알코올중독 환자의 예후 예측에 관한 연구(Ⅱ) : 가족력 및 DRD₂와의 관계를 중심으로

성상경,차성조,이규항,이정균 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.6

알코올중독 환자의 예후인자를 알아보기 위해 나이와 성별을 통제하여 음주군과 단주군 남자환자 각각 30명을 대상으로 비교 연구하였다. 양군간의 인구통계학적 특성, 음주력, 가족력, 자아강도 등의 차이 및 도파민 D2수용체 유전자 분포를 비교하였으며, 질병경과, 가족력 및 도파민 D2수용체 유전자와의 관련성을 알아보았다. 그 결과는 다음과 같다. 1) 단주군은 음주군에 비해 기혼율이 높았으며, 높은 경제상태, 높은 학력 등이 중요한 요소였으나 직업의 종류 및 종교에 있어서는 차이가 없었다. 2) 단주군은 음주군에 비해 과거 음주력상 최대 단주기간이 길었으나 평균 음주량이 더 많았다. 또한 음주군은 단주군에 비해 사회경제적 스트레스 및 정신적 불안정이 주된 음주 이유인 경우가 많았으나 음주기간, 음주양상, 음주시기, 음주시작 연령, 술의 종류에 있어서는 차이가 없었다. 3) 알코올중독의 가족력에 따른 비교에서 단주군과 음주군 사이에 유의한 차이는 없었다. 4) 단주군은 음주군에 비해 자아강도의 평균점수가 더 높았다. 5) 도파민 D2수용체 유전자의 A1 대립유전자 비교에서 단주군에서 A1 대립유전자의 이환율은 70%, 음주군에서는 60%였다. A1 대립유전자의 빈도는 각각 0.38과 0.42로 양군간에 차이는 없었다. 6) 알코올중독 가족력에 따른 도파민 D2 수용체 유전자분포 비교에서 가족력이 있는 군에 A1 대립유전자의 이환율은 70%, 빈도는 0.43이었고, 가족력이 없는 군에서는 이환율이 61%, 빈도는 0.38로 양군간에 유의한 차이는 없었다. 가족력이 있는 경우에 음주시작의 연령이 더 낮았으며 문제음주도 보다 일찍 나타났다. 그러나 평균 음주기간은 가족력이 없는 경우에 더 길었으며, 평균 음주량, 최고 단주기간 및 NAST 비교에서는 차이가 없었다. 결론적으로 알코올중독 환자의 긍정적 예후인자로 기혼, 높은 학력 및 경제상태, 과거 음주력상 보다 긴 단주 기간 및 강한 자아강도를 들 수 있었다. 반면에 직업, 종교, 알코올중독 가족력 유무, 음주기간, 음주양상, 음주시작 연령, 술의 종류 및 도파민 D2수용체 유전자 A1 대립유전자 분포 등에서는 알코올중독의 예후의 의미 있는 상관관계가 없었다. Objectives : The purpose of the study was to identify the prognosis-predicting indicators is alcoholics by the correlation between prognosis and demographic characteristics, ego strength, family history and distribution of dopamine D2 receptor gene A1 allele. Methods : The subjects were composed of 60 alcoholics including 30 psychiatric inpatients(drinking group) and 30 alcoholics abstinent for 6 months or more after discharge(abstinent group). They were investigated with interview, questionnaire, blood sample and review of their charts. Results : The results were as follows ; 1) The abstinent group had higher rate of married state, higher economic status and longer education years than the drinking group. There were no differences in occupation and religion between the two groups. 2) There were no differences between the abstinent group and drinking group according to alcoholic family history. 3) The abstinent group had higher mean score in ego strength scale than the drinking group. 4) In comparision of dopamine D2 receptor gene A1 allele, the prevalence of A1 allele was seventy percent and the frequency was 0.38 in the abstinent group. The prevalence of A1 allele was sixty percent and the frequency was 0.42 in the drinking group. Both groups were not significantly different in A1 allele prevalence and frequency. 5) In comparision of dopamine D2 receptor gene A1 allele according to alcoholic family history, the prevalence of A1 allele was seventy percent and the frequency was 0.43 in the family history positive group. The prevalence of A1 allele was sixty-one percent and the frequency was 0.38 in the family history negative group. Both groups were not significantly different in A1 allele prevalence and frequency. Conclusions : With the above results, the authors think that successful prognostic indicators of alcoholics are married state, higher economic status, longer education years, longer abstinenence period in past history, and strong ego strength. But family history and distribution of dopamine D2 receptor A1 allele were not significantly related to the prognositc indicators of alcoholics.

