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      • KCI등재

        Primary Monophasic Synovial Sarcoma Arising in the Mesentery: Case Report of an Extremely Rare Mesenteric Sarcoma Confirmed by Molecular Detection of a SYT-SSX2 Fusion Transcript

        조수연,조수연,허일영,고재수,진성호,강혜진 대한병리학회 2012 Journal of Pathology and Translational Medicine Vol.46 No.2

        Synovial sarcoma arises in the para-articular tissues, and it can also occur in various unexpected sites. We report a rare case of primary monophasic synovial sarcoma (MSS) arising in the mesentery. A 59-year-old man presented with a palpable abdominal mass. On microscopic examination, the entire tumor comprised a dense proliferation of the spindle cells without epithelial components. The tumor cells were positive for transducin-like enhancer of split 1, bcl-2, epithelial membrane antigen and CD99 but negative for CD34, CD117, alpha-smooth muscle actin, cytokeratin, and calretinin on immunohistochemistry. The reverse transcriptase-polymerase chain reaction revealed a single 151-bp fragment representing the SYT-SSX2 fusion transcript. Because mesenteric MSS is extremely rare and many cases display histologic findings that overlap with those of more frequently involved tumors such as hemangiopericytoma and gastrointestinal stromal tumor, there is a chance of making an incorrect diagnosis that can result in an inappropriate treatment.

      • KCI등재

        Analgesic Effects of Gyejibokryeong-hwan Aqueous Extracts on the Rat Model of Primary Dysmenorrhea

        조수연,김동철,Cho, Su-Yun,Kim, Dong-Chul The Society of Korean Medicine Obstetrics and Gyne 2020 大韓韓方婦人科學會誌 Vol.33 No.3

        목 적: 이 생체 내 연구의 목적은 인도메타신과 비교했을 때 쥐의 원발성 월경통에 대한 계지 복령환 열수 추출물의 진통 및 개선 효과를 관찰하는 것이다. 방 법: 랫트 PD 모델을 만들기 위해, Estradiol benzoate를 10일간 투여한 다음 마지막 10회 estradiol benzoate 투여 1시간 후 1 U/kg의 oxytocin을 투여하였다. 계지복령환 열수 추출물을 500, 250 및 125 mg/kg 용량으로 매일 1회씩 10일간 투여하였다. 이후 체중 및 실험 기간 동안의 체중 증가량, 자궁 중량 및 육안부검 소견, 진통 활성을 나타내는 abdominal writhing test, 자궁 조직 내 지질 과산화(Malondialdehyde, MDA 함량) 및 항산화 방어 시스템 - glutathione (GSH) 함량, superoxide dismutase (SOD) 및 catalase (CAT) 활성, Nuclear factor-κB (NF-κB) 및 cyclooxygenase (COX)-2 mRNA의 발현, 자궁의 조직병리학적 변화, tumor necrosis factor (TNF)-α 및 inducible nitric oxide synthase (iNOS)로 나타나는 면역조직 화학적 변화를 관찰하였다. 계지복령환 열수 추출물의 결과는 인도메타신 투여 쥐의 결과와 비교하였다. 결 과: Estradiol benzoate 및 oxytocin 투여 결과, 현저한 체중 및 증체량, 자궁 GSH 함량, SOD와 CAT 활성의 감소와 abdominal writhing 반응, 자궁 지질 과산화(MDA 함량), 자궁 중량, NF-κB 및 COX-2 mRNA 발현의 증가가 TNF-α 및 iNOS 면역반응세포와 염증세포 침윤 증가, 자궁의 충혈 및 확대와 함께 관찰되었다. 이는 전형적인 염증 및 산화 스트레스성 원발성 월경통이 잘 유도되었음을 의미한다. 한편 이러한 소견은 계지복령환 열수 추출물의 투여에 의해 용량의존적으로 현저히 억제되었으며, 인도메타신의 억제 효과보다는 낮았다. 결 론: 이 연구에서 얻은 결과는 계지복령환 열수 추출물이 estradiol benzoate 및 oxytocin으로 유도된 원발성 월경통에 용량-의존적으로 유리한 진통 및 개선 활성을 가짐을 시사한다. Objectives: The objective of this in vivo study is to observe the analgesic effects or improvements of Gyejibokryeong-hwan aqueous extracts (GJBRHe) on the Primary dysmenorrhea (PD) in rats as compared to those of Indomethacin (IND). Methods: The rats were administered with estradiol benzoate for 10 days and oxytocin 1 hour after the last 10th administration of estradiol benzoate to make the primary dysmenorrhea rat model. Gyejibokryeong-hwan aqueous extracts 500, 250 and 125 mg/kg were orally administrated, for 10 days once a day. Then the changes on the body weights and gains during experimental periods, uterine weights and gross inspections, abdominal writhing response for analgesic activities, uterus lipid peroxidation (malondialdehyde (MDA) levels), antioxidant defense system - glutathione (GSH) contents, activities of superoxide dismutase (SOD) and catalase (CAT), Nuclear factor-κB (NF-κB) and Cyclooxygenase (COX)-2 mRNA expressions, were monitored with uterus histopathology and immunohistochemistry for tumor necrosis factor (TNF)-α and inducible nitric oxide synthase (iNOS). The results of Gyejibokryeong-hwan aqueous extracts were compared to those of Indomethacin adminstered rats. Results: As results of estradiol benzoate and oxytocin treatment, noticeable decreases of body weights and gains, uterus GSH contents, SOD and CAT activities, increases of abdominal writhing responses, uterus lipid peroxidation (MDA level), uterus weights, NF-κB and COX-2 mRNA expressions were observed with increases of TNF-α and iNOS immunolabeled cells, inflammatory cell infiltrations, congestion and enlargement of the uterus at gross and histopathological inspections. These means classic inflammatory and oxidative stress mediated primary dysmenorrhea are relatively well induced. However, these signs were favorably and dose-dependently inhibited by administration of three different dosages of Gyejibokryeong-hwan aqueous extracts, but lesser than those of Indomethacin. Conclusions: The results obtained in this study suggest that Gyejibokryeong-hwan aqueous extracts has favorable analgesic and refinement activities dose-dependently on the estradiol benzoate and oxytocin treatment-induced primary dysmenorrhea signs.

