심장내로 연장된 정맥내 평활근종증 1예 : 심장내 평활근종증 intracardiac leiomyomatosis-case report and literature review

정재헌,민필기,박소영,변영섭,홍그루,임세중,심원흠 대한내과학회 2003 대한내과학회지 Vol.65 No.2

정맥내 평활근종증은 병리학적으로는 양성 질환이나 진행 양상은 악성으로 모든 종양의 적출술이 시행되어야 하며, 자궁적출술시 병리학적으로 정맥내 평활근종증을 진단받은 경우 정기적인 검사를 통해 종양의 재발이나 하대정맥과 심장내로의 연장을 확인하여야 한다. 우측 심장내 종양이 발견된 경우는 점액종을 포함한 원발성 심내 종양 외에도 다른 원인 질환을 확인하여야 하며, 반드시 정맥내 평활근종증을 감별진단하여야 한다. Intravenous leiomyomatosis is a rare benign vascular tumor defined as the extension into venous channels of a histologically benign smooth muscle tumor arising either from a uterus or from the walls of uterine vessels, and about 10% spread to the heart. The treatment of choice is complete resection of the tumor. Hormonal therapy should be considered in cases of unresectable residual tumor. A 46-year-old woman was admitted for abdominal discomfort and pain. She was found to have intravenous leiomyomatosis of the uterus with extension into inferior vena cava and right atrium. The patient underwent surgery employing simultaneous sternotomy and laparotomy. Radical excision was achieved using cardiopulmonary bypass. We herein describe a patient in whom complete removal of intravenous leiomyomatosis with cardiac extension was successfully performed.

자궁원발성 비호지킨 악성림프종 -3예 보고-

박찬필,고영혜,이중달,박문일,김경태,조삼현 대한병리학회 1995 Journal of Pathology and Translational Medicine Vol.29 No.3

구분모우드합성법을 이용한 판의 모우드해석

정재훈,박영필,유원희 연세대학교 산업기술연구소 1991 논문집 Vol.23 No.2

Component mode synthesis which is one of substructure synthesis methods is studied for the determination of vibration characteristics of plate problem. Comparisons are made in terms of accuracy and computational efficiency. As a result, computation time of component mode synthesis is much shorter than that of whole structure analysis. In lower modes natural frequencies obtained from component mode synthesis are almost equal to those obtained from whole structure analysis, but in higher the differences of results obtained from two methods are increased.

봉지종류 및 괘대시기가 ‘원황’ 및 ‘화산’ 배 과실의 수확기 품질에 미치는 영향

정억근,이욱용,안영직,이혁재,황용수,천종필 충남대학교 농업과학연구소 2013 농업과학연구 Vol.40 No.2

We tested fruits quality and skin coloration of two pear cultivar ‘Wonhwang’ and ‘Whasan’ produced by bagging with different kinds of paper bags in the Cheonan area, Chungnam Province, Korea. The fruits were bagged at 35, 45, 55 or 65 days after full bloom (DAFB) with 3 kinds of double layer paper bag which consisted of grey color, yellow color and newspaper for outer layer. The great extent of light interruption was observed in grey colored outer paperbag among three kinds of paperbag which showed only 0.46% of lowest light transmittance when compared with 43.7% and 40.0% of yellow paper and newspaper, respectively. The development of skin redness (a*) increased with the delay of bagging time in two pear cultivars. But the fruits treated at 65 DAFB showed uneven coloration and excessive development of redness which represented low fruit external appearance value. Uniform flesh firmness was attained at the fruits bagged with grey outer color paperbag regardless of bagging time, although the fruit quality indices including soluble solids and titratable acidity did not change significantly by using different kind of fruit bags and bagging time in two pear cultivar. Based on our results, it was explained that the grey-colored fruit bag had positive effect on the development of skin coloration without any detrimental effect on fruit quality factors in ‘Wonhwang’ and ‘Whasan’ pears.

비소세포 폐암 환자의 이차 치료로서 Gemcitabine과 Vinorelbine 혼합 요법의 효과

장필순,강현모,이정은,권선중,안진영,이연선,정성수,김주옥,김선영 충남대학교 암공동연구소 2006 암공동연구소 업적집 Vol.5 No.

