유아기 근섬유종증

장성남(Sung Nam Chang),박태현(Tae Hyun Park),윤경한(Kyeong Han Yoon),김수찬(Soo Chan Kim) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.5

Infantile myofibromatosis is an uncommon, benign, probably hamai tomatous proliferation of myofibroblasts. This lesions are most often present before the age of 2 years, show a male predomenance and may be multiple or solitary. The solitary lesions arise in the dermis, subcutis, or deep soft tissue, most commonly in the head and neek region or trunk. The elinical coirse is benign and spontaneous regression is not infrequent. A female newborn presented with a turmr lesion on the upper portion of the right eyelid. Physical examination showed a firm, non-tender, fixed, erythematous, 3 x 3cm sized tumor. Histologic examinatign revealed a spindle cell tumor in the deimis with a whorled arrangemant and grouped fescicles. There was na evidence for potential visceval and bony involvement. Follow-up examination at 6 months of aige revealed a remarkable degree of spoitaneous involution. (Kor J Dermatol 1994;32(J):907-910)

Dowling - Meara형 단순성 수포성 표피박리증

장성남(Sung Nam Chang),김수찬(Soo Chan Kim) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.4

The Dowling-Meara type of epidermolysis bullosa simplex(EBS) is genetic disease that is transmitted as an autosomal dominant trait and is charscterized clinically by pherpetiform clustering of blisters and palmo-plantar keratoderma. The disease usually presents at with or in early infancy. Although serious and hemorrhagic Wers may occur on any part of the body, the lesions heal without scaning in general. The disease shows a tendency to improve by progressian of age and it usually follows a relatively benign course. Microecopically, there are intraepidermal bli.ter s forming as a result of cytolysis of basal cells. In addition, the is a highly characteristic clumping of tonofilaments of keratinocytes in the lower epidermis, which is not seen in any other form of EBS. We report a case of Dowling-Meara type of EBS that is first destribed in Korean medical literatures. (Kor J Dermatol 10$4; 32(4): 735 739)

서울 강남지역 피부질환의 통계적 고찰 ( 1983 - 1992 )

장성남,이종서,이승헌,박윤기 ( Sung Nam Chang,Jong Seo Lee,Seung Hun Lee,Yoon Kee Park ) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.5

