Web 자원 목록을 통한 주제게이트웨이 서비스에 관한 연구

오경묵 숙명여자대학교 사회·교육과학연구소 2002 사회 교육과학연구 Vol.5 No.2

현재 인터넷 상에서는 초보자이건 전문가이건 원하는 사람이면 누구나 Web을 통해 출판할 수 있는 환경이기 때문에 Web 정보의 품질에 대한 옥석이 구분되어 있지 않은 상태이다. 품질이 보장된 정보원을 이용한다는 것은 이용자들의 검색시간을 절약하게 해주는데, 기존의 사용검색엔진은 만족스럽지 못하다. 전문가들이 IP로 참여하는 주제게이트웨이에 소개된(품질이 관리된) 정보원을 검색하게 되면 정보에 대한 신뢰성, 타당성에 대하여 의심할 필요가 없게 된다. 주제 게이트웨이는 전통적인 도서관 정보서비스 업무를 근거로 개발되는 것으로 현재 인터넷 이용시 혼란스러운 상태에서 보다 현명한 방법으로 원하는 정보를 보다 신속하게 찾도록 하기 위한 전문 포털사이트(portal site)이다. 본 연구를 통해 바람직한 주제 게이트웨이의 활용사례를 제시하고 바람직한 모형을 소개하여, 국내학술 연구기관들이 정보 서비스현장에서 활용할 수 있도록 하였다. Many academic libraries and insritutions are needed to help their users discover high quality information on the Internet in a quick and effective way. Researchers and academics do not always have the time, skills to surf the Internet for resources that could support their work. As Internet publishing and communication become more commonplace this could disadvantage some researchers as they will miss valuable information resources. Therefore, in the Europe and America, there are a number of different models for setting up and running gateways among academic societies. The technology behind these gateways vary considerable by academic subjects. However quality information gateways all have key similarities that make them invaluable resources to their respective user communities. In the traditional information environment human intermediaries, such as publishers and librarians, futer and process information so that users can search catalogues and indexes of organised knowledge as opposed to raw data and disparate information. On the same principle, subject gateways employ subject experts and information professionals to select, classify and catalogue Internet resources to aid search and retrieval for their users. A description of each resource is provided to help academics assess its orgin, content and nature, enabling them to decide if it is worth investigating further. This study is to introduce the role of information gateway, and importance of quality information on the web, and suggest the ideal Korean model for organizing the quality information resources after analysing the model sites which are developed already in the western academic societies. Informarion Gateways are getting a well established feature on the Internet for academics.

서울 서남부지역 노인 인구에서 비만증 유병률과 고지혈증과의 상관성

최경묵,조영직,김경오,김동림,김난희,백세현,안정천,서홍석,오동주,최동섭 대한노인병학회 2000 Annals of geriatric medicine and research Vol.4 No.3

The Effects of Continuation-Maintenance Electroconvulsive Therapy on Reducing Hospital Re-Admissions in Patients with Treatment- Resistant Schizophrenia

Kyung Mook Choi,Soo-Hee Choi,Jung Kyung Hong,Mi Hyun Lee,Joon Hyung Jung,Sang Hoon Oh,Dong Chung Jung,Sung Nyun Kim 대한정신약물학회 2018 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.16 No.3

Objective: Continuation-maintenance electroconvulsive therapy (C/M-ECT) is used to prevent relapse or recurrence in patients with severe mental illnesses. We aimed to investigate the effect of C/M-ECT on reducing hospital re-admissions in patients with treatment-resistant schizophrenia. Methods: We applied a mirror-image design by retrospectively examining re-hospitalization rates of 18 patients with schizophrenia spectrum disorders. We compared the numbers of psychiatric admissions during the actual period over which C/M-ECT was administered with the same period prior to the beginning of C/M-ECT. Results: The number of psychiatric admissions was reduced significantly during C/M-ECT (0.33±0.77) compared with that of the same period prior to C/M-ECT (2.67±1.33) (Wilcoxon signed rank Z=−3.663; p<0.001). Conclusion: This finding shows that C/M-ECT augmentation could successfully reduce the re-hospitalization rates in patients with treatment-resistant schizophrenia.

