MO이론에 의한 Diels-Alder 반응의 배향성과 반응성의 결정 (Ⅱ)

宋基東,朴聖珪,魯鳳五,朴基柱 조선대학교 기초과학연구소 1985 自然科學硏究 Vol.8 No.1

We applied frontier orbital theory to thermal and catalytic Diels-Alder reaction by means of CNDO/2 and EHT-spd methods, in order to predict the substituent and Lewis acid catalytic effect or reactivity on the regioselectivity of (4+2) cycloaddition reaction of the substituted-nitrosobenzenes. On the above reactions ρ>0. So it takes normal electron demand reaction. When electron withdrawing radicals are substituted, HOMO and LUMO energies of dienophiles are reduced, and the reactivity is increased. As the Lewis acid makes complexes of dienophile and polarizes LUMO coefficients of dienophile in an opposite way, the major regioisomer is predicted as B type. Linear correlation is indicated in the graph of E and σ.

농축배양 시료를 이용한 trichlorophenols의 혐기성 분해

송성주,권오섭 인제대학교기초과학연구소 1998 자연과학 Vol.2 No.-

2, 3, 4-trichlorophenol (TCP)에 8∼17개월 적응시킨 장림하수처리장의 혐기성 소화조 슬럿지와 김해시 쓰레기매립장 침출수를 사용하여 몇 가지 TCPs의 환원형 탈염소반응 및 환경요인의 영향을 연구하였다. 비적응 시료에 비해 적응 시료의 TCPs 분해는 지체기의 단축으로 빠른 분해 속도를 나타냈으며, 2, 3, 4-TCP는 초기부터 빠른 분해를 보인 반면 2, 3, 6-TCP나 2, 4, 6-TCP는 9일 정도의 지체기를 나타냈다. TCPs의 혐기성 분해에 미치는 head space gas의 H2 조성비와 혐기성 대사저해제의 영향은 접종시료에 따라 다르게 나타났다. CO₃²-, SO₄²-, NO₃-를 전자수용체로 황산염환원 조건에서 다소 느리게 분해되었다. 2, 3, 4-TCP에서는 2, 3-DCP, 2, 3, 5-TCP에서는 2, 5-DCP, 2, 3, 6-TCP에서는 2, 3,-DCP, 2, 4, 6-TCP에서는 2, 4,-DCP가 주된 부산물로 검출되었으며, monochlorophenols와 phenol도 적은 양이지만 지속적으로 검출되었다. Anaerobic inocula of the anaerobic digester sludge from Jangrim municipal wastewater treatment plant and the leachate from Kimhae landfill site were enriched with 2, 3, 4-trichlorophenol (TCP) for a period of 8∼17 months. As compared with the unacclimated samples, the anaerobic degradation rates of TCPs by the acclimated samples were fast. The degradation of 2, 3, 4-TCP occurred without a lag period, but 2, 3, 6-TCP and 2, 4, 6-TCP had a lag period of 9 days each. The effects of headspace gas composition and inhibitors of anaerobic metabolisms such as methanogen and sulfate reduction were not so significant and varied with the kinds of inoculum. Anaerobic biodegradation of TCPs occurred under methanogenic, sulfidogenic, and denifrifying conditions were occurred. Major dechlorination by-products of 2, 3, 4-, 2, 3, 5-, 2, 3, 6-, and 2, 4, 6-TCPs were 2, 3,-, 2, 5-, 2, 3,-, and 2, 4-DCPs, respectively, and small amounts of monochlorphenols and phenol were also detected.

八味地黃湯 煎湯液의 投與가 마우스의 自然致死 細胞의 活性度 및 免疫反應에 미치는 影響

朱松竹,李彦政,吳昇煥 圓光大學校 韓醫學硏究所 1992 원광한의학 Vol.2 No.1

This study was done to know the effects of Palmijihwangtang(八味地黃湯) on the cytotoxic activity of NK cells, the phagocytic activity of macrophages, the antibody production of B cells, and delayed-type hypersensitivity reaction by T cells in the mouse. The results were as follows. 1. The administration of Palmijihwangtang enhanced the cytotoxic activity of NK cells against YAC-1 cells. 2. The administration on Palmijihwangtang increased the production of reactive oxygen intermediate(ROI) production from macrophages without any effect on phagocytic activity. 3. The administration of Palmijihwangtang decreased the delayed-type hypersensitivity against dinitrochlorobenzene without affecting T cell subtypes. 4. The administration of Palmijihwangtang increased the antibody production against sheep red blood cells. The above results suggest that Palmijihwangtang could be used for the prevention and treatment of the diseases caused by the abnormalties of the body's immune functions.