      • KCI등재후보

        학교도서관 진로독서 북큐레이션 프로그램의 효과에 관한 연구

        조수연 인천대학교 사회과학연구원 2022 사회과학연구 Vol.15 No.2

        The purpose of this study was to verify the effects of information literacy self-efficacy and career maturity by conducting a school library career reading book curation program for high school students in the stage of specific career exploration and career choice. For 50 first and second graders of Gyeonggi-do A comprehensive high school, 25 students in the group applying the career reading book curation program and the other 25 students in the group applying the book report activity, and were executed 8 sessions of reading education and were and their effects were confirmed. The main findings of the study are as follows. First, as a result of analyzing the group homogeneity test for the pre-programming scale, there was no significant difference between groups, so homogeneity was secured. Second, as a result of analyzing the effects of the school library career reading book curation program on information literacy self-efficacy in high school students, information understanding and evaluation, search and use, search execution and information interpretation, integration and utilization, information need recognition, information delivery and process evaluation All of the sub-factors were found to have a positive effect. Third, as a result of analyzing the effect of the school library career reading book curation program on the career maturity of high school students, it was found to have a positive effect on all sub-factors such as career planning, independence, attitude and self-understanding, and rational career decision-making. 본 연구는 진로의 구체적 탐색 및 진로 선택 시기에 있는 고등학생을 대상으로학교도서관 진로독서 북큐레이션 프로그램을 실시하여 정보문해 자기효능감과 진로성숙도에 미치는 효과를 검증하는 것을 목적으로 하였다. 경기도 A 종합고등학교 1, 2학년 50명을 대상으로 진로독서 북큐레이션 프로그램 적용 집단 25명, 독후감 독서활동 적용 집단 25명으로 구성하여 총 8차시의 독서교육을 진행하고 그 효과를 확인하였다. 연구의 주요 결과는 다음과 같다. 첫째, 프로그램 실시 전 척도에대해 집단 동질성 검사를 분석한 결과 집단 간 유의한 차이가 없어 동질성이 확보되었다. 둘째, 학교도서관 진로독서 북큐레이션 프로그램이 고등학생의 정보문해자기효능감 미치는 효과를 분석한 결과 정보 이해 및 평가, 검색 및 이용, 검색실행과 정보 해석⋅통합⋅활용, 정보필요인식, 정보전달 및 과정평가의 하위 요인 모두긍정적인 영향을 주는 것으로 나타났다. 셋째, 학교도서관 진로독서 북큐레이션 프로그램이 고등학생의 진로성숙도에 미치는 효과를 분석한 결과 진로계획성, 독립성, 태도 및 자기이해, 합리적 진로 의사결정 등 하위요인 모두에 긍정적인 영향을주는 것으로 나타났다.

