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      • KCI등재
      • KCI등재

        한국인 공황장애 환자의 트립토판 가수분해 효소와 세로토닌 전달체 유전자 다형성

        최영희,우종민,박헌구,윤경식,조대연,이민수,Choi, Young Hee,Woo, Jong Min,Park, Hun Ku,Yoon, Kyung Sik,Cho, Dae Yeon,Lee, Min Soo 대한생물정신의학회 2004 생물정신의학 Vol.11 No.2

        Objectives:Genetic variations of the tryptophan hydroxylase(TPH) gene and the serotonin transporter linked polymorphic region(5-HTTLPR) polymorphism have been associated with its functional capacity. The authors investigated whether the allelic constitution of the TPH gene and 5-HTTLPR are associated in Korean panic patients. Methods:244 Korean patients with panic disorder and 227 normal healthy controls were tested for a genetic polymorphism of TPH A218C and 5-HTTLPR polymorphism. To assess the severity of panic disorder during the last one month, anticipatory anxiety, panic difficulty, panic distress, agoraphobic difficulty and agoraphobic distress were measured with visual analogue scale(VAS) score, STAI-S & T, BDI, SCL-90-R, ASI-R, CGI, PDSS, and HAMD. Results:There was no significant difference in genotype and allele frequencies of TPH A218C and 5-HTTLPR polymorphism between panic patients and controls. Although we observed some differences in genotype and allele frequencies of TPH A218C polymorphism among male subjects, these differences disappeared after Bonferroni correction. And there were no significant differences in clinical variables. Conclusion:Our results suggested that there are no association between the genetic polymorphism of TPH gene and 5-HTTLPR with panic disorder.

      • KCI등재

        인지행동치료 후 약물 중단 예측 요인에 관한 연구

        최영희,박기환,김한석,하오령,Choi, Young Hee,Park, Kee Hwan,Kim, Han Seok,Ha, Oh Ryeong 대한생물정신의학회 2000 생물정신의학 Vol.7 No.2

        Objective : The authors experienced that cognitive behavioral therapy(CBT) could replace medication for controlling panic attacks and anticipatory anxiety symptoms. The objective of this study was finding out predicting factors of discontinuation of medication after CBT for patients with panic disorder. Method : A hundred forty-eight patients who met DSM-IV criteria for panic disorder with or without agoraphobia for at least 3 months had completed 12 weekly sessions of Panic Control Therapy(PCT ; Barlow et al). Eighty-one patients who could discontinue medication and sixty-seven patients who could not discontinue medication were measured with several scales as the pre- and post-treatment aassessment. The scales were Beck Depression Inventory(BDI), Clinical Global Impression(CGI), Spielberger State Anxiety Inventory(STAI-state), Anxiety Sensitivity Index(ASI), Body Sensation Questionnaire (BSQ), Panic Belief Questionnaire(PBQ), Agoraphobic Cognition Questionnaire(ACQ), Fear Questionnaire(FQ), Toronto Alexithymia Scale(TAS). Results : At the pre-treatment assessment, the scores of BDI, CGI, STAI-state, ACQ, BSQ were higher in the patients who could discontinue medication than in the patients who could not discontinue medication(t=-2.68, t=-4.88, t=-3.07, t=-3.68, t=-3.35, p<0.01). Conclusion : Patients with panic disorder who were less depressed, less anxious, less agoraphobic and who had less negative cognitions for the bodily sensation and who had higher scores in the therapist's assessment could discontinue their medications.

      • KCI등재

        첨가재료에 따른 증편의 관능적 물성적 특성

        최영희,전화숙,강미영 ( Young Hee Choi,Hwa Sook Jeon,Mi Young Kang ) 한국식품조리과학회 1996 한국식품조리과학회지 Vol.12 No.2

        This study was carried out in order to investigate the effect of additives on Jeungpyun (fermented and steamed rice cake) preparation. Soy bean flour, whole milk powder, skim milk powder, egg yolk, egg white, and mugwort were added in the preparation of Jeungpyun. There were not significantly difference in loaf volume between control and experimental groups added egg yolk, egg white and mugwort. In sensory evaluation, the hardness of Jeungpyun containing of soy bean flour, milk powder, and egg were lower than control. The Jeungpyun containing mugwort was more bitter and harder than the control. The rheological properties measured by texturometer were significantly different among the Jeungpyun added with different kinds of additives. The hardness was significantly lower in Jeungpyun containing whole milk powder and soy bean flour and springiness was higher in mugwort Jeungpyun compared with the control. In 4℃ storage, retrogradation of Jeungpyun assessed from hardness measured by texturometer was delayed by addition of soy bean flour and whole milk powder.

