Induction of heme oxygenase-1 protects against podocyte apoptosis under diabetic conditions

Lee, Sang Choel,Han, Seung Hyeok,Li, Jin Ji,Lee, Sun Ha,Jung, Dong-Sub,Kwak, Seung-Jae,Kim, Seung Hye,Kim, Dong Ki,Yoo, Tae-Hyun,Kim, Jin Hyun,Chang, Se-Ho,Han, Dae Suk,Kang, Shin-Wook International Society of Nephrology 2009 Kidney international Vol.76 No.8

Heme oxygenase-1 (HO-1) is an anti-oxidant enzyme normally upregulated in response to oxidant injury. Here we determined the role of HO-1 in podocyte apoptosis in glomeruli of streptozotocin-treated rats and in immortalized mouse podocytes cultured in media containing normal or high glucose. HO-1 expression, its activity, the ratio of Bax/Bcl-2 protein, and active caspase-3 fragments were all significantly higher in isolated glomeruli of diabetic rats and in high glucose–treated podocytes. These increases were inhibited by zinc protoporphyrin treatment of the rats or by HO-1 siRNA treatment of the podocytes in culture. The number of apoptotic cells was also significantly increased in the glomeruli of diabetic rats and in high glucose–treated podocytes. Inhibition of HO-1 accentuated the increase in apoptotic cells both in vivo and in vitro. Our findings suggest that HO-1 expression protects against podocyte apoptosis under diabetic conditions.

한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

말 기생충성 동맥염 2예

신태균,김승호,배종희,이두식,임윤규,이수길 濟州大學校 農科大學 動物科學硏究所 1992 動物科學論叢 Vol.7 No.1

Two cases of verminous arteritis were chosen for this case. These horses were originally submitted for necropsy in the Cheju horse race. Case 1 : At necropy, there was increased ascite, thickened ab-dominal aorta at junction of cranial mesenteric artery. In the aorta, there was a long thrombus embed-ded with strongylus vulgaris larvae. Some larvae were also firmly attached in the aortic intima Histologically, there was infiltration of neutropliils, eosinophils, and macrophages in the tunica media. At the junction of thrombus and arterial intima, there was proliferation of vessels. Case 2 : At necropsy, there was thickened abdominal aorta, which showed typical verminous arteritis with thrombus. Histologically, ceseous tissues with haematopoietic tissue was recognized in the aortic wall.

Newton-Raphson 방법에 기반한 공개키의 암호화 전달

신승호,노희영 강원대학교 정보통신연구소 2009 정보통신논문지 Vol.13 No.-

It is necessary to cipher for secrete of public key in processing of the certification for secrete key. Hence, this paper offers a method based on Newton-Raphson for encryption transmission of public keys that are generated by Diffi-Hellman cipher algorithm.

천정 크레인 시스템의 위치제어와 진동저감에 관한 연구

신승권,이한석,조영호,안두수 成均館大學校 科學技術硏究所 1998 論文集 Vol.49 No.1

Overhead crane systems are widely used for material transportation in many industrial fields. However, undesired swing can always be found during the moving progress, especially at the end location of the transport. The swing may increase the carrying time and cause safety problems. In order to achieve the target position, this paper used a PD controller and used a fuzzy controller to reduce swing angles found during the moving progress. The performance of controller was verified through the experimental results and the simulation results by MATLAB.

