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        • KCI등재후보

          12주간 태음조위탕 투여가 흰쥐의 간기능 효소와 간내 지방축적에 미치는 영향

          윤진환,류성환,정경훈,최덕구,정일규,이희혁,김종오,임은미 한국운동과학회 2002 운동과학 Vol.11 No.1

          윤진환, 류성관, 정경훈, 최덕구, 정일규, 이희혁, 김종오, 임은미. 12주간 태음조위탕 투여가 흰쥐의 간기능 효소와 간내 지방축적에 미치는 영향. 운동과학, 제11권 제1호, 53-65, 2002.본 연구는 태음조위탕의 비만 치료 효과에 대한 생리적인 결과뿐만 아니라 간 조직의 형태 변화에 중점을 두고 흰쥐 체중, 효소활성도틀 비롯해 인체내 대사가 가장 활발한 기관인 간의 조직을 살펴봄으로써 태음조위탕이 비만치료에 미치는 효과를 알아보기 위하여 시행되어졌다. 12주간 태음조위탕를 투여한 결과 다음과 같은 결론을 얻었다. 1) 태음조위탕을 복용한 군이 대조군에 비해 체중의 증가가 현저하게 낮았으며[F_(3,16)=l1324.047 P=.000], 간 무게에 있어서도 태음조위탕을 복용한 군이 대조군에 비해 약간 낮은 것으로 나타났다. 2) 총 콜레스테롤, LDL-Cholesterol, 중성지방, Al의 수준과 동맥경화지수는 대조군에 비해 태음조위탕을 복용한 군이 더 낮게 나타났으며{각각 [F_(3,16)=18.003 P=.001], [F_(3,16)=2456.437 P=.000], [F_(3,16)=413.735 P=.000], [F_(3,16)=465.003 P=.000]}, HDL-Cholesterol은 대조군에 비해 태음조위탕 복용군이 더 높게 나타났다[F_(3,16)=2195.873 P=.000]. 3) 혈중 GOT와 GPT수준은 대조군과 태음조위탕을 복용한 군간에는 유의한 차이는 보이지 않았으나 태음조위탕을 복용한 군에서 약간 낮게 나타났다. 4) Hematoxylin-eosin으로 염색한 결과 실험군의 간소엽에서 세포내 대사율 저하를 암시하는 물질들의 변형과 핵 손실이 나타났으며 수컷보다는 암컷 흰쥐의 간세포 변화가 급격하였다. 5) Sudan Black B로 지질과 지방세포를 염색한 결과 실험군이 대조군에 비해 지방침착정도가 낮았고 암컷 흰쥐가 수컷보다 지방성분이 감소하였다. 따라서 비만치료제로 쓰이는 태음조위탕은 간기능에 부정적 영향을 주지않으며 간내 지방축적을 감소시키고 암컷 흰쥐에서 효과가 더 있는 것으로 나타났다. Yoon, J.H., Ryu, S.H., Jeong, K.H., Choi, D.G, Jeong, I.K., Lee, H.H, Kim, J.O., Lim, EM. Effects of 12 Weeks Taeyeumjoweetang Administration on Enzymes and Fat Accumulation in Rat Liver Cells. Exercise Science, 11(1): 53-65, 2002. Taeyeumjoweetang is associated with improving liver function as well as lowing increased levels of lipid profiles. These factors are known to reduce body fat mass in 'the Taeyeum person'. The purpose of this study was to investigate the effects of acute Taeyeumjoweetang administration on enzymes and fat accumulation in rat liver cells. Sixteen Sprague-Dawley rats(16weeks old) were randomly assigned into two groups; the control group(n=8) and the experimental group(n=8). The experimental rats were given the consumption of 50㎖ of the herb tea a day for 12 weeks. The data for TC, LDL, HDL and AI were measured in plasma blood, and GOT and GPT were measured in liver. An alpha level of .05 was used as the criteria for significance. The obtained results are as follows: 1. There were significant differences in body weight between the two groups. The herb-intake rats were lower than Placebo rats in body weight, but no significant differences in liver weight. 2. There were significant differences in TC, LDL and AI between the two groups. The herb-intake rats were lower than placebo rats in body weight. .But HDL levels in the herb-intake rats were highly than placebo rats. 3. There were no significant differences in GOT, GPT between two groups. But the levels in the herb-intake rats were highly than placebo rats. 4. It was implied that female rats may have more changes in liver cells and nucleus lose than male rats in the herb-intake group. 5. As results of lipid and adipose cell stain, the herb-intake rats were lower than placebo rats in fat accumulation, and female rats had lower fat than male rats in the herb-intake group. Therefore, the data suggest that Taeyeumjoweetang administration has an effect to reduce fat accumulation without the side effects especially in female rats.

