乳牛의 泌乳能力에 影響을 미치는 遺傳과 環境效果에 관한 硏究

梁榮穆,梁熙晟 건국대학교 1989 論文集 Vol.29 No.2

This study was undertaken to investigate the genetic and environmental effects for 305-day and ME 305-day milk yield, far yield and fat percent by using three different mixed model. Lactation records were collected from 1973 to 1987 on Holstein cows in 29 dairy farms of Krung-Ki, Chung-Nam, Kyung-Nam, Kyong-Buk, and Kang-Won provinces. In total there were 778 records and 35 sires. The results obtained in this study are summarized as follows. L. The overall mean of 305-day and ME305-day adjusted lactation traits were 6205.6Kg and 7227.2Kg for milk yield, 220.4Kg and 252.6Kg for fat yield, 3.67% and 3.54% for fat percent, respectively. 2. The effects of herd and sire for all traits, the effects of age at calving for 305-day milk yield, 305-day and ME305-day fat field, ME305-day fat percent under model (2), and the effect of parity for 305-day and ME305-day milk yield, 305-day fat yield under model (3) were highly significant (P< 0.01), respectively. 3. The effect of age al calving was increased over time and after 73∼84 month's age apeared declining. 4. The effect of calving season showed that cows that calved during winter and spring season produced more milk yield and fat yield than cows that calved during summer and autumn season, and that cows that calved during summer season were the highest fat percent. 5. The effect of parity was increased over time and third lactation was the highest milk yield and forth lactation was the highest fat yield, but third lactation was the lowest fat percent. 6. The sire of number 22 was the highest rank for milk and fat yield, the sire of number 32 was the highest rank for fat percent. 7. Use of mixed model(3) that parity was added to mixed model(2) caused to change the ranking of the sires. 8. The sire and error component of variance for milk yield and fat yield were increased, and the error component of variance for fat percent was decreased by age adjustment. The heritabilities for milk yield, fat yield and fat percent of 305-day and ME305-day were increased in ME305-day, were 0.25 and 0.29, 0.25 and 0.27, 0.43 and 0.58, respectively. 9. In the correlation, between age at calving and parity was high and positive value (0.93), between milk yield and fat yield was positive values (0.78∼ 0.79), between fat yield and fat percent was positive values (0.29∼0.31), between milk yield and fat percent was negative values(-0.32∼-0.36).

매쉬-심 용접 판재의 성형 한계

김형목,허영무,양대호,서대교 기계기술연구소 1999 성균관대학교 논문집 기계기술편 Vol.1 No.1

This paper describes experimental investigation on the forming limit for mash-seam welded sheets. The uniaxial tensile test was conducted to evaluate the mechanical properties of weld bead. Experimental forming limit diagrams were investigated for the different thicknesses and properties of welded sheets.

WO₃계 NO_(x)센서의 검지 특성과 바인더 첨가 효과

양종인,한상도,김일진,손영목,임한조 경북대학교 센서기술연구소 1997 센서技術學術大會論文集 Vol.8 No.1

The effects of various binderssuch as PVA, silica sol and alumina on the sensing characteristics of TiO_(2) (4 wt. %)-doped WO_(3)-based NO_(x). sensors were investigated. The sensor with PVA (polyvinyl alcohol) binder showed an improved sensitivity (R_(gas)/R_(air)- in NO_(x) 15 ppm = 375), response time and cross-sensitivity (selectivity) for interference gases (CO, SO_(2), CH_(4), C_(3)H_(8)). It could also be operated at a lower consumption power (about 1.6W at 180℃). The sensors with silica sol and alumina binders showed a decreased sensitivity (R_(gas)/R_(air) in NO_(x) 15 ppm = 63 and 31, respectively) for NO_(x) gas sensing, but they showed an improved cross-sensitivity, response and recovery time (1 -2 min. and 1 min., respectively) than the sensor fabricated without binder.

아나필락시스를 동반한 Sweet 증후군 1례

이영목,어수택,김양기 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Sweet's syndrome is a neutrophilic dermatosis that has various clinical characteristics and is often associated with inflammatory, malignant or autoimmune diseases, so the viral or bacterial antigens and tumor antigens are suspected to play a role in the pathogenesis of Sweet's syndrome. We describe here a Korean male who had Sweet's syndrome accompanied by anaphylaxis.

