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보양환오탕(補陽還五湯)이 혈전생성관여인자(血栓生成關與因子)에 미치는 영향(影響)
박종형,한양희,전찬용,김동우,박세기,이청정혜,고승희,고재철,최유경,박선영,Park, Jong-Hyung,Han, Yang-Hi,Jun, Chan-Yong,Kim, Dong-U,Park, Se-Gi,Lee, Chung-Jung-Hye,Go, Seung-Hi,Go, Jae-Chul,Choi, You-Kyung,Park, Sun-Young 대한한방내과학회 2000 大韓韓方內科學會誌 Vol.21 No.5
Purpose : To investigate the inhibitory effect of BHE on platelet aggregation and erythrocyte deformability, we performed following experiments. Methods : Concentrated Boyanghwanotang (BHE) was fed to rats for 10days. High dose group was treated with $500{\beta}{\partial}/kg$ and low dose group with $500{\beta}{\partial}/kg$. Results : BHE enhanced the blood filtration rate, reduced the platelet aggregability, inhibited granule release from collagen-stimulated platelet, the prostaglandin syn-thesis in platelet and enhanced erythrocyte deformability. Conclusion : BHE should inhibit thrombos formation due to platlete hyperaggregabili-ty and reduction of erythrocyte deformabi-lity.
박환표(Hwan-Pyo Park),한재구(Jae-Goo Han),진경호(Kyung-Ho Chin) 대한설비공학회 2010 대한설비공학회 학술발표대회논문집 Vol.2010 No.6
Recently, international LNG plant construction markets are expending. However, international LNG plant construction projects are high risk and complicated. So, risk management based construction is needed. This research has drew the construction management factors and evaluate its decision weight to secured the technology of construction management in LNG plant EPC phases. And this research has suggested decision making support system to manage construction management considering decision making methodology in LNG Plant project.
박정한(Jung Han Park),김경환(Kyung Hwan Kim),전혜리(Hae Ri Jun),이주영(Ju Young Lee) 한국의학교육학회 1999 Korean journal of medical education Vol.11 No.2
1983년에 전국 규모의 의대생들에 대한 의식 및 가치관 조사를 실시한 이래 그동안 의대 수와 학생정원이 약 2배 증가하였고 사회․경제적 여건도 많이 변하였으므로 의대생들의 의식과 가치관이 어떻게 변하였는지 알아보기 위하여 이 조사를 다시 실시하였다. 1997년 11월 당시 전국의 40개 의대가운데 의학과 4학년까지 재학생이 있는 32개 대학의 의학과 재학생 전원을 모집단으로 하여 각 학년별 학생명부의 출석번호를 이용하여 10명에 1명씩 계통표본추출을 하고, 각 학년의 출석번호 끝번을 추가한 표본을 대상으로 설문조사를 하였다. 설문지는 1983년에 사용한 것을 근간으로 하여 최근 의료환경 변화에 대한 내용과 의대생들의 의학 및 직업관 형성에 관련된 문항을 추가하여 개발하였다. 조사는1997년 12월에서 1998년 1월 사이에 각 대학마다 사전에 위촉된 1명의 조사담당 교수가 조사대상자들에게 설문지를 배부하여 기입하게 하였다. 총 재학생 11,987명중에 설문 조사대상으로 뽑힌 1,386명가운데 1,233명 (89.0%)이 응답하였는데 응답자중 학년 미상 11명과 응답이 부실한 1명을 제외한 1,221명을 최종 분석대상으로 하였다. 몇 가지 특성을 중심으로 모집단과 조사표본을 비교해 본결과 표본의 대표성에는 별 문제가 없었다. 조사내용을 3부분으로 나누어 보고하였는데 1부에서는 조사방법과 조사대상자의 특성 및 응답자들의 의학교육에 대한 태도와 의학에 대한 본인의 적성에 관해 기술하였다. 응답자중 남자가 75.7 %를 차지하였다. 고졸 즉시 의대에 입학한 학생의 비율은 서울지역이 45.8 %, 서울 이외지역은 53.4 %이었다. 본인의 정치적 성향이 보수적이라는 사람이 서울지역은 43.9 %, 서울 이외 지역은 33.0 %로 지방 학생들이 진보적이라는 응답률이 더 높았다. 종교를 가진 사람이 57.2 %이었는데, 기독교가 31.0 %, 가톨릭 15.2 %, 불교 9.5 % 순이었다. 아버지의 교육수준이 대학 또는 그 이상인 사람이 59.8 %로 일반 국민의 교육수준보다 높았다. 아버지의 직업분포도 전문직 21.2%, 회사원 17.2%,공무원 13.1 %, 관리직 11.8 %, 의료인 8.7%로 화이트칼라가 지배적이었다. 의대진학 결정과정에 영향을 미친 사람이 있었다는 사람이 53.7 %이었는데, 이들중 부모가 62.1%를 차지하였다. 의대진학을 권유한 이유중 사회․경제적 측면이 33.5%로 가장 높은 비율을 차지하였다. 의학공부의 재미있는 측면은 생명현상을 배우는것 (47.2 %)과 인간을 배울 수 있다 (44.3%)는 것이었고, 재미없는 측면은 암기식 공부라는 것(39.7%)과 공부 분량이 너무 많다 (34.1%)는 것이었다. 만약 고교 3학년에 되돌아가 다시 대학을 선택할 경우 여전히 의대를 선택하겠다는 사람은 50.3 %이었으나, 지금 전과가 가능하다면 전과하겠다는 사람은 6.0 %에 불과하였다. 의학 공부에 자신의 적성이 맞다는 사람은 64.9%이었고, 이 비율은 학년이 올라갈수록 증가하였다. 