비평형제2상의 용체화거동에 미치는 응고조직의 영향

윤의박,안갑우,서창제,허태수 대한금속재료학회(대한금속학회) 1980 대한금속·재료학회지 Vol.18 No.5

偏析型 2元系合金의 溶體化末期에 있어서 非平衡第2相의 固溶擧動에 대해서는 아직까지 理論的으로 정립되어 있지 않았다. 本 論文에서는 主로 dendrite element의 境界에 晶出된 非平衡第2相의 유효擴散距離로써 1次arm 間隔을 考慮한 擴散 model인 尹의 近似解에 의해 이들 擧動을 調査하였다. 이를 위해 天然가스등의 輸送材料로 囑望되는 高濃度 Al-8%Mg合金을 사용하였다. 實驗結果, 理論的인 尹의 近似解의 實驗値는 近似的으로 一致되었고, 특히 溶體化末期에서는 完全히 一致됨을 알 수 있다. 結局 從來의 Flemings의 解析値보다 더욱 實驗値에 近似하였다. The solution kinetics of nonequilibrium second phase of a segregated binary alloy in the later stages of solution treatment have not yet been made theoretically clear. This paper attempted mainly to investigate this behaviour by Yoon's approximate analysis given by a simple model based upon primary arm spacing as an effective diffusion distance of the second phase which has crystallized at the boundary of dendrite element. For this purpose, we used the high magnesium Al-8% Mg alloy which is expected to be used for transport of liguified natural gas. The theoretically calculated results are in the approximate agreement with that of experiments for complete dissolution time and solution kinetics (expecially at the later stages) of β-phase. The Yoon's approximate analysis was in better agreement with the present experimental results than the Flemings conventional analysis

農家所得增大를 위한 보리쌀 消費增大方案에 관한 硏究 : 보리쌀 炊飯特性 硏究를 통한 보리 利用性 提高方案

尹水弘,徐挺植,金尙玉,玄仁煥 영남이공대학 1981 論文集 Vol.10 No.-

This study was carried out as a program to increase the utilization of barley by improving the acceptable eating quality of Korea's traditional cooked barley of a grain type. The barley's characteristics of cooking and acceptable eating quality according to its pearling rate by pearling it differently in the four classes; 70%, 60%, 50%. 45% (as the weight ratio of pearled barley to covered one) were examined extensively including the general compositions of samples, the time course changes of barley's volume and weight in proportion to the soaking before cooking, the experiments of the physiochemical characteristics (the water-uptake ratio and swelled volume of polished barley when cooked, the pII, iodine color intensity and total solids in the residual cooking liquid) and textural properties by the universal testing machine about the cooked barley as a objective testing method of acceptable eating qualities, the sensory evaluation of cooked barley as a subjective testing method of acceptable eating qualities, etc. The results were as follows: 1. According to the decrease of pearling rates, moisture contents and nitrogen-free extracts of samples were increased slightly, but their components of crude protein, crude lipid, crude fibre and ash were decreased greatly 2. In the time-course changes of the capacity of water-uptake and swelling of volume according to the soaking of samples before cooking, the increased weight ratios were increased in proportion to the decrease of pearling rate of barley, but the increased volume ratios were increased according to the order of covered barley, Akibare(rice), 50% pearled barley, 60% pearled barley, 70% pearled barley, 45% pearled, ane especially the volume increases were marked at the early stage of soaking in 70% pearled barley. 3. According to the decrease of pearling rate, water-uptake ratios during cooking were increased, but swelling of volume had the maximum value at 60% pearled barley, decreased again having the minimum value at 45% pearled barley. 4. pH values of the residual cooking liquid of the cooked barley were decreased according to the decrease of pearling rate and were considerably less than the pH, 6.46 of Akibare. The iodine color intensity and total solids of the residual cooking liquid of the cooked barley were increased greatly according to the decrease of pearling rate, but were considerably lower as compared with those of Akibare as a whole. 5. The texture profile of the cooked barley obtained by the universal testing machine were analyzed by the methods of Bourne. Henry etc. Max. force known to hardness, force to 20% compression, compressive gumminess, compressive chewiness were increased according to the order of pearling rate, 60%, 50%, 45%, 70% and recorded the higher values as compared with those of Akibare. Compressive cohesiveness, peak force, tensile hardness, tensile springiness, tensile cohesiveness, tensile gumminess, tensile chewiness were increased according to the decrease of pearling rate of barley and reached the maximum at 45% pearled barley, but recorded the much lower values as compared with those of Akibare. But springiness did not show some differences between the pearling rates or rice and barley polished. 6. According to the results of panel tests about the cooked barley by the hedonic scoring method based on a 5-point scale, color, tasts, appearance, adhesiveness, total acceptability had significant differences between samples at 95% level, but other quality factors did not and there were no significant differences between panel members. The means of total scores increased according to the order of pearling rate. 60%. 70%, 50%, 45%, and therefore it was shown that 45% pearled barley had the best acceptable eating quality.

