섬진강,영산강 수계 주요 호소의 수질 동향과 영양상태 조사

이상현 ( Sang Hyon Yi ),신용식 ( Yong Sik Sin ),장남익 ( Nam Ik Chang ),김종민 ( Jong Min Kim ),김현구 ( Hyun Ku Kim ),조영관 ( Young Gwan Cho ),정진 ( Jin Jeong ) 한국하천호수학회 2006 생태와 환경 Vol.39 No.3

순차적 마이크로 몰딩 방법을 이용한 이방성 패치 입자 제조 기술

이병진(Byungjin Lee),최창형(Chang-Hyung Choi),김종민(Jongmin Kim),강성민(Sung-Min Kang),남진오(Jin-Oh Nam),진시형(Si-Hyung Jin),이창수(Chang-Soo Lee) 한국고분자학회 2015 폴리머 Vol.39 No.5

본 연구는 이방성 패치를 가지는 마이크로 입자의 제조를 위한 순차적 마이크로 몰딩 기술에 관한 것이다. 희석된 단량체와 젖음성 유체를 사용하여 PDMS 마이크로 몰드 상에서 1차적으로 구형의 입자를 제조하고, 물리적, 화학적 이방성을 가지는 입자를 간편하게 제조하는 기술이다. 본 연구팀은 실제 미키마우스 형태의 입자를 제조하여 제시한 방법이 실제로 구현 가능함을 입증하였고, 또한 휘발성 용매를 이용하여 단량체의 농도를 조절함으로써 미키마우스 형태 입자에서 패치의 크기를 15에서 31 μm까지 제어할 수 있었다. 더 나아가, 물리적, 화학적 특성 이방성을 동시에 가지는 정전기적 이방성 입자를 제조하였고, 수용액 상에서 전하를 가지는 형광염료를 통해 선택적인 염색을 하고 이를 형광 분석을 통해 입증하였다. 본 연구에서 제시한 마이크로 몰딩 기술은 간단한 방법으로 이방성 입자를 제조하는 것이 가능하며 이러한 방법은 자기조립 구조체를 제조하는 방법에 널리 이용이 가능할 것으로 판단한다. This study reports a simple sequential micromolding method to produce monodisperse anisotropic microparticles with precisely controllable patchy size and chemistry of compartmentalization. Specifically, our fabrication procedure involves sequential formation of primary and secondary compartments in micromolds via surface tension-induced droplet formation coupled with simple photopolymerization. We demonstrate the capability of sequential micromolding technique by generating Mickey mouse-shaped particles with precisely controllable patchy size and chemistry of compartment and the fabrication method needs no sophisticated control or expensive facilities. The micromolding technique applied in this study can control the size of patchy diameter from 15 to 31 μm by simply adjusting the concentration of photocurable monomer in ethanol. Finally, the Mickey mouse-shaped microparticles with negatively charged patches are confirmed by selective binding of positively charged fluorescence dyes. These results prove a simple, robust, and scalable fabrication of highly monodisperse and complex anisotropic microparticles in a controlled manner based on sequential micromolding.

마이크로채널 내 이중유화 액적 형성을 통한 마이크로캡슐 제조

남진오 ( Jin Oh Nam ),최창형 ( Chang Hyung Choi ),김종민 ( Jong Min Kim ),강성민 ( Sung Min Kang ),이창수 ( Chang Soo Lee ) 한국화학공학회 2013 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.51 No.5

본 연구는 액적기반 미세유체 장치를 이용하여 단분산성 마이크로캡슐의 간단한 제조방법에 관한 것이다. 본 연구에서 제시한 제조 방법은 이중액적을 생성시키기 위해 기존의 복잡한 표면처리가 필요한 이중 유화과정을 대신하여 하나의 교차점을 가진 단일공정을 사용하고자 한다. 먼저, 분산상은 광중합이 가능한 ethoxylated trimethylolpropane triacrylate (ETPTA) 단량체와 fluorocarbon (FC-77) 오일을 사용하고 연속상은 poly(vinyl alcohol) (PVA) 수용액을 사용하였으며, 미세유체 채널 내부로 흘려 주면 하나의 교차점에 흐름이 집중되어 균일한 이중액적을 생성한다. 생성된 이중액적은 광중합을 통해 마이크로캡슐을 제조한다. 상기 방법은 ETPTA 유체의 부피유속을 조절하여 이중액적의 껍질두께 제어가 가능하고 연속상인 물의 부피유속을 조절하여 전체 직경을 제어할 수 있다. 더 나아가, 본 시스템을 사용하여 다양한 물질들을 함입한 마이크로캡슐을 제작할 수 있으며, 약물전달시스템의 응용 기술에 활용될 것으로 예측된다. In this study, we present simple microfluidic approach for the synthesis of monodisperse microcapsules by using droplet-based system. We generate double emulsion through single step in the microfluidic device having single junction while conventional approaches are limited in surface treatment for the generation of double emulsion. First, we have injected disperse fluid containing FC-77 oil and photocurable ethoxylated trimethylolpropane triacrylate (ETPTA) and water containing 3 wt% poly(vinyl alcohol) (PVA) as continuous phase into microfluidic device. Under the condition, we easily generate double emulsion with high monodispersity by using flow focusing. The double emulsion droplets are transformed into microcapsules under the UV irradiation via photopolymerization. In addition, we control thickness of double emulsion`s shell by controlling flow rate of ETPTA. We also show that the size of double emulsions can be controlled by manipulation of flow rate of continuous phase. Furthermore, we synthesize microcapsules encapsulating various materials for the application of drug delivery systems.