장차 자기 아들을 의대에 보내겠다는 사람은 남학생중 36.6%, 여학생중 26.7%였고, 딸을 의대에 보내겠다는 사람은 각각 33.6%, 27.7%이었다. Since the first survey done in 1983, this is the second national sample survey of medical students about their perception and evaluation on medical study, career plan, and medical care system. One out of every 10 students plus one in each class were systematically sampled from each grade year of 32 medical schools in Korea that had students from freshman to senior in November 1997. A questionnaire was developed by adding items related with recent changes in medical care environment and with viewpoint on medicine and physician as an occupation to the questionnaire used in 1983. The questionnaire was administered at each school under the supervision of designated collaborator of the same school in December 1997 through January 1998. A total of 1,386 students were sampled from a total of 11,987 medical students and 1,233 students(89.0%) filled out the questionnaire. Twelve students were excluded from the analysis because of incomplete response and the final analysis was done for 1,221 students. A few demographic characteristics of the sample were compared with those of the study population to check the representativeness of the sample and found no skew. The contents of the study were divided into three parts and the first part describes the study methods, demographic and other characteristics of the sample, students viewpoint on medical education, and students aptitude for medicine Male students accounted for 75.7% of the sample. The proportion of students who entered medical school right after graduating from a high school was 45.8% in Seoul and 53.4% in other than Seoul area. The students who classified their own political inclination conservative were 43.9% in Seoul and 33.0% in other than Seoul and the percentage of students with progressive inclination was higher in out of Seoul than Seoul area. The proportion of students who have a religion was 57.2%; Christian 31.0%, Catholic 15.2%, and Buddhist 9.5%. The educational level of fathers of students was far higher than the level of general population, e.g. 59.8% had college or higher education. Occupation of fathers was mainly white-collar worker; professional worker 21.2%, company employee 17.2%, government official 13.1%, manager 11.8%, and medical professional 8.7%. In the decision-making process to enter the medical school, 53.7% of the students were influenced by someone else and 62.1% of them were parents. Socio-economic factor was the most common reason for recommending medical school and it accounted 33.5% of the reasons. Medical students enjoy learning life phenomenon(47.2%) and human being(44.3%) in medical study but most disturbing factors are memory work(39.7%) and too much to study(34.1%). If students were given another chance to choose a college as a senior student in high school, 50.3% of them said that they would choose medical school. Only 6% of students have intention to change their major subject of study if they are allowed to change now. The proportion of students who consider their scholastic aptitude is compatible with medical study was 64.9% and such proportion increased with grade. The percentage of students who are going to recommend medical school to their own son in the future was 36.6% for male and 26.7% for female students and to their own daughter 33.6% and 27.7%, respectively.
