Impact of Interferon-Based Treatment on Quality of Life and Work Related Productivity from the Korean Cohort in the MOSAIC Study

( Sang Hoon Ahn ),( Won Hyeok Choe ),( Yoon Jun Kim ),( Jeong Heo ),( Dorota Latarska-smuga ),( Jiho Kang ),( Seung Woon Paik ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Chronic Hepatitis C Virus (HCV) infection increases the risk for progressive liver disease, hepatocellular carcinoma and negatively impacts the patient’s quality of life. HCV treatment is evolving with direct acting antivirals but IFN based therapy has been the standard of care for many years and remains available in some countries. The MOSAIC study aims to characterize patients with chronic HCV infection and assess the impact of IFN-containing treatment on health-related quality of life, work related productivity and health care utilization. Methods: MOSAIC is an international prospective multicenter observational study that has been conducted in 20 countries. Consecutive patients with chronic HCV infection were enrolled and those who initiated an IFN based regimen were prospectively followed for 48 weeks. We report results from the Korean cohort Results: 100 patients were enrolled: 86 were treatment naïve and 14 were treatment experienced. 33 patients initiated an IFN based regimen: 6 patients started IFN + RBV, 26 patients started Peg-IFN + RBV, none started Peg-IFN + RBV + DAA and 1 patient received other treatment. Among the treated cohort, demographic and disease characteristics were the following: the mean age was 54.5 years; 14 patients were male. 14 had minimal or no fibrosis, 2 portal fibrosis, 3 bridging fibrosis and 6 patients suffered from cirrhosis. HCV Genotype distribution was as follows: genotype 1: 11; genotype 2: 19 and genotype 3: 3. Table 1 describes the results at baseline and changes over 4, 12 and 48 weeks and end-of-treatment (EOT) for the quality of life and work productivity outcome measures (EQ-5D-5L, HCV-PRO and WPAI). Conclusions: Results from the Korean cohort of the MOSAIC study show a moderate trend for deterioration of health-related quality of life and work productivity associated with IFN based treatment for patients with chronic HCV infection during treatment period. Acknowledgements: The design, study conduct, analysis, and financial support of MOSAIC study were provided by AbbVie. AbbVie participated in the interpretation of data, review, and approval of the content of the abstract. All authors had access to all relevant data and participated in writing, review, and approval of this abstract. Medical writing support was provided by Olivier Van de Steen of Medeor-consulting, funded by AbbVie. Disclosures: Sang Hoon Ahn: served as an advisor and lecturer for Bristol-Myers Squibb, Gilead Sciences, F.Hoffmann-La Roche, Merck, AbbVie, and has received unrestricted grants from Bristol-Myers Squibb, Gilead Sciences, and F. Hoffmann-La Roche for investigator- initiated trials Won Hyeok Choe: Nothing to disclosure Yoon Jun Kim: Nothing to disclosure Jeong Heo: received a grant from GSK; Research support from BMS, and Roche; Advisor for Abbvie, BMS, Gilead Sciences, Pharma Essentia, SillaJen, and Johnson & Johnson. Dorota Latarska-Smuga, Jiho Kang: are employees of AbbVie, Inc. and may hold stock or stock options. Seung Woon Paik: received grant and research support from AbbVie, BMS, Gilead, GSK, Merck, Novartis, and Roche

고등학생과 대학생의 기체의 성질에 관한 오개념 비교

윤회정,우애자 이화여자대학교 교과교육연구소 2007 교과교육학연구 Vol.11 No.2

본 연구의 목적은 고등학생과 대학생의 기체의 확산과 온도변화에 따른 부피변화에 대한 개념을 살펴보고, 학생들이 가지고 있는 오개념의 종류와 학년 간에 나타나는 오개념의 차이점을 조사하는 것이다. 본 연구를 통해 얻은 결론은 다음과 같다. 전반적으로 대학생은 고등학생에 비하여 기체의 성질을 올바르게 이해하고 있는 것으로 나타났고, 대학생의 경우 학년에 따른 이해도 차이는 거의 없는 것으로 보인다. 대학생은 고등학생보다 적은 종류의 오개념을 가지고 있는데 이는 학습을 통하여 일부 오개념이 수정되기 때문으로 판단된다. 기체에 관한 입자적 수준에서의 이해에 대한 부족으로 생긴 오개념은 학습에 의해 일부 올바른 개념으로 전환되기도 하지만 고등학생과 대학생에게 공통적으로 나타나는 것으로 보아 쉽게 수정되는 것은 아님을 알 수 있다. 또한 학생들은 수업에서 많이 사용되는 익숙한 내용의 문항에는 공식이나 암기한 지식들을 그대로 이용하여 설명하는 경향이 있고, 이런 경향은 고등학생들보다 대학생들에게 더 많이 나타난다.

