol.22 No.1

한국 경산군에 거주하는 여성 중 경구 피임제를 복용한 78명을 복용 기간에 따라 4개군으로 나누어 혈청중 very low density lipoprotein, 및 low density lipoprotein과 high density lipoprotein cholresterol함량을 조사하여 같은 지역에 거주하는 피임제 복용하지 않은 여성 19명의 lipoprotein, 분획high 및 density lipoprotein cholesterol량과 total cholresterol량을 비교하였다. 피임제 norinyl-1의 사용 후 12∼24개월군, 25∼60개월군, 61∼120개월군, 121∼180개월군의 각군과 대조군 사이에 lipoprotein 및 high density lipoprotein cholresterol과 total cholresterol 함량차는 유의하지 않았으며 각 군간 사이에도 유의한 차는 발견되지 않았다. It is well known that the occurrances of atherosclerosis among Koreans are far less frequent than in the Europeans or Americans. After a prolonged research on the concentration of cholesterol in blood and occurrances and sites of atherosclerosis among the Japanese, the team from Cornell University found that the disease starts among the Japanese later in age than their counterparts in Europe and that the initial site is the brain arteries rather than the coronary. Clinical observations also indicated that the disease started in the brain artery among Koreans, too, which might be a common phenomenon of the Orientals. It is also generally known that the onset of the disease in female immediately after menopause owing to estrogen decrease in blood. The use of steroid contraceptives in women might affect both metabolism of estrogen and lipid fractions in the blood. In the past, partial research was conducted on lipids fractions among the women on oral contraceptives. But few of such studies were made among Korean women who are under different factors of diet, climate, and genes. This study is to determine the lipid fractions in the blood of Korean women who have been on prolonged usage of the contraceptives and to detect the early findings of any changes in lipids. 78 women on oral contraceptives and 19 normal subjects matched for parity entered this study. 78 subject were divided into 4 groups according to their duration of oral pill application. Blood samples were collected at Kyungsan Health Center in the morning before breakfast. Serum lipoproteins were determined by the method of Sakurabayashi and Kawai, total cholesterol by the method of Levinson, and high density lipoprotein cholesterol by the method of Lopes-Virella. Values of serum very low density lipoprotein, low density lipoprotein, total cholesterol, and high density lipoprotein cholesterol were respectively 104.9±5.3mg/dl, 216.6±10.1mg/dl, 153.3±4.4mg/dl, and 54.1±2.Omg/dl, in normal subjects. Mean VLDL, LDL, total cholesterol, and HDL-cholesterol in women receiving oral contraceptives for 12-24, 25-60, 61-120, and 121-180 months were respectively as follows; VLDL, 99.1±7.5mg/dl, 104.0±12.3mg/d1, 95.7±7.1mg/dl, and 109.0±18.9mg/dl, LDL; 235.5±15.7mg/dl, 244.0±18.1mg/dl, 242.2±14.9mg/dl, and 210.1±19.Omg/dl, total cholesterol; 162.2±5.Omg/dl, 157.4±7.5mg/dl, 157.4±6.1mg/dl, and 165.5±9.5mg/dl, HDL-cholesterol; 52.8±1.8mg/dl, 50.4±2.3mg/dl, 56.0±2.3mg/dl, and 55.0±2.5mg/dl, No significant differences were observed between women on oral contraceptives and control.