        • 뇌파와 첫인상 호감도 간의 관계 분석

          윤진환,조선희 고려대학교 교과교육연구소 2017 교과교육연구 Vol.10 No.2

          First impressions are important in ones school life. We carried out research into first impressions using EEG. Four middle school students participated in this study. We measured EEG when the participants saw the different facial shape and face color in the prefrontal area. We calculated the ratio of θ, α, β and γ using power spectrum analysis. The results are as followed. When they saw the different facial shape, the ratio of β wave was higher in seeing the good feeling facial picture than the general facial picture in individual analysis and group analysis. When they saw the different face color, the ratio of θ wave was lower in seeing the good feeling facial picture than the general facial picture in individual analysis and group analysis. β wave is much larger portion during the complex cognitive task and θ wave is much larger portion during the calm state. Our results suggest that the brain is more complex state in good feeling first impression and that is somewhat different in calm state.

        • KCI등재후보

          Supine Bicycle Ergometer 운동이 뇌파와 기분상태에 미치는 영향

          윤진환,정일규,김영표,김종오,이희혁,오봉석,김창주 대한스포츠의학회 2003 대한스포츠의학회지 Vol.21 No.1

          In this study we investigated the effects of supine ergometer exercise on physiological and psychological relaxation. Seven healthy young men(aged 24.4±2.00years) volunteered for the experiment. The experiment consisted of the following three successive segments" A pre-exercise period of 10 min, during which the subjects rested in a supine posture with their eyes closed for the final 5 min; an supine ergometer exercise period of approximately 10 min, during which the subjects performed intensity of 50%HRmax exercises; A post-exercise recovery of 5 min, and a recovery of 10 min, which was similar to the pre-exercise rest period. The electroencephalo-graphic(EEG) activity of the central cortex of the brain were measured pre-exercise, post-exercise 5 min, and recovery phase 10min. Fast Fourier Transformation of the EEG was used to obtain power spectrum areas in the delta(0.5~4 Hz), theta(4~8 Hz), alpha(8~13 Hz) and beta(13~30 Hz) frequencies. We compared the relative power values(power %) of the electroencephalogram alpha bands(8~13 Hz) and korean edition of the profile of mood states(K-POMS) before and after the supine ergometer exercise. We also estimated the percentage of maximal heart rate(%HRmax) throughout the experiment to ascertain the intensity of the supine bicycle ergometer exercise. The results of %HRmax indicated that the intensity of supine exercises practised in the experiments ranged from low to moderate. The power % of EEG alpha bands had increased significantly after the supine ergometer exercise compared with the pre-exercise rest(p<0.05). From the POMS results, we observed that positive mood(vigour) increased and negative mood(tension, depression, and total mood)decreased significantly after the supine ergometer exercise(p<0.05). This study found that the subjects showed increased physiological and psychological indices of relaxation after supine bicycle ergometer exercise.

        • KCI등재

          강도별 유산소 운동이 비만 쥐 뇌 조직의 신경 가소성 관련 단백질 발현에 미치는 영향

          윤진환,지현석,황부근 한국생활환경학회 2019 한국생활환경학회지 Vol.26 No.6

          This study was to investigate the effects of an aerobic exercise with different intensities on neuronal plasticity-related protein expression in brain of obese rats. At 4 weeks of age, S.D rats(N=40) were randomly assigned to : high fat diet control group(HF-C, n=10), high fat diet+low intensity exercise group(HF+LE, n=10), high fat diet+moderate intensity exercise group(HF+ME, n=10) and high fat diet+high intensity exercise group(HF+HE, n=10). Rats in the exercise group run on a treadmill at a speed of HF+LE group(8~10m/min), HF+ME(14~16m/min), HF+HE(20~22m/min) for 60 min daily (30-40 min/day) for 8 weeks. After 8 weeks treadmill exercise, serum total cholesterol, LDL-C, triglyceride level were significantly decreased in exercise groups compared with HF-C group(p<.05) and then HDL-C was significantly increased in exercise groups compared with HF-C group(p<.05). In the hippocampus, BDNF mRNA and VEGF mRNA expression were significantly increased in exercise groups compared with HF-C group(p<.05). IGF-1 mRNA and escape latency were non significantly diffrent in exercise groups compared with HFC group. These results showed that 8 weeks treadmill exercise training can improve serum lipid and neuronal plasticityrelated protein expression of hippocampus in obese rats.

