담도 및 췌장 악성종양에서의 CAl9-9의 진단적 가치에 대한 평가

명승재,최승목,김은옥,최호순,이성구,김명환,민영일,류진숙 大韓消化器病學會 1995 大韓消化器病學會誌 Vol.27 No.3

The prediction of the tooth size in the mixed dentition for Korean

Moon, Sung-Hwan,Kim, Seong-Oh,Yu, Hyung-Seong,Choi, Byung-Jai,Choi, Hyung-Jun,Lee, Jae-Ho 大韓小兒齒科學會 2006 大韓小兒齒科學會誌 Vol.33 No.2

이번 연구의 목적은 혼합치열기 아동에서 미맹출된 견치와 소구치의 크기를 예측하는데 있어서 한국인에 맞는 방정식을 만들기 위함이다. 미맹출 치아의 크기를 예측하는 것은 혼합치열기 교정 진단과 치료계획 수립에 있어서 매우 중요하다. 미맹출된 견치와 소구치 크기를 예측하는 방법은 몇가지가 있지만 그중에서도 가장 흔하게 쓰이는 것이 모이어의 예측표와 다나카와 존스턴의 방정식이 있다. 하지만 그것들은 백인을 위해서 제작된 것이고 치아 크기는 인종에 따라서 다르다고 알려져 있다. 이번 연구에서는 치아크기를 측정하여 하악 영구 절치의 크기 합과 견치 및 소구치의 크기 합 사이의 상관관계를 구하고 회귀방정식을 이용해서 한국인에 맞는 예측표를 만들었다. 연세대학교 치과대학에 재학중인 178명의 한국 학생(남 108명, 여 70명, 평균연령 21.63)을 대상으로 실험하였다. 영구치의 근원심 폭경을 석고모형상에서 calipers를 이용해서 측정하였다. 성별간의 치아 크기는 차이가 있었다(p<0.05). Correlation coefficient는 0.57에서 0.64의 범위였고, standard errors of the estimates 는 여성에서 0.6으로써 남성보다 우수하였다. r^(2)값은 0.27에서 0.41의 범위를 나타내었다. Estimating the size of unerupted teeth is an essential aspect of orthodontic diagnosis and treatment planning in the mixed dentition. Several methods were introduced and used for the prediction. The most common methods among these would be Moyers probability chart and Tanaka and Johnston equations. These are currently used widely, but they were developed for Caucasians. Because there are clear racial differences in teeth size, the objectives of this study were to produce correlation coefficients between the combined mesiodistal widths of the permanent mandibular incisors and those of the canines and premolars for each quadrant, and prediction tables with regression equations, specifically for Korean. 178 young adults (70 women, 108 men, mean age 21.63 years) were selected from the College of Dentistry, Yonsei University, Seoul, Korea. The mesiodistal crown diameters of the permanent teeth were measured with calipers. Significant sexual dimorphism was found in tooth sizes. The correlation coefficients between the total mesiodistal width of the mandibular permanent incisors and those of the maxillary and mandibular canines and premolars were found to be between 0.52 and 0.64. The standard error of the estimatation was better (0.60) for women and the r^(2) values ranged from 0.27 to 0.41 for both sexes, Prediction tables were prepared for Korean. This study showed larger canine and premolar diameters than Tanaka and Johnston's and Moyers' studies which might be due to the racial differences. Further investigations with a larger sample size will be needed for more representative data on the Korean population.

동종 골수 이식한 백혈병에서 단반복 유전자로 살펴본 혼합 키메라 현상의 의의

장대영,이정신,서철원,이규형,이제환,지현숙,박찬정,한면수,최동원,김정균,최성준,김성배,김상위,김우건,김상희 대한조혈모세포이식학회 1998 대한조혈모세포이식학회지 Vol.3 No.1

