성견의 2급 치근 분지부 결손에서 자가골막 이식에 의한 치주조직 재생

남승지,정현주,김영준 전남대학교 치과대학 2000 전남치대논문집 Vol.12 No.1

Autogenous periosteal grafts are the attractive alternative to existing barrier membrane materials since they meet the reqiurements of an ideal material. But no histological data are available on the effectiveness of periosteal membranes in the treatment of periodontal defects. The purpose of this study was to evaluate effect of autogenous periosteal graft on periodontal regeneration histologically. Calss Ⅱ furcation defects were surgically created on the second, third and the fourth premolars bilaterally in the mandibles of six mongrel dogs. The experimental sites were divided into three groups according to the treatment modalities; control group - surgical debridement only : Group Ⅰ- autogenous periosteal membrane placement after surgical debridement; Group Ⅱ- autogenous periosteal membrane placement after surgical debridement and bone grafting. The animals were sacrificed at 2, 4 and 12 weeks after periodontal surgery and the decalcified and undecalcified specimens were prepared for histological and histometrical analysis. Clinically all treated groups healed without significant problems. Under light microscope, at 2 weeks, control group showed significant apical epithelial migration and bone remodelling only below the notch area. But for the groupⅠ, Ⅱ with autogenous periosteal graft, less apical migration of epithelium appeared and large amount of osteoid tissue was showen above the notch area. Grafted periosteal membrane was indiscernable at 4 weeks, so periosteal membrane might be organized to surrounding tissues. Histometrically, at 4 and 12 weeks, all the test and control groups didn't show significant change of epithelial zone but new attachment level tended to be gained in the test groups than control group. These results suggest that autogenous periosteal grafts could be a good alternative for guided tissue regeneration.

항갑상선제로 치료한 그레이브스병 환자의 관해예측인자

남일송,윤여일,김선규,김용현,이주영,목지오,윤석기,김철희,김영선,변동원,서교일,유명희 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background: Most cases of Graves' disease have been treated by antithyroid drugs in Korea. The major drawbacks of antithyroid drugs are the relative high rate of relapse and the inconvinience of long term therapy. Measurement of TBII and TRH stimulation test have been considered as the most reliable tests predicting relapse, but the predictive power is not high enough to use in clinical situation. This study was performed to find good prognostic indicators in Graves' disease patients after the discontinuation of antithyroid drug therapy. Subjects and methods : We restrospectively evaluated 96 patients with Graves' disease who showed normal TRH test at the end of antithyroid drug therapy and were followed for more than one year. Serum T3, T4, T3/T4 ratio, TBII, Anti-TPO Ab and TGAb levels were measured at the time of diagnosis and at the end of therapy. Two to three months after withdrawal of antithyroid medication, serum TSH and free T3 responses to TRH were examined. These parameters were compared between the relapse group and the remission group. Results : Among the 96 patients, 22 patients(22.9%) relapsed(Group Ⅱ) and 74 patients(77.1%) remained in remmision(Group Ⅰ). No significant difference was observed between the relapse and the remission group in clinical parameters, serum T3, T4, TSH, T3/T4 ratio, TBⅡ and Anti-TPO Ab determined before and after treatment. Serum TSH and free T3 levels measured after TRH stimulation were also similar in both groups. Serum TGAb levels determined at the end of treatment were significantly higher in the remission group(p<0.05). Relapse following the discontinuation of therapy occured within 24 months in 72.7% of the relapsed cases. After 24 months, relapse rate was reduced significantly. Conclusion : These results suggest that high serum TGAb levels could be a favorable prognostic indicator for the long term remission of Graves' disease treated with antithyroid drugs, and may suggest that Hashimoto's thyroiditis is combined with Graves' disease in those patients.