순차적인 마이크로 몰딩 방법을 이용한 다중 분획 입자의 제조

염수진(Su-Jin Yeom),강성민(Sung-Min Kang),김종민(Jongmin Kim),남진오(Jin-Oh Nam),엄나예(Naye Eom),이소희(Sohui Lee),이창수(Chang-Soo Lee) 한국고분자학회 2016 폴리머 Vol.40 No.3

본 연구는 순차적인 마이크로 몰딩 방법을 이용한 고분자 다중 분획 입자 제조 방법에 관한 것이다. 다중 분획 입자는 poly(dimethylsiloxane)(PDMS) 마이크로 몰드 내로 단량체 혼합물의 주입, 휘발성 용매의 증발, 광중합으로 이루어지는 일련의 과정을 통해 제조한다. 이때, 단량체 혼합물에 포함된 휘발성 용매의 농도에 따라, 다중 분획입자를 구성하는 각 구획의 부피분율을 제어하는 것이 가능하다. 또한 단량체 혼합물의 농도 및 다중 분획 입자 제조공정의 반복횟수에 따라, 단일 입자, 이중 입자, 삼중 입자를 선택적으로 제조가 가능함을 보여준다. 제조한 각각의 다중 분획 입자에 형광염료를 함입하여 특정한 정보를 인코딩한 바코드 입자로써의 활용 가능성을 증명한다. 본 연구에서 제안하는 다중 분획 입자를 제조하기 위한 순차적인 마이크로 몰딩 방법은 쉽고, 빠르며, 고가의 장비를 필요로 하지 않는 장점을 가지며, 제조된 다중 분획 입자는 약물 저장 및 전달 소재, 바이오 센서, 그리고 선택적인 흡착-탈착을 유도할 수 있는 고감도 기능성 재료로서 응용이 가능할 것으로 기대한다. In this paper, we present a fabrication method of polymeric multicompartment particles via a sequential micromolding process composed of injection of photocurable solution, evaporation of volatile solvent, and photo-polymerization. Depending on the concentration of volatile solvent in photocurable solution, the volume fraction of the multicompartment particles can be controlled. Also, the repetition of the sequential micromolding process with controlled composition of photocurable solution provides controlling the number of compartment in the particles. Based on this principle, we can fabricate single particles, Janus particles and triblock particles with desired fraction of the compartment. In addition, the multicompartment particles are able to be applicable for barcode particles embedding fluorescent dyes at each compartment. The barcode particles encode information about their specific compositions and enable simple identification. These sequential micromolding method for multicompartment particles has several advantages including easy, fast, and cost effective process. We envision that the multicompartment particles have various applications such as drug storage, delivery supporters, biosensors, and advanced materials for inducing highly selective adsorption-desorption.

광선각화증에 대한 임상 및 병리조직학적 소견 - 대한피부과학회 피부병리연구분과위원회 공동연구 -

장성남,전수일,김수남,조백기,전재복,김낙인,서기석,조광현,김수찬,고재경,김방순,이승철,원영호,김종민 ( Sung Nam Chang,Soo Il Chun,Soo Nam Kim,Baik Kee Cho,Jae Bok Jun,Nack In Kim,Kee Suck Suh,Kwang Hyun Cho,Soo Chan Kim,Jai Kyoung Koh,Bang Soon 대한피부과학회 1997 대한피부과학회지 Vol.35 No.5