      • KCI등재

        공황장애 환자의 다면적 인성검사 (MMPI) 특성이 인지행동치료 결과에 미치는 영향

        최영희,이정흠,Choi, Young-Hee,Lee, Jung-Heum 한국정신신체의학회 1998 정신신체의학 Vol.6 No.2

        Objective : This study was designed to find the characteristics of MMPI that could influence the outcome of cognitive behavioral therapy(CBT) for panic disorder. Methods : 34 patients who met DSM-IV criteria for panic disorder with or without agoraphobia had completed 11 weekly sessions of cognitive behavioral therapy. All the patients were assessed with MMPI before the initiation of treatment. Five self-report measures including Beck Depression Inventory(BDI), Spielberger State-Trait Anxiety Inventory(STAI), Agoraphobic Cognition Questionnarie(ACQ), Body Sensation Questionnaire(BSQ), and Daily Anxiety Selfrating (0 - 8 scales) were also assessed as a pre- and post-treatment assessment. After the completion of treatment, patients were classified by the High End-State(HES) functioning group and the Low End-State(LES) functioning group for the data analysis. Results : 1) The LES group showed significantly higher scores in Hypochondriasis Scale(HS), Depression Scale(D), Hysterical Scale(Hy), Obsessive Scale(Pt), Schizophrenia Scale(Sc) and Validity Scale(F) of MMPI than the HES group. However, these differences gave impressions that the LES group had more severe symptoms rather than that they could be the factors influencing the outcome of CBT. 2) Though, the severity of symptoms of the LES group in the 5 measures of pre-assessment was basically higher than that of the HES group. The fact that both group showed the similar improvement between pre- and post-assessment supported the above interpretation. Conclusion : In regarding the above results, MMPI was not a proper tool that could provide the factors influencing the outcome of CBT. In the future study, the authors need to use a different tool that can find the personality characteristics more directly.

      • KCI등재

        황화수소 중독 증례

        최영희,남병극,김효경,박지강,홍은석,김양호,Choi, Young-Hee,Nam, Byung-Kuk,Kim, Hyo-Kyung,Park, Ji-Kang,Hong, Eun-Seog,Kim, Yang-Ho 대한임상독성학회 2004 대한임상독성학회지 Vol.2 No.1

        Three workers, field operators in lubricating oil processing of petroleum refinery industry were found unconscious by other worker. One of them who were exposed to an high concentration of H2S was presented with Glasgow Coma Score of 5, severe hypoxemia on arterial blood gas analysis, normal chest radiography, and normal blood pressure. On hospital day 7, his mental state became clear, and neurologic examination showed quadriparesis, profound spasticity, increased tendon reflexes, abnormal Babinski response, and bradykinesia. He was also found to have decreased memory, attention deficits and blunted affect which suggest general cognitive dysfunction, which improved soon. MRI scan showed abnormal signals in both basal ganglia and motor cortex, compatible with clinical findings of motor dysfunction. Neuropsychologic testing showed deficits of cognitive functions. SPECT showed markedly decreased cortical perfusion in frontotemporoparietal area with deep white matter. Another case was recovered completely, but the other expired the next day.

      • KCI등재

        동무(東武) 이제마(李濟馬)의 형상관(形象觀)에 대한 고찰(考察)

        최영희,박성식,Choi, Young-hee,Park, Seong-sik 사상체질의학회 1999 사상체질의학회지 Vol.11 No.1

        1. Purpose : From a viewpoint of Lee Je-ma, We consider the principle of shape(form) and image and try out a share of recognition about shape(form) and image in all its aspects. 2. Method : Especially we compared HeoJun's point of view with Lee Je-ma's point of view. 3. Result & Conclusion 1) The most important thing for an appearance of shape(form) and image is a differential Qi of sorrow- anger-joy-pleasure. 2) Lee Je-Ma chose a point of view from inside to outside in principle. 3) A method of materialism can be used when we give medical treatment. 4) Shape(form) and image is a method of constitutional diagnosis from a viewpoint of Lee Je-ma. 5) Shape(form) and image has a formal(typical) type, but the thing which is fixed do not exist, therefore partial shape(form) and image is possible. 6) We should observe a condition of mind, but objectivity and reappearance always remain.