인슐린 유사성장인자-I 및 인슐린 유사성장인자-I 수용체가 에토포사이드 유도 아포토시스 억제에 미치는 영향

남계현,조태호,이지은 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2

The interaction of insulin-like growth factors(IGF) with the IGF-I receptor promotes cell proliferation and survival. The activation of the IGF-I receptor by its ligands IGF-I, IGF-II, and insulin plays critical role in growth and development. The specific role of the IGF-I receptor in development has been recently revealed that targeted disruption of the IGF-I receptor gene resulted in profound fetal growth retardation. Most cell types require IGF-I for growth in culture. In addition to its role in cell cycle progression. IGH-I promotes cell survival has not been clarified. IGF-I may directly prevent apoptosis. However, IGF-I could also promote cell culture survival by survival inducing the prokiferation of viable cells within a damaged cell population. When exposed to the etoposide, R+ cells that constitutively overexpressed the IGF-IR arrested in S phase and subsequently underwent apoptosis as determined by the appearance of the pre-G1 apoptotic peak when studied by the flowcytometry and the charateristic internucleosomal fragmentation of DNA. The addition of IGF-I markly inhibited etoposide-induced apoptosis in a concentration-dependant manner. IGF-I was less effective in preventing apoptosis in parental R-and TC4 cells. These results demonstrate an important role for the IGF-I receptor as an inhibitor of apoptosis, independent of its mitogenic actions. These findings establish the relationship between IGF-IR levels and the extents of apoptosis. The TC4 cells expressing the truncated IGF-I receptor with a 108-amino-acid C-terminal truncation exhibited a dramatically impared ability to prevent the apoptosis, indication that truncated IGF-I receptor lose the ability to prevent the apoptosis at the intramolecular level.

수열합성 반응에 의한 3mol % 지르코니아 세라믹의 Fe2+, Fe3+, Er3+치환에 따른 상변태와 물성 변화

변지철, 이현철, 김택남, 류재경 배재대학교 공학연구소 2017 공학논문집 Vol.19 No.1

Zirconia is a heat-resistant material with a high melting temperature(2700℃) and has low thermal conductivity and excellent corrosion resistance. However, application has been limited due to brittleness, which is a disadvantage of ceramic materials. As a way to improve this, the addition of Y3+ improves the strength by phase transformation, which can improve the brittle problem, which is a disadvantage of ceramic. Many studies have been conducted on the addition of Y3+ after the addition has been found to be more efficient than the other additives. In this experiment, have studied the additives that replace this Y3+. Expeiments on the possibility of replacing Y3+ by adding an alternative additive considering Zr-sol(Fe2+, Fe3+, Er3+) in consideration of Atomic size, Crystal ionic raddi and Effective Ionic raddi. ZOC(ZrOCl2*8H2O) was dissolved in distilled water and synthesized by hydrothermal synthesis at 160℃ for 24hours. The formed Zr-sol was separated into a supernatant and precipitate. The supernatant was washed with distilled water, and the presence of chloride ion was confirmed using AgNO3. And add to the cleaned Zr-sol an additive that is believed to be a substitute for Y3+. The prepared Zirconia was calcined at 900℃ for 2hours, and the crystal phase was analyzed by XRD similar that of YSZ. The calcined powder was uniaxial pressed and sintered at 1500℃ for 2hours. The sintered specimens were first measured for specific gravity. And the particle size distribution, EDAX and FESEM were measured. 지르코니아는 고온에선 용융하는 (2700℃) 낮은 열전도율과 부식저항이 우수한 세라믹이다. 이에 우수한 파괴인성을 주기 위해 3 mol % Y를 첨가하게 되고, 상온에서 정방정 상으로 존재함으로써 파괴인성이 증가한 것으로 알려져 있다. 따라서 본 실험에서는 Y와 유효 원자 반경이 유사한 Er3+ (89pm)를 첨가함으로써, 과연 어떤 변화가 나타나는지를 알아보았다. 또한 원자가가 유사한 Fe3+와 Fe2+ 를 첨가하여 물성변화와 상변화를 조사하였다. 연구결과 이온 반경이 Y와 유사한 Er3+에서는 완전한 정방정상과 밀도, 투광율 (일부 파장은 제외)을 나타내었으나, 이온 반경이 약1/2 인 Fe2+, Fe3+를 첨가한 경우에는 단사정과 비정질 그리고, 650nm이하의 파장에서는 거의 투광하지 않는 현상을 보였다.

