산업폐수처리장 방류수의 내분비계 장애작용 평가

오승민,김기서,유병택,장형석,이희성,정규혁 한국환경독성학회 2004 환경독성보건학회지 Vol.19 No.4

This study was designed to investigate potential endocrine disrupting effects of several industrial wastewater effluents discharged from cosmetic, plaiting, paint, textile industry using EROD bioassay and E-Screen assay The results of E-screen assay showed that textile industrial wastewater could act as a full agonist and cosmetics and plaiting industrial wastewater could act as a partial agonist On the contrary, the wastewater discharged from paint industry did not show any estrogenic effect Estrogenic activity in the effluents of cosmetic and paint industrial wastewater was lower than that in the influents indicating that the wastewater treatment process minimized the effects of discharges on water quality Despite of these results, it was recognized that wastewater treatment was not always minimize toxic impact In this study, increased estrogenic effect was observed in the effluents of plating and textile wastewater, and EROD activity was increased in the effluents of cosmetic and plating wastewater.

아미노글리코사이드 사용제한에 따른 병원성 균혈증 유발 그람음성간균의 내성변화 및 임상적 의의

오종택,김신우,손종원,도병훈,한승우,신병철,박지현,이종명,김능수 대한감염학회 2003 감염과 화학요법 Vol.35 No.4

목적 : 항균제 오남용으로 인한 내성균의 출현, 약물부작용의 발생 및 약제 비용의 증가는 환자 개인뿐만 아니라 사회적으로 문제가 되고 있다. 본 연구는 항생제의 오남용을 막기 위한 제도의 일환으로 시행한 아미노글리코사이드 사용 제한정책의 비용 효과적인 측면을 조사하고 그람음성간균에 의해 병원성 균혈증이 발생한 환자들을 대상으로 이 정책이 항생제 내성률과 환자 사망률에 미치는 영향을 연구하였다. 방법 : 930병상 규모의 3차 병원인 일개 대학병원에서 아미노글리코사이드 사용제한정책이 시행된 직후인 2002년 3월에서 9월 사이에 그람음성간균(Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Enterobacter cloacae, Enterobacter aerogenes, Serratia marcescens, Stenotrophomonas maltophilia, Burkholderia cepacia)에 의해 발생한 병원성 균혈증 환자 60명(실험군)과, 이 정책이 시행되기 전에 입원한 환자들 중 균주별로 같은 수만큼 선별한 병원성 균혈증 환자 60명(대조군)의 의무기록을 후향적으로 조사하였다. 결과 : 아미노글리코사이드 사용제한정책이 시행된 시기인 2002년 3월에서 9월 사이에 처방된 아미노글리코사이드 사용량 및 비용을 이 정책이 시행되기 전인 2001년 3월에서 9월 사이와 비교한 결과, 아미노글리코사이드의 사용량(antimicrobial utilization density)은 사용제한 후 225.2에서 130.3으로 42% 감소하였고 약제 비용은 44% 감소하였다. 아미노글리코사이드 사용제한 후 병원성 균혈증을 유발한 그람 음성간균의 이 항생제에 대한 내성률은 유의한 변화를 보이지 않았으며 균혈증과 직접 연관된 사망률도 환자의 나이, 성별, 기저질환 및 원발병소 등을 보정할 경우 유의한 차이를 보이지 않았다(40.4% vs. 24.1%, P=0.11). 결론 : 아미노글리코사이드를 5일을 초과한 사용 시 감염전문가의 사전 승인을 필요로 하는 사용제한정책은 아미노글리코사이드의 사용량과 비용을 유의하게 감소시켰다. 또한 이 정책 시행 후 그람음성간균에 의한 균혈증 환자에서 균혈증으로 인한 사망률과 아미노글리코사이드에 대한 내성률은 유의한 차이가 없었다. Objective : To evaluate the effects of an aminoglycoside restriction policy on expenditures for aminoglycosides, antimicrobial resistance rates and clinical outcome of nosocomial bacteremia caused by Gram-negative bacilli (GNB). Methods : Starting in February, 2002, a prior consultation with an infectious disease specialist for using aminoglycoside antibiotics over 5 days was required in a 930-bed university hospital. In retrospective analysis of medical records 7 months after initiation of the aminoglycoside restriction policy, sixty cases of clinically relevant nosocomial bacteremia caused by GNB were found. These bacteremic patients were compared with sixty, species-matched, control patients with nosocomial Gramnegative bacteremia before the policy for total expenditures for aminoglycosides, susceptibility to antibiotics and clinical outcomes of bacteremia. Results : During the same period of 7 months before and after the restriction policy, total expenditures for aminoglycosides decreased by 44% in cost (from 465,030,841 Won to 259,618,337 Won) and the antimicrobial utilization density of aminoglycosides decreased by 42% (from 225,2 to 130.3). On the other hand, the patterns of antibiotic susceptibility and bacteremia-related in-hospital mortality rates after the policy did not show a significant change, compared with those before the policy. Conclusion : Antibiotic restrictions are among the most popular methods to diminish the practice of antibiotic overuse in hospitals. In this study, requirement for prior approval of aminoglycoside use over 5 days led to a significant decrease in the amount and cost of total aminoglycosides without a significant change in susceptibility patterns and bacteremia-related mortality rates.

