안정적인 만성 조현병 환자에서 과거 조증 증상과 병식과의 연관성

이의석,홍나래,정명훈,홍현주,전덕인 대한우울조울병학회 2018 우울조울병 Vol.16 No.2

Objectives : Patient insight is a very important factor in the management of schizophrenia. Manic symptoms can occasionally be identified by the patient, even in cases of schizophrenia. The aim of this study is to examine the relationship among patient insight, the psychotic and manic symptoms, and the demographic clinical variables. Methods : Seventy-four participants (male 44, female 30) with chronic schizophrenia in community mental health facilities were evaluated according to the Korean version of the Scale to assess Unawareness of Mental Disorder (SUMD-K), the Korean version of Mood Disorder Questionnaire (K-MDQ), and the Brief Psychiatric Rating Scale (BPRS). Results : The mean number of previous admissions was 3.85. The mean CGI-S score was 3.8 and a significant negative correlation (r=0.26) was shown with “awareness of mental disorder”. Thirty-five percent of subjects were K-MDQ positive (cutoff point=7 or more). Among the SUMD-K, “awareness of effect of medication” showed a significant negative correlation (r=-0.33) with the total K-MDQ score, but not with the total BPRS score. The negative correlation was more obvious in participants with negative K-MDQ (total K-MDQ score 6 or less, r=-0.31). Conclusion : A possible relationship was observed between these manic symptoms and patient insight. Identification of manic symptoms in schizophrenia would be considerable in a clinical setting

유지방구막 추출물의 air-water interface에서 표면활성 특성변화

이의석,정진만,빈국현,홍순택 한국식품영양과학회 2020 한국식품영양과학회 학술대회발표집 Vol.2020 No.10

치조골신장술과 자가골이식술의 안정성을 비교한 전향적 임상시험연구

이의석,이종현,최혁,윤태승,이학기,김현준,신재희 대한통합치과학회 2016 대한통합치과학회지 Vol.5 No.1

Introduction: The aim of this study was to compare the stability of using auto bone graft and distraction osteogenesis for vertical augmentation of resorbed alveolar ridges for implant installation. Method: A total of 14 patients with extremely resorbed alveolar bone were selected and randomly divided into two groups. Auto bone graft was used in the control group (n=7) and distraction osteogenesis was used for the experimental group (n=7). New bone formation was evaluated radiographically by comparing the differences in alveolar preoperatively, after 4 weeks, after 12 weeks and after 24 weeks. Results: Immediately after surgery (T1), an increase in vertical bone height of 4.12±1.01 mm was obtained in the control group. After 4 weeks (T2), vertical bone height was evaluated in each group (Control Group vs Experimental Group; 3.60±0.86 mm vs 5.77±1.71 mm). After 12 weeks (T3), the increase in vertical height of bone was about 3.18±0.68 mm (Control Group) vs 5.56±1.75 mm (Experimental Group). After 24 weeks (T4), increase in vertical bone height for the control group was 2.70±0.41 mm and 5.43±1.74 mm for the experimental group. Comparing bone resorption in each period, the bone resorption between 4 weeks after and 24 weeks after, showed significant difference between the two groups (p=0.03) (0.89±0.69 mm vs 0.34±0.29 mm). Conclusion: Distraction osteogenesis and auto bone graft can be used for reconstruction of horizontal and vertical alveolar bone defects with high prognosis when properly indicated. With 6 month observation period, distraction osteogenesis showed lower bone resorption, so it was a favorable procedure on alveolar bone augmentation.

A Case of Acute Necrotizing Fasciitis Following Internal Jugular Vein Thrombophlebitis: Lemierre's Syndrome

이의석,박동석,장현석,김현준,Besana,임호경 대한통합치과학회 2017 대한통합치과학회지 Vol.6 No.2

Lemierre’s syndrome is caused by preexisting oropharyngeal infection and characterized by internal jugular vein (IJV) thrombophlebitis. Frequently, this syndrome involves metastatic infection in areas such as the peritoneum, muscles, and spleen. The most common etiologic organism is Fusobacterium necrophorum. In this case, a masticatory space abscess that originated from a tooth caused the IJV thrombophlebitis. The patient had preexisting hypertension, diabetes mellitus, hyperlipidemia, and Parkinson’s disease. Blood culture revealed Streptococcus sanguinis, and the patient received antibiotics that were highly sensitive to mentioned bacterium; additionally, an anticoagulant was used. With the widespread use of antibiotics, Lemierre’s syndrome has become uncommon, and related mortality rates have noticeably decreased. This has led the public to forget about the disease, but it can still be potentially fatal without early diagnosis and appropriate antibiotic treatment.