연구배경 : 동종 골수 이식한 백혈병에서 키메라 현상의 분석은 착상, 질병 재발과 이식 거부를 이해하는데 도움을 줄 수 있다. 최근 STR을 PCR로 증폭한 검사법에 의해 매우 민감하고 유용하게 혼합 키메라 현상을 검출할 수 있다고 보고되고 있으나, 이 방법의 민감도와 임상적 의의는 아직 완전히 정립되지는 않았다. 따라서 PCR-STR검사법이 혼합 키메라 현상을 민감하게 검출하는지 보고, 동종 골수 이식 후 혼합 키메라 현상의 변화 양상을 관찰하고, 키메라 현상의 임상적 의의를 보고자 하였다. 방법 : 형제로부터 동종 골수 이식한 급성 백혈병 6명과 만성 백혈병 2명의 모두 8명을 대상으로 하였다. 44개 골수 검체에서 phenol/chloroform방법에 의하여 단핵세포 DNA를 추출하였다. DNA는 CTT 삼중체, vWA와 amelogenin시발체를 이용하여 증폭하였다. 증폭 산물은 5% 폴리아크랄아미드 젤에서 전기영동 뒤 은 염색으로 확인하였다. 2명의 DNA를 여러 비율로 혼합하여 상기 검사를 하여 검출 가능 최소 농도를 결정하였다. 결과 : 상기 검사법의 검출 가능 최소농도는 0.25%였다. 혼합 키메라 현상은 8명중 4명에서 관찰되었다. 혼합 키메라 현상은 보인 1명에서 급성 및 만성 이식편대 숙주 질환이 나타났고, 완전 공여자 키메라 현상을 보인 1명에서 만성 이식편 대 숙주 질환이 나타났다. 점진적으로 증가하는 혼합 키메라 현상을 보인 2명은 이식 후 12개월에 질병 재발을 보였으나, 완전 공여자 키메라 현상을 보인 경우엔 재발이 관찰되지 않았다. 결론 : PCR-STR검사법은 동종 골수 이식 후 남아 있는 환자 세포를 검출하고 키메라 현상을 관찰하는데 유용한 방법이다. 또한 이 검사법은 동종 골수 이식 후 재발의 조기 진단, 이식편 대 숙주 질환의 평가와 면역 관용에 임상적으로 응용할 수 있으리라 생각한다. Background : Chimerism analysis after allogeneic bone marrow transplantation (BMT) for leukemia could be helpful understanding of the early marrow engraftment, disease relapse, and graft rejection. Recently, a PCR technique which amplifies short tandem repeats(STR) has been reported to be highly sensitive and reliable in detecting mixed chimerism. But its sensitivity and clinical significance has not been established. The purpose of this study was firstly, to confirm whether a PCR-STR in highly sensitive enough ti assess mixed chimerism, secondly to monitor the changing patterns of mixed chimerism after allogeneic BMT, and lastly to determine correlation between the chimeric status and the clinical outcome. Methods : A study was made eight patients (six with acute leukemia and two with chronic leukemia) who underwent unmanipulated allogeneic BMT along with matched donors. DNA was extracted from mononuclear cells of 44 bone marrow samples using a phenol/chloroform method. Amplification of DNA was done using CSFIPO-TPOX-TH01(CTT) triplex with or without vWA or amelogenin primer. The amplified product was separated on 5% polyacrylamide gel and was confirmed by silver staining. The sensitivity of CTT triplex method was determined by mixing DNA from two person in serial proportion using the same method. Results : The sensitivity for CTT triplex method was 0.25% Mixed chimerism was documented in 4 of 8 patients. ONe of four patients with mixed chimerism developed acute and chronic graft versus host disease (GVHD) and one of four patients with complete donor chimerism also developed chronic GVHD. Two patient with progressive mixed chimerism relapsed at 12 months post-BMT, whereas no patient with complete donor chimerism has relapsed. Conclusion : The study has found that PCR-STR was an effective method for the detecting residual host cell and monitoring the chimeric status after allogenic BMT. PCR-STR can also be clinically applicable in early prediction of relapse, appropriate assessment of GVHD, as well as tolerance after allogeneic BMT.

양로원 노인에서 인지기능 평가에 대한 연구

최성환,정은기,김유광 大韓神經精神醫學會 1993 신경정신의학 Vol.32 No.6

The aged population is growing rapidly in Korea. In 1989, the people aged 65 and older marked 4.7% of the population and is expected to exceed 5% in 1993. It has been considered that as the elderly grow older, their cognitive function decline. As the proportion they take in the society is becoming larger, the use of more stable and reliable examination tools become more important to deal with and prevent their cognitive dysfunction. This study looked into the characteristics of cognitive functions of the elderly living in nursing homes. Mini-mental status examination and Brief cognitive rating scale were administered to 530 eldery(mean age 76±7.5) residing in 8 nursing homes located in Kyun-Gi province, vicinity of Seoul, in 1989 and in 1991. Cognitive function correlated with educational level, but not with age. The correlation of MMSE with BCRS was high. According to the results, it was not evident that aging deteriorates cognitive function. The deterioration of cognitive function was related to educational level. MMSE and BCRS were considered appropriate instruments in brief assessment of cognitive function and its prognosis in the elderly. Lengthened follow up interval and the cognitive evaluation of more various groups are desired in the future studies.

再開發地區指定의 設定基準에 관한 硏究

崔昌煥,吳錫氣,安相哲 동아대학교 공과대학 부설 한국자원개발연구소 1982 硏究報告 Vol.6 No.1

This study is for the establishment standard on the blighted degree in urban renewal area. The factors of establishment standard is population density, ratio of a building site, size of a building site, diffusion ratio of road, ground coverage, volume ratio of building, dwelling space of a person, total floor space per building, and others. As a result of this study, the standard of renewal area appointment is as follows. 1) Population density … over 300 person per hectare. 2) Ratio of a building site … over 70 percent. 3) Size of a building site … under 120㎡ 4) Diffusion ratio of the road … under 25 percent. 5) Ground coverage of a building … over 55 percent. 6) Volume ratio of a building … over 120 percent. 7) Dwelling space of a person … under 20㎡ 8) Total floor space per a building … under 80㎡ 9) Age of building … over 40 years.

