12M의 고해상도 360° 카메라를 사용한 주차장의 14면 주차 상태 판단 프로그램

이영지(Young-Ji Lee),이희열(Hee-Yeol Lee),고태영(Tae-Young Ko),곽동훈(Dong-Hoon Kwak),김재형(Jae-Hyung Kim),김주호(Joo-Ho Kim),오승진,이태윤(Tae-Yoon Lee),박상민(Sang-Min Park),이승호(Seung-Ho Lee) 대한전자공학회 2019 대한전자공학회 학술대회 Vol.2019 No.6

In this paper, we propose a program to identify 14 parking status in a parking lot using a high resolution 360° camera of 12M. The proposed program consists of three steps: Match with plane image, parking area detection algorithm, and discrimination of parking using learning method. Tests on a model car to evaluate the program to identify 14 parking status in a parking lot using a high-resolution 360° camera of 12M showed 100% accuracy for both parking and double parking. Therefore, the effectiveness of a program to identify 14 parking status in a parking lot using a high-resolution 360° camera of 12M proposed in this paper has been proved.

Comparison of the Crystallization Behavior of Silica Between Mg and Al‑Phosphate Used in Tension Coatings of Grain‑Oriented Electrical Steel

Hyung‑Ki Park,Min‑Soo Han,Chang‑Hwan Chang,Jong‑Tae Park,박창수,Hyung‑Don Joo 대한금속·재료학회 2020 METALS AND MATERIALS International Vol.26 No.3

The effect of the phosphate component on the thermal stability of tension coatings was investigated with a focus on thecrystallization behavior of amorphous silica in the tension coating. After stress-relief annealing, core loss of samples coatedwith a Mg-phosphate was improved, while that coated with an Al-phosphate was deteriorated. The domain wall spacing ofthe samples coated with Mg- and Al-phosphates was respectively increased and decreased after stress relief annealing. Thismeans that the stress relief annealing did not much diminish the tensile stress for Mg-phosphate coating but much diminishedthe tensile stress for Al-phosphate coating. Based on FTIR and XRD results, we found that the crystallization temperatureof silica with Al-phosphate was lower than that of silica with Mg-phosphate. The crystallization of silica was accompaniedby an abrupt volume change, which formed cracks in the tension coating and deteriorated the tensile stress.

C-reactive protein accelerates DRP1-mediated mitochondrial fission by modulating ERK1/2-YAP signaling in cardiomyocytes

( Suyeon Jin ),( Chan Joo Lee ),( Gibbeum Lim ),( Sungha Park ),( Sang-hak Lee ),( Ji Hyung Chung ),( Jaewon Oh ),( Seok-min Kang ) 생화학분자생물학회 2023 BMB Reports Vol.56 No.12

C-reactive protein (CRP) is an inflammatory marker and risk factor for atherosclerosis and cardiovascular diseases. However, the mechanism through which CRP induces myocardial damage remains unclear. This study aimed to determine how CRP damages cardiomyocytes via the change of mitochondrial dynamics and whether survivin, an anti-apoptotic protein, exerts a cardioprotective effect in this process. We treated H9c2 cardiomyocytes with CRP and found increased intracellular ROS production and shortened mitochondrial length. CRP treatment phosphorylated ERK1/2 and promoted increased expression, phosphorylation, and translocation of DRP1, a mitochondrial fission-related protein, from the cytoplasm to the mitochondria. The expression of mitophagy proteins PINK1 and PARK2 was also increased by CRP. YAP, a transcriptional regulator of PINK1 and PARK2, was also increased by CRP. Knockdown of YAP prevented CRP-induced increases in DRP1, PINK1, and PARK2. Furthermore, CRP-induced changes in the expression of DRP1 and increases in YAP, PINK1, and PARK2 were inhibited by ERK1/2 inhibition, suggesting that ERK1/2 signaling is involved in CRP-induced mitochondrial fission. We treated H9c2 cardiomyocytes with a recombinant TAT-survivin protein before CRP treatment, which reduced CRP-induced ROS accumulation and reduced mitochondrial fission. CRP-induced activation of ERK1/2 and increases in the expression and activity of YAP and its downstream mitochondrial proteins were inhibited by TAT-survivin. This study shows that mitochondrial fission occurs during CRPinduced cardiomyocyte damage and that the ERK1/2-YAP axis is involved in this process, and identifies that survivin alters these mechanisms to prevent CRP-induced mitochondrial damage. [BMB Reports 2023; 56(12): 663-668]

