양성자펌프억제제에 반응하지 않는 인두이물감 환자에서 "뮤코미스트Mucomyst^®" 객담제거 및 상기도 염증치료를 통한 증상개선효과 평가 다기관, 단일군, 전향적 관찰 연구

박한나,박일석,이상혁,이승원,이상준,이병주,천용일,박준욱,오경호,신유섭,Park, Hannah,Park, Il-Seok,Lee, Sang Hyuk,Lee, Seung-Won,Lee, Sang Joon,Lee, Byung-Joo,Cheon, Yong-Il,Park, Jun-Ook,Oh, Kyoung Ho,Shin, Yoo Seob 대한후두음성언어의학회 2022 대한후두음성언어의학회지 Vol.33 No.1

Background and Objectives Globus pharyngeus is one of the most common symptoms of patients visiting otorhinolaryngology out-patient clinic, and usually long-lasting, difficult to treat, and frequently recurrent. Mucomyst^®, N-acetyl cysteine is an inhalation agent mainly used for mucolysis and reducing inflammation in airway via antioxidative effect. The purpose of this study was to evaluate the efficacy of inhaled Mucomyst^® treatment in patients with globus pharyngeus refractory to proton pump inhibitor (PPI). Materials and Method We prospectively evaluated the efficacy of Mucomyst^® in relieving symptoms of globus pharyngeus refractory to PPI in nine medical centers. Three hundred and three patients enrolled and finally 229 patients finished the inhaled Mucomyst^® therapy for 8 weeks. We analyzed the change of Reflux Symptom Index (RSI), Reflux Finding Score (RFS), Visual Analogue Scale (VAS) for globus, and Globus Pharyngeus Symptom Scale (GPS) after use of Mucomyst^® for 4 and 8 weeks. Results The GPS, RSI, RFS, and VAS score significantly decreased serially in patients who finished 8 week-inhalation treatment. The GPS improvement gap was significantly correlated with initial GPS (p<0.001) in multiple regression analysis. Conclusion Inhaled Mucomyst^® therapy was effective for the reduction of both subjective and objective findings in refractory globus patients. This study might suggest new treatment option for patients with globus. However, further thorough studies would be needed to assess the real effect of inhaled Mucomyst^® treatment as a standard treatment for globus.

방문간호사의 감염관리에 대한 지식, 태도 및 수행

박한나,이인숙,김지은,권소현,추진아,Park, Han Nah,Lee, Insook,Kim, Jieun,Gweon, Sohyeon,Choo, Jina 한국가정간호학회 2022 가정간호학회지 Vol.29 No.1

Purpose: Purpose: This study aimed to identify whether infection control practice would correlate significantly with the knowledge and attitude of infection control in the pre-, mid-, and postvisiting rounds among community-visiting nurses. Methods: A descriptive study was conducted based on the knowledge, attitude, and practice (KAP) model by administrating questionnaires during September-October 2020. A total of 65 nurses working for 15 community health centers in Seoul, South Korea were included. The questionnaires were developed based on the epidemiologic triangle model and comprised of 28 items on practice, 18 items on knowledge, and 10 items on attitude. Results: The infection control practice showed a mean of 88.9 (range, 0-100). The infection control knowledge had 89.2% on the host domain, 80.0% on the environment domain, and 74.8% on the agent domain (range, 0-100). The infection control attitude showed a mean of 39.5 (range, 0-50). Higher scores on the infection control practice are significantly correlated with the higher scores on the infection control knowledge about the host domain (p= .004) at the pre-, mid-, and post-visiting rounds. Higher scores on the infection control practice are significantly correlated with the higher scores on the infection control attitude at the mid- (p= .018) and postvisiting rounds (p= .028). Conclusions: The infection control practice by community-visiting nurses may be enhanced with increased knowledge and attitude levels of infection control at the mid- and post-visiting rounds. The enhancement should be included in the on-the-job education for community-visiting nurses.