손마사지가 허혈성 심질환 환자의 불안에 미치는 효과

현경선,이향련,공송심,윤경자,김현섭,김효남,최지원,김운정 성인간호학회 2001 성인간호학회지 Vol.13 No.2

The purpose of this study was to investigate the effect of a hand massage program on anxiety, vital sign and pain in clients with ischemic heart disease. The design utilized for this stuffy was quail-experimental with a nonequivalent control group non-synchronized design The subjects were fifty-four patients, twenty-eight for the experimental and twenty-six for the control group, who were admitted with ischemic heart diease at a cardiac intensive care unfit in K medical center of K university. This study was carried out from May, 1999 to March, 2000. The level of anxiety and pain measured by Visual Analogue Scale, systolic blood pressure, diastolic blood pressure and pulse rate were measured before and after hand massage, the state of Anxiety was measured by the Spielberger (1970) scale at admission and after hand massage for three days. The collected data were processed by using the SPSS PC program and analyzed using χ2-test and t-test. The result of this study are as follows : 1. The scores of VAS anxiety and State of anxiety of the experimental group were lower than those of the control group. 2. The degree of systolic blond pressure, diastolic blood pressure and pulse rate of the experimental group were lower than that of the control group. 3. The score of VAS pain of the experimental group was lower than that of the control group. The results suggested that hand massage can decrease VAS anxiety, State of anxiety, vital signs and VAS pain of patients who were admitted with ischemic heart disease at cardiac intensive care unit Therefore, It Is proposed that hand massage is an appropriate nursing intervention to relieve anxiety of the patients who were admitted with ischemic heart disease at a cardiac intensive care unit.

분기재무보고서를 이용한 기업지배구조와 이익조정에 대한 연구

신현한,남지숙 연세대학교 경영연구소 2005 연세경영연구 Vol.42 No.2

播種期 移動에 따른 차풀의 生育反應, 收量 및 粗成分 變化

玄京卓,趙南棋,吳恩敬,高志棅,趙英一 濟州大學校 亞熱帶農業硏究所 1999 亞熱帶農業硏究 Vol.16 No.-

ABSTRACT This study was conducted to determine influence of planting date, seeding rate and phosphate rate on main growth, characters, yield and chemical composition of senna from March 11, 1998 to December in Cheju Province. Days to flowering was lessened as planting date was delayed. The plant height of senna was the longest at 31 March planting (99cm) than at the other planting date. Stem diameter, number of leaves were increased at 31 March but number of branches was not affected by planting date. And number of withering leaves were increased as planting date was earlier. Fresh forage yield per lOa, for senna was the greatest (4,660kg) at 31 March planting, the second was 4,397kg at 1 April planting and the reduced the 3,473kg at 11 March planting. Also dry matter yield per lOa, crude protein yield and total digestable nutrient (TDN) yield was nearly the same tendency. Crude protein, crude fat percent was the greastest at 11 March planting and than decreased with further increased at planting date. Crude ash and crude fiber percent was decreased tendency as planting date was delayed. Nitrogen free extract (NFE), TDN percent was increased tendency as planting date was delayed. SPAD reading value of leaves had an efficiency increased as planting date was delayed.

봄철 익산지역 환경대기 중 수용성 이온성분의 일별 침적량

김남송,강공언,김정숙,김현아,신지혜,김병수,최석진 원광대학교 대학원 2008 論文集 Vol.40 No.-

Deposition samples were collected in wet gauge and dry gauge containers at downtown of Iksan city, located southwest of the Korean peninsula, from April 20 to May 1, 2004. The volume of 30-50㎖ deionized water was added for wet gauge before sampling, but dry gauge was installed in the dry state with no deionized water adding. These samples were collected twice a day during daytime and nighttime and were analyzed for anions(Cl^(-), NO^(3-), SO₄^(2-)) and cations (NH₄^(+), Na^(+), K^(+), Mg^(2+), Ca^(2+)) using ion chromatography. Data quality was checked by the data obtained from re-injection of standard solution, Dionex cross check standard solutions, and random several deposition samples, and measured data was estimated to be reliable. Considering the deposition sample volume, the sampling time, the surface area of sampling container, and the ion concentration measured, the deposition amounts were calculated in mg/㎡/day. The sum of ion dry deposition amounts for dry gauge and wet gauge was 9.1±6.7 mg/㎡/day and 26.5±9.1 mg/㎡/day, respectively. A significant increase in deposition amount during rainfall days and Asian yellow dust period was observed for both wet gauge and dry gauge, especially during rainfall days having no difference of deposition amount between in wet gauge and in dry gauge. The mean deposition of all ions measured in this study were higher in wet gauge than in dry gauge because of the surface difference of the sampling container. The mean deposition amount of NH₄^(+), SO₄^(2-), and NO^(3-) in wet gauge were found to be about 27.6 times, 5.5 times, and 3.4 times higher. than that in dry gauge, while the rest of the chemical species were equal or a little higher in wet gauge than in dry gauge. Dominant species in dry gauge were SO₄^(2-) and Ca^(2+), accounting for 14.7% and 47.3% of the total ion dry deposition, whereas those in wet gauge were SO₄^(2-) and NH₄^(+), accounting for 27.7% and 27.1% of the total ion dry deposition, respectively.

