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기니이픽 장관의 c-Kit 및 NK 1R 면역반응 세포구조에 대한 공초점 주사현미경적 연구
장인엽,김종중,문정석,김현곤,박찬국,전제열,전규배,조철희,유호진 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.1
Background and Objectives: Immunolabelling of interstitial Cajal(IC) cells in the intestinal wall has recently been developed by using a specific marker, the anti-c-Kit antibody. Substance-P is a well-known neurotransmitter in the gastro-intestinal tract. Since the gastro-intestinal wall structures have already been well documented in the guinea pig, immunohistochemistry was done for the c-Kit-positive IC network and substance-P receptor(NK1R) in an attempt to provide a morphological basis for the mechanism regulating gastro-intestinal movement. Materials and Methods: Cryosection and whole-mount preparations of guinea pig small intestine and colon were single and double immunolabelled using the anti-c-Kit and NK1R antibodies. Immunolabelled specimens were observed under a confocal laser scanning microscope. Results : According to a three dimensional reconstruction study, it was found that (1) the c-Kit-positive celluar networks were widely distributed in the intestinal wall, (2) c-Kit-positive celluar networks encircled the ganlion, with strands in reticular configurations, and (3) the c-Kit-positive cells showed colocalization with NK1R in circular muscle(CM), not myenteric plexus(MY). Conclusion: The charateristic profiles of IC containing c-Kit-positive celluar networks and the relationship between c-Kit-positive and NK1R-positive structures provide a morphological basis upon the mechanism regulating gastro-intestinal motility.
질적비교분석 방법을 이용한 산림 변천 요인에 대한 연구 -아시아 9 개국을 중심으로-
윤여창 ( Youn Yeo Chnag ),최준영 ( Choi Jun Yoeng ) 한국임학회 2014 산림과학 공동학술대회 논문집 Vol.2014 No.-
산림 변천은 한 지역 내에서 산림 파괴가 일어난 후 산림의 질적, 양적인 회복을 설명하는 현상이다. 본 연구의 목적은 아시아 9 개국(중국, 인도, 일본, 한국, 베트남, 라오스, 말레이시아, 인도네시아, 필리핀)에서 수집된 데이터를 질적 비교 방법을 이용하여 산림 변천을 설명하는 필수 요소를 파악하는 것이다. 질적 비교 방법은 제한된 사례 연구를 이용하여 대규모 분석을 수행할 수 있는 비교 방법이다. 본 방법을 위하여 본 연구에서는 산림 변천을 이끄는 네 가지 중요한 결과를 얻을 수있었다. 첫째, 산림 변화는 엄격한 규제 정책 조건 하에서 이루어진다. 둘째, 산림의 농지 변화는 농업 생산력의 상승으로 억제할 수 있다. 셋째, 산림으로부터의 목재에 대한 수요는 목재 수입 자유화에 의해 완화 될 수 있다. 넷째, 목재 무역 규제 하에서 산림에 대한 소유권의 부재는 산림 파괴를 이끌 수 있다. Forest transition means a phenomenon describing forest cover turnover after forest area loss within a given territory. Goal of this research is to identify critical factor or combination of factors for forest transition using qualitative comparative analysis between nine Asian countries: China, India, Japan, Korea, Vietnam, Laos, Malaysia, Indonesia, and Philippines. Qualitative Comparative Analysis is a method that provides analytical tools for implementing rigorous meta-analysis of a limited number of case studies. The results tell us that here are four important factors, which can lead to forest transition or causing deforestation. First, forest transition can occur only with effective regulatory policy execution. Without effective regulatory policy execution deforestation can occur. Second, the demand for land conversion to agricultural activities can be eased by agricultural productivity improvement. Third, the pressure on forest originating from demand for timber can be reduced by liberalization of timber import in timber resource poor countries. Fourth, if there is no forestland tenure secured for poor local residents under timber trade restriction, deforestation can be resulted.
