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      • PE-049 : Impact of Interferon-Based Treatment on Quality of Life and Work Related Productivity from the Korean Cohort in the MOSAIC Study

        ( Sang Hoon Ahn ),( Won Hyeok Choe ),( Yoon Jun Kim ),( Jeong Heo ),( Dorota Latarska-smuga ),( Jiho Kang ),( Seung Woon Paik ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

        Aims: Chronic Hepatitis C Virus (HCV) infection increases the risk for progressive liver disease, hepatocellular carcinoma and negatively impacts the patient’s quality of life. HCV treatment is evolving with direct acting antivirals but IFN based therapy has been the standard of care for many years and remains available in some countries. The MOSAIC study aims to characterize patients with chronic HCV infection and assess the impact of IFN-containing treatment on health-related quality of life, work related productivity and health care utilization. Methods: MOSAIC is an international prospective multicenter observational study that has been conducted in 20 countries. Consecutive patients with chronic HCV infection were enrolled and those who initiated an IFN based regimen were prospectively followed for 48 weeks. We report results from the Korean cohort Results: 100 patients were enrolled: 86 were treatment naïve and 14 were treatment experienced. 33 patients initiated an IFN based regimen: 6 patients started IFN + RBV, 26 patients started Peg-IFN + RBV, none started Peg-IFN + RBV + DAA and 1 patient received other treatment. Among the treated cohort, demographic and disease characteristics were the following: the mean age was 54.5 years; 14 patients were male. 14 had minimal or no fibrosis, 2 portal fibrosis, 3 bridging fibrosis and 6 patients suffered from cirrhosis. HCV Genotype distribution was as follows: genotype 1: 11; genotype 2: 19 and genotype 3: 3. Table 1 describes the results at baseline and changes over 4, 12 and 48 weeks and end-of-treatment (EOT) for the quality of life and work productivity outcome measures (EQ-5D-5L, HCV-PRO and WPAI). Conclusions: Results from the Korean cohort of the MOSAIC study show a moderate trend for deterioration of health-related quality of life and work productivity associated with IFN based treatment for patients with chronic HCV infection during treatment period. Acknowledgements: The design, study conduct, analysis, and financial support of MOSAIC study were provided by AbbVie. AbbVie participated in the interpretation of data, review, and approval of the content of the abstract. All authors had access to all relevant data and participated in writing, review, and approval of this abstract. Medical writing support was provided by Olivier Van de Steen of Medeor-consulting, funded by AbbVie. Disclosures: Sang Hoon Ahn: served as an advisor and lecturer for Bristol-Myers Squibb, Gilead Sciences, F.Hoffmann-La Roche, Merck, AbbVie, and has received unrestricted grants from Bristol-Myers Squibb, Gilead Sciences, and F. Hoffmann-La Roche for investigator- initiated trials Won Hyeok Choe: Nothing to disclosure Yoon Jun Kim: Nothing to disclosure Jeong Heo: received a grant from GSK; Research support from BMS, and Roche; Advisor for Abbvie, BMS, Gilead Sciences, Pharma Essentia, SillaJen, and Johnson & Johnson. Dorota Latarska-Smuga, Jiho Kang: are employees of AbbVie, Inc. and may hold stock or stock options. Seung Woon Paik: received grant and research support from AbbVie, BMS, Gilead, GSK, Merck, Novartis, and Roche

      • Highly Efficient Bifacial Dye-Sensitized Solar Cells Employing Polymeric Counter Electrodes

        Kang, Jin Soo,Kim, Jin,Kim, Jae-Yup,Lee, Myeong Jae,Kang, Jiho,Son, Yoon Jun,Jeong, Juwon,Park, Sun Ha,Ko, Min Jae,Sung, Yung-Eun American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.10