Background : Both gemcitabine and vinorelbine are effective anticancer drugs with mild toxicity on non-small cell lung cancer, and monotherapy of these drugs are effective as a second-line chemotherapy. The aim of this trial was to assess the response and toxicity of a combination of gemcitabine and vinorelbine in patients of previously treated for non-small cell lung cancer. Materials and Methods : 24 patients, initial stage III A/B,IV and previously treated with platinium and taxane based regimens, were enrolled from June 2000 to March 2004. The regimens consisted of vinorelbine 25mg/㎡ followed by an infusion of gemcitabine 1000mg/㎡ on day 1 and day 8 every three weeks. This course was repeated more than twice. Results : Twenty-four patients were analyzed for the response, survival rate, and toxicities. The overall response was 17% with a complete remission rate of 4%. The median time-to progression (TTP) was 3.1 months (95%, CI l-10months), and the survival time was 8.2 months (95%, CI 1-23 months). The grade 3/4 toxicities encountered were neutropenia (12.5%), anemia (0%), thrombocytopenia (0%). Non-hematological 3/4 toxicities were not observed. Conclusion : A combination of gemcitabine and vinorelbine in patients previously treated for non-small cell lung cancer provides a relatively good response rate, and a low toxicity profile. However, further study will be needed to confirm its effectiveness. (Tuberc Respir Dis 2005; 58: 344-351) 배경 : Gemcitabine, paditaxel, docetaxel, vinorelbine, ir-rinotecan 새로운 항종양제의 출현으로 일차 치료의효과가 증대 되고 있고 재발시에도 좋은 신체 활동도를 보이고 있어서 이차 치료의 대상군도 늘어나는 효과를 보이고 있다. 치료의 필요성은 증대 되고 있지만 현재까지 표준 치료가 확립되지 않은 상황에서 Gem-citabine과Vinorelbine모두 독성이 강하지 않아서 혼합 요법이 가능한 장점이 있고 비소세포 폐암에 대한효과도 입증이 되어있어서 본 연구는 반응이 없거나 반응을 보인후에 재발된 진행된 비소세포 폐암에 ge-mdtabine과 vinorelbine 흔합 요법을 시행하여서 치료 반응률과 생존율 그리고 부작용을 평가하였다. 대상 및 방법 :2000년 6월부터 2004년 3월까지 충남대학교병원에내원하여 진행성 비소세포 폐암 IIIA/IIIB, IV로 진단을 받고 일차 항암화학요법치료를 받은 환자중에 초기 치료에 반응이 없거나, 치료에 반응이 있었으나 병이 진행된 환자로 추적 관찰 기간이 6개월 이상인 환자를 대상으로 생존율과 반응률 그리고 독성을 분석하였다. 결과 : 총 치료 반응률은 17%. 반응 유지기간의 중앙값은 3.1개월(1-10개월)이었고 생존기간의 중앙값은 8.2개월 (1-23개월) 그리고 1년 생존율은 35%였다. 항암화학요법에 의한 독성은 3도 이상의 중성구 감소가 12%, 오심과 구토가 12.5% 였다. 결론 : 일차 치료에 반응이 없거나 재발한 비소세포 폐암환자의 이차 치료로 gemcitabine과 vinorelbine 혼합요법은 효과적이라고 생각되며 향후 3상 연구를 통한다른 약제와의 비교 연구가 필요하다고 생각된다.

성장발육에 따른 흰쥐의 악관절 신경분포의 변화

배용철,김영진,박국필,김현정,남순현 大韓小兒齒科學會 1999 大韓小兒齒科學會誌 Vol.26 No.1

The purpose of this study was to investigate the distribution of CGRP immunoreactive nerve fibers in rat squamosomandibular joint with postnatal development. Squamosomandibular joint with adjacent tissue of 8 groups of rats(1,5,10,15,20,25,35-postnatal day and adult groups) were removed en bloc and processed for immunohistochemistry and were subjected to light microscopic examination. The results obtained were as follows; 1. The anterior portion of the articular disk was most densely innervated, followed by the posterior, lateral, and medial portions in each group. 2. Increase of CGRP immunoreactive nerve fibers was evident in 10,15,20 postnatal day groups. 3. Almost no CGRP immunoreactive nerve fibers were observed in articular surface of disk proper, mandibular fossa and condyle head of each group. These result suggest that CGRP immunoreactive nerve fibers increased in synovial membrane and peripheral portion of articular disk during 10-20 postnatal day may play a important role in squamosomandibular joint function after weaning period.

