감염된 가축과의 직접 접촉 없이 발생한 브루셀라증 환자1례와 축산 부산물 시장에서의 역학조사 : Sero-epidemiology Study on Market, by-product, Stock-raising

정성주,김성범,박대원,정혜원,기세윤,권정아,박만석,박미연,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

브루셀라증은 전 세계적으로 발생하는 인수공통 전염병중에 하나로서, 본 증례는 국내에서 감염된 가축에 대한 노출력이 없는 집단에서 현증 브루셀라증이 발생한 첫 증례이기에 문헌 고찰과 함께 보고한다. 또한 환자가 근무하였던 축산물 부산물 시장에서 역학 조사를 실시하여, 현증환자 및 기감염자를 발견하여 축산물 부산물 시장 근무자에서 현증 브루셀라증이 발생할 위험성을 평가하였다. 역학 조사 결과 축산물 부산물을 다루는 일을 하는 사람들에서 감염된 가축과의 직접 접촉이 없이도 브루셀라증이 발생할 수 있음을 알 수 있었다. Brucellosis is a world-wide zoonotic disease. We report the first case of brucellosis in South Korea that is not related to direct contract with intected cattles. The patient had been working in the market of by-product, stock raising for twenty years and complained of 1-month history of fever, chill, and intermittent epistaxis. We confirmed brucellosis by anti-brucella antibody test and PCR. After 6 weeks' treatment with rifampicin and doxycycline, fever and chilling subsided, and, generalized weakness and oral intake improved. We performed seroepidemiology study against workers who were working in the same market as the patient. However, we couldn't find out other cases with seropositivity. We concluded that although the workers of by-product market have a risk of getting brucellosis, the risk is low.

우리나라 입학사정관제 도입의 사회적 논의 과정 분석 : 일간지 보도기사를 중심으로

안정희,배성아 이화여자대학교 교육과학연구소 2009 교육과학연구 Vol.40 No.3

본 연구는 입학사정관제를 둘러싼 사회적 논의의 전개과정을 분석함으로써 입학사정관제의 개념을 보다 정확히 이해하고 우리나라 입시문제를 개선하기 위한 제도로서 정착되기 위하여 어떠한 노력이 필요한지를 모색하는데 목적이 있다. 일간지 분석을 통해 얻은 연구결과, 2004년 도입된 입학사정관제가 2008년, 주요대학을 중심으로 급격히 확산국면으로 접어들었고 2009년도에는 정부가 주축이 되어 입시제도 개선의 주요 해법으로 강조하면서 시행대학 및 선발인원이 급증하는 한편, 제도시행과 관련한 제반 여건이 미흡한 상황에서 학교 현장에 미칠 혼란을 우려하는 목소리가 동시에 높아지게 되었다. 현재 제도의 장점과 단점을 공론화하는 과정을 거쳐 우리나라 교육현실을 고려한 제도로서 새롭게 조정되어야 함이 강조되고 있는 단계이다. 이에 본 연구에서는 입학사정관제가 성공적으로 정착 및 발전하기 위한 방안을 제시하였다. 입학사정관제는 우리나라의 대학입시 문제를 개선해 나가기 위한 여러 가지 방안 중의 하나이며 선진국의 사례를 그대로 이식하기보다는 우리 교육현실에 맞게 재구조화할 필요가 있음을 강조하였다. 또한 입학사정관제 도입을 계기로 고교-대학 간 교육과정 및 학생평가의 과정이 연계될 수 있으며 고등학교 교육에 대한 신뢰를 바탕으로 공교육정상화를 이루어 낼 수 있을 것이라고 기대한다 This study analyzes the Korean AO (admissions officer) system by reviewing issues highlighted in newspapers and further providing some suggestions for its successive establishment in Korea. The AO system was first introduced to Korea in 2004 and spread nationwide in 2008. It is currently viewed as a promising solution for improving our college admissions system. At the same time, however, a sudden increase in social awareness has caused people to be concerned about its negative effects on school education. Accordingly, we should critically consider both the system's strengths and weaknesses from a realistic perspective. In this regard, the study suggested multidisciplinary views of the system. We also emphasized that the AO system could be one option to improve our college entrance system. Furthermore, abruptly implementing a foreign system into the Korean educational situation without considering local factors should be avoided. Through the AO system, the connection between high school and colleges could be stronger in terms of curriculum and student evaluation. This would contribute to strengthening the Korean public education system.