안와골절의 외과적 접근에 대한 증례보고

민승기,이은택,오승환,이동근,고세욱,송종민,최성림 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.3

The Orbital fracture which is often combined with midface fracture can cause decreased visual acuity, limitation of eyeball movement, diplopia, enophthalmos, etc. Traumatic orbital fracture causes change of orbital volume, results in diplopia and enophthalmos thus, accurate repositioning of displaced bone and reconstruction of orbital defect with autogenous materials(cranial, rib, iliac bone, cartilage and fascia lata) or alloplastic materials(gelatin film, polyglactin mesh, methylmethacrylate, Teflon, silicone, Supermid, hydroxyapatite and metal). The key point of reconstruction of orbit is accurate repositioning of displaced orbital floor, lateral, medial orbital wall and sufficient bonegraft in anatomical defect. As this cases, we obtained good results through transconjunctival and coronal approach who were required orbital reconstruction. Also, we accurately diagnosed orbital fracture with C.T., 3D model and good result for orbital reconstruction with sufficient parietal block bone graft during average 16.8 months follow-up.

학교교실의 환경개선을 위한 조명설계 연구

좌승택,오성보 제주대학교 산업기술연구소 1999 尖端技術硏究所論文集 Vol.10 No.2

School illumination with full volume of light and adequate brightness is designed to help students better focus on their education and produce an optimum atmospnere where students can apply their utmost to learning. This paper present to study actual illumination environment of schools in order to figure out illumination prolems. Furthermore, it attempts to suggest an optimum design for schoolroom illumination through computer simulation to attain qualitative improvement effect in school illumination under the illumination plan which is based on illumination maintenance and uniformity ratio that K.S. illumination standard sets.

재발성 가와사끼병의 임상양상과 검사소견

유승택,최은정,이창우,오연균,박승택,윤향석 圓光大學校 醫科學硏究所 2003 圓光醫科學 Vol.18 No.2

복부결핵의 지연진단으로 인하여 발생한 복막농양의 경피적 배액술

김승호,오정택,김강득,위대한 圓光大學校 醫科學硏究所 2008 圓光醫科學 Vol.23 No.2

Abdominal tuberculosis is described in two forms; tuberculous peritonitis and gastrointestinal tuberculosis. Abdominal tuberculosis is usually insidious onset with diverse symptoms and signs. The diagnosis is difficult, especially in areas where the disease is less common, as many patients do not have evidence of pulmonary tuberculosis or a positive skin test. Physicians should obtain a thorough history focusing on risk behaviors for tuberculosis. Delayed diagnosis is common, resulting in high mortality. In general, the same regimens are used to treat pulmonary and abdominal tuberculosis. Most intra-abdominal and other types of fluid collections are now successfully drained percutaneously under image guidance. The utility of percutaneous drainage(PCD) of tuberculous abscesses is less well established. A 43-years-old man, who had been diagnosed as pulmonary tuberculosis about 9 years ago, suffered from peritoneal abscess because of delayed diagnosis. The diagnosis of tuberculosis was confirmed by the PCR tests for the detection of Mycobacterium tuberculosis in the aspirates from the abscess. Drainage was done by catheter under ultrasound guidance and there were no procedural complications. The abscess was successfully and completely evacuated. We present our experience with a case of tuberculous peritoneal abscess which were successfully treated by PCD and antituberculous medication.