Background: Although actinic keratoses is the most common precancerous cutaneous lesion, there has been no clinical and histopathological study about actinic keratoses in Korea. Objective : Our purpose was to carry out a clinical and histopathological study about actinic keratoses in Korea. Methods : 158 patients, diagnosed with actinic keratoses from 1987 to 1995 in Korea, were analyzed clinically and histopathologically. Results 1. The ratio of males to females was 1:2.4 and the most frequent age groups were the 6th(29.1%) and 7th decade(33.5%). 2. The duration of the lesions was more than 1 year in most cases. 3. The most commonly involved sites were the face, in which the cheek, nose and forehead were the most common sites. 4. Clinically, the size of the lesions was less than 1cm in many cases(66.8% ). The color was erythematous in 57.9%, brownish in 26.7%, and dark brownish in 15.3%. Crust and scale were noted in 28.7% and 25.2%, respectively. In 4% of patients, cutaneous horn also was noted. 5. Squamous cell carcinoma was associated with actinic keratoses in 5.7%, basal cell carcinoma in 3.2%, and keratoacanthoma in 1.3%. 6. Histopathologically, hypertrophic types of actinic keratoses were noted in 25.0%, atrophic types in 21.3%, hypertrophic and atrophic types in 18.1%, bowenoid types in 17.6%, acantholytic types in 13.3%, and pigmented types in 4.7%. 7. The most commonly used methods of treatment for actinic keratoses were cryotherapy, surgical excision, 5 FU ointment, and electrodesiccation with good effect. Conclusion : Actinic keratoses in Koreans was present on the face most commonly over 50 years of age. It showed a more frequent incidence in females than males. The clinical course of the lesions was chronic and the association with other cutaneous malignancies was noted to be less than 6%. The various histopathological types were noted, including hypertrophic, atrophic, hypertrophic and atrophic, bowenoid, acantholytic, and pigmented. The most commonly used methods of treatment. for actinic keratoses were cryotherapy, surgical excision, 5-FU ointment, and electrodesiccation. (Korean J Dermatol 1997;35(5): 931-939)

대퇴골 전자부 골절에서 내고정 실패 후 치료

김형규 ( Hyung Gyu Kim ),박병문 ( Byeong Mun Park ),송경섭 ( Kyeong Seop Song ),성창훈 ( Chang Hun Sung ),김종민 ( Jong Min Kim ),조재형 ( Jae Hyung Cho ),김남흔 ( Nam Heun Kim ) 대한골절학회 2005 대한골절학회지 Vol.18 No.2

한국의 발톱진균증 환자의 삶의 질에 관한 연구

조백기,박종갑,김형옥,김성욱,백승철,김진우,김시용,안규중,전재복,오지원,김낙인,이규석,오칠환,김수남,김상태,손숙자,신용우,김동석,이원우,권경술,서대헌,황규왕,이종석,고재경,강원형,정기양,최응호,김기홍,박석돈,강승주,함정희,명기범,김방순,구상완,김병수,원영호,김한욱,송은섭,정병수,노병인,홍창권,박장규,한지윤,김광중,구대원,김종민,김재홍,유희준,양경미 대한의진균학회 1998 대한의진균학회지 Vol.3 No.2

Background: Onychomycosis, especially toenail onychomycosis has become one of the common fungal infection and has historically been regarded as a cosmetic rather than medical problem by many patients, even by physicians. Recently, however, there are several reports that is a refractory disease which may cause a deleterious effect on patiets quality of life (QOL). Objective: The purpose of this study was to investigate the impact of toenail onychomycosis on QOL in Korea and to assess the chandes of QOL after treatment. Methods: Total 1004 patients with toenail onychomycosis which was confirmed by clinical findings and KOH preparation were were enrolled at 47 dermatologic centers in Korea, and interviewed with standardized QOL questionnaire before and after sytemic antifungal treatment. Responses to the questionnaire were scored by 5-point scale (1∼4) and averaged, and were analyzed for 5 dimensions of emotional impact, social impact, symptorn and functional impact, patients views concerning treatment, and relationship with doctor. Results: 1. Before and after treatment, the most serious impact was emotional dimension showing 1.90 and 1.30 in average score (AS), and social (AS: 1.14 and 0.83) and symptom and functional impact (AS: 1.05 and 0.92) was also affected. 2. In female rather than male, statistically more significant impact on patients QOL was observed in all dimensions. 3. After treatment, 3 of 5 dimensions were improved significantly - emotional dimension (AS : from 1.90 to 1.30), social dimension (AS: from 1.14 to 0.83), patients view concerning treatment (AS: from 1.34 to 1.02). 4. The drgree of patients satisfaction at the therapeutic effect was very high- 62.4% (immediately after treatment) and 65.8% (9 months affer initiation of treatment) of patients answered excellent or good. Conclusion: This study confirms that toenail onychomycosis has significant impact on the overall QOL of patients. Also the effect of antifungal therapy on patients QOL were watisfactory. Therefore, both doctor and patient should pay more attention to the treatment of onychomycosis. [Kor J Med Mycol 3(1): 115∼124]