海港都市 木浦의 藝鄕性과 가요 <목포의 눈물> 활용사례

최성환 釜山大學校 韓國民族文化硏究所 2013 한국민족문화 Vol.46 No.-

Mokpo, which is situated at the mouth of the Yeongsan-gang (river), has developed as a seaport city, and today it is called an 'artistic city'. There are many connections between a 'seaport city' and an 'artistic city'. This paper analyzed the process of Mokpo creating an image as an 'artistic city' with the keyword of 'seaport', the success factor of the <Tears of Mokpo>, and the case in which the song is utilized as a cultural resource. The 'artistic city attribute' of Mokpo was based on cultural characteristics as a modern seaport city created after opening the port. The unique humanitarian environment of Mokpo Port, such as the role of a centric region for the distribution of modern culture, the commercial features of a seaport city, and the function of communications and interchanges connecting an island and the mainland, became the background of Mokpo. The most representative case among the public art themed with Mokpo Port is <Tears of Mokpo>, a popular song presented by Lee Nan-yeong in 1935. As one from Mokpo, Lee Nan-yeong best expressed the social emotion of the period of the port under Japanese colonial rule. Her song was a case that was created and commercialized with the motive of showing the culture of Mokpo, which had grown to be one of the major six cities nationwide. Even now <Tears of Mokpo> has a high national recognition. In order to utilize this, Mokpo City has developed various memorial projects since 1965, the time when Lee Nan-yeong died. This has played a role in promoting widely the emotion of 'Mokpo is a port' and an image of a 'city of art'. Also in the future,it is expected to be utilized as a representative cultural resource of Mokpo Port;however, in terms of its direction, it is necessary to improve it in a way to highlight again the cultural meaning of <Tears of Mokpo> rather than exalting the individual singer. 영산강의 길목에 자리한 木浦는 섬과 내륙을 연결하는 海港都市로 발전해 왔으며, 오늘날 ‘藝鄕’이라 불리고 있다. ‘해항도시’와 ‘예술도시’는 많은 연관성이 있다. 본고에서는 ‘海港’이라는 키워드를 가지고 목포가 ‘예향’ 이미지를 형성하게 된 과정, 가요 <목포의 눈물>의 성공 요인과 문화자원으로 활용되고 있는 사례를 분석하였다. 목포의 ‘藝鄕性’은 개항이후 형성된 근대해항도시로서 문화적 특징에 기반 한 것이다. 근대문화 보급의 중심지 역할, 해항도시의 상업성, 섬과 내륙을 연결하는 소통과 교류의 기능 등 목포항이 지닌 독특한 인문환경이 배경이 되었다. 또한 섬에서 이주해 온 예술인이 많다는 점도 특징이다. 목포항을 주제로 한 대중예술 중 가장 대표적인 사례는 1935년 이난영이 발표한 가요 <목포의 눈물>이다. 이난영은 목포 출신으로 항구가 지닌 일제강점기 사회적 정서를 가장 잘 표현하였다. 그의 노래는 전국 6대도시로 성장한 목포의 문화를 모티브로 창작되고 상품화 된 사례였다. <목포의 눈물>은 지금도 국민적인 인지도가 높다. 이를 활용하기 위해 목포시에서는 이난영이 세상을 떠난 1965년 이후부터 현재까지 다양한 기념사업을 전개해 왔다. 이는 ‘목포는 항구’라는 정서와 ‘예술의 도시’라는 이미지를 널리 알리는 역할을 해왔다. 앞으로도 목포항을 대표하는 문화자원으로 활용될 전망이다. 그러나 그 방향성에 대해서는 가수 개인에 대한 선양보다는 <목포의 눈물>이 지닌 문화적 의미를 재조명하는 방향으로 개선될 필요가 있다.

韓國의 都市規模別 計劃人口 密度에 관한 硏究

崔昌煥,吳錫氣,安相哲 동아대학교 공과대학 부설 한국자원개발연구소 1977 硏究報告 Vol.2 No.1

Population is concentrated urban region in Korea. It is leading to over-massed dwelling of urban region and was made worse by the residential environment. This study is comparison of population density by the city size of the Master Plan in Korea. Analytical method decide ranking at thirty-five cities of Korea by the census in 1975 and it divided into city size which is Metropolis (over a million), Large City (300-1,000 thousand), Middle Town (100-300 thousand) and Small Town (under 100 thousand persons). In this study, population density for possible developing area was computed by the presumption of population in 1986. The results of this study are summerized as follows: 1). Population plan was underestimated in Metropolis (Seoul, Busan and Daegu) by policy agreement. 2). The possible developing area's population density will proper in under-a million's city. 3). The Metropolis cause an advance in the population density of possible developing area in 1936 and will bring about a change for the worse of residential environment. (362persons/ha.) 4). A plan of solution to a population density's rising is necessary re-enforcement of re-completed master plan and the plan of arrangements for residential area must be considered in the plan of re-completed master plan.