日帝時代의 體育에 關한 考察 : 學校體育을 中心으로 focused on physical education in school

徐順吉,陳潤洙 忠南大學校體育科學硏究所 1991 體育科學硏究誌 Vol.9 No.1

This study is on the history of sports and physical education in Korea from 1910 to 1945 (the period under Japanese colony) focused on physical education in school. Considering the fact that Korean sports had grown under the Japanese tutelage. it is important to study this theme in connection with the changes of the Japanese colonial policies and the Korean reactions to them in terms of initiatives, morale and motivating force. Until about 1910, argument for the necessity of new physical education persuaded certain segments of the Korean sociaty, and thereby launched physical education programs at Western style schools and athletic mettings in the cummunities. It was during this embryonic stage of physical education in Korea that set the tone of the general direction of physical trainings in schools. A bulk of physical teachers were former army officers of the late Yi dynasty, and they were naturally antagonistic toward the invading Japanese and highly nationalistic in their orientation. Such philosophy was fully reflected in their teachings inculcating nationalism into the youthful minds and, at the same timee, inspired the public with patriotism wherever the sport meetings were held. Moreover, such sportgames held at community levels helped develop a strong sense of solidarity among the people and thus promote unity of the Korean People.

Cybex를 이용한 8주간의 isokinetic training이 하지근력이 저하된 사람의 근력 및 대퇴위 변화에 미치는 효과

김양수,김창환,임영조,서수진,윤진환,강성철 최신의학사 1995 最新醫學 Vol.38 No.4

뇨(尿)중 3-Methylhistidine 함량의 측정과 이용

정수현,서형주,김윤숙,이효구,강덕호 한국식품영양학회 1996 韓國食品營養學會誌 Vol.9 No.2

기존의 방법을 일부 수정하여 뇨중 3-methylhistidine을 분석하였다. 뇨중 3-methylhistidine을 fluorescamine 유도체화하여 HPLC에 주입하고 C_18 column과 10 mM acetonitrile/sodium phosphate buffer(pH 7.5)로 분리·용출시켜 형광검출기로 측정하였다. 3-methylhistidine의 체류시간은 7분 이내이었으며, histidine과의 분리상태도 서로 간섭함이 없이 양호하였다. 뇨에 3-methylhistidine을 첨가하고 이를 분석하였을 때의 회수율은 93∼106%로 높은 수준이었다. 체육학과 남학생중 웨이트 트레이닝 단련자와 비단련자를 대상으로 조사한 단기간의 웨이트 트레이닝에 따른 뇨중 3-methylhistidine 함량의 변화는 두 집단 모두 웨이트 트레이닝후의 3-methylhistidine 분비량이 유의하게 증가하였다. A modified method is given for the precolumn derivatization and subsequent high-pressure liquid chromatographic seperation of 3-methylhistidine from urine. The elution contained isocratic solution with acetonirile and 10 mM sodium phosphate(pH 7.5) requires less than 7 min. The recoveries of 3-methylhistidine from urine control were 93% to 106%. 3-Methylhistidine determinations were performed on urine samples from volunteers who were both male trained and non-trained physical undergraduates. As the result, urinary 3-methylhistidine content of volunteers increased significantly after weight training.