      • KCI등재

        한국의 온천과 온천문화

        조수연,김경철 동북아시아문화학회 2020 동북아 문화연구 Vol.1 No.65

        Since ancient times, hot springs in Korea have been widely used by patients with skin diseases, neuralgia, and gastrointestinal diseases. In the case of the Onyang hot springs, the history of development is the oldest in Korea. Not only the commoners but also the kings of the Joseon Dynasty often visited these hot springs for treatment. In modern times, with the enactment of the Hot Springs Act in 1981, 15 hot spring districts have been designated, and hot spring development has progressed rapidly since. In Korea, all hot water above 25 degrees Celsius is recognized as a hot spring. Unlike Japan, where the Hot Spring Act was enacted in 1948, it was not enacted in Korea until 1981, and the definition of a hot spring was finally established. The Hot Springs Act was established as a preventive measure due to the reckless development of hot springs during increased industrialization. In addition to the differences in hot spring culture in Japan compared to Korea, there are also many differences in hot spring facilities, but also in the amount of hot spring water discharged, which is a shame about our current hot spring use. In this study, the current status of hot springs in Korea is investigated, and accordingly, the method of using hot springs and the hot spring culture are identified. Investigating how to use hot springs in Korea will be the basic foundation for researching treatments and applications using hot springs. There are many records of hot spring baths left in the records, from kings and nobles to commoners. Since ancient times, hot spring bathing has been an essential part of Korean culture. This hot spring culture has been established as a concept of hot spring treatment beyond simple skin scrubs. However, skin scrubs have suddenly become the center of a more modernized hot spring culture rather than just bathing. This is evident from the data from the hot spring report we examined earlier. I think that valuable hot spring resources across the country should be utilized as an active concept of recreation and rehabilitation.

      • KCI등재

        갑상선 미분화암으로 오인된 갑상선으로 전이된 신세포암 1예

        조수연,나형균,배창훈,최윤석 대한이비인후과학회 2021 대한이비인후과학회지 두경부외과학 Vol.64 No.10

        Metastatic cancers to the thyroid gland are rare, while the kidney is the most common primarysite for metastatic cancers, occupying 42%. Metastatic renal cell carcinoma (RCC) to the thyroidgland usually has no specific symptoms or signs, and no characteristic imaging findings. And metastatic RCC takes a long time to occur after curative treatment. Since RCC rarelymetastasizes only to the thyroid gland without the metastasis of other organs, it is difficult todistinguish it from thyroid nodules or cancers with a relatively high prevalence. Unlike metastasesfrom the breast or lung, metastatic RCC to the thyroid gland is difficult to diagnose by afine needle aspiration biopsy, which is usually confirmed by immunohistochemical analysisafter surgery. Therefore, it is difficult to establish a treatment strategy before surgery. Recently,we experienced a rare case of metastatic RCC to the thyroid gland mimicking as anaplasticthyroid carcinoma because of its aggressive clinical course.

      • KCI등재

        Standardized pathology report for breast cancer

        조수연,박소,배영경,김지,김은경,김우경,권영미,이아원,이희진,이지신,박지영,공경엽,윤혜경 대한병리학회 2021 Journal of Pathology and Translational Medicine Vol.55 No.1

        Given the recent advances in management and understanding of breast cancer, a standardized pathology report reflecting these changes is critical. To meet this need, the Breast Pathology Study Group of the Korean Society of Pathologists has developed a standardized pathology reporting format for breast cancer, consisting of ‘standard data elements,’ ‘conditional data elements,’ and a biomarker report form. The ‘standard data elements’ consist of the basic pathologic features used for prognostication, while other factors related to prognosis or diagnosis are described in the ‘conditional data elements.’ In addition to standard data elements, all recommended issues are also presented. We expect that this standardized pathology report for breast cancer will improve diagnostic concordance and communication between pathologists and clinicians, as well as between pathologists inter-institutionally.

      • KCI등재

        3 wt% NaCl 수용액에서 알루미늄과 스테인리스강의 부식에 따른 광 반사 거동

        조수연,나현규,조혜리,문종주,안태정,장희진 한국부식방식학회 2020 Corrosion Science and Technology Vol.19 No.3

        The photo-reflectance of aluminum and AISI 304 stainless steel during cyclic immersion test in 3 wt%NaCl solution was examined in this study. Overall, corrosion was not recognized by a visual inspectionor weight measurement up to 310 h. When evaluated, it was noted that the roughness of the specimensdid not change significantly. However, localized corrosion, which is located at the vicinity of intermetallicprecipitation of aluminum or at the grain boundary of stainless steel, was confirmed by the use of an opticalmicroscope and scanning electron microscopy after tens of hours of utilizing the corrosion test. In this respect,an increase of the peak intensity for metallic Al after 90 h of test, and for metallic Fe after 153 h wasdetected from the X-ray photoelectron spectra. In this context, it was shown that from the photo-reflectancespectra, the reflection of the visible light from the tested samples was changed noticeably over the testduration. As a result, the intensity of reflected light was decreased up to 90 h ~ 153 h, and thereafterwas shown to increase higher than the initial intensity before the corrosion test.

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