전위된 관절내 종골 골절의 수술적 치료 후 방사선학적 계측치와 임상 결과와의 관계

손홍문,임만택,문현식 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.3

Objectives: The purpose of our study was to evaluate the relationship between radiographic parameters and clinical results after operative treatment of the displaced intra-articular calcaneal fractures. Materials and Methods: We analyzed 35 patients of unilateral displaced intraarticular calcaneal fractures who had been treated by operative treatment. At the last follow up, we measured the radiographic parameters including Bohler angle, Gissane angle, heel height, calcaneal length, talocalcaneal angle, talar declination angle, and subtalar incongruity between normal and affected site. Clinical results were measured by Creighton-Nebraska Health Foundation Assessment Score (CNH). And then the correlation between the radiographic parameters and the clinical results were analysed by Pearson correlation method. Results: The average difference between normal and affected site were Bohler angle 15˚ (0-35), Gissan angle 6.5˚(0-20), heel height 4.7mm (1-12), calcaneal length 2.0mm (0-7), talocalcaneal angle 5.5˚(1-19), talar declination angle 2.2˚(0-8), calcaneal width 4.0mm (1-9), subtalar incongruity 0.54mm (0-2.5). The correlation coefficients between radiographic parameters and CNH score were Bohler angle 0.066 (p=0.75), Gissane angle 0.038 (p=0.829), heel height 0.019 (p=0.916), calcaneal length 0.091 (p=0.386), talocalcaneal angle 0.059 (p=0.737), talar declination angle 0.118 (p=0.501) , calcaneal width 0.250 (p=0.291), and subtalar incongruity 0.784 (p=0.002) respectively. Among the all radiographic parameters, The subtalar incongruity shows strong linear correlation with clinical results. Conclusion: We suggested that the subtalar incongruity was significantly correlated with the' clinical results after operative treatment of the displaced intraarticular calcaneal fractures.

시클로프로판 고리가 없는 피레트린계 농약 Oxime O-Ether의 합성과 Fenvalerate의 합성 연구

강석구,문홍식 성균관대학교 기초과학연구소 1985 論文集 Vol.36 No.1

An Oxime O-ether(Shell's pyrethroid), a pyrethroid insecticide not containing a cyclopropane ring, was synthesized from chlorobenzene and isobutyryl chloride. Friedel-Crafts acylation of chlorobenzene and isobutyryl chloride in the presence of AlCl_3 gave 1-(4-chlorophenyl)-2-methyl-1-propanone. Oximation of the above ketone with NH_2OH·HCl, followed by O-alkylation of the oxime with m-phenoxybenzyl bromide afforded an oxime O-ether. NaBH_4 reduction of 1-(4-chlorophenyl)-2-methyl-1-propanone, followed by bromination with PBr_3 yielded 1-(4-chlorophenyl)-2-methyl-1-propyl bromide, which would be a good intermediate for the synthesis of fenvalerate, a pyrethroid insecticide not containing a cyclopropane ring.

살균제, 페나진-5-옥시드의 합성

강석구,문홍식 成均館大學校 科學技術硏究所 1983 論文集 Vol.34 No.1

Phenazine-5-oxide was industrial1y synthesized by reaction of 2-nitrodiphenylamine with thienyl chloride in the presence of pyridine. 2-Nitrodiphenylamine was obtained by treating aniline with 2-chloronitrobenzene in a nuclophilic aromatic substitution reaction. 아닐린과 2-클로로니트로벤젠을 방향족의 친핵성 치환반응에 의해 2-니트로디페닐아민을 얻은 다음 용매 피리딘 존재하에서 티오닐클로라이드로 고리화시켜서 페나진 -5-옥시드를 공업적으로 합성하였다.

銅鑛山廢水로부터 分離한 구리 耐性菌(P.stutzeri)의 菌體內 구리 蓄積 特性

許鍾秀,曺周植,韓文圭,李洪宰,林永成 경상대학교 환경보전연구소 1994 環境保全硏究所報 Vol.2 No.1

Of the copper-tolerant 215 bacterial strains isolated from polluted river water, wastewater and activated sludges of wastewater treatment plants, or wastewater and soils of the copper mine aera in Gyeongnam province a strain, which showed considerably higher growth rate in the agar plate containing 2000ppm of copper than any other strains, was identified as a Pseudomonas stutzeri or its similar strain when analyzed by taxonomical charicteristics. Optimum pH and temperature for the growth of the P. stutzeri were 7.0 and 30℃ respectively. This strain was resistant to antibiotics, such as ampicillin and tetracycline, and heavy metals, such as lead and chromium. This strain utilized phenol benzen or toluene as a sole carbon source. The rate of copper accumulation in P. stutzeri cell was enhanced at low concentration of Cu in the growth media. The maximum copper absorption by this strain grown in 10ppm of Cu at 3 days after culture was 49%, but in 50ppm and 100ppm of Cu was 38% and 32%, respectively. The optimal temprature and pH for the effective intracellular accumulation of copper were 30℃ and initial pH 8.0 under shaking culture.