9세 남아에서 진단된 선천성 낭포성 유선종 폐기형 1례

송명학,정주영,김상우,임성직 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.3

Congenital cystic adenomatoid malformation(CCAM) is a developmental abnormality with immaturity and malformation of the small airways and distal lung parenchyma. Depending on the time and type of pulmonary insult, 4-26% of cases have associated congenital abnormalities. Most of the patients with CCAM are diagnosed in neonatal period, and up to 90% within the 2 years of age. Patients present with respiratory distress, cyanosis, or recurrent pneumonia. Rarely presentation may be delayed until late childhood or adulthood. We report a case of CCAM in 9 year old boy.

흉부 둔상 후 8년간 지속된 삼첨판폐쇄부전의 치료 1예

송현주,남승현,최영주,박성훈,박시훈,한재진 대한순환기학회 2004 Korean Circulation Journal Vol.34 No.4

소양호 동물성플랑크톤의 수직분포

조규송,박영춘,조성주 江原大學校 附設 環境硏究所 1989 環境硏究 Vol.6 No.-

본 연구는 소양호의 동물성 플랑크톤의 군집조사를 파악하기 위해 플랑크톤의 수직분포를 알아보았다. 조사기간은 1986년 3월부터 9월까지 실시하였다. 본 호수의 동물성 플랑크톤은 담수 초기에 출현된 종이 그대로 장착되고 있으나 식물성 플랑크톤은 종 및 밀도가 증가햐였으며 이는 수여고한경의 변화를 시사해 주고 있다. 개체군 밀도가 가장 높은 시기는 5월과 6월로 ㎥당 개체수가 40,000개에 달하고 가장 적은 시기는 3, 4월로 약 5,000개 정도 였다. 동물성 플랑크톤의 수직분포에서 정체기와 순화기때 서로 다른 양상을 보이는 종들로는 Keratella cochlearis, Therrnocycolps

리튬이온 이차전지의 활물질 합성 및 전기화학적 특성

김우성,이송주 광주보건대학 1999 論文集 Vol.24 No.-

The electrochemical properties of LiCoO₂ and LiMn₂O₄ synthesized by carbonate method was investigated by spectroscopic and electrochemical method. Electrochemical measurements showed that two samples had potential interest as cathode electrodes in lithium-ion cell since it displayed discharge capacity of 163 mAh/g and 130 mAh/g in the range 3.0 to 4.3Ⅴ.

韓國産 景天科 植物에 關한 本草學的 考察

朴柱性,新民敎,宋昊埈 圓光大學校 韓醫學硏究所 1994 원광한의학 Vol.4 No.1

For the purpose of developing Korean Herbalogy with the plants of Crassulacea which grow wild and is planted in Korea, the these and writings in hirbalogy, from literature of successive generations, have been throughly investigative and the results obtained were as follows; 1. There were totaled to 9 genera and 55 species in Korea and among them medicinal plants are 5 genera, 17species. Some 31% in total but the number of species may be added because of the similiar plants. 2. According to sum of 55 species in Crassulacea family, they were classified into Sekum genera 33, Orastachys 8, Rhodiola genera 4, Bryophyllum genera 3 etc. 3. According to the oriental names which can be used for medical purpose, the medicinal plants belonging to the Crassulacea family were classified as Herba 10, Radix 4, Folium 3, Flos 1. Thus it was noticed that Herba was the main kind. 4. According to nature of medicinal plants, they were classified into cold, cool, 6: balance, 3 ; warmth, 1. Thus it was noticed that cold, cool is the main in nature of medicinal plants. 5. According to properties and principal curative action, they were classified into drugs to remove dramatic swelling 9 drugs for hemostatis 7, to remove toxic heat with febri fugal and detoxicant drugs 6. From this result, it was revealed that the plants for medical purpose in Crassulacea was 31% of the whole, in which Herba was mostly abundunt. It is considered that many experiments and clinical apporaches must be continued to use Crassulacea plants widely.

베체트병에서 만성 기침으로 발현한 폐동맥류 1예

정승현,송주경,정성수,강성욱 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

저자들은 만성 기침이 있었으나 정확한 원인을 찾지 못한 채 보존적 치료만 받던 베체트병이 있는 37세 여자환자를 경험하였고 흉부 방사선사진과 흉부 전산화 단층 촬영으로 폐동맥류로 진단하고 고용량의 스테로이드로 치료하였고 이 과정에서 대량 객혈이 있었으나 보존적 치료로 호전된 베체트병 1 예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Pulmonary Artery Aneurysm Manifesting as Chronic cough in Behcet's disease Behcet's disease is a relapsing chronic inflammation disorder of unknown etiology. Although Behcet's disease has originally been described as a triad of recurrent oral aphthous ulceration, genital ulceration and uveitis, it is now recognized as a multisystem disease with vasculitis as the main pathological finding. Clinical manifestations additional to this triad include involvement of the skin, joints, large vessels, lung, gastrointestinal and genitourinary tracts, brain. We report a case of pulmonary artery aneurysm manifesting as chronic cough in Behcet's disease. She was a 47 year-old woman with Bechet's disease treated with prednisolone and colchicine. She had suffered from chronic cough for several years, but been treated only with antitussive agents. Chest CT revealed multifocal patchy consolidation in lung parenchym and aneurysmal dialatation of pulmonary artery. We diagnosed pulmonary aneurysm with CT finding as the cause of chronic cough.