자가 면역성 간염에서 자가항체의 발현 양상과 스테로이드 치료의 효과

박기오,채경훈,허원석,강윤세,정재훈,김연수,문희석,이엄석,김선문,이병석,김남재,이헌영 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

목적 : 최근 8년간 본원에서 경험한 자기면역성 간염의 혈액학적 특징과 스테로이드의 치료효과를 알아보고자 본 연구를 시행하였다. 방법 : 1996년 이후부터 2002년까지 충남대학교 병원에서 1999년 International Autoimmune Hepatitis Group(LAHG)에서 제시한 수정 진단 기준안에 의거하여 총 진단점수가 probable 이상에 해당하는 환자들을 대상으로 임상적 특징, 검사실 및 조직 소견과 스테로이드와 azathioprine의 치료 효과를 후향적으로 조사하였다. 결과 : 9예의 환자들은 여성이 78%, 40대가 많았고, 급성 발병이 33.3%, 피로감, 식욕부진 및 황달 등이 나타났으며, 항핵항체가 55.6%에서 그리고 항평활근 항체가 77.8%에서 양성이었고, 동반 질환은 류마치스 관절염이 2예, 특발성 혈소판 감소증 1예, Henoch-Sch nlein 자반증 및 그레브스병이 각각 1예 씩이었다. 7예에 대해서 스테로이드와 azathioprine으로 치료하여 생화학적 임상적 완해가 이루어져서 유효한 치료 결과를 얻었다. 결론 : 자가면역성 간염은 우리 나라에서 원인을 찾을 수 없는 만성 간질환의 경우, 특히 중년여성에서 다른 자가면역성 질환이 동반되었을 때 자가면역성 간염을 의심하여 자가항체 선별검사를 시행해 보아야 할 것으로 생각된다. 향후 다기관 연구를 통하여 좀 더 많은 증례를 모으고 전향적인 연구를 시행하여야 할 필요가 있다. Although autoimmune hepatitis(AIH) is common in western contries, some studties have been reported in Korea. The aim of the study was to analyze the clinical and histological features and expression pattern of the autoantibody and to examine clinical course of AIH in Korea. For 9 patients diagnosed as having AIH in our hospital since 1996, we reviewed medical records and analyzed clinical and laboratory findings retrospectively. They had a probable or definite AIH according to the revised criteria of International AIH group. The mean age was 42.7(21∼68)years and 7(77.8%) were female. Three of them(33.3%) showed acute hepatitis and five of them showed cirrhosis. Fatigue and anorexia were the most frequently complained symptoms(55.6%). Four patients(44.4%) were accompanied with other autoimmune diseases. Antinuclear antibody was detected in 5(55.6%) and anti-smooth muscle antibody was detected in 7(77.8%). Three patients showed focal picemeal necrosis and four showed periportal fibrosis. Among 7 patients who received immunosuppressive therapy, six patients(85.7%) showed initial response. and biochemical and serologic remission were achived in 5(71.4%) and 3(42.8%) patients, AIH seems to be partly responsible for chronic liver disease of unknown etiology in Korea. AIH should be suspected in female patients with unknown chronic liver disease of unknown etiolgy, especially accompanied with other autoimmune disease. The clinical characteristics of AIH may not be quite different from those of Western countries.

The comparison of surgical outcomes and learning curves of radical hysterectomy by laparoscopy and robotic system for cervical cancer: an experience of a single surgeon

( Yoon Jung Heo ),( Seongmin Kim ),( Kyung Jin Min ),( Sanghoon Lee ),( Jin Hwa Hong ),( Jae Kwan Lee ),( Nak Woo Lee ),( Jae Yun Song ) 대한산부인과학회 2018 Obstetrics & Gynecology Science Vol.61 No.4

Objective The aim of this study was to compare and determine the feasibility, surgical outcomes, learning curves of robotic radical hysterectomy with lymph node dissection (RRHND) to conventional laparoscopic radical hysterectomy with lymph node dissection (LRHND) performed by a single surgeon, in patients with cervical cancer. Methods Between April 2009 and March 2013, 22 patients underwent LRHND and 19 patients underwent RRHND. Variables such as age, body mass index, International Federation of Gynecology and Obstetrics stage, histological results, number of dissected lymph nodes, operative time, estimated blood loss, days of hospitalization and complications were reviewed. Learning curves of operation time was obtained using cumulative sum (CUSUM) method. Results Both groups showed similar patient and tumor characteristics. In surgical outcome analysis, RRHND (51.8±10.4 minutes) showed longer preparing time than LRHND (42.5±14.1 minutes). In the LRHND group, 8 patients experienced postoperative complications (5 void difficulty, 1 postoperative bleeding, 1 right basal ganglia infarction, 1 fever). On the other hand, in the RRHND group, 4 patients experienced a postoperative complication (2 bleeding, 1 peritonitis, 1 dehiscence of trocar site). Using CUSUM method, the learning curves were obtained by plotting the cumulative sequential differences between each data point and the average operation time, and showed two distinct phases in both type of operations. Conclusion RRHND would be appropriate surgical approach in patients with cervical cancer with favorable outcome of less voiding difficulty. A minimum of 13 cases of robotic radical hysterectomies are required to achieve surgical improvement in the treatment of cervical cancer.