외팔보 진동의 시간 최적제어

박영필,정승호 연세대학교 산업기술연구소 1986 논문집 Vol.18 No.1

The feedback controller for the active control of a cantilever beam vibration is developed using time optimal bang-bang control theory. The effects of I)the constraint of the control force magnitude and II)the actuator positions are investigated numerically. The results show that I)the magnitude of the constraint force and control time are inversely proportional, II)the control effect is increased as the actuator position moves toward the free end of the beam, and III)the controller gives Coulomb damping effect to the system.

여자 리듬체조의 변천과정

이필영,최정현 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.1

It is important to investigate various gymnastics and dances that have influenced the origin of rhythmic sportive gymnastics in order to understand its cultural values and the importance of feminine sports. Therefore, the purposes of this study are to inquire into the backgrounds and to clarify the process of changes in rhythmic sportive gymnastics from its origins to the present. Rhythmic sportive gymnastics can be defined as a sport in which one expresses oneself in feminine beauty and rhythmic motion. Formed under the influence of dances and gymnastics such as basic gesture of ballet, free gymnastics, water polo gymnastics, expressive gymnastics, artistic gymnastics, etc., rhythmic sportive gymnastics has developed into a sport entry. The World Tournament has been held every two year since the rhythmic sportive gymnastics firstly appeared as a sport entry at the first World Tournament in Budapest in 1963. It was officially adopted as a sport entry in the 1984 Los Angeles Olympics. Since then, its rules have become more elaborate and have undergone some changes. In the 1980s, the rules of the game were firmly set and its techniques significantly improved as it was rapidly settled as a sport entry. As a result, in 1990s, the focus of the rules was shifted to technical skills from its original feminine beauty and internal expression. For these reasons, feminine beauty, the power of expression, creativity and inner beauty, which are the essence of rhythmic sportive gymnastics, have gradually been disappearing.

신체관과 건강관의 관계 규명

이필영,최정현 龍仁大學校 體育科學硏究所 2003 體育科學硏究論叢 Vol.13 No.2

In modem society, health means a balanced state of body and mind, and a state of living without being given any threats of accidents in a desirable environment. It is the most important factor in determining the quality of life. Health is defined in various ways in different times and situations. Most of the cases, views on body are directly projected in views on health. The purpose of this study is to investigate different views on health based on the assumption that views on body and health will actually influence the health of contemporary people. For this purpose, relationships between views on body and on health which were closely examined through inquiring various documents and research articles on health. Body can be said to be a crucial factor in determining views on health. Basic conceptions of 'the health' are formed according to views on body. Views on body have been changed from the one that it is merely physical material, to the one that it is related to internal functions, and to the one that body and health are considered as the quality of life. These changes in views on body are connected with views on health: health is simply related to diseases and physical injuries; it is linked with the internal functions of the body; body and mind are one unit closely connected with each other; and body itself is the very quality of life.

심혈관 위험요인과 청력역치의 상관성

조영채,이태용,이동배,정성필,김수영 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.2

To investigate the effects of cardiovascular risk factors on hearing loss, hearing threshold and cardiovascular risk factors such as blood pressure, hematologic values, and serum lipid levels of 3,827 persons who visited the Health Center of a University Hospital in Kumi for health examination from January 1, 1995 to July 31, 1997 were analysed. The results were summarized as follows; 1. Hearing threshold was shifted highly in both sex groups with age increased. Smoking did not influence increase of hearing loss, but drinking alcohol amount increased the hearing threshold when sex was adjusted. The most highly increased hearing threshold showed among farmers group, but next was blue collars group. Hearing threshold increasing basis with BMI increased. 2. Systolic and diastolic blood pressure and hematocrit value increased the hearing threshold in both sex groups, but hemoglobin value did not related to the hearing threshold. 3. Total cholesterol, LDL-cholesterol, triglyceride, and atherosclerosis index were significantly increased with the grade of hearing loss increased, when age was adjusted. 4. In the logistic regression analysis, the atherosclerosis index, age, and hematocrit value revealed risk factors which contributed in that orders, though the values were small they showed statistical significaces, but the risks were lowered when hemoglobin values increased, in both sex groups. Consequently, hyperlipidemia was significantly related to the hearing loss when age was adjusted.