병원획득 Klebsiella pneumoniae 균혈증 분석을 통해 본 Ciprofloxacin 내성과 Extended-Spectrum β-Lactamase생성 간의 연관성

김미영,추은주,곽이경,송문희,나성수,송태준,김성혜,전재범,최상호,정진용,김남중,김양수,우준희,류지소 대한감염학회 2004 감염과 화학요법 Vol.36 No.5

목적 : K. pneumoniae는 ciprofloxacin내성 증가가 전세계적으로 문제가 되고있는 extended-spectrum beta-lactamase (ESBL)를 생성하는 대표적인 세균으로 최근 외국에서 ciprofloxacin 내성과 ESBL 생성사이에 관련이 있다는 2-3편의 보고들이 있었다. 본 연구에서는 병원획득 K. pneumoniae 패혈증이 있었던 환자들을 대상으로 ciprofloxacin 내성과 관련된 인자를 알아보고자 하였다. 재료 및 방법 : 2001년 1월 부터 2002년 12월 사이에 2200병상의 3차 의료기관인 한 대학병원에서 입원 후 72시간 이후에 나간 혈액배양에서 K. pneumoniae가 배양된 입원환자를 대상으로 의무기록과 전산기록을 분석하여 환자의 성별, 나이, 병동, 기저질환, 이전의 항생제 사용력, 패혈증 발생당시까지의 재원기간, 이전 입원력, 원인균의ESBL 생성유무 등을 파악하였고 이들 변수가 ciprofloxacin 내성과 관련이 있는지를 분석하였다. 재발성 패혈증의 경우는 첫 번째 경우만을 분석에 포함하였다. 결과 : 연구대상 환자는 총154명이었고 K. pneumoniae의 ciprofloxacin에 대한 내성률은 28.6% (44/154)였다. Ciprofloxacin 내성균주 중 ESBL 생성균주의 비율은 95.5% (42/44)였고 ciprofloxacin 감수성균주에서 ESBL 생성균주의 비율은 24.5% (27/110)였다(P<0.001). ESBL생성외에 단변량 분석에서 유의한 관련을 보인 변수로는 남자, 나이가 많은 경우, 패혈증 당시 중환자실 재원, 기저질환이 고형암, 혈액암, 담도계 질환인 경우, 패혈증 발생이전 1달 이내의 항생제 사용력, 3세대 cephalosporin, metronidazole, fluroquinolone, carbapenem 투여력이 있었다. 다변량 로지스틱 분석을 시행 하였을 때는 나이가 많은 경우(Adjusted odds ratio[A0R]; 1.04, 95%confidence interval[CI]; 1.01-1.06)와 ESBL 생성(AOR; 81.35, 95% CI; 17.76-372.53)이 유의하게 ciprofloxacin 내성과 관련이 있었다. 결론 : 패혈증을 일으킨 병원획득 K. pneumonias에서의 ciprofloxacin 내성은 ESBL 생성과 유의한 관련을 보였고 향후 이에 관련된 원인이나 기전을 분석하기위한 분자역학적·분자생물학적 연구가 필요하겠다. Background : Strains of ciprofloxacin-resistant Klebsiella pneumoniae have emerged worldwide. We investigated the epidemiology of ciprofloxacin resistance and its relationship to ESBL production in nosocomial K. pneumoniae bacteremia. Materials and Methods : Using the computerized database of clinical microbiology, we identified all patients whose blood culture had yielded K. pneumoniae between January 2001 and December 2002 at a 2200-bed university-affiliated tertiary-care hospital. During the study period, total of 392 episodes of K. pneumoniae bacteremia were documented of which 163 episodes were acquired nosocomially. 9 cases of recurrent episodes were excluded. Results : The resistance rates to ciprofloxacin was 28.6% (44/154). ESBL-production was significantly more common in ciprofloxacin-resistant isolates than in ciprofloxacin-susceptible isolates (95.9% [42/44] vs. 24.5% [27/110], P<0.001). In univariate analysis, following factors were significantly associated with resistance to ciprofloxacin: older age, male sex, ICU admission at the time of bacteremia, prior use of antibiotics within 1 month before bacteremia, solid tumor, hematological malignancy, or biliary disease as underlying disease, and ESBL-production. The prior use of 3^(rd)-generation cephalosprins, metronidazole, fluroquinolone, or carbapenem were also risk factors. Independent risk factors for ciprofloxacin resistance were older age (adjusted odds ratio [AOR]; 1.04, 95% confidence interval [CI]; 1.01-1.06) and ESBL production (AOR; 81.35, 95% CI; 17.76-372.53). Conclusion : The close relationship between ciprofloxacin resistance and ESBL production was documented in nosocomial K. pneumoniae bacteremia. Further epidemiological and molecular studies to determine factors and mechanisms involved in the relationship are needed.