하중 제어 모델에서의 미사일 유도 법칙 하중 제어에 관한 연구

왕현민(Wang, Hyun-Min),유정봉(You, Jeong-Bong) 한국산학기술학회 2008 한국산학기술학회논문지 Vol.9 No.6

현재 움직이는 물체의 운동을 제어하기 위해 하중이라는 개념의 사용이 시도되고 있다. 하중이라는 제어 개념으로 불확실성으로 인한 비선형성을 포함한 시스템에서 신뢰성 있는 제어값을 찾기 위해 MIN 설계 방법이 제안되었다. 이러한 MIN설계 방법에서는 기존의 선형화 방법에 의한 상태방정식에서의 제어값을 찾는 문제와 달리 비선형 하중 모텔에서 직접 제어 값을 찾는 방식을 보이고 있다. 본 논문에서는 미사일 하중 운동역학과 유도 기하학의 비선 형 역학을 고려한 하중 제어값을 찾는다. 즉 시선각 또는 미사일의 받음각 변화에 따른 진행방향에 대한 미사일의 속 도 조건을 만족하기 위한 제어값과 표적을 따라가기 위한 선회 각도을 위한 제어값을 구한다. 즉 본 논문에서는 미사 일 시스템과 추적 동역학에서 하중 제어값을 구해본다. 이렇게 구해진 하중 제어값으로 유도 제어 법칙을 비선형 시스템에서 직접 쉽게 구할 수 있음을 확인해 보았다. Recently it is tried to use load control for maneuver moving object. MIN design method proposed to solve control problem of nonlinear system using load concept. Min design method shows direct method for finding control value on the load control model. In this paper, is shown load control value for problem of line of sight on missile guidance. The load control value keep given velocity of missile and angle of attack for tracking target.

젊은 성인에서 신체 만족도에 따른 문제해결양식, 대인관계문제와 우울증상과 자살사고와의 관련성

차승민,김태성,강문희,권명진,김정란,왕성근,지익성 대한생물치료정신의학회 2011 생물치료정신의학 Vol.17 No.2

Objectives:The aim of this study was to evaluate that problem solving styles, interpersonal problems, depression and suicidal ideation according to body image satisfaction. Methods:One hundred and nineteen young healthy normal subjects filled out administered the Body Dysmorphic Disorder Examination-Self Report (Korean version of BDDE-SR K-BDDE-SR), Problem Solving Style Scale(Korean version PSS), Korean Inventory of Interpersonal Problem(KIIP), Korean version of the Depression Anxiety Stress Scale(KDASS-21), Korean version of Beck Scale for Suicidal Ideation(Korean version SSI) and Korean version of Reynolds Suicidal Ideation Questionnaire(Korean version SIQ) for a month. Results:Out of the 119 subjects, 39%(N=46) was male and 61%(N=73) was female. In high K-BDDE-SR group (higher than 67), helplessness was significantly higher than low K-BDDE-SR group(lower than 67), and problem-solving confidence, creative style, approach style were significantly lower than low K-BDDE-SR group. Also, Higher level of all KIIP factors in High K-BDDE-SR group was significantly differ than low K-BDDE-SR group. In High K-BDDE-SR group, K-DASS-21, SSI, and SIQ were significantly higher than low K-BDDE-SR group. Using multiple regression analysis contributing variance toward the total factor score of K-BDDE-SR of participants were K-DASS-21 and SIQ. Conclusion:Our results indicates that high tendency of dissatisfied body images have differences in helplessness, problem-solving confidence, approach style, interpersonal problems, depression and suicidal ideation compared to low tendency of dissatisfied body images. It is necessary to study body dysmorphic disorder patients group in the future.

市販 INSIDE-BELT의 接着에 관한 硏究(II) : The Changes of Morphology of Adhesion and Exfoliation and Exfoliation Strength with Wet Cleaning and Dry Cleaning Wet cleaning 및 Dry cleaning에 따른 接着과 剝離形態 및 剝離强度變化를 中心으로

王仁淑,孫旼貞,朴鐘範 慶星大學校 1993 論文集 Vol.14 No.4

In order to investigate the relationship between morphology of adhesion and exfoliation and exfoliation strength with repeated wet cleaning and dry cleaning samples were pressed, and then wet-cleaned and dry-cleaned. The following results were obtained. 1. Irrespective of the associated sample, the exfoliation strength declined with wet cleaning and dry cleaning cycles. This tendency arises much more in the case of dry cleaning than in that of wet cleaning. In the case of the first wet cleaning and ironing, however, exfoliation strength was greater rather than that of initial because of ideal adhesion. 2. The exfoliation morphology associted with inside-belt B₁and B₂exhibited pattern(B) which was breaking of interface of resin and face cloth and resin break.. In the case of samples combined with inside-belt B₃and B₄,it appeared to be a different exfoliation pattern according to nature of face cloth. Hence samples combined with face cloth F₁and F₂exhibited pattern(A) which was a breaking of interface of resin and face cloth. Especially in the case of samples combined with face cloth F₃,pattern(B) as well as pattern(D) which were a mixed type of pattern(B) and breaking of inside-belt bundle appeared.