상악 제3대구치 발거후 발생한 광범위한 피하기종

이은택,민승기,오승환,이동근 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.1

Subcutaneous air emphysema is a relatively uncommon phenomenon. It has been reported in both the medical and dental literature following such various procedures as rectal biopsy, nasogastric intubation, radical neck dissection, tonsillectomy, adenoidectomy, root canal treatment, dental restoration and extraction of maxillary and mandibular teeth. The most common cause involves extraction of mandibular third molar. Subcutaneous emphysema of the head, neck and thorax is a swelling caused by introduction of air into the space of the connective tissue. The clinical signs are local swelling, tenting of the skin, and crepitation on palpation. In extreme casesk, air has been reported to pass through the masticatory space into the parapharyngeal and retropharyngeal space, and penetrate into the mediastinum. If the inflowing air contains bacteria, serious infection may ensue. The first case of subcutaneous emphysema associated with a dental procedure was first reported in 1900. This emphysema is a often limited only to the spaces of head and neck, but also can involve deeper structure. This case is diffuse subcutaneous emphysema following maxillary third molar extraction with a high-speed drill.

NADPH의 안정화 및 이온토포레시스를 이용한 피부투과

신현택,이승연,오승열 숙명여자대학교 약학연구소 2005 약학논문집-숙명여자대학교 Vol.22 No.-

Nicotinamide Adenine Dinucleotide Phosphate (NADPH) has antioxidant effect in the body and thus decreases the symptoms of senility. The development of a transdermal delivery formulation for NADPH is a very difficult task, due to its rapid decomposition by oxidation, low partition coefficient into stratum corneum, high molecular weight and electrical charge at neutral pH in aqueous solution. The purpose of this work is to test several anti-oxidants as the stabilizing agent for NADPH in the aqueous formulation, and to study the effect of these agents on the in-vitro iontophoretic transport through hairless mouse skin. The stability of NADPH in aqueous solution with/without various antioxidants such as butylated hydroxy toluene (BHT), resveratrol, a-tocopherol and Vitamine C was studied. BHT an a-tocopherol (0.01 % w/w) exhibited minimal stabilizing effect, however resveratrol and vitamine C showed significant stabilizing effect. Stabilizing effect of vitamine C was proportional to the concentration in aqueous solution. Although vitamine C increased the stability ofNADPH significantly, it decreased flux of NADPH in a concentration dependent fashion, therapeutic amount ofNADPH can be delivered through skin using iontophoresis and These results suggest that, in order to develope a efficient iontophoresis formulation, it is important to choose a stabilizing agents which are not only potent in stabilizing effect but also not competitive for the delivery of NADPH.

학교교실의 조명설계 최적화 연구

좌승택,김덕구,오성보 濟州大學校 産業技術硏究所 2000 산업기술연구소논문집 Vol.11 No.2

School illumination with full volume of light and adequate brightness is designed to help students better focus on their education and produce an optimum atmosphere where students can apply their utmost to learning. This paper presents study on actual illumination environment of schools in order to figure out illumination problems. Furthermore. it attempts to suggest an optimum design for schoolroom illumination through computer simulation. We try to attain qualitative improvement effect in school illumination under the illuminaion plan which is based on illumination maintenance and uniformity ratio that K.S. illumination standard sets.

중안면부 골절이 하악 과두 골절에 미치는 영향에 관한 임상적 연구

민승기,이동근,오승환,이은택,조이수,김종구 大韓顎顔面成形再建外科學會 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.6

This is clinico-statistical & retrospective study of 30 patients with only unilateral mandibular condyle fracture and combined with 24 midface fracture patients who were treated with open reduction in Wonkwang University Dental Hospital during the period 1993 to 2000. The results were as follows : 1. In mandibular condyle fracture combined with midface fracture, the most incident type is associated with zygomaticomaxillary complex fracture and level Ⅳ of mandibular condyle fracture combined with ZMC fracture is the most related(33.32%). 2. In the period of intermaxillary fixation, unilateral mandibular condyle fracture group (9.8 days) is shorter than combined with midface fracture group (15.3 days), but no statistical difference between two groups(p.>0.05). 3. In the mouth opening recovery, unilateral mandibular condyle fracture group is faster than combined with midface fracture group in post-operative 1 month, but no significant difference between two-groups after 3 months postoperatively (p>0.05). 4. In two-groups, treatment method is almost open reduction with internal fixation(ORIF) and overall 25% temporary complications were shown, but little lower incidence in unilateral condylar fracture group.