XML 문서의 효율적인 구조 검색을 위한 동적 색인 모델

신승호,손충범,유재수 충북대학교 컴퓨터정보통신 연구소 2001 컴퓨터정보통신연구 Vol.9 No.2

XML문서는 정보 표현의 기본 단위인 엘리먼트로 구성되어져 있다. 이러한 정보 표현의 기본 단위인 엘리먼트가 XML문서 내에서 구조 변정 이 발생 할 경우 보다 빠른 검색을 위해 기존의 색인 구조 정보의 변경 없이 효율적으로 처리 되어져야 한다. 이를 위해 본 논문에서는 XML 문서의 구조 변정 시 기존의 색인 구조에 효을적으로 수용될 수 있는 동적 색인 모뗄을 제안한다. 본 논문에서 제안 하는 동적 색인 모뗄을 위한 구조정보는 기존의 EID(Element Id), ETID(Element TrPe Id), SORD(Sibling ORDer) SSORD(Same Sibling ORDer), Ccount 구조정보 추출 방법에 SSORD를 대신한 STSOL(Same TyPe Sibling ORDer List). Scount (STSOL내의 SORD 개수). 그리고 COL(Child ORDer List)을 추가함으로써 구성된다. 이러한 구조정보를 이용해 효율적인 검색을 지원하기 위한 동적 색인 구성 알고리즘을 기술하고 제한하는 색인 기법이 기존의 동적 색인을 지원하는 기법 보다 내용 색인, 구조 색인, 애트리뷰트 색인 측면에서 우수함을 성능 평가를 통해 보인다. XML documents consist of elements that are basic units of information. When the structure of XML documents is changed dynamically, we need to update structure information efficiently without changing the information of an index structure for fast retrieval In this Paper, we propose a dynamic index modelling scheme that update index struoture in real time as the structure of XML documents is changed by insertion and deletion of elements. In recent, for indexing XML documents. we have proposed a structural information representation method such as element ID(EID), element type ID(ETID), sibling order(SORD). same sibling order(SSORD) and child count(Ccount). Besides them, our proposed dynamic index modelling method in this paper extracts additional structural information, such as same type sibling order list(STSOL) that substitutes for SSORD. Scount that is the number of SORDS in STSOL. and child order Bist(COL). We design a dynamic indexing technique with our structural information. We show through various experiments that our method outperforms existing enes in processing various types of queries such as content based queries, structural queries and hybrid queries.

지속적 운동습관과 행동수정요법이 비만 아동의 생리적 변인에 미치는 영향

신호주,정승환 명지대학교 예체능연구소 2003 藝體能論集 Vol.14 No.-

This research is aimed at implanting confidence in solving obesity to growing obese children, haying them maintain dietary habit, and providing a method to early control factors of losing weight and developing adult diseases by understanding the status of their weight control, and applying behavioral correction therapy and constant exercise habit for managing the obese child's weight. For this, 80 students with over 20% obesity (male'40, female . 40) using 50 percentile value of weight by Korean children measured by Korea Podiatric Association in 1985 were sampled among the students attending a primary school located at K City, and 10 male and female students were randomly participated at the 4 groups of aerobic exorcise therapy, behavioral correction therapy, combined behavioral correction and aerobic exercise therapy, and comparison group for 12 weeks, and its difference between groups analyzed, then following conclusion was obtained. The group whose weight and physical fat were reduced most at the 12 week program was at both male and female students who carried out the combined behavioral correction and aerobic exercise therapy. At both male and female groups, the biggest weight loss was indicated between 8 weeks and 12 weeks. As for the physical fat of male and female students in terms of the program application term, the group whose physical fat was most reduced was that carried out combined aerobic exercise therapy and behavioral correction therapy, which was statistically significant. In the measurement time, physical fat was most reduced between 8 weeks and 12 weeks. The measurement of physical fact during the program's application was generally more in male students than female students. As for the maximum and minimum blood pressure of male and female students, the group carrying out the combined aerobic exercise therapy and behavioral correction therapy was reduced most, and the descending highest rate was the exercise therapy group, behavioral correction therapy group, comparison group, which was statistically significant.. As for total cholesterol (TC) of blood fat, the group at both male and female students that reduced it most was that who carried out the combined aerobic exercise therapy and behavioral correction therapy, which was statisticalIy significant. As for high density fat (HDL) of male and female students, the group carrying out the combined aerobic exercise therapy and behavioral correction therapy increased most and the descending highest rate was the aerobic exercise therapy group, behavioral correction therapy group, comparison group, which was statistically significant. As for neutral fat (TG) of male and female students, the group reducing it most was that who carried out the combined aerobic exercise therapy and behavioral correction therapy, which was statistically significant. In measurement time, TG volume was reduced most between 4 weeks and 8 weeks. As for low density fat (LDL) of male and female, the group reducing it most was that who carried out the aerobic exercise therapy and behavioral correction therapy. It was statistically significant in terms of program application period. The groups reducing calorie intake amount most was those who carried out the aerobic exercise therapy and the behavioral correction therapy, and the descending highest rates were the behavioral correction therapy, the exercise therapy group, the comparison group. Both male and female students reduced calorie intake amount most between previous term and 4 weeks.