서울 남서부 지역 남자 노인 인구에서 음주 , 흡연과 혈압 및 혈중 지질 농도와의 연관성

최경묵(Kyung Mook Choi),김경오(Kyung Oh Kim),조영직(Young Jik Cho),김동림(Dong Rim Kim),김난희(Nan Hee Kim),박이병(Ie Byung Park),백세현(Sei Hyun Baik),최동섭(Dong Seop Choi) 대한내과학회 2001 대한내과학회지 Vol.60 No.6

N/A Background : It is known that the effects of cigarette smoking and alcohol consumption on cardiovascular disease are very diverse. We investigated the effects of cigarette smoking and alcohol consumption on cardiovascular risk factors such as hypertension and dyslipidemia in male elderly living in Seoul, Korea. Methods : We examined the relationship of smoking and alcohol consumption to cardiovascular risk factors in 236 Korean men aged over 60 years in the community-based cross-sectional study from August 1999 to October 1999. Results : Alcohol users had higher systolic blood pressure, HDL cholesterol and lower LDL cholesterol, total cholesterol compared with non-users. After adjustment with age, body mass index and amount of smoking, partial correlation analysis showed that amount of alcohol consumption positively correlated with systolic blood pressure (r=0.1479, p<0.05) and negatively correlated with LDL cholesterol (r=0.2704, p<0.01) and total cholesterol (r=0.1800, p<0.05). But smokers didn't show any difference of body mass index, blood pressure, and lipid profile compared with non-smokers. Conclusion : In Korean male elderly, alcohol consumption was associated with increased systolic blood pressure. Also alcohol consumption was confirmed to be associated with decreased LDL cholesterol and total cholesterol, which might have a protective effect on coronary heart disease. We couldn't find the correlation between blood pressure, lipid profile and cigarette smoking.(Korean J Med 60:521-528, 2001)

단말용 저사양 저복잡도 고효율 비디오 코딩 인코더 구현

오경묵(Kyung-Mook Oh),김영조(Young-jo Kim),김재석(Jae-Seok Kim) 대한전자공학회 2015 대한전자공학회 학술대회 Vol.2015 No.6

Colloids Produced by Simple Self-Assembly of Inorganic Tennis Balls and Nonrigid Polypyridyl Ligands

Oh, Kyung-Eun,Lee, Han-Young,Kim, Ki-Hyun,Kim, Youn-Sang,Nam, Won-Woo,Kim, Kwan-Mook Korean Chemical Society 2007 Bulletin of the Korean Chemical Society Vol.28 No.12

Laboratory Investigation of Sexually Transmitted Infections in the Elderly Population of South Korea

Oh, Eun Ju,Kim, Jang Mook,Kim, Jae Kyung The Korean Society for Microbiology and Biotechnol 2022 한국미생물·생명공학회지 Vol.50 No.2

This study analyzed the epidemiological trends of sexually transmitted infections (STIs) according to age and sex among individuals aged 50 years or older in South Korea from September 2018 to December 2020. We found that the positivity rate for Gardnerella vaginalis was the highest in the study group, followed by the positivity rate for Ureaplasma parvum (UP). Interestingly, the positivity rates for Mycoplasma hominis and UP were higher in female participants than in male participants. The positivity rate for Treponema pallidum was very low in the female participants. During the study period, the positivity rate for herpes simplex virus 2 increased in the female participants, while the positivity rate for Candida increased in the male participants. These results show that the STI positivity rate varies according to age and sex, and a difference was observed in the average age of positive participants according to the type of STIs. We found a clear pattern of infection in the elderly population and according to sex. Our findings are expected to be used as baseline data for future research, education, and prevention of STIs in the elderly population.