경부 피부에서 발생한 저등급 근섬유모세포 육종 증례 보고

박한나라(Hannara Park),임준현(Junhyun Lim),박효천(Hyochun Park),여현정(Hyeonjung Yeo) 대한두경부종양학회 2022 대한두경부 종양학회지 Vol.38 No.2

Myofibroblastic sarcoma can be classified as low-, intermediate-, and high-grade. Low-grade myofibroblastic sarcoma (LGMS) is uncommon and rarely appears on the skin. LGMS is diagnosed based on histopathological and immunohistochemical findings. Additionally, LGMS metastases are rare as well. Herein, the authors describe a case of cutaneous LGMS in the neck. To the best of our knowledge, there are no cases regarding cutaneous LGMS in the neck present in the existing literature. Surgical resection is considered as the most important treatment for LGMS. Therefore, a complete tumor resection was performed in this case. However, another mass in the uterus was identified on abdominal computed tomography performed post-surgery.

환원력이 다른 폴리올을 이용한 은 나노입자의 제조 및 특성 고찰

박한나,김민희,박원호,Park, Hanna,Kim, Min Hee,Park, Won Ho 한국섬유공학회 2015 한국섬유공학회지 Vol.52 No.3

In this study, silver particles were prepared using two polyols at different reduction rates under controlled experimental conditions. Isosorbide was employed as a novel polyol reductant for silver particles, and its reduction rate in the polyol process was compared with ethylene glycol (EG). When the isosorbide reductant was used in the polyol process, silver particles could be formed. However, the reduction rate of isosorbide was slower than that of EG, and the resultant silver particles thus had anisotropic shapes. Additionally, the size of silver particles was dependent on the presence and amount of the PVP stabilizer. Therefore, the shape and size of silver particles were mainly affected by the reduction rate and stabilizer, respectively.

철골보의 내화시간 평가를 위한 구조 및 열적 변수해석

박한나,안재권,이철호,Park, Han Na,Ahn, Jae Kwon,Lee, Cheol Ho 한국강구조학회 2009 韓國鋼構造學會 論文集 Vol.21 No.6

본 연구에서는 다양한 설계조건 하에서 철골보의 내화시간을 평가할 수 있는 산정식을 열-구조 연성해석(fully coupled thermo-mechanical analysis)을 토대로 제안하였다. 본 연구에서 제안하는 산정식은 철골보의 화재거동에 미치는 주요 인자를 구조변수 및 열변수로 명시적으로 반영하므로 각 설계변수의 내화성능에 대한 영향을 설계자가 쉽게 정량적으로 파악할 수 있는 강점이 있다. 광범위한 변수해석을 수행하기에 앞서 실물대 화재실험 결과를 활용하여 본 연구의 열-구조 연성해석모델의 타당성을 검증한 후, 철골보에 붕괴처짐(run-away deflection)이 발생할 때까지 화재거동에 대한 각 변수들의 영향력을 검토하였다. 이러한 수치해석결과를 다양한 설계조건에서 철골보의 내화시간 예측에 활용할 수 있도록 다중선형회귀분석을 통해 통계학적으로 신뢰도가 높은 평가식을 제안하였다. 현행 사양설계기준에서의 활용법을 사례를 들어 예시하였고, 제시된 식으로부터 얻어지는 경제성과 장점을 입증하였다. This paper proposes a versatile formula which can be used to evaluate the fire resistant time of steel beams under various design conditions. Towards this end, the key parameters which affect the fire performance of steel beams were first determined through thermo-mechanical considerations, and classified into two groups: structural parameters and thermal parameters. Then the degree of influence of each parameter on the fire performance was investigated through a fully coupled thermo-mechanical analysis up to the occurrence of run-away deflection. The accuracy of the numerical model used was verified using an available full-scale fire test before conducting an extensive parametric analysis. Multiple linear regression analysis was performed to obtain the formula which can be used to predict the fire resistance time of steel beams under various design conditions. The statistical analysis showed that the proposed formula is very robust. The application of the formula in practical fire design under the current code was illustrated in detail. The economy and other advantages of the proposed formula were clearly shown.