      • KCI등재

        주요우울장애가 동반된 공황장애 환자의 임상 특징과 심박변이도

        최영희,김원,김민숙,윤혜영,최승미,우종민,Choi, Young-Hee,Kim, Won,Kim, Min-Sook,Yoon, Hye-Young,Choi, Seung-Mi,Woo, Jong-Min 대한수면의학회 2005 수면·정신생리 Vol.12 No.1

        Objectives: This study was designed to evaluate the differences in clinical characteristics and severity of symptoms between panic patients with and without comorbid major depressive disorder, and to ascertain the differences in the function of the autonomic nerve system measured by heart rate variability (HRV). Methods: The subjects were 60 patients who have panic disorder without major depressive disorder and 19 patients who met DSMIV criteria for both panic disorder and major depressive disorder. First, they drew up symptom checklists and self-rating scales, and were measured by Anxiety Disorder Inventory Schedule-Panic Attack & Agoraphobia (ADIS-P&A), Clinical Global Impression (CGI), Hamilton Rating Scale for Depression (HAM-D), Panic Disorder Severity Scale (PDSS) and Heart Rate Variability (HRV). For statistical analysis, we performed t-test to compare the scores of self reported scales and clinician’s rating scales in panic patients with comorbid major depressive disorder and those without major depressive disorder. ANCOVA was used to compare the variables of HRV, considering age as a covariate. Results: The subjective severities of depression and anxiety that comorbid patients complained of were higher than those of patients with only panic disorder. Futhermore, comorbid patients were more sensitive to anxiety and physical sensations, and they tend to be more negative in their thinking. The scores of clinician-rating scales such as CGI and PDSS were also higher in the comorbid patients. However, there were no significant differences in HRV variables between both groups, despite a tendency to low heart rate variability in the comorbid group. Conclusion: This study suggests that patients with panic disorder and comorbid major depressive disorder tend to complain of more symptoms and to be more sensitive to various symptoms than those with panic disorder without comorbid depression. However, in this study comorbid major depressive disorder did not have a significant impact on the HRV variables of patients with panic disorder.

      • KCI등재

        치과 임플랜트 보철 수복시 각 상부구조의 형태에 따라 발생되는 응력의 광탄성학적 분석

        최영희,조인호,Choi Young-Hee,Cho In-Ho 대한치과보철학회 1993 대한치과보철학회지 Vol.31 No.4

        The osseointegrated implant conducts the stress directly to the bone due to lack of cushoning effect of periodontal ligament. So, the design and material quality of superstructure plays an important role in resolution and diffusion of stress. Recently, the various superstructures have been developed to improve esthetics and resolve various complicated conditions. The purpose of this study was to evaluate the stress induced by various system on the osseointegrated implant using UCLA abutment, EsthetiCone abutment, Anatomic abutment as well as Branemark conventional abutment. The stress distribution was evaluated by the photoelastic method which can simultaneously observe all around stress distribution. The superstructures embedded in epoxy resin specimen were loaded at various angle with a force of 15Kg to analyse the stress distribution of the fixture. The results of this study were obtained as follows : 1. Under vertical loading, the large and broad stress was distributed below the fixture in all systems. 2. The fringe order of the stress was increased in proportion to tillting the specimen. The largest stress was shown in 25 angled degree tilting case. 3. The Branemark conventional abutment showed the lowest value, and EsthetiCone abutment, Anatomic abutment and UCLA abutment showed the stress value in accending order.

      • 모유수유부의 모유수유실천에 따른 관련요인 분석

        최영희,김혜숙,박현경,이영희,Choi, Young-Hee,Kim, Hae-Sook,Park, Hyoun-Kyoung,Lee, Young-Hee 대한간호협회 1997 대한간호 Vol.35 No.5

        The purpose of this study is to identifY the problems and factors which are closely related to the breastfeeding practice in Korea. The subjects are breastfeeding mothers who have participated in the First Healthy Breastfeeding Child Contest. The 50.8% of subjects are resided in Seoul. The 68.3% of subjects are in their twenties and the 50% of them are high school graduates. Also, 81.4% of the subjects have no job. The 50% of subjects consider that the breastfeeding practice is good for the physical development and health of the child. The 73.9% of the subjects believe that the promotion of breastfeeding practice can be achieved through breastfeeding education through mass media. The 50.4% of subjects consider that the appropriate length of breastfeeding and duration is 9 months. Subjects did proper care of their breast and nipples and did proper measures for the breastfeeding practice. The 95.8% of subjects practiced breastfeeding voluntarily and their breastfeeding practice was not inhibited through factors which were given in the questionnaire lists. In conclusion, the practice of breastfeeding is mostly dependent on the efforts and the positive attitude of breastfeeding mothers. Also the friendly breastfeeding environments in terms of social norms and social practice are the most pertinent factors in promotion of breastfeeding practice.

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