구리 耐性菌(Pseudomonas stutzeri)의 菌體內 구리 蓄積機作

許鍾秀,曺周植,韓文圭,李洪宰,林永成 경상대학교 환경보전연구소 1994 環境保全硏究所報 Vol.2 No.1

In order to study the mechanism of the copper accumulation in the cell of copper-tolerant bacterium, Pseudomonas stutzeri, distribution of the copper in the cell were investigated. Approximately 61% of the accumulated copper was distributed on the cell wall and the other 39% portion was in cytoplasm. 78% of the copper in the cell wall fractions was present in the polyphosphate and polysaccharide fractions, but most of copper in the cytoplasm fractions was in protein and nucleic acid. Copper affected the protein synthesis in P. stutzeri. The intracellular protein content was decreased by copper addition, but the soluble protein precipitated by ammonium sulfate(30-75% saturation) was increased as compared to that from the cells grown without copper. Furthermore, in the cells grown with copper, high-molecular-weight soluble protein was increased, compared with the cells grown without copper, but low-molecular -weight soluble protein was decreased. These results indicate that copper inhibited the intracellular protein biosynthesis but enhanced the biosynthesis of the high-molecular-weight soluble protein precipitated by ammonium sulfate(30-75% saturation).

플라즈마 이온주입기에서의 시변환 쉬스 연구

김곤호,김건우,김영우,최영도,김종식,김상진,한승희,홍문표 漢陽大學校 工學技術硏究所 1998 工學技術論文集 Vol.7 No.1

Abstract- In a plasma source ion implantation, the target is successively biased by negative voltage pulses with an intrinsic finite rise time, resulting in the time-dependent sheath formation around the target. Measurement of time-dependent sheath during the pulse rise show the ion matrix sheath development which is in proportion to square root of time and pulse rise rate over plasma density but independent of the ion mass.

항정신병약물 사용 중인 정신분열병 환자에서 올란자판으로의 교체 방법에 관한 연구(II) : Comparison of Safety 안전성 비교

안용민,권용실,권준수,민성호,박두병,양문정,소형석,송종호,신윤식,우행원,유범희,이홍석,정한용,한창환,김용식 大韓神經精神醫學會 2002 신경정신의학 Vol.41 No.5

연구목적: 이 다기관 공동임상연구는 사용 중인 항정신병약물을 ’직접 교체 방법’또는 ’시작-감량 교체 방법’중 한 가지 방법으로 올란자핀으로 교체한 후, 안정성 측면에서 두 교체 방법 간의 비교와 교체후의 변화를 관찰하기 위한 것이다. 방법: 국내 13개 병원의 입원 및 외래에 내원한 환자들 중 ICD-10 지단기준으로 정신분열병에 해당되며, 임상적으로 항정신병약물 교체가 필요한 환자를 대상으로 하였다. 두 가지 교체 방법 중 한 가지를 무작위로 피험자에 적용하였으며, ’직접 교체 방법’에 배정된 경우에는 사용중인 항정신병약물을 일시에 중단하고 10㎎의 올란자핀을 바로 투여하였고, ’시작-감량 교체 방법’에 배정된 경우는 10㎎의 올란자핀 투여하고 2주에 걸쳐서 기존 약물을 감량하여 중단하였다. 올란자핀 사용기간은 총 6주이며, 용량은 5∼20㎎ 범위로 제한하였다. 한정성 평가를 위해서 체중, 생명징후, 자발적인 이상반응 복, 실험실 검사 그리고 Simpson-Angus Scale(SAS), Barnes akathisia rating scale(BARS), Abnormal involuntary movement scale(AIMS). Liverpool University neuroleptic side effect rating scale(LUNSERS)등을 이용하였다. 결과: 총 103명의 정신분열병 환자를 대상으로 하였다. 사용한 올란자핀의 용량, 벤조디아제핀의 병용률, 탈락률과 탈락 사유, 자발적인 이상반응 보고, 생명징후, 실험실 검사 그리고 대부분의 부작용 척도 상에서 임상적으로 의미 있는 차이를 두 교체 방법간에 발견하지 못하였다. 다만 AIMS의 감소는 ’직접 교체 방법’군에서 보다 적었고, 항콜린제의 병용률은 ’시작-감량 교체 방법’군에서 보다 많았다. 기저 상태에서 전체 피험자의 SAS와 BARS 점수는 각각 3.5점과 1.8점이었으며 70% 이상의 피험자가 고프로락틴 혈증을 보였다. 올란자핀으로 교체한 후, SAS, BARS, AIMS 점수의 유의한 감소가 있었으며 고프로락틴 혈증을 보인 피험자 분율도 약 30%이하로 감소하였다. 그러나 교체 방법과 상관없이 올란자핀 교체 후 유의한 체중 증가가 있었다. 결론: 이 연구를 통해 교체 방법에 관계없이 비교적 안전하고 용이하게 올란자핀으로 교체 할 수 있음을 알 수 있었다. 그리고 기존 항정신병약물을 올란자핀으로 교체함으로써 일부 부작용들을 줄일 수 있음을 간접적으로 관찰할 수 있었다. 하지만 이 연구는 여러 제한점과 문제점을 지니고 있기 때문에 보다 체계적인 연구를 통해 검정이 필요하리라 생각된다. Objectives: This multicenter clinical trial involving 13 hospital sites compared the safely of switching to olanzapine between ’direct switching method’ and ’start-tapering switching method’. Method: This study included both inpatients and outpatients who fulfilled the criteria for schizophrenia as defined in the ICD-10, and were in need to be appropriate for switching antipsychotics. Subjects were randomly assigned to one of the two switching methods. For ’direct switching method’group, previous antipsychotics were abruptly discontinued and 10㎎ of olanzapine was administered, and previous antipsychotics was gradually tapered for 2 weeks. Olanzapine was used for 6 weeks and the dose was adjusted within the range of 5-20㎎. The safety of switching to olanzapine was measured with vital sings including body weight, adverse events reported spontaneously, laboratory tests, and various scales such as Simpson-Angus Scale(SAS), Barnes Akathisia Rating Scale(BARS). Abnormal Involuntary Movement Scale(AIMS), and Liverpool University Neuroleptic Side Effect Rating Scale(LUNSERS). Results: 103 patients were switched to olanzapine in this study. The comparison between two switching methods did not show any significant difference in the dosage of olanzapine used, the concomitant use of benzodiazepine, the rate and reasons of drop-out, the adverse events, vital signs, laboratory tests, and most scales for measuring side-effects. However, the decrease in AIMS scores was significantly lower in ’direct switching method’ group, and the concomitant use of anticholinergics was comparatively greater in ’start-tapering switching method’ group. At baseline, SAS and BARS scores were 3.5 and 1.8 points respectively, and more than 70% of the subjects showed hyperprolactinemia. After switching to olanzapine, SAS, BARS, and AIMS scores were significantly decreased and the proportion of the patients with hyperprolactinemia was also decreased to less than 30%. However significant weight gain after the treatment of olanzapine was observed regardless of switching method. Conclusion: This study may suggest that switching to olanzapine can be done with relatively high safety regardless of switching methods and olanzapine can significantly decrease some side-effects induced by other antipsychotics.