Colwyn, Age 5 1/2, “Protecting Mom and Dad”

Klaus G. Witz,Sung Ah Bae,Hyunju Lee,Youngcook Jun,Yongsock Chang 아시아질적탐구학회 2022 아시아질적탐구 Vol.1 No.1

The present paper is part of a larger case study of a 5 1/2 year old Korean boy, Colwyn, with his mother, Dr. Bae. Dr. Bae interviewed Colwyn twice, about 2 months apart; the first interview was audiotaped, the second videotaped. The present paper is based primarily on the second interview where Colwyn tells several wildly imaginative stories of himself like a superhero “protecting mom and dad.” Our aim is to communicate a sense of Colwyn’s “feeling, consciousness, state” when he is telling these “stories”, using the portraiture philosophy of Lawrence-Lightfoot and Davis and the “Participant-as-ally - Essentialist portraiture” approach of Witz and his students. The paper suggests that Colwyn’s “telling stories” in that Interview involves a highly self-actualized way of “being involved with his ‘I’”, which was apparently prompted by Interview 1 and is expressed in the drawing in Fig. 1. (In Interview 2 he constantly comes back to this drawing and uses it as a jumping off point for ideas in the stories). In addition, when he is telling a story, his whole being (feeling and mind) is “as if flowing in a direct channel,” manifesting as a constant stream of inspiration (creativity), ideas and diverse kinds of energy which is coming from within him, and that is carried on a powerful undercurrent of moral feeling of “being good.” At the same time telling the story represents a state of “subjectively being in a unity with” his mother’s feelings of appreciation and love. These things represent intense genuine spiritual engagement that at the same time manifests itself as creative expression in painting and in verbal interaction, already at this young age. This conclusion is supported by various additional data available.

랫드에서 인체 재조합 적혈구 조혈인자, rHuEPO의 13주 정맥투여 아만성독성에 관한 연구

김형식,곽승준,천선아,박현선,한하수,임소영,안미영,김원배,김병문,안병옥,홍성렬,이병무 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

A recombinant human erythropoietin (rHuEPO) was administered intravenously at dosage levels of 0, 100, 500, and 2500 IU/㎏/day for a period of 13 weeks. There were no observed clinical signs and deaths related to treatment in all groups tested. Decreases in body weight gain and food consumption were observed only in males of 2,500 IU/㎏ group after 2 weeks. In hematological parameters, erythrocyte content, hematocrit values and hemoglobin concentration were dose-dependently increased in rHuEPO treated groups. The ratio between kidney weight and whole body weight was significantly increased in females of 500 and 2,500 IU/㎏ groups. The spleen weight was also increased in both sexes of 500 and 2,500 IU/㎏ groups. However, the absolute weight change of other organs was not observed. In histopathological examinations, the renal tubular basophilia was observed only in males and females of 2,500 IU/㎏ groups. From these results, it is concluded that the no-observed adverse effect level(NOAEL) of rHuEPO is 100 IU/㎏ in rats in the present study.

Bortezomib과 Dexamthasone으로 치료한 골수외 형질세포종 4예

백종현,이은영,장리라,손창배,신은경,서정아,이지숙,이호섭,이상민,신성훈,김양수 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Despite the use of aggressive local and systemic treatment including autologous stem cell transplantation in multiple myeloma, extramedullary recurrences are common and the prognosis of these patients is poor. Many novel drugs such as thalidomide, lenalidomide and bortezomib improve the response of treatment of multiple myeloma, but some reports failed to describe thalidomide has effect in extramedullary plasmacytoma. Recent data report on the successful treatment plasmacytomas with bortezomib in patients with advanced multiple myeloma. We treated 4 relapsed or refractory extramedullary plasmacytomas with bortezomib at our institution. We recognized all these extramedullary plasmacytomas decreased and showed more than partial response. This report lends support to the efficacy of bortezomib in the treatment of plasmacytoma and describes the safe use of bortezomib. Responses may, however, be of short duration. Therefore, despite our limited experience, we propose that bortezomib may be considered a therapeutic option for such patients who have risk of radiation therapy

비글개에서 인체 재조합 적혈구 조혈인자, rHuEPO의 아만성 정맥독성에 관한 연구

조명행,성하정,김형식,곽승준,천선아,한하수,임소영,안미영,김원배,김병문,안병옥,홍성렬,이병무 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

The subchronic toxicity study of rHuEPO, a newly developed recombinant erythropoietin, was investigated for 13 weeks in Beagle dogs intravenously treated with doses of 100,500 and 2,500 IU/㎏/day. There were no significant changes in body weight, food intake, physical and opthalmic examination, urine analysis, etc. Any toxic response was not observed except for enlarged spleen and extramedullary hematopoiesis. These results indicate that the no-observed adverse effect level (NOAEL) of rHuEPO is 100 IU/㎏ in Beagle dogs.

