중심핵(CENTRAL CORE)병 3례

고준태(June Tae Ko),김동욱(Dong Wook Kim),김기중(Ki Joong Kim),고태성(Tae Sung Ko),황용승(Yong Seung Hwang),이춘기(Choon Ki Lee) 대한소아신경학회 1993 대한소아신경학회지 Vol.1 No.1

Central core disease is one of benign childhood myopathies, charactorized by its histological feature. Mitochondrial oxidative enzyme activity is absent in this cental core area. Patients shows motor weakness in early childhood and motor developemental delay. The muscle involvement is generalised and symmetrical in the trunk and limbs. The deep tendon reflexes are normal of deminished. Skeletal deformities are not nucommon. Creatine kinase serum levels are normal and the electromyographic abnormalities are nonspecific. The disease course in benign and the electromyographic abnormalities are nonspecific. We experienced 3cases of central core disease. The case 1, a 5 year girl, is the first report in our country. All of the cases showed motor weakness and motor developemental delay. In the case 1 and 3, skeletal deformities were detected such as hip joint contracture, kyphoscoliosis. The were treated with physial therapy and had operative correction. We report 3 cases of Central core disease with brief revew of the litratures.

토혈이 동반된 멕켈 게실에 의한 회회맹장형 장중첩증 1례

배순호,권영대,강호석,황수경,고준태,Bae, Soon Ho,Kwon, Young Dae,Kang, Ho Seok,Hwang, Su Kyung,Ko, Joon Tae 대한소아소화기영양학회 2005 Pediatric gastroenterology, hepatology & nutrition Vol.8 No.1

저자들은 7세의 여아가 구토, 미만성 복통과 복부 팽만, 혈성 설사 후 토혈이 있어 검사한 복부 초음파 검사상 장중첩증이 발견되었고, 개복수술 시 멕켈 게실이 발견된 증례를 경험하였다. 장중첩증이나 멕켈 게실이 있는 소아에서 토혈이 동반되는 경우는 드물기에 이를 보고하는 바이다. Intussusception is the most common cause of intestinal obstruction in early childhood and characterized by periodic colicky abdominal pain or irritability, vomiting, current jelly stool, and sausage-like abdominal mass. Meckel's diverticulum is common intestinal anomaly presenting with painless rectal bleeding during first 2 year of age. It is recognized as a common leading point of intussusception in childhood. Hematemesis is the rare clinical manifestation of both intussusception and Meckel's diverticulum. A 7-year-old girl presented with hematemesis was diagnosed as having intussusception by abdominal ultrasonography. Meckel's diverticulum was the leading point of intussusception in this case.

제 2형 당뇨병 환아에서 동반된 중증 당뇨병성 케톤산증 1례

유재성,강호성,진현주,고준태 대한소아내분비학회 2011 Annals of Pediatirc Endocrinology & Metabolism Vol.16 No.1

Ketosis-prone diabetes includes heterogeneous disease groups characterized by provoked or unprovoked ketoacidosis (ketosis), with a typical phenotype of autoimmune type 1 diabetes. As the incidence of obesity and type 2 diabetes is universally increasing, the rate of type 2 diabetes in diabetic ketoacidosis in children and adolescents is exptected to increase rapidly. The clinical presentation of atypical ketoacidosis with type 2 diabetes has been reported mostly in adults. We recently experienced a case of a 10-year-old obese girl with new-onset type 2 diabetes who initially presented with severe diabetic ketoacidosis, and introduce it with literature reviews.(J Korean Soc Pediatr Endocrinol 2010;15:46-50) Ketosis-prone diabetes (KPD)는 전형적인 자가면역성 제1형 당뇨병을 포함한 다양한 당뇨병 형태를 포함한다. 최근 비만과 제2형 당뇨병의 빠른 유병율 증가로 제2형 당뇨병이 KPD에서 차지하는 비율의 큰 증가가 예상된다. 지금까지 주로 성인을 대상으로 한 KPD에 대한 연구만 있어 저자는 ketosis-prone 제2형 당뇨병 10세 여아 1례를 문헌 고찰과 함께 보고한다

소아 요로 감염 원인균의 항생제 감수성 고찰(2003-2005)

권영대,김명진,김희운,송진영,고준태,강호석,오세호,Kwon, Young-Dae,Kim, Myung-Jin,Kim, Hee-Un,Song, Jin-Young,Ko, Joon-Tae,Kang, Ho-Seok,Oh, Sei-Ho 대한소아신장학회 2006 Childhood kidney diseases Vol.10 No.2

