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기립성 단백뇨와 특발성 만성 피로를 동반한 Nutcracker 증후군 1례
전지현,유병원,이재승,김명준,Juhn Ji Hyun,Yoo Byung Won,Lee Jae Seung,Kim Myung Jun 대한소아신장학회 2001 Childhood kidney diseases Vol.5 No.1
Nutcracker증후군은 좌측 신정맥이 대동맥과 상장간막 동맥에 압박되어 발생하는 드문 질환으로 혈뇨, 단백뇨, 기립성 단백뇨의 원인이 된다. 초음파와 도플러 검사로 진단이 가능하다. 저자들은 기립성 단백뇨와 특발성 만성피로를 보인 보기드문 심한 Nutcracker 증후군 환아를 경험하였기에 문헌고찰과 함께 보고하는 바이다. The nutcracker syndrome is the congestion of left renal vein due to the compression of left renal vein by the aorta and the superior mesenteric artery and has been known as tile cause of hematuria with or without left renal flank pain, mild to moderate proteinuria and orthostatic proteinuria. We present here one case of 13.5 year of girl has severe typical nutcracker syndrome with orthostatic protinuria and idiopathic chronic fatigue. (J. Korean Soc Pediatr Nephrol 5 . 64- 8, 2001)
호장근, 당귀, 고삼, 우방자 혼합 한약제의 LC-MS/MS 분석 및 약물동태학 연구
전지현 충남대학교 약학대학 의약품개발연구소 2018 藥學論文集 Vol.33 No.-
4 MIX, provided by Korea Institute of Oriental Medicine, is candidate of a new herbal medicine consisted by Polygoni Cuspidati Radix, Angelicae Gigantis Radix, Sophorae Radix, and Arctii Semen. The aim of this study is to investigate the pharmacokinetics of herbal medicines by analyzing plasma concentrations of 4-MIX in experimental animal s. For the pharmacokinetic study of 4-MIX, matrine and decursinol were selected as marker compound by contents analysis using LC-MS/MS by multiple reaction monitoring with an electro spray ionization source in positive ionization mode for the determinations. After administration of 4-MIX in rat, analysis of plasma sample was also performed on a LC MS/MS for the determinations of matrine and decursinol in 4- MIX. Quantitative ion transitions of m/z 249.1 • 148.2, and 247.3 • 213 were monitored for matrine and decursinol respectively. The calibration curves of the analytes exhibited good line arity (r2 > 0.99) over the range of 500 ∼6000 ng/mL for vitexin and 10-2500 ng/mL for matrine and decursinol. The NCA result of matrine showed that Cma.x was 1510.08 and 5193.19 n밍ml , AUC= was 12332.97 and 34771.69 ng · hr/ml and Tma< was 0.9 and 0.8 hr for the doses of 5 and 10 밍kg, respectively‘ The NCA result of decursinol showed that Cmax was 362.26 and 2183.24 n밍ml, AUC= was 1936.37and 10104.54 ng·hr/ml and Tmax was O‘6 and 0.7 hr for the doses of 5 and 10 밍kg, respectively. The results of pharmacokinetics study of candidate of new oriental herbal medicine can be used for drug approval‘ With this pharmacokinetic result, it is possible to establish the correlation with the drug efficacy in the future, which is expected to maximize the efficiency of the drug development of the herbal medicine.
RE-11 : Metformin modulates the GnRH - induced ERK activation in LβT2 gonadotropes
전지현,박소연,정경아,정혜원,이사라 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-
목적: Metformin has been used as a new treatment option in PCOS women. Most recently, the spectrum of metformin`s targets has been expanded, and molecular studies have explored the tissue-specific mechanisms of metformin in the liver, the muscle, the endothelium, and the ovary. Among various mechanisms that reported to be related with Metformin`s action in PCOS, we want to evaluate the effect on reactive oxygen species (ROS) in the GnRH induced ERK activation. 방법: The primary gonadotrope cell line, LβT2 was maintained in DMEM supplemented with glulcose, 10% fetal bovine serum, and 5% penicillin/ streptomycin and incubated in a humidified atmosphere of 5% carbon dioxide. Cells were treated for 5 min of GnRH and Metformin (50 and 500ng/ml) for 1hr, 6hr, and 24hr. Western blotting was performed with 1:1,000 dilution of anti phospho-ERK primary antibody and anti-ERK rabbit primary antibody to control. Immunofluoresence was used and quantification of total ERK phosphorylation was performed relative to total ERK in the same lane. 결과: ERK phosphorylation by GnRH was significantly reduced with Metformin (50 ng/ml) for 24hr treatment (p<0.05) and Metformin (500ng/ml) for 1, 6, and 24hr treatment compared with control. (p<0.05) 결론: Metformin decreased the GnRH induced ERK activation in LβT2 gonadotropes in time dependent manner.
전지현 한국영어교육학회 2009 ENGLISH TEACHING(영어교육) Vol.64 No.4
As globalization becomes more of a reality, “communicative competence” has become the focus of English language learning and teaching in Korea. Teachers seem to agree on the importance of gaining “communicative competence” in English; however, their positive beliefs about the communicative approach often do not coincide with their actual practice in the classroom because of constraints in reality. The present study reports on key issues in implementing the communicative approach in Korea. Key issues were first identified through a two-round Delphi technique. The issues identified were then presented to teachers (elementary, middle, and high school level) with a 10-point response scale to assess the degree of importance of each issue to them. Teachers’ responses obtained in the beginning stage of 1996 and in the current stage of 2008 when was after 12 years’ of implementing the communicative approach were compared to see changes in the degree of importance of the issue over time. Issues were analyzed along with the various teacher variables such as the degree of understanding, agreement to the premises of the communicative approach, teacher motivation, and self rated English aural/oral proficiency. Results are discussed in terms of their implications on teacher training, curriculum improvement, and material use in class.
X-linked Myotubular Myopathy in a Family with Two Infant Siblings: A Case with MTM1 Mutation
전지현,이철,남궁란,박민수,박국인,이진성,김세훈 연세대학교의과대학 2011 Yonsei medical journal Vol.52 No.3
X-linked myotubular myopathy (XLMTM) is a rare congenital muscle disorder, caused by mutations in the MTM1 gene. Affected male infants present severe hypotonia,and generalized muscle weakness, and the disorder is most often complicated by respiratory failure. Herein, we describe a family with 2 infants with XLMTM which was diagnosed by gene analysis and muscle biopsy. In both cases, histological findings of muscle showed severely hypoplastic muscle fibers with centrally placed nuclei. From the family gene analysis, the Arg486STOP mutation in the MTM1 gene was confirmed.