Sol-Gel법으로 제조된 PZT Thin Film

오지현,권근희,김남철 공주대학교 생산기술연구소 2002 論文集 Vol.10 No.-

This paper presents ferroelectric Pb(Zr_0.52Ti_0.48)O_3 (PZT) thin film by sol-gel synthesis with metal-organic precursors. Sol-gel reaction sequences with metal-organic precursors were confirmed through DTA and FT-IR measurements and perovskite phase formation was investigated by rapid thermal annealing technique. The structural and morphological properties of PZT thin film were investigated by XRD and SEM. Perovskite phase PZT single phase was appeared at temperature of 650 ℃ and the second phase, pyrochlore, was decreased as increasing the annealing temperature, which was clearly indicated by investigating the size of 'rosette structure' and pyrochlore phases at different annealing temperatures. The P-E loop measurement indicated the relation of the applied voltage vs. domain alignments in the PZT thin film system.

소아에서 발생한 악골의 다발성 각화낭성 치성종양의 치험례

김지영,김영진,김현정,남순현 大韓小兒齒科學會 2009 大韓小兒齒科學會誌 Vol.36 No.3

악골에서 다수로 발생하는 낭은, 단독으로 발생하는 낭에 비해 매우 드물게 나타난다. 증후군을 동반하지는 않고, 악골 내에 다수의 낭이 발생한 경우를 다발성 악골낭 이라고 하는데, 소아에서 발생하는 다발성 악골 낭의 대부분은 각화낭성 치성종양(Keratocystic odontogenic tumor, KCOT)이다. 소아에서 나타나는 악골의 다발성 각화낭성 치성종양은, 기저세포모반증후군의 한 증상으로 발생할 수 있으므로, 악골의 방사선 사진에서 다발성 낭이 발견되면, 증후군을 의심해보고 임상 및 병리 검사를 하게 된다. 본 증례는, 다발성 악골 낭을 주소로 내원한 소아환자들로, 기저세포모반증후군을 의심하였으나 현재까지 증후군의 다른 증상들은 보이고 있지 않으며, 단지 수년간에 걸쳐서 종양의 재발과 수술을 반복하고 있는 경우이다. 악골의 다발성 낭 이외의 기저세포모반증후군의 증상들이 나타나지 않더라도, 나이가 들면 증후군의 다른 증상들이 나타난 경우의 보고도 있으므로, 소아에서 이러한 다발성 치성종양이 관찰되면, 지속적으로 방사선 및 임상 검사를 시행하여 증후군으로의 진행 여부를 관찰하는 것이 중요한 것으로 사료된다. Occurrence of multiple cysts in jaw bone is rare compared to solitary cysts. numerous cysts occurring in jaw bone which not accompany any syndromes are defined as multiple jaw cysts. and most of these cases in children are keratocystic odontogenic tumor(KCOT) Multiple KCOT occurring in children are often associated with basal cell nevus syndrome(BCNS), so if multiple cysts are found on the radiograph. we suspect this syndrome and pursue clinical and pathological tests. In this case, a pediatric patient, reporting with multiple cysts in the jaw was suspected of BCNS, but hasn't shown any other symptoms of this syndrome up to date, and has kept repeating surgical operation and recurrence of the tumor. Although no symptoms besides multiple jaw cysts is present, it is often reported that other symptoms appear late in the patient's age. Therefore, in cases where multiple odontogenic tumors are found in children, continuous radiographic and clinical follow-ups in order to check the progress of the syndrome is considered important.