Rifampicin에 의한 Clostridium difficile-associated disease 1예

김양기,이영목,어수택 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Clostridium difficile-associated disease (CDAD) is a common cause of antibiotics-associated diarrhea. Rifampicin is one of the first line agents in treatment of tuberculosis and a large number of patients are exposed to its potential adverse effects. We report a case that diarrhea due to CDAD after receiving antituberculous medication, and which was probably caused by rifampicin. A 76-year-old female was admitted with general weakness and fever of 6 days duration. The patient was diagnosed as active pulmonary tuberculosis following sputum AFB smear. She was started on isoniazid, rifampicin, ethambutol and pyrazinamide as antituberculous medication. She complained watery diarrhea at sixth days after antituberculous medication, and was positive result for C.difficile toxin. She was diagnosed as CDAD, and treated with oral metronidazole and continuous antituberculous medication without rifampicin. Diarrhea did not recur after antituberculous medication without refampicin continued. In patients with persistent diarrhea receiving anti-tuberculosis treatment, rifampicin associated CDAD should always be kept in mind.

Rat의 복강내에 투여한 5-fluorouracil-polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

강대영,송규상,최정목,노승무,정경수,오정연,김진향,양준묵,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

For more effective intraperitoneal chemotherapy, the authers made 5-fluorouracil-polyglycolic acid composite disks(FU-PGA disks) with 5-fluorouracil and polyglycolic acid, a biodegradable polymer. We inserted the FU-PGA disk into the peritoneal cavites of Sprague-Dawley male rats, the control and three experimental groups; one FU-PGA disk insert group(300mg/kg), two FU-PGA disk insert group(600mg/kg), and three FU-PGA disk insert group(900mg/kg). The control group received a similar number of PGA disk inserts. A pharmacokinetic study was performed to measure the 5-fluorouracil concentration in the peritoneal fluid, blood, and tissues(liver, kidney and heart) at 24 hours, 72hours and 168 hours after insertion of the FU-PGA disk. Light and electron microscopic studies were done. The results were as follows: 1) The number of white blood cells and platelets decreased after FU-PGA insertion. The degree was proportional to the duration and amounts inserted. The change in the number of red blood cells varied slightly. 2) Light microscopically, slight changes were noted at 168 hours in the 3 disk insert group (900mg/kg). Mild fatty change and hepatocyte degeneration around the central veins of the liver were noted, with vacuolar degeneration in the proximal convoluted tubules of the kidney. 3) Electron microscopically,the liver showed focal increases of lipid droplets in the hepatocytes, and irregular nuclear membrane with focal nucleolar segregation of the fibrillar and granular elements. Also the double membranous structure of the hepatocytes and Kupffer cells was widened with bleb formation. The kidney showed wide separation of the nuclear double membrane in the proximal convoluted tubular cells and mesangial cells, with vacuolation and myelin figure formation in the mitochondria of the proximal convoluted tubular cells, at 72 hours and 168 hours in the 2 to 3 FU-PGA insert groups. The heart showed focal loss of cristae,vacuolation and myelin figure formation in the mitochondria of the 2 to 3 FU-PGA insert groups. In conclusion, despite the large amont of FU-PGA inserted, the histopathological changes in the liver, kidney and heart were slight, and consonant with the very low amount of 5-fluorouracil concentrations detected in the liver, kidney and heart. The above results suggest that the FU-PGA composite can serve as a new device for releasing drugs in a controlled manner and easily targeted to intraperitoneal organs. This device can improve the efficacy of intraperitoneal chemotherapy for gastric cancer.

해외에서 유입된 정상 면역 성인의 Varicella 폐렴 1예

조영관,박은경,김양기,이영목,어수택,김태형 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Varicella-zoster virus, an unusual pathogen of community acquired pneumonia in adult, may causes respiratory distress and death. Since the first description by Waring et al. in 1942, the disease has been recognized by roentgenography, pathologic study, and virus studies as a special syndrome of the varicella virus. Immunocompromized conditions such as leukemia, malignant lymphoma and corticosteroid therapy predispose patients to varicella pneumonia. It occurs rarely in immunocompetent patients. The clinical manifestations of varicella zoster pneumonia exhibit a wide spectrum of disease from asymptomatic to death. Acyclovir is the recommended treatment and corticosteroid can be used in severe varicella pneumonia. We report a case of varicella pneumonia developed in a immunocompetent patient.