S-352 : Glycaemic and Haemoglobin A1c Thresholds for Detecting Diabetic Retinopathy

( Sung Bae Cho ),( Yong Moon Park ),( Seung Hyun Ko ),( Yu Bae Ah ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1

Objective: We investigated the association between diabetic retinopathy (DR) and fasting plasma glucose (FPG) and A1C levels among Korean adults. Method: Using data from the Korea National Health and Nutrition Examination Survey (2011), a total of 5,212 adults (≥ 19 years old) were analysed. When participants had diabetes mellitus and/or a suspicion of DR in two-field nonmydriatic fundus photography, 7 standard photographs were obtained after pupil dilatation. DR was defined as the presence of ≥ 1 retinal microaneurysms or blot haemorrhages with or without more severe lesions. Result: The overall appropriate glycaemic thresholds for diabetes-specific retinopathy were 6.3 mmol/l for FPG and 6.2% for A1C. The diagnostic accuracy was better for DR than for FPG (area under curve: 0.908 for FPG and 0.953 for A1C, p=0.007). After being controlled for other covariates, the odds ratio for the risk of DR increased significantly in the category of 6.2-6.6% for A1C and 6.3-7.0 mmol/l for FPG (Reference; <5.7% of A1C, <5.5 mmol/l of FPG). Conclusion: According to this nationally representative data, the current diagnostic value of FPG and A1C based on DR may be lowered for the Korean population.

Clinical outcomes of three- or five-day treatment with clomiphene citrate combined with gonadotropins and a timed intercourse cycle in polycystic ovary syndrome patients

Bae, Sung-Ah,Joo, Jong-Kil,Choi, Jong-Ryeol,Kim, Sun-Suk,Lee, Kyu-Sup The Korean Society for Reproductive Medicine 2015 Clinical and Experimental Reproductive Medicine Vol.42 No.3

Objective: This study aimed to investigate the effect of a new clomiphene citrate (CC) regimen on preventing thin endometrial lining in polycystic ovary syndrome (PCOS) patients receiving CC plus gonadotropin treatment with a timed intercourse cycle. Methods: A total of 114 women with PCOS were included in this trial. Patients were divided into two groups and treated in accordance with the controlled ovarian stimulation (COS) protocol. In group A, 104 COS cycles in 67 patients were included, and in each cycle 150 mg CC was given for three days, starting from day 3. In group B, 69 COS cycles in 47 patients were included, in which 100 mg CC was given for five days, starting from day 3. The thickness of the endometrium was measured on the day of human chorionic gonadotropin (hCG) injection. Timed intercourse was recommended at 24 and 48 hours after the hCG injection. Results: Additional doses of human menopausal gonadotropin and the number of days of hCG administration were not significantly different between the two groups. Endometrial thickness on the day of hCG administration was significantly larger in group A than group B (4$9.4{\pm}2.1mm$ vs. $8.5{\pm}1.7mm$, p=0.004). The pregnancy rate was significantly higher in group A than in group B (38.4% vs. 21.7%, p=0.030). Conclusion: Three-day CC treatment resulted in a significantly higher pregnancy rate than the standard five-day CC treatment in a timed intercourse cycle in PCOS patients. Facilitating adequate endometrial growth via the early discontinuation of CC might be a crucial factor in achieving a higher pregnancy rate.