중증외상환자에서 TRISS를 활용한 예방가능 중증외상사망률 지표: PARK Index

박찬용 ( Chan Yong Park ),유병철 ( Byung Chul Yu ),김호현 ( Ho Hyun Kim ),황정주 ( Jung Joo Hwang ),이정남 ( Jung Nam Lee ),조현민 ( Hyun Min Cho ),박한나 ( Han Na Park ) 대한외상학회 2015 大韓外傷學會誌 Vol.28 No.3

Purpose: To calculate Preventable Trauma Death Rate (PTDR), Trauma and Injury Severity Score (TRISS) is the most utilized evaluation index of the trauma centers in South Korea. However, this method may have greater variation due to the small number of the denominator in each trauma center. Therefore, we would like to develop new indicators that can be used easily on quality improvement activities by increasing the denominator. Methods: The medical records of 1005 major trauma (ISS >15) patients who visited 2 regional trauma center (A center and B center) in 2014 were analyzed retrospectively. PTDR and PARK Index (Preventable Major Trauma Death Rate, PMTDR) were calculated in 731 patients with inclusion criteria. We invented PARK Index to minimize the variation of preventability of trauma death. In PTDR the denominator is all number of deaths, and in PARK Index the denominator is number of all patients who have survival probability (Ps) larger than 0.25. Numerator is the number of deaths from patients who have Ps larger than 0.25. Results: The size of denominator was 40 in A center, 49 in B center, and overall 89 in PTDR. The size of denominator was significantly increased, and 287 (7.2-fold) in A center, 422 (8.6-fold) in B center, and overall 709 (8.0-fold) in PARK Index. PARK Index was 12.9% in A center, 8.3% in B center, and overall 10.2%. Conclusion: PARK Index is calculated as a rate of mortality from all major trauma patients who have Ps larger than 0.25. PARK Index obtain an effect that denominator is increased 8.0-fold than PTDR. Therefore PARK Index is able to compensate for greater disadvantage of PTDR. PARK Index is expected to be helpful in implementing evaluation of mortality outcome and to be a new index that can be applied to a trauma center quality improvement activity. [ J Trauma Inj 2015; 28: 115-122 ]

굴참나무(Quercus variabilis) 코르크 내 수베린의 항미생물 활성 평가

박한나 ( Hanna Park ),김병호 ( Byeongho Kim ),박경찬 ( Kyoung-chan Park ),김예선 ( Yesun Kim ),장재혁 ( Jae-hyuk Jang ),김남훈 ( Nam-hun Kim ),박세영 ( Se-yeong Park ) 한국목재공학회 2022 한국목재공학회 학술발표논문집 Vol.2022 No.1

굴참나무(Quercus variabilis)는 참나무과에 속한 낙엽교목이며, 일본, 중국 및 우리나라에 주로 분포하는 참나무 수종이다. 국내 참나무류 중 굴참나무는 수피에 코르크층이 두껍게 발달 되어있는 것이 특징이다. 이러한 코르크는 수베린(suberin)이 주성분으로 함유되어 있으며, 전체 조성에서 약 50%를 차지한다. 한편, 선행된 연구인 갈색부후균(Fomitopsis palustris)과 백색부후균(Trametes versicolor )에 대한 내후성 평가를 통해 내후성 등급이 매우 큰 것을 확인하였으며, 이를 토대로 본 연구에서는 굴참나무 코르크 내 수베린 성분에 대한 항미생물 활성 평가를 수행하고자 하였다. 코르크 내 수베린 추출을 위해 먼저 디클로로메탄, 에탄올, 물로 추출물을 추출한 후 메탄올분해 반응을 수행하였으며, 그 결과 굴참나무 내 수베린 함량은 약 52%로 나타났다. 추출된 수베린에 대한 항미생물 활성 평가를 위해 Agar well diffusion과 Paper disc법을 수행하였으며, 균주는 Fomitopsis palustris, Trametes versicolor와 표면오염균인 Penicillium glabrum, Trichoderma harzianum 및 Aspergillus niger를 사용하였다. 또한, 성분에 대한 항산화 활성 평가를 위해 DPPH 활성 및 ABTS 라디칼 소거법을 수행하였다.