화상에 의한 간상해에 Anti-prostaglandin이 미치는 영향

김용송,임정교,손윤경,서인수,손태중 慶北大學校 醫科大學 1991 慶北醫大誌 Vol.32 No.1

저자는 anti-prostaglandin의 화상독에 의한 간상해에 미치는 영향에 관하여 알아보고자 Sprague-Dawley계 흰쥐 수컷의 체표 30%에 3도 화상을 일으키고 생리식염수와 anti-prostaglandin제제인 flurbiprofen을 투여한 후 각각 5일과 10일 후 도살하여 간의 변화를 관찰하였으며 성적은 다음과 같다. 생리식염수를 투여한 실험군에서는 화상 5일 후 간세포에 mitochondria의 상해와 ER의 확장이 있었고 유동내에는 호중구 등 염증세포의 침윤이 있었다. 화상 10일 후에는 상기한 mitochondria의 상해가 거의 수복되고 ER의 확장도 감소되었으며 유동내의 염증세포도 거의 보이지 않았다. flurbiprofen을 투여한 실험군에서는 화상 5일후 mitochondria의 상해와 ER의 확장이 관찰되었으며 이는 화상 10일 후 까지 지속되었다. 이상의 성적으로 보아 중증화상후에 간은 화상독에 의하여 간세포 mitochondria의 상해를 주로하는 손상을 받게되나 이는 시간이 지나면 수복 가능한 가역적인 상해라 보아진다. 또한 anti-prostaglandin제제는 화상독에 의한 간세포상해에 거의 영향을 미치지 못할 것으로 생각된다. An ultrastructural study was carried out to investigate the effects of burn toxin to liver. Thermal burns wee tried on the skin of Sprague-Dawley rats with severity of 30% and 3rd degree. Flurbiprofen (a kind of anti-prostaglandin) and normal saline was administered every day after burn. The animals were sacrificed at 5 days and 10 days after burns and the livers were extracted for electron microscopic observation. The liver cells of saline intake groups at 5 days after burns were characterized by generalized mitochondrial injury, such as swelling, loss of cristae and membrase destruction. Dilatation of ER and lysosomal increase are also noted. The sinusoid revealed neutrophilic infiltration. At 10 days after burns the liver cells demonstrated nearly normal structure without mitochondrial injury. Mild dilatation of ER was seen. The flurbiprofen intake groups revealed that mitochondrial swelling, loss of critae and destruction of mitochondrial membrane with dilatation of ER and lysosomal increase at 5 days after burns. These features were continued to 10 days after burns. According to these results, it would be concluded that the effects of burn toxin to liver is characterized by mitochondrial injury and it is reversible change. And the anti-prostaglandin drugs may not be effective to inhibit the progressive injury induced by burn toxin.

관동맥질환에서 각종 지질 및 지단백의 변화

황석순,김권배,손수인,서영숙,김기식,김윤년 啓明大學校 醫科大學 1990 계명의대학술지 Vol.9 No.3

To evaluate the relationship between coronary artery disease(CAD) and the various levels of lipid and lipoproteins, we performed coronary angiography to the patient, who were suspected coronary artery disease from January 1988 to August 1989. And compared it with normal control group. The number of control group were 41(21 men, 20 women), and the patient group were 52(42 men, 10 women). The age was not differ between two groups. The results were as follows; 1. In CAD group, the plasma concentration of total lipid, triglyceride, total cholesterol, phosphlipid, and TC/HDL ratio were significantly higher than in control group. But, though, the concentration of HDL was lower in CAD group, had no significant difference between two groups. 2. The severity of CAD were well correlated with total lipid, cholesterol, LDL, trigylceride, phospholipid, TC/HDL, LDL/HDL levels. HDL level didnt's show significant correlation with the degree of CAD. We concluded that total lipid, cholesterol, trigylceride TC/LDL ratio were valuable markers of CAD in Korean, but futhur studies of lipoproteiins and other risk factors in the large population will be recommended.

Heparin이 망내계세포에 미치는 영향에 관한 초미형태학적 연구

이동철,김중길,임정교,손윤경,서인수,손태중 慶北大學校 醫科大學 1991 慶北醫大誌 Vol.32 No.3

저자들은 heparin 투여후 세망내피계의 초미형태학적 변화를 관찰하기 위해 Sprague-Dawley계 숫쥐에 heparin과 endotoxin을 투여한 후 비장을 채취하여 실험에 이용하였다. 실험군은 heparin 전처치군과 heparin 후처치군으로 나누었으며 비교군으로 heparin 단독투여군과 endotoxin 단독투여군을 설정하여 각각을 투약후 비장을 채취하여 광학현미경 및 전자현미경적 검색을 실시하였다. 실험결과를 요약하면 heparin 단독투여군은 대식세포, 형질세포양 림프아구 및 다핵백혈구가 증가되었고, 대식세포의 탐식능도 항진되었다. 그러나 대식세포자체의 소기관 발달은 현저하지 않았다. Endotoxin 단독투여군은 시간이 갈수록 대식세포의 탐식능이 저하되고, 파괴가 증가되어 수가 감소하였다. 미소혈전이 자주 관찰되었으며 기타세포들의 파괴가 관찰되었다. Heparin 전처치 및 후처치군은 공히 endotoxin군에 비해 대식세포 탐식능이 증가되었다. 이상의 성적으로 보아 heparin의 망내세포에 대한 영향은 주로 대식세포의 탐식능과 수의 증가로 생각되며 이는 정상 및 병적상태 모두에서 일어난다고 생각된다. 또한 ET 투여 전후 heparin을 투여한 실험군에서 공히 대식세포 탐식능이 증가되었으므로 이는 ET shock 후 조직손상으로 분비되는 세망내피계 저하물질에 대해 heparin이 길항작용을 할 것으로 생각된다. 또한 heparin의 대식세포 탐식능항진에 대한 효과는 세포의 직접적인 자극이라기 보다는 탐식과정중 특히 oposonization에 효과를 미칠 것으로 생각된다. The authors studied an ultrastructural changes of reticuloendothelial system after administration of heparin. Male Sprague-Dawley rats were examined after administration of heparin and endotoxin. The experimental groups were divided into heparin pretreated groups and heparin posttreated groups. The control groups were divided into heparin-only groups and endotoxin-only groups. Each animals were sacrificed and spleens were extirpated and examined by light and electron microscopy. The results obtained were summarized as follows: Heparin-only groups showed proliferation of macrophages, lymphocytes and neutrophils. The phagocytic activity of marcophage is enhanced. The cytoplamic organellar change is not remarkable except increase of secondary lysosomes. Endotoxin-only groups showed decrease of phagocytic cells. The phagocytic activity is also depressed. Destruction of macrophages and other cells are noted. Microthrombi are frequently seen. Both heparin pretreated and heparin posttreated groups revealed relative enhancement of phagocytic activity compaired to endotoxin-only groups. From the result of the experimental study, it appears that the effect of heparin on the reticuloendothelial system is enhancement of phagocytic activity of macrophages both in the coditions of normal and pathologic one. And it also suggests that heparin may act as an antagonizing factor to the reticuloendothelial depressing agent that may be derived from injured organ of endotoxin shock. And the effect of heparin to the phagocytic activity of macrophage may be related to the process of phagocytosis such as opsonization or to the direct cellular stimulation.