대학생의 숙달목표지향성과 진로적응성과의 관계에서 대학생활적응의 매개효과

배성아(Sung Ah Bae),김수영(Sooyoung Kim) 학습자중심교과교육학회 2019 학습자중심교과교육연구 Vol.19 No.5

본 연구는 대학생의 진로적응성에 숙달목표지향성과 대학생활적응이 어떤 영향을 미치는지 살피고, 대학생활적응이 숙달목표지향성과 진로적응성과의 관계에서 매개효 과를 보이는지를 알아보고자 하였다. 본 연구는 C지역의 4년제 대학교에서 2014학년도 1학기에 운영한 교양과목을 수강 중인 445명을 대상으로 하였다. 완료된 설문지 420개로 위계적 회귀분석을 한 결과, 숙달목표지향성과 대학생활적응이 진로적응성에 유의미한 영향을 미치고 있었고, 대학생활적응이 숙달목표지향성과 진로적응성과의 관계에서 부분적인 매개효과를 보이는 것으로 나타났다. 이로써, 본 연구를 통하여 대학생의 숙달목표지향성이 높을수록 대학생의 대학생활적응과 진로적응성이 높아지고, 숙달목표를 추구하면서 대학생활적응력이 높은 학생이 숙달목표지향성만 높은 학생보다 진로적응성이 높음을 알 수 있다. 이는 대학생의 숙달목표지향성이 진로적응성에 직접 영향을 주고, 대학생활적응을 매개로하여 진로적응성에 간접적 영향을 미치고 있음을 의미하는 것이다. 본 연구결과를 바탕으로, 대학당국은 진로상담이나 취업 프로 그램을 운영할 때, 학생들의 숙달목표지향성을 고려하여 프로그램을 설계 및 개발하 고, 대학생활적응력을 함께 증진시키는 방안을 마련할 필요가 있다. This purpose of the current study is to examine the relationships among college students mastery goals, their perceived adaptation to college life study, and career adaptability. In particular, this study attempts to explore the mechanism beyond the relation between college students mastery goals and their perceived career adaptability by investigating the mediating role of their adaptation to college life. In the first semester of 2014, we collected data from 445 students at a private college based in C region, and 420 responses were included for the analysis for the study. Hierarchical regression analysis has shown that college students mastery goals are positively related to their adaptation to college life and to their career adaptability. In addition, the adaptation to college life was found as a partial mediator between college students mastery goals and their perceived career adaptability. Based on these findings, the study proposes that college administration need to not only consider students’ mastery goals when designing and developing career counseling or coaching programs, but also find ways to promote students adaptability to college life.

대학의 동료 튜터링 프로그램 운영 사례 연구: 튜터의 경험과 인식을 중심으로

배성아(Bae, Sung Ah),노수림(Noh, Soo Rim) 학습자중심교과교육학회 2014 학습자중심교과교육연구 Vol.14 No.3

본 연구에서는 대학생 튜터들의 경험을 토대로 대학의 동료 튜터링 프로그램의 현황과 발전방안에 대해 살펴보고자 하였다. 이를 위하여 A 대학의 동료 튜터링 프로그램에 참여하고 있는 튜터들을 대상으로 설문조사와 심층면담 조사를 병행하였 으며, 설문에 참여한 117명 중 19명을 무작위로 선정하여 인터뷰를 실시하였다. 본 연구의 결과는 다음과 같다. 첫째, 동료 튜터링 프로그램에 대한 튜터들의 인식조사결과, 튜터들은 전반적으로 자신이 튜터 역할을 잘 수행하였다고 인식하고 있었고, 튜터로서 프로그램에 참여한 것에 대한 만족도도 높았으나, 학교 측의 프로그램 운영 및 관리에 대해서는 상대적으로 낮은 인식을 보였다. 둘째, 튜터링 과정에서 튜터들이 경험한 난점에 대해 조사한 결과, 다수의 튜터들이 학업지도의 어려움과 튜티 와 학습시간 맞추기 및 튜터링을 위한 학습공간 확보하기에서 어려움을 직면하였던 것으로 나타났다. 이 밖에도, 심층면담 결과, 튜터들은 ‘튜티의 참여의지 부족’으로인하여 많은 난관에 봉착하였음을 알 수 있었다. 마지막으로, 대학의 동료 튜터링 프 로그램 활성화 방안에 대한 튜터들의 의견을 살펴본 결과, 이들은 ‘튜티와 시간 맞추기’와 ‘학습공간 확보하기’ 문제 해결을 위한 학교의 지원 확대, 튜터교육의 개선, 그리고 튜티의 참여의지 제고방안 마련이 필요하다고 인식하고 있었다. 본 연구의 결 과는, 향후 대학의 동료 튜터링 프로그램이 지속적으로 발전하기 위하여, 프로그램의 내용 및 운영 개선의 방향을 제안한 자료로써 대학의 학습공동체 발전을 위해 유용하게 활용될 것으로 기대한다. The purpose of this study was to analyze the perceptions of student tutors who were part of a peer tutoring program at a university. A survey was distributed to university student tutors (N=117) who participated in the peer tutoring program and in-depth interviews were conducted based on a sub-sample (n=19) of the participants. There were three significant findings from this study. First, tutors had positive perceptions on their tutoring performance and peer tutoring program participation, but they had relatively negative perceptions of program management. Second, tutors perceived that a lack of teaching skills and logistical difficulties (i.e., scheduling, finding available space) were the most challenging aspects in tutoring. In particular, in-depth interviews revealed that tutors perceived a “lack of motivation” of tutees as the biggest obstacles in tutoring. Lastly, tutors believed that the university administration should support programs by providing protected tutoring hours and space for this service, improved training for all tutors. Finally, tutors felt that the administration should encourage active participation of tutees. The current research highlights the importance of tutor training support, of improving training programs for tutors, and of encouraging tutees’ active participation.