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박욱화(Wook Hwa Park),이석준(Seok June Lee),이일주(Il Joo Lee),전수일(Soo Il Chun) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.1
T-cell lymphomas primarily involving subcutaneous tissue and minicking panniculitis have rarely been described. In addition, some cases may have been orviously reported as malignant histiocytosis. Some of the affected patients have developed a hemohagocytic syndrome. A 44-year-old wornan showed multiple, recurrent, ill-defined, sarble sized, erythematous, tender subcutnaeous nodules on the trunk and extremities. Histopathological findings levealed the infiltration of hyperchrorriatiatypical large lymphocytes and nurnerous beanbag-like cells in the subcutaneous fat. The infitrted cells were positively stained with Leucocyte common antigen, UCHL-1 antigen, Lysozyme, that ot with CD20. Bone marrow biopsy showed mild erythreid hyperplasia and erythorophagocytic. hitiocytes. These histopathological features were consistent with cutnaeous T cell lymphoma involvnig the subcutaneous tissue. (Kor J Dermatol 1995; 33(1), 188-192)
박욱화(Wook Hwa Park),박태현(Tae Hyun Park),박경득(Kyung Deuk Park),방동식(Dong Sik Bang),전수일(Soo Il Chun) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.1
The onset of systemic scleroderma in the first. decade of lif occurs in less than 1.5% of instances. Systemic sclerodrma in childhood have been characterized by less severe visceral involvement and a benign course We report a boy, aged 7 years, with a history of Raynaid; phenomenon and dysphagia. He had a mask-like face, flexion contracture of hands and knee joints, digital pitting scars, ichthyosiform skin change on leg and hyperpigrnented induration on all extremities and trunk. Antinuclear antibodies were positive in nucleolar type and Scl-70 antiocy was also present. On radiologie study, the pattern of reflux esophagitis and resorption of the listal ends of all phalanges were nated. Histopathological findings were compatible with sclerodma. He was treated with Penicillamine-D and oral corticosteroic with good improvernent. (Kor J Dermatol 1995; 33(1): 183-187)
이상주 ( Sang Ju Lee ),장성남 ( Sung nam Chang ),박욱화 ( Wook Hwa Park ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.1
Acute generalized exanthematous pustulosis(AGEP) is a disease entity caused mostly by drugs or viral infections. Clinically it manifests as generalized erythema, erythema multiforme and amicrobial pustules with fever. Histologically, AGEP is composed of neutrophilic subcorneal and spongiform pustules. A 70-year-old female, with no personal or family history of psoriasis, was given medication including diltiazem for hypertension. Fourteen days after taking the medications, pustular eruptions appeared on the face and rapidly spread to the trunk and limbs. A Laboratory examination revealed neutrophilic leukocytosis and an elevated erythrocyte sedimentation rate. The skin biopsy showed subcorneal and spongiform pustules. We report here a case of AGEP probably due to diltiazem. (Korean J Dermatol 1998;36(1): 125-128)
괴저성 농피증 ( Pyoderma gangrenosum ) 14예에 대한 임상적 고찰
방동식 ( Dong Sik Bang ),윤미라 ( Mi Ra Youn ),장성남 ( Sung Nam Chang ),박욱화 ( Wook Hwa Park ) 대한피부과학회 1998 大韓皮膚科學會誌 Vol.36 No.5
Background : Pyoderma gangrenosum is a rare disease in which a painful nodule or pustule breaks down to form a progressive enlarging ulcer. Until now, only 8 cases of pyoderma gangrenosum have been reported in Korea. Therefore, we thought it necessary to perform a clinical analysis of pyoderma gangrenosum in Korea with a review of literature. Objeetive: Our purpose was to find the clinical features of pyoderma gangrenosum in Korea. Metbods: Fourteen cases with pyoderma gangrenosum were investigated by reviewing medical records. Results There were 6 males and 8 females. The onset age was between 4 years and 65 years, and most(9 cases) had developed the condition between the ages of 20 and 60. Thirteen cases involved the extremities and 3 cases had whale body involvement, Seven cases(50%) had multiple lesions. All cases had pain at the lesional sites. Two cases were classified as the bullous type and the others were ulcerative in nature. The histological fmdings were non-specific. Dense inflarnmatory infiltrates composed of lymphocytes and predominant neutrophils were found in the epidermis and dermis associated with ulceration. Two cases were treated only with systemic steroids, and 2 cases with dapsone and steroids, 2 cases with colchicine and steroids, and 1 case with steroids, dapsone and colchicine. One case was treated with colchicine and anti-Tbc drug, 1 case with dapsone, 3 cases with antibotics, 1 case with the anti-Tbc drug and 1 case with anti-cancer drugs. Systemic disease was present in 5D% of the cases. The associated diseases were Behcets disease(3 cases), tuberculosis(2 cases), systemic lupus erythematosus(1 case), pancytopenia(1 case), iron deficiency anemia(1 case), acute leukemia(1 case), and colon adenoma(1 case). Recurrence developed in 2 cases and positive pathergy reactions were observed in 3 cases. Conclusion . Pyoderma gangrenosum was eccompanied with systemic disease in 50% of the cases and the most common therapeutic drugs were steroids. It is therefore impartant to detect the presence of any underlying disease and to treat this alongside pyoderma gangrenosum. (Korean J Dermatol 1998;36(5) 780-786)
백반증 치료에 있어서 narrow - band UVB 의 효과
김종윤(Chong Yun Kim),윤미라(Mi Ra Youn),유정환,박욱화(Wook Hwa Park) 대한피부과학회 2002 大韓皮膚科學會誌 Vol.40 No.7
N/A Background : Many modalities of treatment for vitiligo have been elucidated and yet the treatment of vitiligo remains to be a challenge. Objectives : The purpose of this article is to review our results and experiences with narrow-band ultraviolet B phototherapy for vitiligo. Method : We studied 9 patients with vitiligo who received narrow band UVB phototherapy for 6 months in our department. This is a retrospective analysis of our experiences and results. Results : Nine patients were able to be evaluated for the purpose of this analysis. Their ages ranged from 6 to 68 years(mean, 18.4 years). Six patients of 9 patients achieved more than 75% repigmentation with a mean of 25 sessions of phototherapy. The remaining three patients had 50%, 40% and 30% repig entation after 44, 40, and 45 sessions of phototherapy, respectively. Adverse effects were mild. Conclusion : Narrow-band UVB is a useful and well-tolerated therapy for vitiligo in comparsion with other therapies.
D - Penicillamine에 의한 담즙 정체성 황달
이준상(Joon Sang Lee),백옥지(Ok Ji Paik),김한성(Han Sung Kim),박성수(Sung Su Park),한경근(Kyung Keun Han),박양훈(Yang Hun Park),제영성(Yeong Sung Jae),박욱화(Wook Hwa Park) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.4
Since 1966, D-Penicillamine has been used in the management of scleroderma. However, its therapeutic usefulness has been limited by a high incidence of a variety of adverse reactions. Cholestatic jaundice secondary to D-Penicillamine administratiori has been reported infrequently. We have experierced a case of acute chotestatic jaundice in a patient with scleroderma treated with D- Fenicillamine. We have encountered a patients who recovered from this complication whn D Penicillamine therapy was withdrawn. Literature was re!iewed briefly.