모든 질환의 발생빈도는 생활환경에 의해 많은 영향을 받지만 이중에서도 외부에 직접 노출되어 있는 피부에서 발생하는 질환은 더욱더 환경적 요인에 의해 영향을 받는다. 그러나 실제로 피부질환의 발생과 분포양상은 환경적 요인에 의해 영향을 받는다. 그러나 실제로 피부질환의 발생과 분포양상은 환경적 요인뿐만 아니라 인구, 문화, 기후, 사회경제적 요인들에 의해 광범위하게 영향을 받는 것이 사실이다. 이와 ??이 여러가지 다양한 요소에 의해 영향을 받는 피부질환의 발생과 분포양상을 규명하는데는 실제로 많은 어려움이 따르며 전체 모집단을 대상으로 하기에는 많은 계약이 있다. 이런 이유로 대부분의 연구가 사회집단전체에 대한 연구보다는 병원에 내원하는 환자를 대상으로 연구가 시행되어 왔다. 병원단위의 환자통계는 한 인구집단의 유병률이나 발생분포를 정확히 평가할 수 없으나 간접적으로 그 지역의 유병상태를 추구하는 수단으로 제시되어 왔다. 국내에서도 여러 저자들에 의해 외래환자들을 대상으로 병원단위의 통계가 보고되어 왔으며, 지역별로 질환의 발생빈도 및 분포에 일부 치이점을 보고하고 있으나 서울의 강남지역에서는 이에 대한 보고가 없었다. 이에 본 연구에서는 본원(영동세브란스 병원)이 개원한 이래 현재까지 10년간(1983-1992) 피부과외래에 내원한 환자들을 대상으로 피부질환의 분포를 조사하고 국내외 다른 지역의 보고와 비교분석 하고자 하였다. Background:There has been no statistical study of dermatoses in the Gangnam area of Seoul which has been rapidly developing in the last 10 years. Objective:We evaluated the recent distributions of dermatoses in the Gangnam area of Seoul and compared them with the previous reports in Seoul and other provinces of Korea. Methods:47,015 new outpatients who visited the Yongdong Severance Hospital from 1983 to 1992 were analyzed statistcally. Results:The study results are summarized as follows: 1. Among the 47,015 outpatients, the total number of male patients were 20,180(42.9%) and female patients 26,835(5701%) 2. In age distribution, the most frequent age groups were the 3rd decade(21.3%), the 1st decade(19.5%), and the 4th decade(19.2%) amounting to 60% of the total outpatients. 3. The most common 15 dermatoses were dermatophytosis, atopic dermatitis, urticaria, irritant contact dermatitis, acne vulgaris, allergic contact dermatitis, seborheic dermatitis, other eczemas, warts, vitiligo, and syphilis. Dermatophytosis and bacterial infection showed a decreasing tendency. 5. Seasonal distribution showed that those diseases occurring most frequency during the summer were dermatophytosis, urticaria, allergic contact dermatitis, vitiligo, herpes zoster, and bacterial infection. The incidence of atopic dermatitis and psoriasis increased during the winter season. 6. In sexual distribution, acne, allergic contact dermatitis, and irritant contact dermatitis were more frequent in femals, and the remainding common dermatoses did not show any difference. 7. In age distribution, atopic dermatitis and bacterial infection were most frequent in the 1st decade. Urticaria, allergic contact dermatitis,acne, drug eruption, psoriasis, and syphilis were most frequent in the 3rd decade, with warts and vitiligo in the 2nd decade and herpes zoster in the 6th decade. 8. The distributions of dermatoses as disease groups were eczema(24.9%), urticaria-drug eruption(13.2%), dermatophytosis(10.7%), skin appendage disorder(10.?%), vital infection(10.1%), pigmentary disorders(4.5%), and papulosquamous diseases(4.0%) which constituted 78% of the total. 9. In patients dwelling in apartments, atopic dermatitis and molluseum contagiosum showed a more frequent tendency in comparison to those living in houses. 10. The most common 10 dermatoses among children were atopic dermatitis, urticaria, contact dermatitis, molluscum contagiosum, bacterial infection, dermatophytoses , vitiligo, other viral infections, and nevo-cellular nevi. On the other hand, the most common 10 dermatoses among the elderly were dermatophytosis, other eczemas, urticaria, herpes zoster, pruritus, contact dermatitis, drug eruption, lichen simplex chronicus, seborrheic dermatitis, and vitiligo. Conclusion:In contrast to an earlier published report from Seoul, the infectous dermatoses, sepecially parasitic infestation, showed a decreasing tendency, The distribution pattern of the skin diseases did not differ from other provinces of Korea in general. (Kor J Dermatol 1994;32(5):872~885)

광선각화증에 대한 임상 및 병리조직학적 소견 - 대한피부과학회 피부병리연구분과위원회 공동연구 -

장성남,전수일,김수남,조백기,전재복,김낙인,서기석,조광현,김수찬,고재경,김방순,이승철,원영호,김종민 ( Sung Nam Chang,Soo Il Chun,Soo Nam Kim,Baik Kee Cho,Jae Bok Jun,Nack In Kim,Kee Suck Suh,Kwang Hyun Cho,Soo Chan Kim,Jai Kyoung Koh,Bang Soon 대한피부과학회 1997 대한피부과학회지 Vol.35 No.5

Background: Although actinic keratoses is the most common precancerous cutaneous lesion, there has been no clinical and histopathological study about actinic keratoses in Korea. Objective : Our purpose was to carry out a clinical and histopathological study about actinic keratoses in Korea. Methods : 158 patients, diagnosed with actinic keratoses from 1987 to 1995 in Korea, were analyzed clinically and histopathologically. Results 1. The ratio of males to females was 1:2.4 and the most frequent age groups were the 6th(29.1%) and 7th decade(33.5%). 2. The duration of the lesions was more than 1 year in most cases. 3. The most commonly involved sites were the face, in which the cheek, nose and forehead were the most common sites. 4. Clinically, the size of the lesions was less than 1cm in many cases(66.8% ). The color was erythematous in 57.9%, brownish in 26.7%, and dark brownish in 15.3%. Crust and scale were noted in 28.7% and 25.2%, respectively. In 4% of patients, cutaneous horn also was noted. 5. Squamous cell carcinoma was associated with actinic keratoses in 5.7%, basal cell carcinoma in 3.2%, and keratoacanthoma in 1.3%. 6. Histopathologically, hypertrophic types of actinic keratoses were noted in 25.0%, atrophic types in 21.3%, hypertrophic and atrophic types in 18.1%, bowenoid types in 17.6%, acantholytic types in 13.3%, and pigmented types in 4.7%. 7. The most commonly used methods of treatment for actinic keratoses were cryotherapy, surgical excision, 5 FU ointment, and electrodesiccation with good effect. Conclusion : Actinic keratoses in Koreans was present on the face most commonly over 50 years of age. It showed a more frequent incidence in females than males. The clinical course of the lesions was chronic and the association with other cutaneous malignancies was noted to be less than 6%. The various histopathological types were noted, including hypertrophic, atrophic, hypertrophic and atrophic, bowenoid, acantholytic, and pigmented. The most commonly used methods of treatment. for actinic keratoses were cryotherapy, surgical excision, 5-FU ointment, and electrodesiccation. (Korean J Dermatol 1997;35(5): 931-939)