        <P>Dye-sensitized solar cells (DSCs) are promising solar energy conversion devices with aesthetically favorable properties such as being colorful and having transparent features. They are also well-known for high and reliable performance even under ambient lighting, and these advantages distinguish DSCs for applications in window-type building-integrated photovoltaics (BIPVs) that utilize photons from both lamplight and sunlight. Therefore, investigations on bifacial DSCs have been done intensively, but further enhancement in performance under back-illumination is essential for practical window-BIPV applications. In this research, highly efficient bifacial DSCs were prepared by a combination of electropolymerized poly(3,4-ethylenedioxythiphene) (PEDOT) counter electrodes (CEs) and cobalt bipyridine redox ([Co(bpy)<SUB>3</SUB>]<SUP>3+/2+</SUP>) electrolyte, both of which manifested superior transparency when compared with conventional Pt and iodide counterparts, respectively. Keen electrochemical analyses of PEDOT films verified that superior electrical properties were achievable when the thickness of the film was reduced, while their high electrocatalytic activities were unchanged. The combination of the PEDOT thin film and [Co(bpy)<SUB>3</SUB>]<SUP>3+/2+</SUP> electrolyte led to an unprecedented power conversion efficiency among bifacial DSCs under back-illumination, which was also over 85% of that obtained under front-illumination. Furthermore, the advantage of the electropolymerization process, which does not require an elevation of temperature, was demonstrated by flexible bifacial DSC applications.</P> [FIG OMISSION]</BR>


        Hyperglycemia increases the expression levels of sclerostin in a reactive oxygen species- and tumor necrosis factor-alpha-dependent manner

        Kang, Jiho,Boonanantanasarn, Kanitsak,Baek, Kyunghwa,Woo, Kyung Mi,Ryoo, Hyun-Mo,Baek, Jeong-Hwa,Kim, Gwan-Shik Korean Academy of Periodontology 2015 Journal of Periodontal & Implant Science Vol.45 No.3

        Purpose: Sclerostin, an inhibitor of Wnt/${\beta}$-catenin signaling, exerts negative effects on bone formation and contributes to periodontitis-induced alveolar bone loss. Recent studies have demonstrated that serum sclerostin levels are increased in diabetic patients and that sclerostin expression in alveolar bone is enhanced in a diabetic periodontitis model. However, the molecular mechanism of how sclerostin expression is enhanced in diabetic patients remains elusive. Therefore, in this study, the effect of hyperglycemia on the expression of sclerostin in osteoblast lineage cells was examined. Methods: C2C12 and MLO-Y4 cells were used in this study. In order to examine the effect of hyperglycemia, the glucose concentration in the culture medium was adjusted to a range of levels between 40 and 100 mM. Gene expression levels were examined by quantitative reverse transcription-polymerase chain reaction and Western blot assays. Top-Flash reporter was used to examine the transcriptional activity of the ${\beta}$-catenin/lymphoid enhanced factor/T-cell factor complex. Tumor necrosis factor-alpha ($TNF{\alpha}$) protein levels were examined with the enzyme-linked immunosorbent assay. The effect of reactive oxygen species on sclerostin expression was examined by treating cells with 1 mM $H_2O_2$ or 20 mM N-acetylcysteine. Results: The high glucose treatment increased the mRNA and protein levels of sclerostin. High glucose suppressed Wnt3a-induced Top-Flash reporter activity and the expression levels of osteoblast marker genes. High glucose increased reactive oxygen species production and $TNF{\alpha}$ expression levels. Treatment of cells with $H_2O_2$ also enhanced the expression levels of $TNF{\alpha}$ and sclerostin. In addition, N-acetylcysteine treatment or knockdown of $TNF{\alpha}$ attenuated high glucose-induced sclerostin expression. Conclusions: These results suggest that hyperglycemia increases sclerostin expression via the enhanced production of reactive oxygen species and $TNF{\alpha}$.


        Vapor-Deposited Tungsten Carbide Nano-Dendrites as Sulfur-Tolerant Electrocatalysts for Quantum Dot-Sensitized Solar Cells

        Kang, Jin Soo,Kang, Jiho,Chae, Jiyoung,Son, Yoon Jun,Jeong, Juwon,Kim, Jin,Kim, Jae-Yup,Kang, Soon Hyung,Ahn, Kwang-Soon,Sung, Yung-Eun The Electrochemical Society 2018 Journal of the Electrochemical Society Vol.165 No.14