IL-β의 인슐린 분비 자극효과와 그 과정에 관여하는 인자들

정인경,오승훈,강동묵,정재훈,민용기,이명식,이문규,김광원 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.24 No.4

연구배경: IL­1β는 용량과 노출시간에 따라 인슐린분비에 대해 상반되는 효과를 가지고 있다. IL­1β의 인슐린 분비 억제효과는 제1혁명 당뇨병의 자가면역 기전과 관련되어 잘 알려져 있으나 인슐린 자극효과에 대해서는 아직 명백히 밝혀지지 않았다. 이에 저자 등은 IL­1β의 다양한 농도에 따라 백서의 췌도세포에서 인슐린 분비에 미치는 영향을 살펴보고, 그 기전으로 인슐린 생합성, iNOS의 발현, 칼슘통로의 활성도 변화여부를 알아보고자 하였다. 방법:200∼300g인 수컷 Sprague­Dawley 백서의 췌도를 변형된 Lacy&Kostianovsky's 방법으로 분리한 후 IL­1β의 다양한 농도(0, 0.5, 5, 50, 500pmol/L)에 2, 6, 24시간 노출시켜 췌도세포의 형태, 생존능을 관찰하고 인슐린 분비능 및 췌도세포내 인슐린 함량을 측정하였으며, 전전구 인슐린 mRNA발현, iNOS mRNA발현을 RT­PCR을 통해 확인하였고, 세포의 칼슘 통로 활성도 변화 여부를 측정하였다. 결과:1) IL­1β에 노출되 췌도의 생존능:2시간 노출시는 대조군과 차이가 없었으나, 6시간 고농도군과 24시간 모든 군에서 생존능이 감소되었다. 2)인슐린 분비능은 IL­1β를 2시간 5poml/L이상의 고농도와 6시간 0.5pmol/L 저농도 처리시 대조군에 비해 의미있게 증가하였으나, 6시간과 24시간 5poml/L이상의 고농도에서는 의미있게 인슐린의 분비가 억제 되었다. 3)췌도내 인슐린양의 변화는 IL­1β의 시간과 농도에 따라 배지내의 인슐린 변화와 비슷한 경향을 보였으나 통계학적으로 의미있는 차이는 없었다. 4)전전구인슐린의 mRNA발현은 2시간 50pmol/L이상 고농도의 IL­1β에서 의미있게 증가하였고, 6시간 처리군에서는 의미있는 차이는 없었으나, 24시간에서 IL­1β의 용량의존적으로 억제되었다. 5)iNOS mRNA는 IL­1β 처리 후 2시간부터 발현되기 시작하여, 6시간에 최고에 달한 후 24시간에는 점차 감소하였다. IL­1β의 처리시간과 무관하게 5poml/L이상의 고농도에서 용량에 따라 발현이 증가하였다. 6)칼슘통로 활성도는 IL­1β의 농도나 시간에 따라 유의한 차이가 없었다. 결론: IL­1β는 단시간 고용량이나 장기간 저용량에서 인슐린 분비와 생합성을 증가시키며, 이런 효과는 iNOS나 칼슘 통로 활성도 변화와는 무관한 것으로 생각된다. Background : The inhibitory effort of IL-1β on the insulin secretion has been validated in pathogenesis of type 1 diabetes, but complex results about the stimulatory effect of IL-1β have been reported. The aims of this study are to clarify the effects of IL-1βon insulin secretion of pancreatic islets and to investigate the mechanisms in terms of preproinsulin synthesis, inducible NOS expression, and calcium channel activity. Method : Islets were isolated from male Sprague-Dawley (SD) rat by modified Lacy-Kostianovsky's method. After islets were treated with different concentrations (0, 0.5, 5, 50, 500 pmol/L) and exposure time (2, 6, 24 hours) of IL-1β, morphology, viability, static stimulation of insulin to glucose, insulin content, preproinsulin mRNA expression, iNOS mRNA expression and calcium channel activity were measured. Results : 1) Viability o islets was reduced in high concentrations of long term exposure of IL-1β. 2) Insulin secretion was stimulated in islets treated with 5, 50, and 500 pmol/L of IL-1β for 2 hours. 3) Insulin content was not significantly different regardless of concentration and exposure time of IL-1β. 4) Preproinsulin mRNA expression increased in islets treated with 50, 500 pmol/L of IL-1β for 2 hours. After 24 hours, it decreased in dose dependent manner. 5) iNOS mRNA expression was detectable after 2 hours in the presence of IL-1β, peaks at 6 hour and decreased after 24 hours. It was increased above 5 pmol/L of IL-1β in dose dependent manner. 6) Activities of the voltage-dependent Ca^2+ channels were not different among groups. Conclusion : IL-1β plays a positive role in terms of insulin secretion and insulin synthesis in high concentration of short term or low concentration of long term. These effects of IL-1β might be neither dependent of iNOS pathway nor Ca^2+ channel activity (J Kor Diabetes Asso 431~443, 2000).