표면 활성화 처리가 비정질 규소 박막의 결정화에 미치는 영향

이의석,김영관 한국결정성장학회 1999 한국결정성장학회지 Vol.9 No.2

본 연구에서는 비정질 규소 박막의 결정화를 촉진시키기 위하여 표면 활성화 처리의 영향을 관찰하였다. 표면 활성화 방법으로는 습식 연마법(Wet Blasting)과 Nd:YAG 레이저의 빔을 사용하였고, 700~$800^{\circ}C$에서 관상로 열처리를 행하여 고살 결정화에 미치는 영향을 보았다. 결정화 정도의 기준으로는 XRD 분석을 통해 얻은 (111) 피크강도를 이용하였으며, 결정의 품질을 분석하기 위해 Raman 분석을 행하였다. 결정화의 표면 형상에 대한 관찰은 주사전자 현미경(SEM)을 사용하였다. 본 실험 결과 표면 활성화 처리는 비정질 규소박막의 결정화를 촉진하고, 결정의 품질을 향상시키는 것으로 확인되었다. 습식 연마법(Wet Blasting)의 경루 2 Kgf/$\textrm{cm}^2$의 압력이 가장 효과적이었고, 레이저의 에너지는 100~200mJ/$\textrm{cm}^2$가 효과적이었다. 이것은 표면활성화처리를 통하여 비정질 실리콘 박막의 표면에 strain energy가 형성되어 결정화에 필요한 엔탈피에 영향을 미친 효과 때문으로 예상된다. The effect of the surface activation treatment on the crystallization of the amorphous silicon film was investigated. The amorphous silicon film was deposited on the silica substrate with LPCVD technique. Wet blasting with silica slurry or exposure with Nd:YAG laser beam was applied on the amorphous silicon film before annealing for the crystallization. For the analysis of the crystallinity, XRD, Raman, and SEM were employed. In this investigation, the prior surface activation treatment like silica wet blasting or Nd:YAG laser beam exposure before annealing for the crystallization were found to be effective in the enhancement of the crystallization. It is believed that these treatment lower the activation energy required for the crystallization of the amorphous silicon film.

백서의 두개골 결손부에서 제대혈 유래 간엽줄기세포의 골재생에 관한 연구

이의석,장현석,권종진,이진용,임재석,서병무,윤정현,임재형 대한통합치과학회 2013 대한통합치과학회지 Vol.2 No.1

It has been suggested that umbilical cord blood (UCB) contains multipotent stem cells. Some authors suggest that within UCB are cells with potential for differentiation down mesenchymal lineages and UCB is one of the readily available sources of stem cells that may be used for bone regeneration. Isolation and characterization of these cells has been accomplished in some centers. Differentiation of these cells down multiple lineages has been documented. The use of UCB derived stem cells was investigated in this animal studies. Polycaprolactone‐20% tricalcium phosphate (PCL‐TCP) polymers allow for cellular adherence and differentiation and are adequate scaffolds for bone regeneration in tissue engineering strategies. The purpose of this study was to evaluate the potential of MSCs from UCB seeded onto PCL‐TCP composite scaffolds for bone tissue engineering. MSCs were isolated from UCB. MSCs from UCB seeded onto PCL‐TCP scaffolds were then implanted in calvarial bone defect of the athymic mouse. As a control, in each mouse was treated with scaffold only. At six and twelve weeks post‐implantation, histological examinations were performed. MSCs from UCB with PCL‐TCP scaffolds did not exhibited bone regeneration in calvarial bone defects in athymic mouse. Histological examination did not reveal the presence of regenerated bone of the defect. MSCs from UCB should be considered further applications in tissue‐engineered bone regeneration.