PHA로 자극된 T cell에서 분비된 미지의 물질이 지니는 Human Neutrophil의 수명연장, Superoxide 및 Leukotriene C₄생산증가 작용효과

허억,양영목 大韓免疫學會 1993 大韓免疫學會誌 Vol.15 No.-

There are several direct and indirect ways in which T cells could enhance the anti-bacterial capabilities of neutrophils. However it is not yet clear out which molecule or cytokine produced by T cells is involved in the phagocytic action and viability sustaining activity of neutrophils. The aim of this study was about a factor, which produced by the phytohaemagglutinin(PHA)-stimulated T cells, may control those neutrophil actions. Human peripheral blood T cells and neutrophils were isolated by Ficoll-paque density sedimentation from heparinized blood of healthy adult donors. The purity of these cells were more than 90%. T cells were stimulated in various dose(0.1-10gg/ml) of PHA for various times of incubation(0-3 days), and then PHA-stimulated T cell conditioned medium was collected in order to find an optimal dose and incubation time for the neutrophil viability. It was found out that 1,ug/ml of PHA in 12 hours incubation was maximal effective condition for the neutrophil sustaining viability. The effects of PHA-stimulated T cell conditioned medium(TCM) on the neutrophils were used for the comparison with PHA-nonstimulated TCM or enriched medium alone. Neutrophil sustaining viability with PHA-stimulated TCM for 24 hours incubation was significantly higher than other groups (80 ± 10 vs 25 ±15 vs 13 ± 9; p <0.01). The superoxide prodution from neutrophils with PHA-stimulated TCM for 24 hours incubation were also significantly higher than other groups(25±4 vs 11±4 vs 7±5; p <0.01). In the leukotriene C4 (LTC4) release, neutrophils with PHA-stimulated TCM for 24 hours incubation were different from other group (105 ± 20 vs 65 ±1O vs 25 ± 32 ; p <0.01), and unlikely other parameters the cells with PHA-nonstimulated TCM was different from the cells with enriched medium alone(65 -1:10 vs 25-± 32; p<0.05). In two dimension electrophoresis it was shown that PHA-stimulated T cells enhanced three proteins(66kD, 60kD, 45kD) and diminished one(40kD) in the production and/or release of proteins in comparison with PHA-nonstimulated T cells. These data suggest that these proteins from the PHA-stimulated T cells might be involved in the phagocytic actions of neutrophils.

백서의 복강내에 투여한 Mitomycin-C-Polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

송규상,강대영,최정목,노승무,정경수,오정연,김진향,양준목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

To evaluate the in-vivo effects of mitomycin-C-polyglycolic acid composite(MMC-PGA) the disk: shaped composite were implanted into the peritoneal cavity of the Sprague-Dawley rats. The pathologic changes were examined at various time points up to 12 weeks. Initially the soft tissue around the inserted disks showed capillary congestion at 3 days. Inflammatory infiltrates with foreign body giant cells appeared from the 2nd week and reached peak response at 6-8 weeks. These reaction diminished prominently at 12 weeks. No specific pathologic change was found in the liver, the kidneys, and the heart. The above results suggest that the MMC-PGA composite can serve as a new device for intraperitoneal chemotherapy of various types of cancers.

난치 천식으로 오인된 기관지 카르시노이드 종양 1례

어수택,김양기,이영목 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

A bronchial carcinoid tumor is identified in the patients with cough and normal chest PA or during routine examination of chest PA. Sometimes it is very difficult to diagnose the bronchial carcinoid tumor with normal chest PA, especially if the patient complains the typical symptoms of bronchial asthma. We experienced a 30 year-old female, who had been suffered from coughing and dyspnea in spite of asthma medications for 1 year, with bronchial carcinoid tumor. We describe here a case of bronchial carcinoid tumor mimicking refractory bronchial asthma.