        • KCI등재

          운동이 좌골신경 손상 F344쥐의 Neurotrophins, BDNF, NT-3, GAP-43 단백질 발현과 축삭재생에 미치는 영향

          윤진환,서태범,Yoon,Jin-Hwan,Seo,Tae-Beom 한국생명과학회 2006 생명과학회지 Vol.16 No.3

          본 연구에서는 흰쥐의 좌골신경을 손상시킨 후 트레드밀 운동을 적용하여 신경돌기 성장과 좌골신경의 축삭 재생 및 신경성장 인자 발현 그리고 신경기능지수의 변화를 연구했다. 본 연구결과 좌골손상 후 트레드밀 운동을 실시한 그룹이 비운동군에 비해 축삭재생이 촉진되었고, 원위부의 좌골신경에서도 NGF, BDNF단백질 발현이 상당히 증가된 것으로 나타났다. 또한 좌골신경지수를 검사한 결과에서도 운동을 실시한 흰쥐가 비운동 흰쥐에 비해 기능적 회복이 상당히 빠른 것으로 나타났다. 이러한 결과는 좌골손상 후 운동의 실시가 좌골신경의 축삭재생 촉진과 신경영양인자의 발현증가를 통해 기능적 회복에 도움이 될 수 있음을 보여주는 것이다. Peripheral nerve injuries are a commonly encountered clinical problem and often result in severe functional deficits. In the present study, the effects of treadmill exercise on neurotrophin expressions and functional recovery following sciatic crushed nerve injury were investigated. Animals were randomly assigned into four groups: the sciatic nerve injury group, the sciatic nerve injury and 3-day-exercise, the sciatic nerve injury and 7-days-exercise, and the sciatic nerve injury and 14-days-exercise groups. Sciatic nerve injury was caused by crushing the right sciatic nerve for 30 s using a surgical clip. A the light-exercise was applied to each of the exercise group over the respective number of days. In the present results, we identified enhanced axonal re-growth in the distal stump of the sciatic nerve 3-14 days after crush injury with treadmill training. Dorsal root ganglion (DRG) neuron when cultured from animals with nerve injury and treadmill training showed more enhanced neurite outgrowth than that of sedentary animals. Nerve growth factor (NGF) protein levels in low-intensity treadmill training group were highly induced in the injured sciatic nerves 3, 7 and 14 days after injury compared with sedentary group, and brain-derived neurotrophin factor (BDNF) protein levels in treadmill exercise group were highly induced in the injured sciatic nerve 3 days after injury compared with sedentary group. Then, treadmill exercise increased neurotrophic factors induced in the regenerating nerves. We further demonstrate that motor functional recovery after sciatic nerve injury was promoted by treadmill exercise. Thus, the present data provide a new evidence that treadmill exercise enhanced neurotrophins expression and axonal regeneration after sciatic nerve injury in rats.