한국사람 손등피부신경의 분포 양상

안동춘,황규성,백두진,한승호,정호삼 대한체질인류학회 1999 해부·생물인류학 (Anat Biol Anthropol) Vol.12 No.1

한국사람 손등피부신경의 분포양상을 알아보기 위해 59구(남자 39, 여자 20)의 시체에서 113예(오른손 58/ 왼손 55)의 손등을 해부하여 관찰하였다. 분포유형은 노선경의 분포영역을 기준으로 자신경과의 분포 범위에 따라 구분하여 다음과 같은 결과를 얻었다. 1. 노신경과 자신경으로 이루어진 손등피부신경의 분포양상은 10가지 유형이 관찰되었다. 2. 노신경이 셋째손가락 노쪽절반까지, 자신경이 셋째손가락 자쪽절반까지 이르는 경우(제VIII형)가 33.9%로 가장 많이 관찰되었다. 3. 노신경과 자신경이 셋째손샅에서 혼재하는 경우로, 노신경이 넷째손가락 노쪽절반까지, 자신경이 셋째손가락 자쪽절반까지 이르는 경우(제III형)가 25.7%, 노신경이 셋째손가락까지, 자신경이 셋째손가락 자쪽절반까지 이르는 경우 (제VI형)가 11.0%였다. 4. 노신경과 자신경의 등쪽손가락신경이 셋째손샅에서 합쳐져 하나의 신경가지를 이루는 경우(제IV형)가 12.8%로 나타났다. 5. 두 신경이 둘째손샅과 셋째손샅에서 혼재하거나 둘째손샅에서 합쳐져 분포하는 제III, VI, IX, X, XI 형은 새롭게 관찰된 유형이었다. 6. 근육피부신경이 노신경을 대신하였던 경우는 4가지 유형으로 각각 1예씩 관찰되었다. 7. 손등피부신경의 분포양상을 성별 및 왼손과 오른손에 따라 비교한 결과 통계학적으로 유의한 차이는 없었다. 이상의 결과로 보아 한국인의 손등피부신경은 노신경과 자신경이 셋째손가락 양쪽까지 이르는 경우가 가장 흔한 유형임을 알 수 있었다. In order to investigate the distribution patterns of the dorsal digital nerves of the radial and ulnar nerve in the Korean, authors dissect the 113 hands (right 58/left 55) of the 59 cadavers(39 males/20 females). The types were classified by the area of radial dorsal digital nerves and the ulnar digital nerves. The difference in the distribution pattern between males and females, right and left hands was analysed by x^(2)-test in the case presenting the prequency more than 10%. The results as follows; I. The ten types of the distribution patterns consisted of the radial and ulnar nerves were observed on the dorsum of the hands. 2. The case of the highest prequency was type VIII(33.9%), in which radial nerve supply the radial side of the 2½ of digits and ulnar nerve extends the ulnar side 2½ of digits. 3. In the cases of the both nerve mingling in the third digital web, the incidences in which the radial nerves extend to the radial half of ring finger and ulnar nerve to the ulnar half of middle finger(type III) were 25.7%, and that the radial nerves extend to the ulnar half of middle finger and ulnar nerve to the ulnar half of middle finger(type VI) were 11.0%. 4. Type IV as combined branch between the radial and the ulnar nerve extend to the third digital web was observed in the 12.8%. 5. The type III, VI, IX, X, XI showing the both nerves mingling in the third digital web and in the second digital web or combining in the second digital web were new observed in the Korean. 6. The musculocutaneous nerve replaces the superficial branch of the radial nerve in 4 cases. 7. There was no statistical difference in the distribution pattern between males and females, right and left hands. From the above results, it was suggested that the majority of the cases were that the ulnar digital nerves supplied the ulnar half of the middle finger in the Korean.