폐주물사를 혼입한 콘크리트의 내구특성에 관한 연구

박제선,윤경구,이주형,용석응 江原大學校 産業技術硏究所 1997 産業技術硏究 Vol.17 No.-

This study was conducted to evaluate durability of concrete which are increasingly demanded recently. Concrete durability properties incorporating waste foundry sand was performed with the variable of W/C ratio, Sand/Waste foundry sand ratio and Air entrainment-Non air entrainment. Cylinder specimens were made and subjected to freezing and thawing cycle at -18℃ and 4℃. Dynamic modulus of elasticity were as F/T cycle increase. The results show that decreasing W/C ratio and AE concrete makes improved resistance of freezing and thawing improved. Especially, resistance for freezing and thawing is improved by Fine aggregate/Waste foundry sand ratio which is 50%, 25%, 0% in a row.

3kW 태양광발전시스템의 실증시험(Ⅰ)

박정민,조금배,백형래,최창주 조선대학교 에너지.자원신기술연구소 2004 에너지·자원신기술연구소 논문지 Vol.26 No.1

Consider the optimal design for PV system, it is apply to 3㎾ interconnected electric power PV system, that is a point of reference for 3㎾ PV the spread residential section system. Through the driving various practical system, we look into that fbr efficiency of generation and stability of interconnected system. Using obtained data acquisition, It can be suggest that installation and management for system parameter to optimal design maximum generation electric power. PV system have some losses that are variation radiation, shadow, change temperature, unbalanced grid connection, serial circuit loss, MPP deference loss, PCS loss and so forth. Using obtained various performance characteristic result, we can make database in the future, through the this study, we can get the reliance and have regard to spread PV system.

셀레콕시브 및 그 합성유도체들의 항암활성 스크리닝

박정란,강진형,구효정,노지영,류형철,박상욱,고동현,조일환,이주영,황다니엘,김인경 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.2

Selective COX (cyclooxygenase)-2 inhibitors including celecoxib have been shown to induce apoptosis and cell cycle changes in various tumor cells. New inhibitors are recently being developed as chemomodulating agents. We evaluated celecoxib and screened 150 synthetic compounds for anti-proliferative activities in vitro. Effects of celecoxib on COX activity, cell growth, cell cycle distribution, and apoptosis induction were determined in A549 COX-2 overexpressing human non-small cell lung cancer (NSCLC) cells. The COX inhibition of celecoxib increased with concentration up to 82% at 1μM after 24 hr exposure. Forty μM and 50μM of celecoxib induce G_1 arrest, and TUNEL-positive apoptotic cells, respectively. Among 150 compounds, several compounds were selected for having greater COX-2 inhibitory activity and higher selectivity than celecoxib with growth inhibitory activity. Celecoxib showed concentration-dependent COX inhibitory activity, and ability to induce cell cycle arrest and apoptosis in human NSCLC cells in vitro. Among synthetic analogues screened, several compounds showed promising in vitro activity as COX-2 inhibitory anticancer agents, which warrant further evaluation in vitro and in vivo.

마약길항제의 방출 제어형 제제 (제1보) : 생체분해성 polyphosphazenes의 합성과 나록손 이식제제의 제조 및 용출특성 Synthesis of Biodegradable Polyphosphazenes and Preparation and Release Characteristics of Naloxone Implant