빈발재발성 미세변화 신증후군환아에서 발생한 다발성 뇌경색증

조성옥,한헌석,차상훈,이경희,박범수,하태선,채수안 충북대학교 의과대학 충북대학교 의학연구소 1995 忠北醫大學術誌 Vol.5 No.2

신증후군에서는 동맥 및 정맥의 혈전에 의한 혈전색전증의 위험이 높다. 이는 혈 중 응고인자 Ⅰ, Ⅱ, Ⅶ, Ⅷ, Ⅹ등의 증가와 뇨소실로 인한 antithrombin Ⅲ의 감소, 섬유소 용해계의 변화, 혈소판 응집력의 증가에 기인하며 그 외 스테로이드 투여, 이뇨제 투여, 저체액 상태도 관여한다고 생각하나 이런 과응고현상에 대한 정확한 병태생리는 규명되고 있지 않다. 저자들은 내원 21개원 전 처음 신증후군 증상을 보였고 신장 조직 검사상 미세변화 신증후군으로 진단을 받고 스테로이드와 면역 억제제를 사용하였으나 6개월에 3-4회의 재발을 보이던 중 내원 1달 전 보호자 자의로 모든 약물 복용을 중단한 채로 지내다가 고열과 반혼수 상태를 보여 내원한 7세 남아에서 다발성 뇌경객증을 발견하였기에 문헌 고찰과 함께 보고하는 바이다. The risk of thromboembolism by arterial or venous thrombosis is high in the nephrotic syndrome. This may be due to the increased serum concentrations of the factor Ⅰ, Ⅱ, Ⅶ, Ⅷ, Ⅹ etc, decrease of antithrombin Ⅲ due to urinary loss, the change of thrombolytic system, increase in the platelet aggregation capacity, the use of steroid, diuretics, and hypovolemic state. But, the pathophysiology of this hypercoagulable state has not been clear. A 7-year- old boy had been diagnosed as having frequently relapsing minimal change nephrotic syndrome, 21 months ago. In spite of the administration of prednisolone and cytoxan, he had presented recurrent proteinuria in the frequency of 3-4 times per 6 months. From 1 month prior to visiting emergency room, his parents discontinued his medications, therefore, he showed fever and semicomatous mental status. In brain MRI study, multiple cerebral infarcts were noted. So, the authors report a case of multiple cerebral infarcts in a patient with frequently relapsing minimal change nephrotic syndrome with a brief review of related literature.

교액성 폐쇄공탈장 1예

조태웅,민영돈,김경종,정권율,강성인,류소연,임성철 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.1

Obturator hernia is a rare pelvic hernia, occuring most frequently in elderly, extra-thin or debilitated women. Because of the anatomic character of the obturator foramen and the nonspecific symptoms in the presence of the hernia, the risk of strangulation of the herniated bowel is high, which leads to high morbidity and mortality rate. The authors experienced an unusual case of left obturator hernia with strangulation of the small bowel in an 80-year old female. The hernia was diagnosed by abdomino-pelvic computed tomography (CT) scan. Through the lower midline transperitoneal approach, resecting the strangulated small bowel, the hernia sac was ligated and the obturator foramen was repaired using adjacent broad ligament. We report these findings with a brief review of the literature.

원전의 가동중검사 관련 각국의 기술기준 비교고찰

신호상,김경조,장창희,강석철 한국비파괴검사학회 2004 한국비파괴검사학회지 Vol.24 No.2

각국의 법령에서는 원자력발전소에서 발생할 수 있는 사고로부터 국민의 건강과 재산을 보호하기 위해 원자력발전소의 압력경계 주요 용접부 등에 대해서는 주기적으로 열화의 정도를 파악하기 위한 가동중 비파괴검사를 수행하도록 규정하고 있으며, 이를 뒷받침하기 위한 가동중검사 기술기준을 제정하여 이행하고 있다. 최근 리스크를 반영한 가동중검사 프로그램을 개발하여 적용을 시도하고 있지만, 기존의 결정론적 검사대상 선정 프로그램은 아직도 상당한 의미가 있다고 할 수 있다. 본 논문에서는 가동중검사에 관한 선진국 즉, 미국, 프랑스, 캐나다, 일본 등의 기술기준과 IAEA에서 제시하는 안전지침에 비교검토를 통하여 현재 국내 가동중검사 기술기준의 개선방안을 모색하고자 하였다. In each country, the periodic ISI(In-Service Inspection) is required by the law to protect the public health and property from the potential accident of the nuclear facilities. To support the implementation of ISI program, the prescriptive ISI technical standards have been established. As the key parts of the ISI program, the non-destructive examination techniques are widely used to identify the degree of degradation of the pressure boundary components and welds. Recently, the risk informed-ISI program has been developed and implemented in several countries. Nonetheless, the existing ISI program which prescriptively decides the scope of inspection still has its own significance. In this article, the technical standards of ISI in leading countries like US, France, Canada, and Japan are reviewed and compared with the safety guide by IAEA. An outline to revise the domestic technical standards of ISI has been suggested.