Evaluation of Lactic Acid Bacteria Isolated from Kimchi as Antidiabetic Agents

Yoon Seok Kim,Ye Jin Lim,Dong Hoon Lee,Wan Heo,Seok Min Yoon,Sung Keum Seo,Mi Ri Park,Si Young Yang,Jun Ho Kim,Young Jun Kim 한국식품영양과학회 2017 한국식품영양과학회 학술대회발표집 Vol.2016 No.10

NAFTA and its Economic Consequence

Yoon Heo(허윤) 한국관세학회 2003 관세학회지 Vol.4 No.1

This paper documents major predictions made by economists during the debate over the potential economic effects of NAFTA. We focus our attention on employment, trade, and investment. The consensus concluded that the effects of NAFTA would be positive but small for the U.S. and Canada economies, and positive and large for Mexico. From the post-NAFTA evidences, we evaluated the ex-ante predictions. The result shows that the forecasts are basically correct; expansion of trade and investment through the agreement has created more stable, better-paying jobs in the region. The facts indicate that all three countries have been winners. Valuable lessons from the NAFTA experience are drawn.

Experimental comparison of torque balance controllers for power-assisted wheelchair driving

Heo, Yoon,Hong, Eung-pyo,Chang, Yoon-hee,Jeong, Bora,Mun, Mu-sung ELSEVIER 2018 MEASUREMENT -LONDON- Vol.120 No.-

<P><B>Abstract</B></P> <P>A power-assisted wheelchair amplifies the user’s propulsion power. If the user’s arm strength is unbalanced, this can affect the driving balance. In order to correct this imbalance, a method of producing an assisting torque by cross-referencing the opposite input torque was developed. One proposed torque balance control scheme involves automatically controlling the cross-reference proportion according to the amplitude ratio of the left and right input torques. However, this scheme cannot improve the driving performance under all conditions because instability is inherent to the user’s propelling torque. To resolve this problem, a new torque balance control method is proposed that considers not only the proportion of input torques but also the temporal difference. This study examined the usefulness of the proposed torque balance control method based on the temporal difference through a comparison with the existing method via a driving simulation and experiment.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Power-assisted wheelchairs are difficult to control with unbalanced input torques. </LI> <LI> New torque balance controller considers the temporal difference between inputs. </LI> <LI> Superior straight/rotation driving performance compared to existing control methods. </LI> </UL> </P>

Anti-asthmatic activities in mycelial extract and culture filtrate of Cordyceps sphecocephala J201.

Heo, Jin-Chul,Nam, Sung-Hee,Nam, Dong-Yoon,Kim, Jong-Guk,Lee, Kwang-Gil,Yeo, Joo-Hong,Yoon, Cheol-Sik,Park, Chul-Hong,Lee, Sang-Han D.A. Spandidos 2010 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.26 No.3

<P>This study investigated the effects of mycelial extract and culture filtrate of Cordyceps sphecocephala J201 on airway hyper-responsiveness, pulmonary immune cell infiltration, and Th2 cytokine expression in animal models of asthma. After Concanavalin A (Con A) activation of mouse primary spleen cells, the IL-4 and IL-13 cytokine expression were significantly decreased in the presence of the mycelial extract and culture filtrate of Cordyceps sphecocephala J201. The asthma model was induced by sensitization to ovalbumin by intraperitoneal (i.p.) injection treatment in mice. The Cordyceps sphecocephala J201 mycelial extract was injected in order to assess the effects of anti-asthmatic activity by comparing lung cell infiltration in ovalbumin-induced asthmatic mice. The results revealed that the increased IL-4, IL-13 and IL-25 expression were controlled by the mycelial extract and culture filtrate of Cordyceps sphecocephala J201, indicating that the extracts reduced the undesirable immune responses and/or cytokine expression exhibited in asthma.</P>

The Endogeneity of Tariffs in Korea

Yoon Heo,Yurie Chung 한국무역학회 2006 한국무역학회 국제학술대회 Vol.2006 No.12

This article examines the validity of the 'endogenous tariff model' in Korea. For many developed countries, accounting for a tariff winth its endogenous naotion has become increasingly important as special interest groups play pivotal roles in shaping trade policy. Yet, little evidence exists on the determinants of tariffs in Korea has hardly been documented. Korea is an interesting case in that its protectiveon measures have been strategically designed and extensively implemented as a means tof successful economic development. With a full set of industry specific cross sectional data, utilizing a simultaneous equation system, the study finds that: 1) a smaller number of establishments alleviates the free rider problem, reducing transaction costs, and thereby increasing the level of protection, 2) even though import competition intensifies in the short run, it does not necessarily lead to a higher level of protection, 3) the level of assistance dispensed by the government in terms of tariff concessions is biased toward industries that are characterized by comparative disadvantage, slow growth, and a large workforce.

Symmetry-Broken Atom Configurations at Grain Boundaries and Oxygen Evolution Electrocatalysis in Perovskite Oxides

Heo, Yoon,Choi, Seungkyu,Bak, Jumi,Kim, Hye-Sung,Bae, Hyung Bin,Chung, Sung-Yoon Wiley (John WileySons) 2018 Advanced energy materials Vol.8 No.34