염해환경하 철근콘크리트의 철근 부식 및 방식기법 연구

문홍식(Mun, Hong Sik),이상국(Lee, Sang Kuk),송호진(Song, Ho Jin),정영수(Chung, Young Soo) 한국콘크리트학회 2001 한국콘크리트학회 학술대회 논문집 Vol.2001 No.5

Bacillus 균이 생산하는 구성효소로서의 이눌라아제

홍재식,변시명,엄태붕,손희숙,박문국 한국농화학회 1985 Applied Biological Chemistry (Appl Biol Chem) Vol.28 No.3

Recently, we investigated characteristics of a bacterium which has never been reported as an inulin hydrolyzing microorganism. Several properties of the isolated microorganism were aerobic, rod typed, spore forming and Gram positive. According to the Bergey's manual, this bacterium tentatively appeared to be Bacillum subtilis. This bacterium produced inulase constitutively in the media containing glucose, sucrose or cellulose without inulin as a sole carbon source. Also, inulase activities of the bacterium per unit culture volume showed 1.1 unit/㎖ comparable to 0.9 unit/㎖ of Kluyveromyces fragilis with a relatively short culture time.

액체 이산화탄소 추출법에 의한 생강(Zingiber officinale Roscoe) 의 향기성분

홍재식,김명곤,나문수,정순택 한국농화학회 1992 Applied Biological Chemistry (Appl Biol Chem) Vol.35 No.1

The essential oil of Korean ginger(Zingiber officinale Roscoe) was isolated by liquid carbon dioxide extraction method and fractionated into one hydrocarbon fraction and two oxygenated hydrocarbon fractions by using silica gel column chromatography. The compositions of the resulting oils were investigated by GC and GC-MS spectrometry. Out of 102 identified compounds, 44 were identified by comparing GC retention time and mass spectral data with authentic samples and 58 were tentatively identified according to mass spectral data only. The major compounds of hydrocarhon fraction were zingiberene, β-sesquiphellandrene, γ-bisabolene, γ-cardinene, ar-curcumene, and those of oxygenated hydrocarbon fractions wee geranal, sesquisabinene hydrate, borneol and zingiberenol. The major compounds of ginger oil were zingiberene, citronellol+β-sesquiphellandrene, geranial, γ-bisabolene and ar-curcumene+geranyl acetate, and ginger oil contained higher amounts of sesquiterpene hydrocarbons. The yield of extract was 6.96%.