Jia-Kang Wang,Shu-jun Guo,Bao-qing Tian,Chnag-jun Nie,Hai-long Wang,Jia-lang Wang,An Hong,Xiao-jia Chen 대한독성 유전단백체 학회 2017 Molecular & cellular toxicology Vol.13 No.4
Fibroblast growth factors(FGFs) and their receptors (FGFRs) modulate a wide range of biological functions, especially tumor genesis. The aim of this study was to investigate the possible association of FGFR expression with the susceptibility of digestive system and reproductive system cancers in Chinese population. In total, 343 patients with digestive or reproductive system cancers were enrolled in this study. The expression levels of four highly-conserved FGFRs including FGFR1, FGFR2, FGFR3 and FGFR4 were measured by immunohistochemistry (IHC). The expression levels of FGFRs were compared between carcinoma and para-carcinoma tissues. FGFR1 expression significantly differed between carcinoma and para-carcinoma tissues in colon and gastric cancers. FGFR2 expression significantly differed between carcinoma and para-carcinoma tissues in esophageal cancer. FGFR3 expression was significantly different between carcinoma and para-carcinoma tissues in liver and gastric cancers. FGFR2 showed the highest expression probability in all the selected cancers and FGFR4 showed the lowest expression probability. FGFR1 and FGFR3 showed comparable moderate expression probabilities. Our findings have demonstrated significant differences regarding FGFR expression levels between carcinoma and para-carcinoma cells in digestive or reproductive system cancer patients. The data also implicated that FGFR2 and FGFR4 could serve as two prominent factors closely related to the susceptibility of digestive and reproductive system cancers.
경골외과 골절의 외측 반월상 연골판 절개를 이용한 도달법
이기행,김형민,정창훈,최문구,송현준 대한골절학회 1997 대한골절학회지 Vol.10 No.1
Exposure to the posterolateral comer of the tibial condyle was difficult due to narrow joint space and meniscus. From l995. 1. to l996. 4.. the authors operatively reduced and internally fixed 9 cases of lateral tibial plateau fractures using lateral meniscal incision with minimal detatchment and retraction to improve visualization posterior aspect of articular cartilage Eight of the 9 cases were studied with three dimentional computerised tomogram and 1 case with roentgenographic tomogram to evaluate the shape, site and degree of comminution of the fracture fragments. ROM exercise was started at weeks postopratively, manipulation under anesthesia were done in 3 cases at 12 weeks postoperatively. The follow up period was 13 months (from 8M to lyr 11M). The results were obtained as follows, 1. Seven cases were split depression type, one was pure depression type and one was bicondylar type. 2. Articular depression were posterolateral aspect in 8 cases, and lateral aspect in one case. The degree of depression was average 15 mm(range from 6mm to 22mm). 3. Six of the 9 cases had peripheral tear of the lateral meniscus 4. Second look arthroscopy shows that the incision site of the meniscus were thinned but completely healed in 3 cases. 5. The ROM of the knee joint were 0 - over l35 in seven cases. 0° - 90° in one case, 30- 60° in one case. This meniscal incision approach was one of the effective methods that provides exposure of the entire articula surface of the lateral tibial condyle easily to allow accurate reduction.
일주일 3제병합 Helicobacter pylori 항균요법의 제균 효과에 관한 전향적 무작위 연구
김영호,이화영,손희정,류광현,이규택,김재준,최규완,백승운,최문석,고광철,이풍렬,노재형,허진석,성인경,심상군,이종철,김창섭 대한소화기학회 2000 대한소화기학회지 Vol.35 No.1
Background/Aims: Proton pump inhibitor-based triple therapy is recommended as the first-line treatment for Helicobacter pylori (H. pylori) eradication. We compared the efficacy of two different regimens of triple therapy in patients with H. pylori-associated duodenal ulcer. Methods: Forty-one patients were prospectively randomized to receive either regimen OCA (omeprazole 20 mg, clarithromycin 500 mg, amoxicillin 1 g, all twice daily) or OCM (omeprazole 20 mg, clarithromycin 500 mg, metronidazole 500 mg, all twice daily) for one week. H. pylori infection was confirmed by CLO testTM, histology (Giemsa stain) and culture at the beginning of this study. H. pylori eradication was defined as an absence of H. pylori infection on histology (two antral and two corpus) and culture (two antral and two corpus) four weeks after the completion of therapy. Results: The overall eradication rate of two regimens was 65.9%. H. pylori eradication rate was 57.1% in the group of OCA and 75.0% in the group of OCM. Patient's sex, age, smoking status, alcohol consumption, or history of ulcer had no significant effect on the eradication of H. pylori. Conclusions: Both one-week OCA and OCM therapy resulted in relatively low eradication rates. No difference was found in H. pylori eradication efficacy between OCA and OCM regimens. Thus, further studies focusing on the treatment period may be required.