        <P>Recent advances in optoelectronic properties of quantum dots (QDs) have led to significant improvement in QD-sensitized solar cells (QDSCs); however, for practical utilization of these devices, performance of the constituent electrocatalytic counter electrodes (CEs) needs to be further enhanced. Pt CEs are prone to severe sulfur poisoning by polysulfide redox electrolytes in QDSCs, and Cu<SUB>2</SUB>S CEs with state-of-the-art activity are vulnerable to light-induced degradations. In this study, for the first time, tungsten carbide (W<SUB>2</SUB>C) films were used as CEs for QDSCs. Instead of the conventional methods of carbide nanomaterial synthesis that involve thermal treatments in toxic/explosive atmospheres, room-temperature vapor deposition was employed for the preparation of W<SUB>2</SUB>C electrodes, and dendritic nanostructures with large surface areas were obtained. Although the electronic structures of Pt and W<SUB>2</SUB>C are highly similar, W<SUB>2</SUB>C was completely inert to sulfur poisoning. This led to a substantial improvement in the electrocatalytic performance for polysulfide reduction, and ∼27% enhancement in power conversion efficiency was achieved when Pt CEs were replaced with W<SUB>2</SUB>C CEs in QDSCs. Moreover, QDSCs comprising W<SUB>2</SUB>C CEs manifested excellent photostability, and they showed performances superior to those of QDSCs comprising state-of-the-art Cu<SUB>2</SUB>S electrodes within 40 min of operation, without any sign of drop in efficiency.</P>

      • Tailoring the porosity of MOF-derived N-doped carbon electrocatalysts for highly efficient solar energy conversion

        Kang, Jin Soo,Kang, Jiho,Chung, Dong Young,Son, Yoon Jun,Kim, Seoni,Kim, Sungjun,Kim, Jin,Jeong, Juwon,Lee, Myeong Jae,Shin, Heejong,Park, Subin,Yoo, Sung Jong,Ko, Min Jae,Yoon, Jeyong,Sung, Yung-Eun The Royal Society of Chemistry 2018 Journal of materials chemistry. A, Materials for e Vol.6 No.41

        <P>Metal-organic framework (MOF)-derived carbon materials have been widely used as catalysts for a variety of electrochemical energy applications, and thermally carbonized zinc-2-methylimidazole (ZIF-8) has shown particularly high performance owing to its microporous structure with a large surface area. However, in the presence of bulky chemical species, such as triiodide, in mesoscopic dye-sensitized solar cells (DSCs), the small pore size of carbonized ZIF-8 causes a significant limitation in mass transfer and consequentially results in a poor performance. To resolve this problem, we herein report a simple strategy to enlarge the pore sizes of ZIF-8-derived carbon by increasing the dwelling time of Zn in ZIF-8 during the thermal carbonization process. A thin and uniform polydopamine shell introduced on the surface of ZIF-8, with the aim of retarding the escape of vaporized Zn species, leads to a dramatic increase in pore sizes, from the micropore to mesopore range. The porosity-tailored carbonized ZIF-8 manifests an excellent electrocatalytic performance in triiodide reduction, and when it was applied as the counter electrode of DSCs, an energy conversion efficiency of up to 9.03% is achievable, which is not only superior to that of the Pt-based counterpart but also among the highest performances of DSCs employing carbonaceous electrocatalysts.</P>

      • Quantification of protein interaction in living cells by two‐photon spectral imaging with fluorescent protein fluorescence resonance energy transfer pair devoid of acceptor bleed‐through

        Kim, Jiho,Li, Xiaolan,Kang, Moon‐,Sik,Im, Kang,Bin,Genovesio, Auguste,Grailhe, Regis Wiley Subscription Services, Inc., A Wiley Company 2012 Cytometry. the journal of the International Societ Vol.a81 No.2