사춘기에 우측상지에서 발생한 혈관육종

박태현,장성남,김동건,신규호 ( Tae Hyun Park,Sung Nam Chang,Dong Kun Kim,Kyoo Ho Shin ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.3

Cutaneous angiosarcorriias occur most commonly on the face and scalp of elderly individuals and are characterized by poor prognosis. We present a case of angiosarcoma in a 17-year-old boy not associated with any predisposing factors. The patient had three, ill-defined, 3 to 5 cm sized, erythematous, indurated subcutaneous nodules on the right upper extremity with a duration of 3 months. On histological examination, there were extravasated erythrocytes and irregular vascular channels lined by atypical endothelial cells in the dermis and subcutaneous tissue. The tumor cells appeared to dissect the collagen bundles. The patient was treated by wide surgical excision and post operative radiation therapy. However, 16 months after the operation, local recurrence was found to involve the close areas to the excision site on the right upper extremity and right axillary lymph nodes. (Kor J Dermatol 1997;35(3): 536-540)

Palisaded Encapsulated Neuroma

홍창의,장성남,김동건 ( Chang Eui Hong,Sung Nam Chang,Dong Kun Kim ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.4

해파리 자상 2예

이상주 ( Sang Ju Lee ),장성남 ( Sung Nam Chang ),최은선 ( Eun Sun Choi ),박욱화 ( Wook Hwa Park ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.4

급성 전신성 발진성 농포증

이상주 ( Sang Ju Lee ),장성남 ( Sung nam Chang ),박욱화 ( Wook Hwa Park ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.1

Acute generalized exanthematous pustulosis(AGEP) is a disease entity caused mostly by drugs or viral infections. Clinically it manifests as generalized erythema, erythema multiforme and amicrobial pustules with fever. Histologically, AGEP is composed of neutrophilic subcorneal and spongiform pustules. A 70-year-old female, with no personal or family history of psoriasis, was given medication including diltiazem for hypertension. Fourteen days after taking the medications, pustular eruptions appeared on the face and rapidly spread to the trunk and limbs. A Laboratory examination revealed neutrophilic leukocytosis and an elevated erythrocyte sedimentation rate. The skin biopsy showed subcorneal and spongiform pustules. We report here a case of AGEP probably due to diltiazem. (Korean J Dermatol 1998;36(1): 125-128)

조직 및 혈액 호산구증을 동반한 Cutaneous T cell lymphoma, pleomorphic, small/medium sized

오상호 ( Sang Ho Oh ),김형섭 ( Hyoung Sup Kim ),기정혜 ( Jung Hye Kee ),장성남 ( Sung Nam Chang ),김동건 ( Dong Kun Kim ) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.4

Cutaneous T cell lymphoma, pleomorphic. small/medium-sized is a primary cutaneous lymphoma that consist, of less than 30% of large, pleomorphic T cells and mostly small/medium-sized, plemorphic T cells stained negatively CD30. This entity presents clinically with o several red-purple nodules without patches & plaques and histopathologically infiltration of small/medium-sized T cells with a dense nodular or diffuse pattern in the dennis. Usually cellular infiltration consist of atypical lymphocytes without eosinophils plasma cells and neutrophils but there are cases infiltrated with atypical lymphocytes and eosinophils. We report a case of cutaneous T cell lymphoma, pleomorphic, smell/medium-sized in a cast 55-year-old male who was presented with hard nodules on both elbows, both ankles, left 1st interdigital web, both wrists and both lateral sides of thigh. Histopathological findings showed diffuse and nodular infiltrates with atypical lymphocytes and eosinophils in the dennis not involving die epidermis. Bone scan, bone marrow biopsy and CT scan taken to find out involvement of other organs showed neutral finding except for eosinophilia at bone marrow biopsy.

유두의 미란성 선종증

윤미라(Mi Ra Youn),장성남(Sung Nam Chang),조영호(Young Ho Cho),전수일(Soo Il Chun),박욱화(Wook Hwa Park) 대한피부과학회 1999 대한피부과학회지 Vol.37 No.9

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