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소화기 양성질환 및 악성종양에 있어서 CA 19 - 9 , CEA , CA125 및 AFP 에 관한 연구
문한규(Han Kyu Moon),허윤(Yoon Huh),차광수(Kwang Soo Cha),양웅석(Ung Suk Yang),최장락(Jang Rack Choi),강필중(Pill Joong Kang),이광욱(Kwang Uk Lee) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.2
Serum concentrations of CA19-9, CEA, and CA125 in 147 patients with gastrointestinal and hepatobiliary diseases, 68 malignant and 79 nonmalignant, were investigated to analyze the clinical significance of these tumor markers, and furthermore, these tumor markers were compared with AFP in the patients with hepatic diseases, both benign and malignant. The results were summarized as following: 1) The serum concentrations of CA19-9, CEA, and CA125 were much higher in the malignant diseases than those of benign diseases, and also significantly higher sensitivities were observed in CA19-9 and CA125 in the malignant diseases. But the sensitivities of CEA inthe malignant and benign diseases were not showed statistical difference (28% vs 15%). 2) The serum concentrations of AFP in patients with hepatoma were significantly higher than those of liver cirrhosis or other benign liver diseases, and also significantly higher sensitivity of AFP was observed in the patients with hepatoma than the others. 3) Between the each disease and each tumor marker, there were no significant correlations. 4) According to the presence of metastasis or not, no significant diffetence in the mean values of the tumor markers was observed. But in the patients with hepatoma, much higher value of AFP was obtained in the patients with metastasis (107.7 +- 148.9 ng/ml vs 281.8 +- 108.1 ng/ml, p<0.05). 5) ln the patients with cancer of biliary tract, pancreas and colorectal region, there noted high serum levels and sensitivities of CA19-9, and highest sensitivity of CA19-9 in the patients with benign biliary tract disease, mainly composed of acute cholangitis. But the statistical significance was not defined in these small number of groups. 6) In the patients with the malignant diseases, the sensitivity of CA125 was 46%, and with color- ectal, pancreatic, and stomach cancer, the sensitivities of CA125 were 60%, 56%, and 53% in order. 7) Single CEA test is not sufficient for the screening of gastrointestinal malignancy. Combined tumor marker tests among CEA, CA19-9 and CA125 were more accurate than single test.
박옥성,김종환,이광욱,윤성훈,강동구,이승욱,조상기 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2
Acute myocarditis complicating coronary vasospasm after smallpox vaccination is very rare complication that can be generally developed within less than 30 days after vaccination. Clinically and biochemically, this disorder is often mimic and highly suggestive of acute myocardial infarction. We report 21 years old man that had a history of a smallpox vaccination 3 weeks ago and prodromal symptoms(fever, malaise etc) a few days ago. hIe visited to our hospital because of abrupt onset of severe substernal chest pain, dyspnea and diaphoresis. At admission, electrocardiography was ST elevation in lead Ⅰ, aVL, V4, V5, and V6. The CK-MB level was 68 U/L, LDH level was 760 U/L, Troponin-Ⅰ was 24.64 ng/㎖, and Troponin-T was positive. 2D-echocardiograpy was normal left ventricular function, Clinically we presumed this disorder as acute myocardial infarction and we promptly performed the coronary angiography and revealed focal spasm in distal left coronary artery territory without critical stenosis in both coronary arteries. We diagnosed this disorder as coronary vasospam complicating acute myocarditis that is different with acute myocardial infarction, and we prescribed nitroglycerin and nifedipine. After discharge, he is now well without any symptoms and has been following up monthly at our outward department for 6 months.
정종필,김윤아,서강석,김태현,김춘호,박정복,이광욱 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2
The gastrointestinal involvement in rheumatoid arthritis may be broad and includes many causes: drug induced colitis, colitis associated with infectious agents, vasculitis in gut, autoimmune disease located in gut. Rheumatoid arthritis is a chronic multisystemic disease of unknown cause. Although a number of mixed autoimmue disease exist, there were rare reports about Ulcerative colitis with Rheumatoid arthritis associated. We report one case of Rheumatoid arthritis patient who diagnosed as Ucerative colitis by colonoscopic and histologic finding with review of literature.
류마치스성 관절염과 동반된 Ochronosis(조직갈변증) 1 예
김상현,이종수,김진도,문한규,최장락,강필중,이광욱,나하연,이헌직,여동승,윤영권,황병욱,곽임수 대한내과학회 1991 대한내과학회지 Vol.41 No.1
Ochronosis, which is autosomal recessive, results from a decreased amount of the enzyme homogentisic acid oxidase, due to which tyrosine and phenylalanine cannot be broken down via the normal pathway. The clinical manifestations of ochronosis usually appear after the age of 30 as a result of the deposition of pigment in the extracellular macromolecules of the connective tissue, particular of the skin and joints. The diagnosis is made by determination of urinary homogentisic acid excretion, and the clinical and radiological findings can help to diagnose this disease. We report a case of Ochronosis with Rheumatoid arthritis presented with skin pigmentation and migrating polyarthritis in a 57-year-old female patient who was managed with an antiinflammatory agent, steroids, and symptomatic care.