두경부 편평세포암종에서 치료 실패와 제 17번 다염색체 소견의 의의

채성원,최건,최종욱,정광윤,김용환,황순재 대한이비인후과학회 1998 대한이비인후과학회지 두경부외과학 Vol.41 No.5

FCL(5-FU, Carboplatin, Leucovorin) 항암 화학요법에서 Gm-CSF의 효과

최지영,김현수,김종숙,박상준,윤환중,조덕연,남상륜,김삼용 忠南大學校 癌共同硏究所 1998 癌共同硏究所 硏究誌 Vol.2 No.1

Background: One of the major side effects of cancer chemotherapy is myelosuppression. Neutropenia and/or thrombocytopenia are dose-limiting factors in chemotherapy. Colony-stimulating factor induces proliferation and functional maturation of hematopoietic progenitor cells. GM-CSF is primarily active on progenitor cells of granulocytic and monocytic lineage. Methods: Fifteen patients with histologically proven malignancy diagnosed at Chungnam National University Hospital from January 1993 to August 1995 were included in this study. We could evaluate the clinical efficacy of GM-CSF in 13 patients undergoing FCL(5-FU, Carboplatin and Leucovorin) chemotherapy; the first cycles involved no GM-CSF while the second cycles involved GM-CSF on day 6 through 15 of chemotherapy. Results: 1) The subjects were fifteen patients in all, there were five patients with head and neck cancer, which was the most common types of maligancy. There were four patients with colon cancer, two patients with stomach cancer, and one patient with breast cancer, gallbladder cancer, cervix cancer and cholangiocarcinoma respectively, two patients, who did not complete two cycles of chemotherapy were excluded. 2) Age distribution was from 38 years to 78 years with a median age of 57. 3) In FCL chemotherapy cycles with GM-CSF, the duration of neutropenia(<500/μL) was 0.5±0.3 day, while FCL chemotherapy cycles without GM-CSF, it was 2.9±0.7 day(P=0.008). 3) There was no significant difference in platelet count between the two chemotherapy cycles(P=0.133). 4) Febrile duration without GM-CSF was 4.9±2.1 day, but with GM-CSF the duration was 1.3±0.7 day, which was significantly different(P=0.003). The duration of antibiotics use with GM-CSF was 1.7±1.2 day and without GM-CSF was 6.8±3.2 day, also significantly different(P=0.002). But hospital stay between the two cycles were not significantly different(P=0.064). Conclusion: GM-CSF was effective in preventing or restoring bone marrow depression after FCL chemotherapy.

3個의 耕耘날을 利用한 平衡振動式 耕耘裝置(Ⅴ) : 運動解析과 要因分析

金成泰,金容煥,崔圭洪,金成泰 慶尙大學校 1988 論文集 Vol.27 No.1

This is the fifth part of series of reports on the study on a blanced-type oscillating tillage implement using triple blades system. Previous reports were made on the characteristics of power requirement and vibration with which tillage implements were oscillated parappep and perpendicular to the travelling direction. In this paper, the locus and motion analysis of the tillage blade and factor analysis were carried out. Obtained results are as follows : 1. The loci od the blade edge were described as helix curve at vertical oscillation and as lacerated curve at horizontal oscillation to the soil bin movement. 2. The motion equations of blade edge are estimated as follows. Vertical forced vibration ?? ?? Horizontal forced vibration ?? ?? 3. The multiple regression equations for resultant oscillating acceleration draft, specific resistance, and torque were established by using frequency, amplitude, life angle of tillage blade, and velocity of carriage as indepentent vibrations, respectively. 4. By reducing the velocity ratio is increased providing higher effect of the reduced draft. But this effect contradicted to achieve the reduced osillating acceleration. Both effects should be considered simultaneously to find out the optimum operating condition. 5. The reduction effect of the oscillating acceleration was slightly favoured to the horizontal forced vibration type, but traction efficiency could be lowered due to the increased slippage. Therefore, it can be concluded that the vertical forced vibration type is more appropriate considering overall performances. 6. From the experimental results, the optimum operating conditions of the vertical forced vibration type are recommended as follow ; life angle 30 degree, operation velocity 0.15 metre per second, amplitude 4-6 millimetre, and frequency 22.5 hertz.