참오동나무 목질부 추출물의 생리활성

박한나 ( Hanna Park ),박경찬 ( Kyoung-chan Park ),김병호 ( Byeongho Kim ),박세영 ( Se-yeong Park ) 한국목재공학회 2021 한국목재공학회 학술발표논문집 Vol.2021 No.2

속성 조림수인 참오동나무(Paulownia tomentosa (Thunb.) Steud.)는 오동나무과(Paulowniaceae) 오동나무속(Paulownia)이며 낙엽활엽 교목이다. 한국, 중국, 일본에 분포하고 있으며 국내에서는 중부이남에서 자생하고 있다. 참오동나무는 예부터 장롱이나 거문고와 같은 전통 악기를 제작하기 위해 목재 이용 목적으로 생육되어져 왔다. 한편, 참오동나무에는 내후성이 좋은 것으로 알려진 lignan류 중 (+)- paulownin과 (+)- sesamin 등이 있다고 알려져 있다. 따라서 국산 참오동나무로부터 추출된 천연 내후성 물질을 탐색하고자 하였으며, 참오동나무 목질부로부터 분리된 추출성분 분석을 통해 효율적 이용을 위한 기초적인 자료를 얻고자 하였다. 사용된 공시재료는 강원대학교 학술림에서 채취한 참오동나무를 이용하였으며, 목질부를 분쇄하여 60% 에탄올로 상온 침지한 후 조추출물(crude)로 회수하였다. 농축된 조추출물은 n-hexane, chloroform, ethyl acetate 순으로 분획을 실시하였다. 본 연구에서는 추출물의 분획물에 대한 박층 크로마토그래피, 항산화 활성 및 항진균 시험을 수행하였다. 항산화 활성 평가에는 DPPH radical 소거법을, 항진균에 대한 활성 시험에서는 한국 목재 내후성 평가용 공시 부후균인 백색부후균(Trametes versicolor ), 갈색부 후균(Fomitopsis palustris) 대한 paper disc 확산법을 수행하였고, 이에 대한 결과를 보고하고자 한다.

외식고객의 외식정보탐색 속성 및 유형에 관한 연구

박한나(Park, Han-Na),경영일(Kyoung, Young-Il) 한국외식산업경영학회 2013 외식산업경영연구 Vol.9 No.1

This research wished to examine food service Information seeking of attribute by food service customer’s. It is purpose of this research that wished to develop customer reaction about food service marketing that illuminate food service corporations marketing activity means configurationally and present ne classification system of marketing operation and strategic practical way. Periods achieve during 55days from July 1, 2012 to August 25 all. If summarize analysis result of collected data. Food service Involvement, food service satisfaction, result search for information that execute factor for brand difference earth’s crust and believability analysis are 3 factor, food service satisfaction is 3 factors.

국내외 대도시 지하철 노선도 색채 현황 조사

박한나(Hanna Park),백진경(Jinkyung Paik) 한국색채학회 2019 한국색채학회 학술대회 Vol.2019 No.5

현시대의 버스, 철도, 지하철과 같은 대중적 교통수단 이용비중은 나날이 증가하고 있다. 그 중, 원하는 목적지 및 관련정보를 광범위한 사용자들에게 전달할 수 있는 지하철 노선도는 대중교통을 이용하는 이들에게 없어서는 안 될 필수적인 시스템이다. 또한 이용자와 안내정보를 연결하는 매개체로서의 기능도 중요하므로 보다 판별이 쉬운 디자인으로 구성되어야한다. 이에 본 연구는 국내외 지하철 노선도 현황을 조사하고 각 노선도를 색채 관점에서 분석하였다. 연구 범위는 9개 이상의 노선이 있는 국내외 대도시 서울, 베이징, 도쿄, 영국, 런던을 대상으로 하였다. 이를 바탕으로 정확한 색채분석을 위해 각 노선도가 가지고 있는 색채 구성 현황을 한국표준색 색채분석(KSCA) 프로그램을 사용하여 평균적인 L*a*b*값으로 분석하고 현황을 비교분석 하였다.