Doxylamine succinate 과량복용후 섬망상태를 일으킨 여아 1례

안동성,이기철,이정호 인제대학교 1994 仁濟醫學 Vol.15 No.2

항히스타민제는 습관성, 금단증상이 없는 비교적 안전한 약물로 의사의 처방없이 약국을 통하여 쉽게 구입이 가능하다. 이런 까닭에 이 약물에 의한 사고와 자살목적으로 과량복용하는 일이 발생하고 있는데 급성중독에서는 중추신경 흥분작용이 심각하게 발생하여 행동과다, 보행실조, 흥분, 환각, 섬망, 진전 및 경련까지 유발되며 또한 중추신경계의 억제작용이 중복되는 경우 혼수상태를 초래하고, 호흡부전, 심부전을 일으켜 사망의 원인이 되기도 한다. 저자들은 doxylamine succinate(Zamero) 625mg을 자살 목적으로 복용한 소아에서 선명한 환시, 환촉과 지남력 장애를 동반한 급성 섬망상태를 보인 증례 1례를 치험하였기에 문헌고찰과 함께 보고하였다. The authors experienced a case of delirium induced by doxylamine overdose. A 12 year- old female patient ingested 25 tablets of Zamero for the purpose of suicide. The patient showed symptoms of delirium such as prominant visual and tactile hallucination with cognitive deficit, and other autonomic dysfunctions due to anticholinergic effects of doxylamine succinate. The patient was recovered from delirious strate with general symptomatic care including diazepam, lorazepam and haloperidol administration. The emotional crisis on the intrafamilial conflicts and the psychosocial functioning of patient was intervened through the psychotherapeutic approach and the familial support.

男性不育에 關한 文獻的 考察

安世永,曺東鉉,杜鎬京,朴民豪 慶熙大學校韓醫科大學韓醫學硏究所 1995 慶熙韓醫大論文集 Vol.18 No.2

I could get to the conclusions as follows after studying our professors Drs' books and current magazine on Male Infertility. 1. Most of Drs. considered the reason of male infertility as Weakness(虛勞), which specially meant Jung(精)(the essence of life, or in this case could be semen) scarcity, Jung coldness, Jung lackness. They attributed the infertility to the seminal disorder. 2. In the treatment for male infertility, they emphasized the principle of reinforcing Shin(腎) and rearing Jung and presented correcting inclination as the major treatment. 3. In the medication for male infertility, they presented both special decoction and common medication through analyzing clinical symptoms. Especially, they warned to be deliberate in using hot and blazing ingredients. 4. They emphasized the regimen as the way of gathering and preserving Jung. 5. The unification of Oriental and occidental medicine is the current trend in treating the male infertility. And the analysis of the causes using the advanced diagnostic exams is prominent. 6. Spleen weakness(脾虛), liver stagnation(肝鬱) and phligm stasis(痰壅) could be the cause of male infertility, but the main cause was Shin weakness(腎虛). 7. New trials such as Acupoint Injection and Heating Acupunture as well as new decoction, acupuncture and moxibustion are being explored for curing the male infertily.

VLM-ST 공정과 삼단역전 쾌속 툴링 공정을 이용한 3차원 제품 정형가공에 관한 연구

안동규,이상호,양동열 한국공작기계학회 2003 한국공작기계학회 춘계학술대회논문집 Vol.2003 No.-

The technical combination of RP and RT has a potential for rapid manufacturing of three-dimensional parts. In the present work, a new RP system, VLM-ST, is proposed to manufacture net shapes of 3D prototypes. ㅁ human head shape and a knob shape are manufactured by the VLM-ST apparatus. In addition, a new RT technology, which utilizes a RTV molding technique and a triple reverse process technique, is proposed to manufacture net shapes of 3D plastic parts using prototypes of VLM-ST. A plastic part of the knob shape is produced by the proposed RT technology. The combination of the proposed RP and RT enables the manufacture of a plastic knob within two days.

고출력 레이저에 의한 이종금속 용접특성

신호준,유영태,임기건,안동규 한국공작기계학회 2004 한국공작기계학회 추계학술대회논문집 Vol.2004 No.-

For many years and primarily for economical reasons, Dissimilar Metal Welds have been used as transition joints in a variety of equipment and applications. But Dissimilar Metal Welds have several fabrication and metallurgical drawbacks that can often lead to in-service failures. In this paper, the laser weldability of STS304 stainless steel and SM45C at dissimilar metal welds using a continuous wave Nd:YAG laser are experimentally investigated. An experimental study was conducted to determine effects of welding parameters, on eliminating or reducing the extent welding zone formation at dissimilar metal welds and to optimize those parameters that have the most influence parameters such as focus length, power, beam speed, shielding gas, and wave length of laser were tested.