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문한규(Han Kyu Moon),조중현(Joong Hyeon Cho),김영훈(Young Hoon Kim),한상영(Sang Yeoung Han),김치호(Chi Ho Kim) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.1
N/A The serum ferritin levels were measured by radioimmunoassay in 25 normal subjects and 88 patients with various liver diseases, and compared with serum transaminase activity and with alpha-fetoprotein in liver cirrhosis and primary liver cancer. The results were as follows; 1) The serum ferritin levels in 25 normal subjects were in a range of 27.2 191.0 ng/ml, and the mean value was 88.3+-39.4ng/ml. 2) The serum ferritin levels in various liver diseases were as follows: 500.7+-422.8 ng/ml in acute viral hepatitis, 73.6+64.5 ng/ml in chronic persistent hepatitis, 281.4+-214.7 ng/ml in chronic active hepatitis, 317+- 368.7 ng,'ml in liver cirrhosis, 703.2+-509.7 ng/ml in primary liver cancer with cirrhosis, 383.2+-475.9 ng/ml primary liver cancer without cirrhosis, 734.0+-320.0 ng/ml in cancer metastasis to liver, 252.7+-89.1 ng/ml in obstructive jaundice, 289.3+-117.7 ng/ml in liver abscess. Serum ferritin levels of each disease group were significantly higher than normal control (p<0.01) except chronic persistent hepatitis, and good correlation existed between serum ferritin and serum transaminase activity which suggested that the elevation of the serum ferritin level was due to leakage of storage ferritin by hepatocellular damage. 3) In acute viral hepatitis, on following, the decrease in serum ferritin accompanied with the decreasing of SGPT during recovery stage. 4) In the differential diagnosis between liver cirrhosis and primary liver cancer, measurement of the serum ferritin did not show more significant value than alpha-fetoprotein.
문한규(Han Kyu Moon),허윤(Yoon Huh),양웅석(Ung Suk Yang),김치호(Chio Ho Kim),최장락(Jang Rack Choi),강필중(Pill Joong Kang),유방현(Bang Byun Liu),박희욱(Hee Ug Park) 대한소화기학회 1989 대한소화기학회지 Vol.21 No.3
The presence of aberrant right subclavian artery which causes dysphagia in adults is rare. However its recognition as a possible cause of dysphagia is important because of its benign prognosis. This type of dysphagia must be considered in the differential diagnosis of difficulty in swallowing in the elderly as well as in children and young adults. We report a case of an aberrant right subclavian artery (Dysphagia Lusoria), 53-year-old woman who presented dysphagia. This case was confirmed and treated by surgical operation.
만성 활동성 간염에 있어 생화학적 , 혈청학적 및 조직학적 소견의 비교 관찰
문한규(Han Kyu Moon),심원보(Won Bo Shim),서영도(Yeong Do Suh),윤명순(Myeong Soon Yoon),김영훈(Ywong Hoon Kim),박형구(Hyung Koo Park) 대한소화기학회 1985 대한소화기학회지 Vol.17 No.1
N/A The authors have evaluated thirty-two patients of chronic active hepatitis ccnfirmed by needle biopsy of liver to compare the biochemical values in the group of HBeAg with those in the group of HBeAg(-), and to compare the biochemical values according to histologic severity. The patients were composed of male 26, female 6, and the mean age was 35. 5 years. There was not any significant difference of age between male and female. The incidences of HBV markers were 75% in HBsAg, 19% in Anti-HBs, 97% in Anti-HBc, 47% in HBeAg, and 16% in Anti-Hbe by radioimmunoassay, but there was not any significant difference of the incidences of HBV markers according to histologic severity. The activity of aminotransferase was elevated more in the group of HBeAg(+) compared to the group of HBeAg(-), but there was not any significant difference between the two groups. The activity of aminotransferase and the value of globulin were elevated more in the group having bridging necrosis compared to the group having piecemeal necrosis only or with focal necrosis without bridging necrosis, but there was not any significant difference between the two groups. The authors conclude that it is absurd to predict the histologic severity of chronic active hepatitis with the persistence of HBsAg or HBeAg, or with the values of biochemical test.
소화기 양성질환 및 악성종양에 있어서 CA 19 - 9 , CEA , CA125 및 AFP 에 관한 연구
문한규(Han Kyu Moon),허윤(Yoon Huh),차광수(Kwang Soo Cha),양웅석(Ung Suk Yang),최장락(Jang Rack Choi),강필중(Pill Joong Kang),이광욱(Kwang Uk Lee) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.2
Serum concentrations of CA19-9, CEA, and CA125 in 147 patients with gastrointestinal and hepatobiliary diseases, 68 malignant and 79 nonmalignant, were investigated to analyze the clinical significance of these tumor markers, and furthermore, these tumor markers were compared with AFP in the patients with hepatic diseases, both benign and malignant. The results were summarized as following: 1) The serum concentrations of CA19-9, CEA, and CA125 were much higher in the malignant diseases than those of benign diseases, and also significantly higher sensitivities were observed in CA19-9 and CA125 in the malignant diseases. But the sensitivities of CEA inthe malignant and benign diseases were not showed statistical difference (28% vs 15%). 2) The serum concentrations of AFP in patients with hepatoma were significantly higher than those of liver cirrhosis or other benign liver diseases, and also significantly higher sensitivity of AFP was observed in the patients with hepatoma than the others. 3) Between the each disease and each tumor marker, there were no significant correlations. 4) According to the presence of metastasis or not, no significant diffetence in the mean values of the tumor markers was observed. But in the patients with hepatoma, much higher value of AFP was obtained in the patients with metastasis (107.7 +- 148.9 ng/ml vs 281.8 +- 108.1 ng/ml, p<0.05). 5) ln the patients with cancer of biliary tract, pancreas and colorectal region, there noted high serum levels and sensitivities of CA19-9, and highest sensitivity of CA19-9 in the patients with benign biliary tract disease, mainly composed of acute cholangitis. But the statistical significance was not defined in these small number of groups. 6) In the patients with the malignant diseases, the sensitivity of CA125 was 46%, and with color- ectal, pancreatic, and stomach cancer, the sensitivities of CA125 were 60%, 56%, and 53% in order. 7) Single CEA test is not sufficient for the screening of gastrointestinal malignancy. Combined tumor marker tests among CEA, CA19-9 and CA125 were more accurate than single test.