미세알부민뇨를 동반한 인슐린 비의존성 당뇨병 환자에서 혈장 Endothelin의 변화

서예경,정상원,남직화,신병호,전종민,김정국,김동희,하승우,김보완 慶北大學校 醫科大學 1996 慶北醫大誌 Vol.37 No.3

목적 : 혈관내피세포에서 생성되는 endothelin(ET)는 강력한 혈관수축작용을 가진 펩타이드로 당뇨병 환자에서 혈관내피세포의 손상여부에 따라 혈중 농도가 증가할 수 있으며 혈관합병증과 관련이 있다는 보고가 있다. 그러나. 혈중 ET치의 상승과 당뇨병성 합병증의 상관성에 대해서는 논란이 많다. 이에 저자들은 인슐린 비의존성 당뇨병 환자에서 미세알부민뇨의 동반유무에 따른 혈중 ET치의 변화 및 혈장 ET치와 요중 알부민 배설률과의 상관성을 검토하였다. 대상 및 방법 : 인슐린 비의존성 당뇨병 환자중 미세알부민뇨를 보인 22명과 정상알부민뇨를 보인 43명을 대상으로 하였으며 혈장 ET를 측정하여 요중 알부민 배설률, 당뇨병성 망막증 및 당뇨병 관련인자들과의 관계를 비교하였다. 결과 : 당뇨병성 망막증이 합병된 군에서 망막증이 합병되지 않은 군에 비하여 혈장 ET치가 유의하게 높았던 반면 (각각 1.9±0.66, 1.5±0.76pg/㎖, p<0.05) 미세알부민뇨를 보인 군과 정상알부민뇨를 보인 군사이에 혈장 ET치는 통계학적으로 유의한 차이가 없었다(각각 1.9±1.14, 1.7±0.69pg/㎖). 또한 요중 알부민 배설률과 혈장 ET치 사이에 유의한 상관관계는 없었으며 미세알부민뇨를 동반한 인슐린 비의존성 당뇨병 환자군에서 혈장 ET치는 당뇨병의 관련인자들과도 유의한 상관관계가 없었다. 결론 : 인슐린 비의존 당뇨병 환자에서 혈장 ET치가 초기 당뇨병성 신증의 합병여부나 미세알부민뇨의 정도를 반영하기는 어려울 것임을 시사한다. Background : Endothelin(ET), a potent vasoconstritor peptide released from vascular endothelial cells, is known to be increased in diabetic patients with vascular damage and related with diabetic angiopathy. However, whether plasma ET levels may be related to diabetic complications is controversial. We studied the change of ET levels in non-insulin dependent diabetics with microalbuminuria and relation between ET and urinary albumin excretion rate. Methods : Plasma ET levels of 22 non-insulin dependent diabetics with microalbuminuria and 43 patients with normoalbuminuria were measured and relations of plasma ET to diabetic complications such as urinary albumin excretion rate, retinopathy and other associated factors were studied. Results : Plasma ET levels were significantly higher in patients with diabetic retinopathy than those without retinopathy(1.9 ± 0.66 vs 1.5 ± 0.76 pg/㎖. p<0.05). The difference, however, between diabetics with and without microalbuminuria was not significant(1.9 ± 1.14 vs 1.7 ± 0.69 pg/㎖). There were no correlations of plasma ET to urinary albumin excretion rate and to the other associated factors in non-insulin dependent diabetics. Conclusion : These results suggest that plasma ET levels may not seem to act as a predictor of diabetic nephropathy or microalbuminuria in non-insulin dependent diabetics.

대전시 가로수 식재지 토양의 화학적 특성에 관한 연구

고소현,박관수,강길남,방병욱,김동일 충남대학교 농업과학연구소 2005 농업과학연구 Vol.32 No.1

This study was carried out to examine the effect of heavy traffic on chemical properties of soil in roadside trees of Daejeon city. Soil samples at 0~10cm and 10~30cm depths were collected from soil of the roadside trees, Platanus occidentalis. and Ginko biloba. Soil pH in heavy traffic regions were around 7.0 at 0~10 cm and 10~30cm soil depths because of spraying of calcium chloride for snow moving. The concentrations of Fe, Cd, Cu, Zn, and Pb in soil were higher in heavy traffic regions(Daejeon Station and Daehwa Industrial Complex) than in light traffic region(Chungnam National University). The result could be from rubbing and wear of car tire and metals when they travel.