영국 문헌정보학계의 발전방향

오경묵,Oh Kyung-Mook 한국문헌정보학회 1999 한국문헌정보학회지 Vol.33 No.2

본 논문은 변화가 요구되는 한국문헌정보학계 및 업계를 위해, 영국에서의 문헌정보학계 동향을 소개한 것이다. 영국문헌정보학계 및 업계의 역사와 그 발전단계, 커리큘럼의 변천 그리고 새로운 정보시장의 출현 및 영향 등에 대한 최근의 움직임을 살펴보았다. 크게 네 가지로 변천추이가 밝혀졌는데 그 내용은 다음과 같다. 첫째로 학과 명칭의 변화가 있다. 둘째, 학과 교과목의 재편성이 일어나고 있다. 셋째, 다른 학과와의 통합현상이 일어나고 있다. 넷째, 정보기술교육이 강조되고 있다. The purpose of this paper is to introduce current trends of library and information science in UK universities, based on their history, developments, curriculum changes and new information market. Since 1980 there were fundamental changes, both in departmental structure and recruitment. The impact of the evolving information markets has meant an introduction of new way of thinking and new methods into the traditional subjects of librarianship and information studies. The review on this topic has found trends in library and information studies departments as follows. - Name changed : many of the changes have been made for pragmatic and financial reasons with professional development. - Restructuring and reorganisation : there were a general move away from a traditional small subject-based departments to broadly based information studies structures. - Mergers with other academic departments: department of library and information studies tended to be put with other technology-based subjects. - Emphasis on information technology based teaching and learning.

Hepatic Lipase C514T Polymorphism and its Relationship with Plasma HDL-C Levels and Coronary Artery Disease in Koreans

Park, Kyung-Woo,Choi, Jin-Ho,Chae, In-Ho,Cho, Hyun-Jai,Oh, Se-Il,Kim, Hyo-Soo,Lee, Myoung-Mook,Park, Young-Bae,Choi, Yun-Shik Korean Society for Biochemistry and Molecular Biol 2003 Journal of biochemistry and molecular biology Vol.36 No.2

Hepatic lipase is a key enzyme that is involved in HDL-C metabolism. The goal of this study was to find out the frequency of the hepatic lipase C514T polymorphism, and evaluate its relationship with plasma HDL-C levels and coronary artery disease (CAD) in Koreans. Two hundred and twenty four subjects with no previous history of lipid-lowering therapy, 118 patients with significant CAD, and 106 controls were examined with respect to their genotypes, lipid profiles, and other risk factors for CAD. The frequency of the -514T allele was 0.37 in men and 0.35 in women, which were higher than the frequency that was reported in Caucasians, but lower than the frequency that was reported in African-Americans. The -514T allele was associated with significantly higher HDL-C levels in women. After controlling for age, gender, BMI, DM, and smoking, the non-CC genotype was significantly associated with HDL-C levels, and explained 6% of the HDL-C variation in this study. When the genotypes-distribution was compared between the CAD and non-CAD patients, the hepatic lipase C-514T polymorphism was not associated with the presence of CAD. Koreans have a higher frequency of the hepatic lipase gene 514T allele than Caucasians, and the -514T allele is associated with higher plasma HDL-C levels in Korean women, and perhaps non-smoking men. However, our data does not suggest an association between the polymorphism and an increased risk of CAD.