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문병산,윤주용,Mi-Yeon Kim,이상훈,Thomas Choi,최강열 생화학분자생물학회 2009 Experimental and molecular medicine Vol.41 No.2
Bone morphogenic protein 4 (BMP4), a member of the TGF-β superfamily, induced neural differentiation of neural stem cells (NSCs) grown in a medium containing basic fibroblast growth factor (bFGF). The Ras protein level and the activities of the downstream ERKs were increased by transfection of BMP4 or treatment with recombinant BMP4. The effects of BMP4, including activation of the Ras-ERK pathway and induction of the neuron marker β-tubulin type III (Tuj1), were blocked by co-treatment of the BMP4 antagonist, noggin. The roles of the Ras-ERK pathway in neuronal differentiation by BMP4 were revealed by measuring the effect of the ERK pathway inhibition by dominant negative Ras or PD98059, the MEK specific inhibitor. BMP4 is a transcriptional target of Wnt/β-catenin signaling, and both the mRNA and protein levels of BMP4 were increased by treatment of valproic acid (VPA), a chemical inhibitor of glycogen synthase kinase 3β (GSK3β) activating the Wnt/β-catenin pathway. The BMP4- mimicking effects of VPA, activation of the Ras-ERK pathway and induction of Tuj1, also were blocked by noggin. These results indicate the potential therapeutic usage of VPA as a replacement for BMP4.
유방암에서 Nitric Oxide Synthase의 발현
이해경(Hae Kyung Lee),조백현(Back Hyun Cho),허민희(Min Hee Hur),강성수(Sung Soo Kang),이지현(Jee Hyun Lee),이성공(Sung Kong Lee),김혜선(Hye Sun Kim),김의정(Yee Jeong Kim),문병산(Byoung San Moon),김세중(Sei Joong Kim),한혜승(Hae Seung 대한외과학회 2002 Annals of Surgical Treatment and Research(ASRT) Vol.63 No.2