        • KCI등재

          운동과 태음조위탕 처방이 흰쥐의 간기능 효소와 간내 지방축적에 미치는 영향

          윤진환,류성환,정경훈,최덕구,정일규,이희혁,김종오,정진욱 한국운동과학회 2002 운동과학 Vol.11 No.2

          윤진란, 류성환, 정경훈, 최덕구, 정일규, 이희혁, 김종오, 정진욱. 운동과 태음조위탕 처방이 흰쥐의 간기능 효소와 간내지방축적에 미치는 영향. 운동과학, 제11권 제2호, 345-358, 2002. 본 연구는 태음조위탕과 운동처방이 비만치료에 생리학적, 조직학적으로 미치는 영향에 중점을 두고 흰쥐 체중, 효소활성도를 비롯해 인체내 대사가 가장 활발한 기관인 간의 조직을 살펴봄으로서 비만치료법으로서의 효과에 대해 알아보기 위하여 실시하였다. 본 연구결과는 다음과 같다. 운동+태음조위탕군이 다른 그룹(운동군, 태음조위탕 처방 군, 대조군) 보다 체중의 증가가 가장 낮게 나타났으며, 태음조위탕군과 운동군의 비교에 있어서는 운동군에 있어서 체중의 증가가 더 낮게 나타났다. 간 무게는 운동+태음조위탕군이 다른 그룹(운동군, 태음조위탕 처방 군, 대조군)에 비해 가장 낮았으며 운동과 태음조위탕군의 비교에 있어서도 운동군의 간무게가 더 낮음을 알 수 있었다. 총 콜레스테롤, LDL-C, 중성지방, Al의 수준은 운동+태음조위탕군이 다른 그룹(운동군, 태음조위탕 처방 군, 대조군)에 비해 더 낮게 나타났으며{각각 [F(3.36)=3.190 P=.035], [F(3.36)=123.544 P=.000], [F(3.36)=565.624 P=.000], [F(3.36)=193.935 P=.000]}, HDL-C는 운동군, 태음조위탕 처방 군, 대조군에 비해 운동+태음조위탕군이 더 높게 나타났다[F(3.36)=327.767 P=.000]. 혈중 GOT와 GPT수준은 운동군, 태음조위탕 처방 군, 대조군에 비해 운동+태음조위탕군이 낮게 나타났다. Hematoxylin-eosin은 간세포질 모두를 염색하는 방법으로 본 연구에서는 세포질 구성물질 정도가 대조군>태음조위탕 처방군>운동군>운동+태음조위탕 처방군 순으로 나타났다. Sudan Black B는 간세포내 지방성분을 알아보기 위하여 행해지는 염색법으로 본 연구에서는 다음과 같이 지방성분 함량이 대조군>태음조위탕 처방군>운동군>운동+태음조위탕 처방군 순으로 나타났다. PASS 염색을 실시한 결과 당함량이 대조군에서 가장 많고 태음조위탕 처방군>운동군>운동+태음조위탕 처방 군 순으로 나타났다. 이상과 갈이 태음조위탕과 운동의 처방은 간기능에 부정적 영향을 주지 않고 간내 지방 축적을 감소시켜 비만치료에 효과가 있는 것으로 나타났다. Yoon, J.H, Ryu, &H, Chung KK, Choi, D.G., Jeong I.G, Lee, H.H., Kim, J.O., Chung J.W. Effects of Taeyeumjoweetang and exercise administration on enzymes and fat accumulation of the liver tissue in rats. Exercise Science, 11(2): 345-358, 2002. Taeyeumjoweetang is associated with improving liver function as wall as improving lipid profile. These factors are known to reduce body fat mass in re Taeyeum person'. Exercise also can improve liver function in patients with fatty liver. The purpose of this study was to investigate the effects of both Taeyeumjoweetang and exercise on enzymes and fat accumulation in rat's liver cells. 40 Sprague-Dawley rats(14weeks old)were randomly assigned into four group; the control group(n=10), the herb tea group(n=10), the exercise group(n=10) and the herb+exercise group(10). The herb tea group were given the consumption of 50㎖ of the herb tea a day for 8weeks. The exercise protocol consisted of treadmill running for 8 weeks. The data fof TC, LDL, HDL and Al were measured in plasma Wood, and GOT and GPT were measured in liver tissue. An alpha level of .05 was used as the criteria for significance. The Obtained results are as follows: 1. There were significant differences in body weight among three groups. The herb+exercise group was lower significantly than other group. 2. There were significant differences in liver weight among three groups. The herb+exercise group was lower significantly than other group. 3. There were significant differences in TC, LDL and Al among three groups. The herb+exercise group was lower significantly than other group. But HDL levels in the herb+exercise group was highly significantly than other group. 4. There were significant differences in GOT, GPT among three groups. The herb+exercise group was lower significantly than other group, showing lowest liver cell damage. 5. In composition material quantity of liver' cell cytosol shown by Hematoxylin-eosin stain, The herb+exercise group was lower significantly than other group. 6. As results of lipid and glucose stain, The herb+exercise group was lower significantly than other group in fat accumulation and glucose levels. These findings demonstrate that both the herb tea and exercise have an effect to reduce fat and glucose accumulation but exercise effects is higher than these of the herb tea. Also these effects is highest brought about by the herb+exercise.

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