        <P><B>Abstract</B></P><P>Fluorescence resonance energy transfer (FRET) between fluorescent proteins (FPs) is a powerful method to visualize and quantify protein–protein interaction in living cells. Unfortunately, the emission bleed‐through of FPs limits the usage of this complex technique. To circumvent undesirable excitation of the acceptor fluorophore, using two‐photon excitation, we searched for FRET pairs that show selective excitation of the donor but not of the acceptor fluorescent molecule. We found this property in the fluorescent cyan fluorescent protein (CFP)/yellow fluorescent protein (YFP) and YFP/mCherry FRET pairs and performed two‐photon excited FRET spectral imaging to quantify protein interactions on the later pair that shows better spectral discrimination. Applying non‐negative matrix factorization to unmix two‐photon excited spectral imaging data, we were able to eliminate the donor bleed‐through as well as the autofluorescence. As a result, we achieved FRET quantification by means of a single spectral acquisition, making the FRET approach not only easy and straightforward but also less prone to calculation artifacts. As an application of our approach, the intermolecular interaction of amyloid precursor protein and the adaptor protein Fe65 associated with Alzheimer's disease was quantified. We believe that the FRET approach using two‐photon and fluorescent YFP/mCherry pair is a promising method to monitor protein interaction in living cells. © 2011 International Society for Advancement of Cytometry</P>

      • Two-photon spectral imaging with high temporal and spectral resolution

        Im, Kang-Bin,Kang, Moon-Sik,Kim, Jiho,Bestvater, Felix,Seghiri, Zahir,Wachsmuth, Malte,Grailhe, Regis The Optical Society 2010 Optics express Vol.18 No.26

        <P>We introduce a fast spectral imaging system using an electron-multiplying charge-coupled device (EM-CCD) as a detector. Our system is combined with a custom-built two-photon excitation laser scanning microscope and has 80 detection channels, which allow for high spectral resolution and fast frame acquisition without any loss of spectral information. To demonstrate the efficiency of our approach, we applied this technology to monitor fluorescent proteins and quantum dot-labeled G protein-coupled receptors in living cells as well as autofluorescence in tissue samples.</P>

      • KCI등재

        계층적 인용관계분석을 통한 선행기술 탐색방법론

        강지호(Jiho Kang),김종찬(Jongchan Kim),이준혁(Joonhyuck Lee),박상성(Sangsung Park),장동식(Dongsik Jang) 한국지능시스템학회 2017 한국지능시스템학회논문지 Vol.27 No.1

        선행기술조사는 지식재산의 창출 및 활용 과정에서 발명자 및 출원인, 등록 가부를 판정하는 심사관, 변리업계 종사자 등에 의해 수행되는 기술경영의 핵심적인 프로세스이다. 그동안 체계적인 선행기술 탐색방법론에 관한 학술연구가 충분히 뒷받침되지 못한 결과, 현장에서는 조사자의 주관적 판단에 의존하여 선행기술조사를 수행하는 경우가 많다. 시맨틱 기반으로 선행기술을 탐색하는 기존 연구들 또한 동일한 기술사상이 다양한 용어로 표현되는 특허문서의 특성상 주요 선행기술의 유사성을 저평가할 위험이 있다. 본 연구는 특허의 인용정보를 활용한 계층적 인용관계분석을 기반으로 하는 효과적인 선행기술탐색 방법론을 제안한다. 제안하는 방법론은 특허성을 검토하고자 하는 특허를 중심으로 인용관계에 있는 특허들 중 상대적인 중요도에 따라 가중치를 산정함으로써 핵심 선행기술을 선별하는 명확한 기준을 제시한다. 제안 방법론의 실제 적용가능성을 검증하기 위해 디스플레이 분야의 특허 1건에 대한 핵심 선행기술을 탐색하는 사례연구를 수행한 결과 206건의 선행 특허 중 10건의 핵심 선행기술 후보군을 선별 가능하였다. Prior art search is a core process of technology management performed by inventors and applicants, patent examiners, and employees in the patent industry. As a result of insufficient academic research on a systematic prior art search methodology, the process has been often carried out depending on the subjective judgment of researchers. Previous studies on exploring prior arts based on semantics have also have the risk of underestimating the similarity of major prior arts due to the nature of patent documents where the same technical ideas are expressed in various terms. In this study, we propose an effective prior art search methodology based on hierarchical citation analysis, which provides a clear criterion for selecting core prior arts by calculating weights according to the relative importance of the collected patents. In order to verify the feasibility of the proposed methodology, a case study was conducted to explore the core prior art of one patent in the display field. As a result, 10 core prior art candidates were selected out of the 206 precedent patents.

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