Purpose : We studied the degree of changes in antibiotic sensitivity toward causative organisms, prevalence and clinical manifestations of extended-spectrum $\beta$-lactamase(ESBL)-producers of urinary tract infection(UTI) for a period of three years. This serves to provide useful information in selecting adequate drugs for the treatment of UTI. Methods : We recruited 137 patients who grew more than $10^5$ CFU/mL in their urine culture among 250 patients who visited and were admitted to Handong University's Sunlin Hospital for UTI treatment from January 2003 to December 2005. We retrospectively analyzed the data from the medical records. Results : The common pathogenic organisms were Escherichia coli(65.0%), Klepsiella pneumoniae(14.0%), Enterococcus faecalis(5.8%) and Proteus vulgaris(2.9%) in consecutive order. The prevalence of ESBL-producers among isolated E. coli and K. pneumoniae was 4.5%(4 cases) and 14.3%(2 cases), respectively. The antibiotic sensitivity rates of E. coli were relatively high to amikacin(100%), imipenem(100%), ceftriaxone(95.5%) and tobramycin(91.4%) while relatively low to TMP/SMZ(55.4%), ampicillin/sulbactam(29.4%) and ampicillin(24.2%). Conclusion : The use of ampicillin, ampicillin/sulbactam and TMP/SMZ, which have been the first choices in the treatment of UTI, should be reconsidered due to the low sensitivity rates towards these antibiotics. Due to the high incidence and antibiotic tolerance of ESBL that might have risen from the development of new antibiotics and increased antibiotic use, it is necessary to consider changing the standard antibiotics that have been used in the treatment of UTI.

끝이 잘린 피라미드형 거울을 이용한 87Rb 원자 포획 및 원자빔 생성

서선영,김은강,Ashish Kumar Sharma,고준태,김중복 한국물리학회 2020 새물리 Vol.70 No.7

In this study, a truncated pyramidal mirror was used to generate a magneto-optical trap (MOT) of 87Rb atoms and a continuous cooled atomic beam therefrom. The pyramidal mirror has an angle of 90◦ between facing sides, and the tip has a squarehorn shape with an 18-mm length on one side. The size of the cut is 6 mm × 6 mm. The number of trapped atoms was measured to be about 107 atoms. The mean velocity of the atomic beam inside the pyramidal mirror is 3.58 m/s - 20.8 m/s, the flux is 3.6 × 107 atoms/s - 2.1 × 108 atoms/s, the atomic beam velocity distribution is 0.73 m/s - 7.34 m/s and the atomic beam temperature is 4 mK - 323 mK, respectively. This study confirms the feasibility of miniaturization of a continuously cooled atomic beam generator and provides basic data for the commercialization of atomic precision measurement technology. 본 연구에서는 끝이 잘린 피라미드형 거울을 이용하여 87Rb 원자를 광자기 포획하고 그로부터 연속적인 냉각된 원자빔을 생성하였다. 피라미드형 거울은 마주보는 면 사이의 각이 90◦ 이고 한 변의 길이가18 mm인 정사각뿔의 끝이 잘려 있는 형태로 잘린 부분의 크기는 6 mm × 6 mm이다. 광자기 포획된원자의 수는 약 107 개 정도로 측정되었다. 피라미드형 거울 내부에 생긴 원자빔의 평균 속도는 3.58 m/s – 20.8 m/s, Flux는 3.6 × 107 atoms/s - 2.1 × 108 atoms/s이고, 원자빔의 속도 분포는 0.73 m/s – 7.34 m/s로 원자빔의 온도는 4 mK – 323 mK으로 측정되었다. 본 연구는 연속적인 냉각된 원자빔 발생장치의 소형화 가능성을 실험적으로 확인하였으며, 원자기반의 정밀측정 기술의 상용화에 있어 기초적인자료가 될 수 있을 것이다.

포항지역에서 발생한 무균성 뇌막염 환아의 역학적 양상 연구 : 1997~2002

김석헌,배순호,정해관,정철,이선주,고준태,김문규,정은영,Kim, Seog Heon,Cheong, Hae-Kwan,Jung, Cheoll,Lee, Seonju,Ko, Joon Tae,Kim, Moon Kyu,Jeoung, Eun Young,Bae, Sun Ho 대한소아감염학회 2003 Pediatric Infection and Vaccine Vol.10 No.2