증례 : 호습기 ; 크론병 환자에서 종양 괴사 인자 길항제 재시작 후 재발한 결핵
박소정 ( Sojung Park ),양지영 ( Ji Young Yang ),송민주 ( Min Joo Song ),천재경 ( Jaekyung Cheon ),김수한 ( Soo Han Kim ),김미진 ( Mi Jin Kim ),조경욱 ( Kyung Wook Jo ) 대한내과학회 2015 대한내과학회지 Vol.88 No.6
본 증례는 TNF 길항제 사용 중 발생한 결핵에 대하여 적절한 항결핵 치료를 시행한 후 다시 TNF 길항제를 사용한 후에 결핵의 재발이 가능하다는 것을 보여준 첫 증례이다. 따라서 TNF 길항제를 다시 시작할 때 결핵 재발의 가능성에 대해서 염두에 두고 주의 깊은 경과관찰이 필요할 것으로 생각된다. The use of tumor necrosis factor inhibitors (TNFi) increases a patient’s risk of developing tuberculosis (TB). There is no consensus on whether restarting a TNFi after treating an active TB infection caused by previous TNFi exposure is safe. We report the first case of TB recurrence after recommencing a TNFi in a 37-year-old woman with a history of active TB infection caused by previous TNFi treatment. (Korean J Med 2015;88:701-705)
대전시 공공하수처리시설 유입수 수질자료의 통계적 특성 및 추계학적 모의
박기정 ( Gi Jung Park ),정민재 ( Min Jae Jung ),이한샘 ( Han Saem Lee ),김덕우 ( Deok Woo Kim ),윤재영 ( Jae Yong Yoon ),백경록 ( Kyung Rock Paik ) 한국물환경학회 2012 한국물환경학회지 Vol.28 No.1
In this study, we analyze statistical characteristics of influent water quality in Daejeon waste water treatment plant and apply a stochastic model for data generation. In the analysis, the influent water quality data from year 2003 to 2008, except for year 2006, are used. Among water quality variables, we find strong correlations between BOD and T-N; T-N and T-P; BOD and T-P; CODMn and T-P; and BOD and CODMn. We also find that different water quality variables follow different theoretical probability distribution functions, which also depends on whether the seasonal cycle is removed. Finally, we generate the influent water quality data using the multi-season 1st Markov model (Thomas-Fiering model). With model parameters calibrated for the period 2003~2005, the generated data for 2007~2008 are well compared with observed data showing good agreement in general. BOD and T-N are underestimated by the stochastic model. This is mainly due to the statistical difference in observed data itself between two periods of 2003~2005 and 2007~2008. Therefore, we expect the stochastic model can be applied with more confidence in the case that the data follows stationary pattern.
뇌경막 동정맥루를 동반한 장기간 지속된 외상성 경동맥-해면정맥동루 - 증례보고 -
박경범,박인성,김준수,김기정,황수현,김은상,정진명,한종우,김재형,Park, Kyung Bum,Park, In Sung,Kim, Joon Soo,Kim, Ki Jeong,Hwang, Soo Hyun,Kim, Eun-Sang,Jung, Jin-Myung,Han, Jong Woo,Kim, Jae Hyung 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.1
Traumatic carotid-cavernous fistula is a rare complication of moderate to severe head injury. For the treatment of carotid-cavernous fistula, detachable balloon occlusion is the best method of choice. A 26 year old male patient was hurt with a left periorbital penetrating injury 20 years ago, and then left side exophthalmos, bruit and right hemiparesis developed 10 years later. We experienced the very rare case of direct carotidcavernous fistula with cavernous dural arteriovenous fistula. Brain MRIs and cerebral angiograms revealed that direct carotid-cavernous fistula was accompanied by cavernous dural arteriovenous fistula due to longstanding venous hypertension and development of collateral circulation. Detachable balloon occlusion and surgical internal carotid artery ligation were not enough to occlude fistular flow, so cavernous dural arteriovenous fistula embolization was necessary. The authors present a case of long-standing traumatic carotid-cavernous fistula with cavernous dural arteriovenous fistula, with review of the literature.
생체외 류마토이드 관절염 실험 모델에서 청열사습탕(淸熱瀉濕湯)의 효과
박진상 ( Jin Sang Park ),한명금 ( Myeng Gum Han ),임양의 ( Yang Eui Lim ),이수경 ( Su Kyung Lee ),신병철 ( Byung Cheul Shin ),권영달 ( Young Dal Kwon ),송용선 ( Yung Sun Song ) 한방재활의학과학회 2004 한방재활의학과학회지 Vol.14 No.2
Objective: This study was designed to understand the mechanism of action of Cheongyeolsaseup-tang(Qingrexieshi-tang) (CYSST) leading to control of mast cells on inflammatory condition like RA. Methods: Viability of cells was evaluated by MTT colorimetric assay for 8 h incubation after stimulation of PMA plus A23187. HMC-1 cells (3×105 cells/㎖) were stimulated for 8 hour incubation with PMA plus A23187, we investigated the effect of CYSST on the production of cytokines by activated human mast cell line HMC-1. Results: When CYSST (1 mg/ml) was added, the production of tumor necrosis factor (TNF)-α, interleukin (IL)-6 was significantly inhibited by 37% and 33.6%, respectively in phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated HMC-1 cells. RA is an aggressive inflammatory disease in which chemokines are thought to recruit leukocytes and induce angiogenesis. CYSST also inhibited by 48% the production of IL-8 in HMC-1 cells. In addition, CYSST inhibited the expression of Nuclear factor-κB(NF-κB) in HMC-1 cells. Conclusions: When CYSST was added, the production of TNF-α, IL-6, IL-8 was significantly inhibited. These results imply that CYSST has a critical role on the treatment of the bone damage associated with rheumatoid arthritis.