벼 생산경영 종합관리 S/W개발

김웅,김창수,김동원,국중덕,송영주,오남기,최영근 한국농업정보과학회 2001 농업정보과학 Vol.3 No.1

This programme consisted of 8 menus, which are basic information, job worksheet, technique information, management analysis, file management, window management, help and conclusion. The major functions of this programme by menus classified as follows : 1. The basic information menu, which consisted of a lots of basic farm management information, can be easily accessible to get general farm status of S/W users and inputted data used as basic data for farm management analysis. 2. In worksheet menu, users can easily access to record and search of farm work planning, contents of work, agricultural materials and selling status. 3. In management achievement menu, lots of indexes which represent one years' management achievements are produced and can be compare this years' achievements with last years' ones. This programme Delphi5 and Object pascal programme were used for tools and languages. Also Paradox4 and BDE were used for DB and DB engine respectively.

악성 난소 종양으로 오인된 거대 위장관계 기질성 종양 1예

남동국 ( Dong Guk Nam ),김영재 ( Young Jae Kim ),천상훈 ( Sang Hoon Cheon ),이수진 ( Su Jin Lee ),김경태 ( Kyung Tae Kim ),문형 ( Hyung Moon ) 대한산부인과학회 2007 Obstetrics & Gynecology Science Vol.50 No.6

위장관계 기질성 종양은 위장관계에서 발생하는 중배엽성 종양 중 가장 흔하게 발생하나 전체 위 장관 악성 종양의 3% 이하로 발생률은 매우 드문 종양이다. GIST는 위장에서 가장 호발하며, 이외에도 소장, 기타 장관계 및 장간막에서도 발생한다. 일반적으로 무증상인 경우가 많아서 복강경수술, 기타 다른 개복술 혹은 방사선학적 검사 중 우연히 발견되는 경우가 대부분이며, 간혹 골반 내 종양인 부인과적 질환으로 오인되는 경우가 있다. 종양은 CD34나 CD117 같은 특수한 면역조직학적 검사에서 양성반응을 나타낸다. 저자들은 본원 산부인과에서 난소 악성 종양으로 오인된 거대 위장관계 기질성 종양 1예를 경험하였기에 간단한 문헌 고찰과 함께 보고하는 바이다. Gastrointestinal stromal tumors are common mesenchymal tumors of the gastrointestinal tract. But represent only less than 3% of gastrointestinal malignant neoplasm. Stomach is most common site of localization, followed by the small intestine, other parts of the GI tract, and the omentum. These tumors occasionally misdiagnosed as gynecological tumors. We report a case of gastrointestinal stromal tumor (CD117 positive and CD34 negative) giving an impression of ovarian malignancy with a brief review of the literatures.

Ultrasound Backscattering from Erythrocyte Aggregation of Human, Horse and Rat Blood under Rotational Flow in a Cylindrical Chamber

Nam, Kweon-Ho,Paeng, Dong-Guk,Choi, Min-Joo The Acoustical Society of Korea 2006 韓國音響學會誌 Vol.25 No.e4

Human, horse and rat bloods in a cylindrical chamber where flow was controlled by a stirring magnet were used for studying red blood cell aggregation. Ultrasound backscattered powers from blood were obtained from the backscattered signals measured by a 5 MHz focused transducer in a pulse-echo setup. The experimental results showed the differences in red blood cell (RBC) aggregation tendency among the three mammalian species with an order of horse > human > rat. The ultrasound backscattered power decreased with stirring speed in human and horse blood, but no variations were observed in rat blood. Sudden flow stoppage led to the slow increase of the backscattered power for human and horse blood. There was no self-aggregation tendency in rat blood. The enveloped echo images showed the spatial and temporal variations of RBC aggregations in the cylindrical chamber. These observations from the different mammalian species may give a better understanding of the mechanism of RBC aggregation.