市販 INSIDE-BELT의 接着에 관한 硏究(Ⅰ) : Wet cleaning 및 Dry cleaning에 따른 物性變化를 中心으로 The Changes of Properties with Wet cleaning and Dry cleaning

王仁淑,孫旼貞,朴鐘範 慶星大學校 1992 論文集 Vol.13 No.3

In order to investigate the such properties as shrinkage, stiffness, crease recovery, elastic recovery and exfoliation strengh with repeated wet cleaning and dry cleaning samples were pressed, and then wet-cleaned and dry-cleaned. The following results were obtained. 1. The shrinkage that influence outward apperance and dimensional stability was more stable in dry cleaning than wet cleaning and it increased with repeated wet cleaning and dry cleaning cycles. moreover the shrinkage of associated samples relied on those of inside-belts. 2. The stiffness of the associated samples were found to be proportional to that of the outer face cloth and decreased with repeated wet-cleaning and dry cleaning cycle. this decline tendency was more severe in the dry cleaning than wet cleaning. 3. The crease recovery and elastic recovery of elongation increased gradually as the repeated wet cleaning and dry cleaning increased.

Ex Vivo Live Full-Thickness Porcine Skin Model as a Versatile In Vitro Testing Method for Skin Barrier Research

( Jee-hyun Hwang ),( Haengdueng Jeong ),( Nahyun Lee ),( Sumin Hur ),( Nakyum Lee ),( Jeong Jun Han ),( Hye Won Jang ),( Wang Keun Choi ),( Ki Taek Nam ),( Kyung-min Lim ) 한국피부장벽학회 2021 한국피부장벽학회지 Vol.23 No.2

Since the European Union (EU) announced their animal testing ban in 2013, all animal experiments related to cosmetics have been prohibited. Here, we investigated whether an ex vivo live porcine skin model can be employed to study the safety and skin barrier-improving effects of hydroxyacids widely used in cosmetics for keratolytic peels. Glycolic acid (1-10%), salicylic acid (0.2-2%), and lactobionic acid (1.2-12%) were used as representative substances for α-hydroxyacid (AHA), β-hydroxyacid (BHA), and polyhydroxyacid (PHA), respectively. When hydroxyacids were applied at high concentrations on the porcine skin every other day for 6 days, tissue viability was reduced to 50-80%, suggesting that the toxicity of cosmetic ingredients can be evaluated with this model. Based on tissue viability, the treatment scheme was changed to a single exposure for 20 min. The protective effects of a single exposure of hydroxyacids on skin barrier function were evaluated by examining rhodamine permeability and epidermal structural components of barrier function using immunohistochemistry (IHC) and immunofluorescence (IF) staining. Lactobionic acid (PHAs) improved skin barrier function most compared to other AHAs and BHAs. Most importantly, trans-epidermal water loss (TEWL), an important functional marker of skin barrier function, could be measured with this model, which confirmed the significant skin barrier-protective effects of PHAs. Collectively, we demonstrated that the ex vivo live full-thickness porcine skin model can be an excellent alternative to animal experiments for skin studies on the safety and efficacy of cosmetic ingredients. Funding: This study was funded by the Health Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (Grant no. HP20C0061).

다발성 간종괴의 형태로 나타난 특발성 과호산구 증후군 치험1예

최승오,연규민,이승민,김순제,왕준호,박형석,이재동,진춘조,이창훈,신현준,김정은 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-

Hypereosinophilic syndrome is characterized by persistent blood eosinophilia of 1,500/ul or more in the absence of known causes and multiorgan dysfunction by eosinophil-related tissue damage. In Korea, some cases of hypereosinophilic syndrome with hepatic involvement have been described with prolonged benign clinical courses. Most of them were diffuse or multifocal lesions in imaging studies, and a few case presenting as a single mass has been described. Here we report a case of hypereosinophilic syndrome with hepatic involvement in a 65-year-old man who presented with multifocal mass lesions. By abdominal US and CT scan, multiple, ill-defined nodules were detected in throughout the liver. Liver biopsy revealed severe eosinophilic hepatitis, suggestive of hypereosinophilic syndrome. Hepatic mass lesions improved after steroid administration for several weeks.