GT rotary file을 이용한 만곡 근관형성시 작업 효율 및 file 변형 발생에 관한 연구

신주희,백승호,배광식,임성삼,윤수한,김병현 대한치과보존학회 2001 Restorative Dentistry & Endodontics Vol.26 No.5

Root canal preparation process is of utmost importance in successful treatment of root canal. Also, one of the most important purpose of the root canal preparation is to enlarge the root canal three dimensionally without changing the curvature of the root canal. However, as the curvature of the root canal increases, there are many difficulties involved in formation of optimum root canal. Therefore, in order to solve the above mentioned problems, new developments in methods of root canal preparation and equipments for such purposes were made. Recently, vigorous studies about newly introduced engine-driven nitckel-ti-tanium rotary file are conducted. As shown in research results to dates, it is well established that the use of nickel-titanium file is better suited for curved root canal than stainless steel file in maintaining the curvature of root canal and reducing the deformation of root canal. However, it is also acknowledged that there are a few discrepancies in research results according to protocol, due to failure to remove variables in experiments. In addition, although it is recommended by the manufacturer that the GT rotary file should maintain a low rotational speed of 150∼350rpm and 'light pressure' as light as not to break the lead of a pencil, academic studies about the vertical force which is not yet standardized are not sufficiently explored. Therefore, this research devised and utilized a special research equipment to standardize the appropriate range of vertical force for GT rotary file through experiments by breaking of the lead of a pencil as expressed by the manufacturer and to accurately measure factors involved through repeating and recreating the environment of root canal preparation. Forming nine experimental groups by varying the vertical forces (150g, 220g, 300g) and rpm (150rpm, 250rpm, 350rpm), the effects of changing vertical forces and rpm on working efficiency were measured in terms of time expended in root canal preparation by crown-down method using a transparent resin block with 35 degree curvature and GT rotary file (z-test). The following research using this special research equipment that involved nine experimental groups and varying the vertical force for root canal preparation from 300g which is within the normal vertical force range to 700g and 1000g which fall outside the normal rpm range. The results were as follows : 1.Analysis of the experiment results revealed that the tome spent in root canal preparation decreased as the vertical forces and rpm increased (p<0.05). Also, the effects of rpm were greater than those of the vertical forces within the normal vertical force range (β-weight test) . 2.Observation of the deformation of GT rotary file revealed that deformation increases in a direct correlation with the vertical force increase and in a reverse correlation with the rpm decrease, In the case of the vertical forces close to the normal range, the probability of GT rotary file deformation were quite different depending on the rpm changes. In the case of◎eater tier◎cal forces, the occurrences of deformation of the file were more frequent regardless of the rpm changes. 3.Deformation and breakage of file were also commonly observed in the expended time measurement experiments and GT rotary file deformation experiments in which low speed rpm (150rpm) was used and at the curved portion of the resin block. Key words : GT rotary file, Crown-down method, Working efficiency, Vertical force, Rpm, Deformation and breakage of file

제7차 고등학교 체육과교육과정에 대한 인식

신승호,한상준 江原大學校附設體育科學硏究所 2003 江原大學校附設體育科學硏究所論文集 Vol.- No.26

The purpose of this study was to examine how much the high school students understand the 7th physical education curriculum, to find out the better teaching method for physical training class and to give basic data needed for using selection focused curriculum. To attain this purpose, this paper dealt with the survey with the 1st-2nd grade students, 1173 students who live in cities and counties whose population is more than 200,000 and less than 100,000. The results are as follows. Most students felt positive about the structures and class aims of the 7th curriculum in high school physical education. boy students and high graded group had relatively higher regards and participation of the 7th physical education curriculum. They also had positive regards about the present physical training evaluation. In other words, boy students, high graded group and county's group had more positive thought about the evaluation process and results of the physical training class than girl students, low graded group and city's group.

프로젝트관리 시스템을 위한 범위관리 알고리즘 개발

신호균,전승호,김만균 대한설비관리학회 2004 대한설비관리학회지 Vol.9 No.2

This study present the method to cope with the limitations of the existing study that has uniformly been customizing the methodology by only project's complexity. We show how the applied model(ODW) is implemented in PMS using knowledgebase and modelbase which are designed for a scope management algorithm. An ODW model is used for implementation of a WBS identification module and regression model is used for measuring project's complexity. Scope management algorithm is simulated in MS-Excel for estimating its effectiveness and the interrelationship among the knowledgebase, modelbase and database is derived.