Original article : 6-Amino-2,4,5-trimethylpyridin-3-ols: A new general synthetic route and antiangiogenic activity

( Dong Guk Kim ),( Youra Kang ),( Hyunji Lee ),( Eun Kyung Lee ),( Tae Gyu Nam ),( Jung Ae Kim ),( Byeong Seon Jeong ) 영남대학교 약품개발연구소 2014 영남대학교 약품개발연구소 연구업적집 Vol.24 No.0

A new synthetic strategy for preparation of a wide range of 6-amino-2,4,5-trimethylpyridin-3-ols from pyridoxine·HCl via a six-step sequence has been developed. This approach features an introduction of various amino groups to C(6)-position of 3-benzyloxy-6-bromo-2,4,5-trimethylpyridine (13), a key intermediate, by a Buchwald-Hartwig amination reaction using palladium(0) transition metal, which certainly renders an expanded scope of amino substituents. Some analogs prepared using the methods described here showed high level of antiangiogenic and antitumor activities in chick chorioallantoic membrane (CAM) assay, demonstrating the potential of these new aminopyridinols as antiangiogenic agents.ⓒ2014 Elsevier Masson SAS. All rights reserved.

Three-dimensional reconstruction of the 'bright ring' echogenicity from porcine blood upstream in a stenosed tube

Dong-Guk Paeng,Kweon-Ho Nam,Min Choi,Shung, K.K. IEEE 2009 and Frequency Control Vol.56 No.4

<P>To investigate the echogenicity variation due to blood flow disturbance near a stenosis under pulsatile flow, a series of in vitro experiments were performed in a rigid tube with an eccentric stenosis of 70% area reduction in a mock flow loop. An ultrasonic B-mode with a Doppler spectrogram was used to correlate echogenicity with flow speed and stroke rate. This paper reports echogenicity variation upstream of a stenosis under pulsatile flow. The experimental results showed that blood flow disturbed by the stenosis affects echogenicity and red blood cell rouleaux upstream. A hypoechoic ldquoblack holerdquo was shown at the center of the stream at systole. During diastole, the ldquobright ringrdquo in cross-sectional images was observed as eddy-like or parabolic profiles in longitudinal images. These images could be reconstructed into a 3-dimensional animation, providing a better understanding of dynamic changes of the rouleaux distribution upstream of a stenosis under pulsatile flow.</P>

Prevalence of Diabetes Mellitus in the Elderly of Namwon County , South Korea

(Sang Guk Kim),(Seung Won Yang),(An Soo Jang),(Jeong Pyeong Seo),(Sang Woo Han),(Chung Ho Yeom),(Yong Chul Kim),(Sung Hee Oh),(Jung Seok Kim),(Hae Sung Nam),(Dong Jin Chung),(Min Young Chung) 대한내과학회 2002 The Korean Journal of Internal Medicine Vol.17 No.3

N/A Background : Ethnic and geographic differences exist in the prevalence of diabetes mellitus which has increased dramatically in South Korea. A few community-based epidemiologic studies with oral glucose tolerance test were performed in South Korea. The purpose of this study was to determine the prevalence of diabetes mellitus by the World Health Organization (WHO) and the American Diabetic Association (ADA) diagnostic criteria and to investigate their associated risk factors. Also, we compared and analyzed the characteristics of Koreans by WHO and ADA diagnostic criteria. Methods : Between March 22, 1999 and July 14, 1999, a random sampling of 1,445 residents over 40 years of age in five villages (3 myons and 2 dongs) in Namwon City, Chollabuk-do Province, South Korea was carried out. WHO and ADA diagnostic criteria were used for the prevalence of DM, IGT and IFG. The associated factors of subjects were analyzed. Results : After age adjustment for the population projection of Korea (1999), the prevalence of DM and IGT was 13.7% and 13.8%, respectively, by WHO criteria, while the prevalence of DM, IGT and IFG was 15.8%, 12.8% and 5.7%, respectively, by ADA criteria, and the previous diagnosed diabetics were 5.8% in 665 adults over 40 years of age in the Namwon area. The age-adjusted prevalence of previously diagnosed diabetics was 5.8%. When the subjects classified by both criteria were compared, the level of agreement between WHO and ADA diagnostic criteria, except IFG, was very high ( =0.94; p 0.001). The ROC curve analysis determined FSG of 114.5 mg/dL (6.4 mmol/L) to yield optimal sensitivity and specificity corresponding to a PP2SG 200 mg/dL (11.1 mmol/L). The prevalence of DM and IGT with ADA diagnostic criteria rose with increasing age (p 0.05). The body mass index was mean 23.8 3.4 in all the subjects, 23.75 3.46 in NGT group and 23.67 3.16 in DM group, but the differences in the prevalence of DM, IGT and IFG by BMI were not significant. The prevalence of DM rose significantly with the increase in the waist-hip ratio (p 0.05). The prevalence of DM significantly increased in subjects by increases in blood pressure, and triglyceride and the relative risk in the prevalence of DM was significantly high with dyslipidemia (Odds ratio 2.29, 95% CI: 1.16-3.49). Conclusion : The prevalence of Diabetes Mellitus in the population over 40 years of age in Namwon City, South Korea remarkably increased compared with the 1970s and 1980s and was similar to that of the West. Ethnic differences in obesity of normal, DM and IGT subjects and in the effect on the prevalence of DM may exist in the Korean population, but they were not significant. As there is a limit in number, it is considered that a general population-based epidemiologic study on a large scale is required to investigate ethnic and geographic differences for the risk factors of DM in South Korea. The level of agreement, except IFG, by WHO and ADA diagnostic criteria was high, which indicates that these results may show that not only fasting serum glucose but also postprandial 2-h serum glucose are important for diagnosing diabetes in Korean.