박주애,이승진,김형국,김길수 梨花女子大學校 藥學硏究所 1995 藥學硏究論文集 Vol.- No.5

For the administration of narcotic antagonist with short half-life and low patient compliance. the sustained release system using biodegradable matrix is effective. Polyphosphazenes are of considerable interest as biodegradable matrix systems for controlled release of drugs. In this study. biodegradable polyphosphazenes available for the sustained release implantable device were synthesized. and their application was examined. Poly〔dichlorophosphazene〕 was synthesized by solution polymerization method and confirmed with IR spectrum. Poly〔bis(ethyl glycinate) phosphazene〕 and poly[(diethyl glutamate)-co-(ethyl glycinate)phosphazene] were then produced by substitution of amino acid alkyl esters for chloride side groups. Using these polymers. the implantable devices of 1 ㎜ thickness and l0 × 10 ㎜ size containing naloxone hydrochloride were prepared and their release and degradation profiles were measured. In the case of poly〔bis(ethyl glycinate)phosphazene〕 with swelling characteristics, degradation rate was slower than the release rate, showing that the release rate is partly dependent on the swelling rate. In contrast, the degradation rate of poly〔(diethyl glutamate)-co-(ethyl glycinate)phos-phazene〕 matrix was identical with release rate of naloxone hydrochloride. On the basis of these results, it is expected that these polymers can be applied to sustained release implantable systems delivering narcotic antagonist.

Irbesartan과 Lercanidipine의 병용요법이 고혈압 및 혈관재형성에 미치는 효과

이도형, 임태완, 조은지, 박현수, 정상혁, 한주희, 병창선 충남대학교 약학대학 의약품개발연구소 2017 藥學論文集 Vol.32 No.-

Hypertension is one of the major risk factor for cardiovascular disease and can lead to or make worse many complications, heart disease, atherosclerosis and diabetes. Thus, managing blood pressure effec tively using therapeutic drugs such as angiotensin II receptor blocker (ARB) and Ca2+ channel blocker (CCB) can be prevent other complications. Therefore, we investigated the synergistic effect of these two drugs, ir besartan and lercanidipine, for antihypertension, cardioprotection and antidiabetes. Irbesartan (28.74 mg/kg, 14.37 mg/kg) or lercanidipine (1.92 mg/kg, 0.96 mg/kg) alone or combination was administered to sponta-neously hypertensive rats (SHRs) and C57BL/6 mice. A two-week treatment of combination with irbesartan and lercanidipine significantly attenuated systolic blood pressure (SBP) and mean arterial pressure (MAP) compared with monotherapy. Futhermore. the combination therapy protected myocardial ischemia reperfusion injury more effectively than monotherapy. In vascular remodeling, combination therapy significantly diminished cuff -induced neointima formation and reduced serum -indllced vascular smooth muscle cells (VSMCs) pro-liferation compared with monotherapy. However, combination therapy had no significant synergistic effect of blood glucose regulation. Taken together, present study suggest that the combination therapy of irbesartan and lercanidipine may be more effective therapeutic strategy for the treatment of hypertension and related complications, myocardial infarction and arterial restenosis than monotherapy

폐타이어로 성형제조된 부정형 과립담체에 부착된 미생물의 측정방법

박종웅,송주형 대한상하수도학회 2003 상하수도학회지 Vol.17 No.2

This study was carried out to know the physicochemical properties and determine the measurement method of attached biomass in irregular shape granular (ISG) media molded with waste tire. The size of ISG media and specific surface area were Φ4-10㎜ and 0.00412㎡/g, respectively. The using of pretreatment agents as 0.8N CuSO_4-0.7N Sulfamic acid was proper to prevent self-oxidation of attached biomass on ISG media. The detaching method of attached biomass in ISG media was suitable for conducting ultrasonic and alkali treatment at the same time. The optimum alkali concentration and washing time were 0.125N NaOH and 120min, respectively. Finally, it was concluded that the result of this study could be establishing as a measurement method of attached biomass on ISG media molded with waste tire.

중증 객혈환자의 구명을 위한 새로운 외과적 접근 : 흉골 정중절개에 의한 폐엽의 기관지-혈관 격리술

박형주,이철세,고정관 순천향대학교 1994 논문집 Vol.17 No.4

Major hemoptysis is not only a clinical challenge but also the most critical situation when it is aspirated into the tracheobronchial tree especially in the chronic debilitated patients. Recently, bronchial artery embolization(BAE) is the most effective measure for the primary conservative management and salvages a lot of lives in the emergency situations. However, as the recurrence rate of hemoptysis after embolization is significant and there are very poor cases that cannot be controlled by every medical efforts, emergency surgical resection is the only way of lifesaving. In these high risk group of patients, standard lobectomy resulted in high mortality and morbidity. Since October, 1993, we introduced a new surgical approach of "Broncho-vascular Isolation Lobectomy" for the lifesaving of medically failed life-threatening hemoptysis. Now we report 3 cases treated by this approach and would like to suggest future implications in the treatment of major hemoptysis.