우관상동맥 개구부 완전 폐쇄가 동반된 대동맥 판상부 협착증 1례

임상현,김종진,김희열,진승원,전희경,노태호,채장성,김재형,홍순조,최규보,윤정섭,김치경 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

배기 저항의 능동제어를 통한 배기 시스템의 최적화에 관한 연구

임경빈,류봉조,이규섭,김상덕,송시영,이상훈 한밭대학교 생산기반기술연구소 2002 생산기반기술연구소 논문집 Vol.2 No.1

Automobile exhaust system has difficulty in concentrating contrary technology, which has diminishing effect of maximum exhaust noises and mininum exhaust pressure for output efficiency improvement into on system. This thesis has the purpose in management of basis study for silence and output efficiency improvement which can be satisfy low noises and low exhaust pressure at the same time through maximizing engine efficiency dealing with activity as the condition of engine controlling exhaust impedance actively. In this thesis, we obtained positive result by making experiment high efficiency exhaust induced shaped silencer in order to satisfy contrary matters which device the improvement of engine efficiency and low perception of exhaust noises at the same time. That is, we proved that it has more excellent in low perceiving noises of exhaust system and output improving efficiency than existing muffler by active controlling the exhaust impedance.

아접선력을 받는 보의 동적안정성에 미치는 고유치 감도해석

류봉조,최상경 한밭대학교 산업과학기술연구소 2001 논문집 Vol.5 No.-

This paper deals with the eigenvalue sensitivity of a finite element formulation on vibration and dynamic stability of an elastically restrained cantilevered beam under subtangential forces. Governing equations are derived by energy expressions using extended Hamilton's principle. In order to more quickly and efficiently obtain the critical subtangential force for a given system, a technique which utilizes the eigenvalue sensitivity with respect to the system parameter is introduced. More accurate results are obtained for both variations in the spring position, spring stiffness, as well as the subtangential parameter.

녹차 음용이 알루미늄을 투여한 흰쥐의 혈청 효소 활성도에 미치는 영향

신미경,한성희,한경조 동아시아식생활학회 1996 동아시아식생활학회지 Vol.6 No.2

This study was performed to investigate the effects of green tea activities in rats with administration of aluminum in drinking green tea. Male Sprague Daweley rats were divided into five groups consisting of the control, aqueous green tea at the level of 1.5%, a aquous green tea(1.5%) and aluminum sulfate solution 500ppm, before the 2 weeks administration by aquous green tea(1.5%) and after the 2 weeks aluminum sulfate solution 500ppm, aluminum sulfate solution 500ppm. After 4weeks of feeding, serum enzymes activities were measured for experimental rats, and analyzed the activities of alanine amino trans aminase(ALT), asparate amino transminase(AST), lactate dehydrogenase(LDH) cholinesterase(ChE). Comparing to control group, Alanine amino trans aminase(ALT) was decreased in aqueous green tea administrated group and increased significantly administration by aluminum sulfate solution 500ppm group. Alanine amino trans aminase(ALT) was decreased administration by aqueous green tea group and increased addition to aluminum sulfate solution 500ppm group as compared to control group. Lactate dehydrogenase(LDH) was increased compared to control group by experimental group and increased significantly administration by aluminum sulfate solution 500ppm. Cholinesterase(ChE) activity was decreased compared to control group by experimental group.

삶의 질 향상과 지속가능한 지역경쟁력 : 호순환 관계의 모색

장지상,이성진,조정재,권우현,김애경 慶北大學校 1997 經商論集 Vol.25 No.1

계절조절법 X11과 X11-ARIMA 적용에 관한 실증적 연구

金常照,宋東燮,張外景 상명대학교 경영연구소 1993 경영학연구 Vol.- No.1

Time series refers to the collection of variabies we obverved as time goes on. The seasonal variation adjustment in time series means raw series minus the factor of seasonal variation such as the repetion of seasons, social and economic customs. The methods of seasonal adjustment are Act 11, X11, which was made by the Bureau of Sensus in the Minstry of commercial affairs in America, and X11-ARIMA, which was made by the Bureau of statistics in Canada. In X11, seasonal index, index of seasonal adjustment and the measurement of seasonal adjustment index for a year are produced by applying moving average many times. In X11 ARIMA raw series is expanded to the ARIMA model and applied it to X11. This study tries t o compare the differences of standard models between X11-ARIMA and X11 on the time series of our economy such as industrial production index, shipment, whole sale and consumer received index. The conclusion is that the application of X11-ARIMA is more suitable than that of X11. X11 is, however, more suitable in manufacturing, shipment index, unemployment rate. There is little difference between them in the productive index and whole sale and consumer received index. The X11 ARIMA which is now used in Canada was provided by the Bureau of Statistics of Canda so that it was fit for the economic situation of the country. Therfore, to use it efficiently in our country we should review the characteristics of the time series in our country and set up a proper critia on the basis of the review.