지방조직 유래 줄기세포의 조골세포로의 분화에 대한 실험적 연구

이의석,장현석,권종진,임재석,Lee, Eui-Seok,Jang, Hyon-Seok,Kwon, Jong-Jin,Rim, Jae-Suk 대한악안면성형재건외과학회 2008 Maxillofacial Plastic Reconstructive Surgery Vol.30 No.2

Stem cells have self-renewal capacity, long-term viability, and multiline age potential. Adult bone marrow contains mesenchymal stem cells. Bone marrow-derived mesenchymal stem cells (BMSCs) are progenitors of skeletal tissue components and can differentiate into adipocytes, chondrocytes, osteoblasts, and myoblasts in vitro and undergo differentiation in vivo. However, the clinical use of BMSCs has presented problems, including pain, morbidity, and low cell number upon harvest. Recent studies have identified a putative stem cell population within the adipose tissue. Human adipose tissue contains pluripotent stem cells simillar to bone marrow-derived stem cells that can differentiate toward the osteogenic, adipogenic, myogenic, and chondrogenic lineages. Human adipose tissue-derived stem cells (ATSCs) could be proposed as an alternative source of adult bone marrow stem cells, and could be obtained in large quantities, under local anesthesia, with minimal discomfort. Human adipose tissue obtained by liposuction was processed to obtain ATSCs. In this study, we compared the osteogenic differentiation of ATSCs in a specific osteogenic induction medium with that in a non-osteogenic medium. ATSCs were incubated in an osteogenic medium for 28 days to induce osteogenesis respectively. Osteogenic differentiation was assessed by von Kossa and alkaline phosphatase staining. Expression of osteocyte specific bone sialoprotein, osteocalcin, collagen type I and alkaline phosphatase, bone morphogenic protein 2, bone morphogenic protein 6 was confirmed by RT-PCR. ATSCs incubated in the osteogenic medium were stained positively for von Kossa and alkaline phosphatase staining. Expression of osteocyte specific genes was also detected. Since this cell population can be easily identified through fluorescence microscopy, it may be an ideal source of ATSCs for further experiments on stem cell biology and tissue engineering. The present results show that ADSCs have an ability to differentiate into osteoblasts. In the present study, we extend this approach to characterize adipose tissue-derived stem cells.

성견에 있어서 치조제보존술을 위한 치아뼈이식재의 효과

이의석,주현중,장환용,이진용,임재석,장현석 대한통합치과학회 2014 대한통합치과학회지 Vol.3 No.2

Purpose: The purpose of this study was to compare histologic evaluation of autogenous and allogenous tooth material on bone-healing response in dog. Materials and Methods: Allogenous tooth biomaterial was grafted in the extraction socket of the premolar region in the left lower jaws and autogenous tooth biomaterial was grafted in the right side after 2 weeks. Three dogs were sacrificed after 4, 8, 12 weeks each for histological evaluation. Results: In the histologic analysis, there were no signigicant differences between group 1 (autogenous tooth bone biomaterial) and group 2 (allogenous tooth bone biomaterial) at 4, 8, 12 weeks. Statistical analysis showed that group 1 was more higher bone volume levels than group 2 at 4 weeks (P⁄0.05, Mann-whitney test). Group 2 showed more higher bone volume levels than group 1 at 8 weeks and group 1 more than group 2 at 12 weeks but that showed no significant differences (P¤0.05, Mann-whitney test). Conclusion: Histologically, autogenous and allogenous tooth biomaterial reveals similar healing patterns in extraction socket in dogs. The result of this study suggested that tooth biomaterials could be useful materials for socket preservation.

홍삼정과 부산물 첨가한 쿠키의 품질특성연구

이의석,류관모,김선형,지연선,박은정,전병선,홍순택 한국식품영양과학회 2016 한국식품영양과학회 학술대회발표집 Vol.2016 No.10

유채박 유래 표면활성물질 정제

이의석,김산성,길나영,박은정,이기택,장영석,홍순택 한국식품영양과학회 2014 한국식품영양과학회 학술대회발표집 Vol.2014 No.10