목 적 : 1997년부터 2002년까지 6년 동안 포항지역에서 발생한 무균성 뇌막염의 역학적 양상을 연도별로 비교하고 누적발생률을 확인하여 추후 무균성 뇌막염의 전파양상 규명과 예방에 기초자료를 제공하기 위해 본 연구를 시행하였다. 방 법 : 1997년부터 2002년까지 포항지역 3개 종합병원에 무균성 뇌막염으로 1일 이상 입원한 15세미만 환아 중 소아과 전문의와 전공의의 의무기록지 검토를 통해 확인된 1,750명을 대상으로 역학적 발생양상을 조사하고, 누적발생률을 산출하였다. 결 과 : 전산기록으로 확인한 환아의 95.2%(1,750명 : 남아 1,078명, 여아 672명)를 무균성 뇌막염으로 확인하였다. 6개년도 모두 남아가 여아보다 많았으며(1.6 : 1), 1997년에 464명이 발생한 이후 발생수가 감소하였다가 2000년 이후 다시 증가하여 2002년 648명으로 가장 많이 발생하였다. 발생월별 분포는 6월이 31.3%로 가장 많았으며, 5월부터 8월까지 4개월간 집중적으로 발생하여 전체 발생의 84.2%를 차지하였다. 증상 발현일부터 입원까지 걸린 기간은 0일에서 35일까지 다양하였으며, 평균 $4.19{\pm}2.96$(중앙값 3일)일이 소요되었다. 5일 이내가 1,417명(81.0%)을 차지하였다. 증상발현 당일 입원한 경우는 3명(0.2%)에 불과하여 증상이 진행된 후에 병원을 방문하는 것으로 확인되었다. 환아의 연령을 3단계로 구분하여 각 연도별로 인구 10만명당 누적발생률을 조사한 결과 각 연도마다 다발 연령군이 상이한 결과를 보였으며, 매년 특정 연령군 대에 환아가 집중하지 않는 것으로 확인되었다. 결 론 : 1997년부터 2002년까지 포항지역 3개 종합병원에서 입원 치료받은 무균성 뇌막염 환아의 역학적 양상을 조사하였다. 포항지역의 무균성 뇌막염 환아가 매년 지속적으로 보고되고 있으므로 원인을 규명하고 장기적인 예방대책을 수립하기 위한 연구가 계속되어야 할 것이다. Purpose : This study was performed to investigate the epidemiologic feature of aseptic meningitis in Pohang city for 6 years from 1997 to 2002. Methods : We reviewed the clinical records of 1,839(1,138 male and 701 female) aseptic meningitis patients who had been admitted to 3 general hospitals in Pohang city from 1997 to 2002. Results : 1,750 cases(1,078 male and 672 female) were selected as aseptic meningitis by reviewing clinical records. The ratio of male to female was 1.6 : 1. Aseptic meningitis occured in children of all age groups, and the prevalent age group was different by year. The most common developed month was June(31.3%), and 84.2% of cases were focused from May to August. The time from the initial manifestation to hospital admission was $4.19{\pm}2.96$ (median 3 days). Conclusion : We were performed to investigate the epidemiologic feature of clinical records of Aseptic meningitis pediatric patients who had been admitted and treated to 3 General hospitals in Pohang city from 1997 to 2002. We have to keep up Our study for consideration of the basic of Aseptic meningitis epidemiology and long term control is necessary to prevention the impact of Aseptic meningitis because Aseptic meningitis pediatric patients were continuously recorded by Epidemiological annual report in Pohang city.

Transmission of Seasonal Outbreak of Childhood Enteroviral Aseptic Meningitis and Hand-foot-mouth Disease

박수경,박보영,기모란,김호,이관,정철,손영모,최성민,김두권,이동석,고준태,김문규,정해관 대한의학회 2010 Journal of Korean medical science Vol.25 No.5

This study was conducted to evaluate the modes of transmission of aseptic meningitis (AM) and hand-foot-mouth disease (HFMD) using a case-control and a casecrossover design. We recruited 205 childhood AM and 116 HFMD cases and 170non-enteroviral disease controls from three general hospitals in Gyeongju, Pohang,and Seoul between May and August in both 2002 and 2003. For the case-crossover design, we established the hazard and non-hazard periods as week one and week four before admission, respectively. In the case-control design, drinking water that had not been boiled, not using a water purifier, changes in water quality, and contact with AM patients were significantly associated with the risk of AM (odds ratio [OR]=2.8, 2.9, 4.6, and 10.9, respectively), while drinking water that had not been boiled, having a non-water closet toilet, changes in water quality, and contact with HFMD patients were associated with risk of HFMD (OR=3.3, 2.8, 6.9, and 5.0, respectively). In the case-crossover design, many life-style variables such as contact with AM or HFMD patients, visiting a hospital, changes in water quality, presence of a skin wound, eating out, and going shopping were significantly associated with the risk of AM (OR=18.0, 7.0, 8.0, 2.2, 22.3, and 3.0, respectively) and HFMD (OR=9.0, 37.0, 11.0, 12.0, 37.0, and 5.0, respectively). Our findings suggest that personto-person contact and contaminated water could be the principal modes of transmission of AM and HFMD.