Massive pulmonary hemorrhage in enterovirus 71-infected hand, foot, and mouth disease

Lee, Dong Seong,Lee, Young Il,Ahn, Jeong Bae,Kim, Mi Jin,Kim, Jae Hyun,Kim, Nam Hee,Hwang, Jong Hee,Kim, Dong Wook,Lee, Chong Guk,Song, Tae Won The Korean Pediatric Society 2015 Clinical and Experimental Pediatrics (CEP) Vol.58 No.3

Hand, foot, and mouth disease (HFMD) is an acute, mostly self-limiting infection. Patients usually recover without any sequelae. However, a few cases are life threatening, especially those caused by enterovirus 71 (EV71). A 12-month-old boy was admitted to a primary hospital with high fever and vesicular lesions of the mouth, hands, and feet. After 3 days, he experienced 3 seizure episodes and was referred to our hospital. On admission, he was conscious and his chest radiograph was normal. However, 6 hours later, he suddenly lost consciousness and had developed a massive pulmonary hemorrhage that continued until his death. He experienced several more intermittent seizures, and diffuse infiltration of both lung fields was observed on chest radiography. Intravenous immunoglobulin, dexamethasone, cefotaxime, leukocyte-depleted red blood cells, fresh frozen plasma, inotropics, vitamin K, and endotracheal epinephrine were administered. The patient died 9 hours after intubation, within 3 days from fever onset. EV71 subgenotype C4a was isolated retrospectively from serum and nasopharyngeal swab by real-time reverse transcription-polymerase chain reaction. Here, we report a fatal case of EV71-associated HFMD with sudden-onset massive pulmonary hemorrhage and suspected encephalitis.

Induction of Cytokines and Nitric Oxide in Murine Macrophages Stimulated with Enzymatically Digested Lactobacillus Strains

Kim, Dong-Woon,Cho, Sung-Back,Yun, Cheol-Heui,Jeong, Ha-Yeon,Chung, Wan-Tae,Choi, Chang-Weon,Lee, Hyun-Jeong,Nam, In-Sik,Suh, Guk-Hyun,Lee, Sang-Suk,Lee, Byong-Seak The Microbiological Society of Korea 2007 The journal of microbiology Vol.45 No.5

Based on observations that lactic acid bacteria have the ability to activate macrophages, we assessed the potential effects of eight different Lactobacillus strains treated with gastrointestinal enzymes on the production of nitric oxide and various cytokines in macrophages. RAW 264.7 murine macrophage cells were cultured with either precipitates or supernatants of Lactobacillus strains digested with pepsin followed by pancreatin. The increased production of nitric oxide and interleukin $(IL)-1{\beta}$, IL-6, IL-12 and tumour necrosis factor $(TNF)-{\alpha}$ were observed when cultured with precipitates, and this effect was largely strain-dependent. In contrast, the exposure of RAW 264.7 cells to supernatants produced weaker or nearly undetectable effects in comparison to the effects of exposure to precipitates. The induction of nitric oxide appeared to be unaffected. These results demonstrate that nitric oxide and cytokines were effectively induced when the bacterial precipitate was treated with macrophages. The results of the present study also indicate that Lactobacillus strains treated with digestive enzymes are capable of stimulating the production of nitric oxide and cytokines in macrophages, which may modulate the gastrointestinal immune function of the host when it is given as a feed additive.