삼일열 말라리아의 감염시 혈중 지질변화

신철,임동준,송태진,이규철,서인범,윤수영,임채승 대한감염학회 2001 감염 Vol.33 No.1

Background : Alteration in plasma lipid levels during malaria attacks was studied to evaluate the diagnstic values in vivax malaria. Methods : The plasma levels of total cholesterol, triglycerides, HDL-cholesterol (HDL-c), and LDL-cholesterol (LDL-c) were analyzed and compared in 32 patients with vivax malaria at presentation, in 10 patients after 17-days of treatment with anti-malaria drug, and in 40 control individuals. Interrelation of lipid profile with other parameters including parasitemia level, platelet count, hemoglobin and WBC counts were analysed. Results : In patients with malaria, serum total cholesterol, triglycerides, HDL-c and LDL-c concentrations were significantly lower than those of control subjects. None of lipid profile showed any correlation with the parasitemia level. After treatment, HDL-c was significantly elevated. Conclusion : These results suggest that lipid profile, especially decreased of HDL-c, may be a valuable information in the diagnosis of the malaria. (Korean J Infect Dis 33:58∼61, 2001)

세포질내 정자주입법(ICSI)에 있어서 정자흡입 및 난자내 주입방법에 관한 연구

이택후,김항진,송건호,김대근,전상식,박윤규,서태광,전병균,류은경,이은숙,문진수,김광철 경북대학교 의학연구소 2000 경북대학교병원의학연구소논문집 Vol.4 No.1

Study on Method of Sperm Aspiration and Injection into an Oocyte in Intracytoplasmic Sperm Injection(ICSI) Immobilization of spermatozoa prior to intracytoplasmic sperm iniection(ICSI) sometimes results in crooked tail and this makes it difficult to aspirate sperm into an injection pipette tail first. Head-first sperm aspiration into an injection pipette avoid this problem due to the bigger size of the sperm head. The effect of head or tail-first sperm injection into an oocyte on fertilization cleavage, percentage of grade I embryos and development to blastocyst stage in ICSI program has been studied. A single living immobilized spermatozoa from oligoasthenozoospermic patient was injected into an oocyte head-first or tail-first according to the treatment. Eighteen hours after microinjection, oocytes ware inspected for survival and fertilization Fertilized oocytes with two pronuclei were cultured in 30μl drop of mHTF supplemented with 10% heat-inactivated follicular fluid(FF) at 37℃. On day 2. embryo transfer was performed with cleaved embryos. The remaining 2-8 cell stage embryos were co-cultured with BRL cells in mHTF + 10% FF for 72 hours and the developmental stage was observed. The data were analyzed by Analysis of Variance. A total of 164 oocytes from 36 cycles were assigned to earth treatment and ICSI was performed(88 head-first, tail-first). The rates of normal fertilization were 81.8% and 76.3% for head-first and tail-first, respectively. Of the fertilized oocytes, the percentage of cleaved embryos and the percentage of grade 1 embryo among cleaved embryos were 88.9% and 68.8%, 93.1% and 74.1% for head-first and tail-first, respectively. Of the 2-8 cell embryos cultured, 44.4%(16/36) and 50.0%(10/20) for head first and tail first, respectively developed to blastocyst stage. There were no differences in fertilization, cleavage, rates of grade 1 embryos, and development to blastocyst stage. In conclusion, head-first or tail-first sperm injection into an oocyte in ICSI program does not affect fertilization and subsequent embryo development to blastocyst stage in vitro.