전단자극 시 나트륨-칼슐 교환체 활성에 의한 횡방향 심방 근세포 Ca2+ 웨이브의 발생

김준철, 왕준, 손민정, 김경희, 우선희 충남대학교 약학대학 의약품개발연구소 2017 藥學論文集 Vol.32 No.-

In the present study, we investigated possible mechanism for the triggered global CaH wave from local Ca2+ wave in atrial myocytes under shear stress. Shear stress was applied onto single cells isolated from rat atria and two-dimensional confocal Ca2+ imaging was performed to measure Ca2+ signal. Shear stress of 16 dyn/cm2 induced local Ca2+ wave, which was followed by a rapid transverse global Ca2+ wave inhibition of Na + -ci+ exchange using KB-R7943 suppressed the occurrence of rapid transverse wave ob served under shear stress, but not the shear-induced local wave. in the presence of this chemical local wave was developed to global wave under shear stress which results in slower time to peak of peripheral and central CaH transients. As the preceding local Ca"+ wave signal was higher, the latency of the occurrence of transverse global wave was shorter, suggesting Ca2+ dependence of transverse Ca2+ wave. The results sug-gest that shear stress may activate Na+ -Ca2+ exchange via local CaZ+ wave, triggering the rapid global Ca2+ wave

Aerobic exercise training enhances cell proliferation and reduces IL-2 and IL-6 cytokine production in spleen of high fat diet-induced obese mice

( Hee Geun Park ),( Deog Jo Jung ),( Jun Hyun Jeong ),( Jong Kui Jun ),( A Ram Yoon ),( Young Ran Lee ),( Kyung Eun Min ),( Myung Hwa Kim ),( Kwang Moo Lee ),( Wang Lok Lee ) 한국운동영양학회 2013 Physical Activity and Nutrition (Phys Act Nutr) Vol.17 No.1

This study investigated the effect of aerobic exercise training on immune cell proliferation and inflammatory cytokine production in the spleen of high fat diet-induced obese mice. C57B1J6 male mice (4 weeks aged. n20) were fed a high fat diet (45% fat) for 5 weeks so that obesity was led intentionally. Then, these obese mice were divided into 2 groups: control group (CON. n10) or exercise group (EXE, n=l0). EXE performed treadmill running for 30-60 min/day at 10-22 m/min, 0% grade, five times per week for 8 weeks. After 13 weeks, all the splenocyte was collected and Con A (Concanvalin A 10 ㎍/ml) was used to stimulate the cell proliferation. MTS and BIOPLEX assay were used for cell proliferation and cytokine production. Independent t-test was used and a p-value under 0.05 was considered as statistically significant. In the results, body weight, IL-2 and IL-6 production were significantly reduced and Splenocyte proliferation was significantly increased after 8 weeks of exercise training. These findings suggest that aerobic exercise training has a positive effect for improving the obese-induced immune dysfunction.

Development of Self-microemulsifying Drug Delivery System for Enhancing the Bioavailability of Atorvastatin

( Shun Ji Jin ),( Won Kyung Cho ),( Hee Jun Park ),( Kwang Ho Cha ),( Jun Sung Park ),( Ja Seong Koo ),( Hun Sik Wang ),( Jeong Soo Kim ),( Min Soo Kim ),( Sung Joo Hwang ) 한국약제학회 2011 Journal of Pharmaceutical Investigation Vol.41 No.2

The objective of the study was to prepare self-microeulsifying drug delivery system (SMEDDS) incorporating atorvastatin calcium and evaluate its properties and oral bioavailability. Solubility of atorvastatin in various vehicles was determined. Pseudo-ternary phase diagrams were constructed to identify the good self-emulsification region. The droplet size distributions of the resultant emulsions were determined by dynamic light scattering measurement. The mean droplet size of chosen formulation (20% ethyl oleate, 40% tween-80, 40% Carbitol(R)) was 23.4±1.3 nm. The SMEDDS incorporating atorvastatin calcium appeared to be associated with better performance in dissolution and pharmacokinetic studies, compared with raw atorvastatin calcium. In dissolution test, the release percentage of atorvastatin from SMEDDS mixture could rapidly reach more than 95% within 3 min. Oral AUC0→8(hr)values in SD rats was 1994±335 ng·hr/mL, which significantly increased (P<0.05) compared with raw atorvastatin calcium. The SMEDDS formulation was relatively stable when stored at 4˚C during 3 months. Our studies illustrated the potential use of SMEDDS for the delivery of hydrophobic compounds, such as atorvastatin, by the oral route.

Mitochondrial Genome-based Phylogenetic Positioning of Hesperiidae in Lepidoptera with the Description of Newly Sequenced Five Skippers

Min Jee Kim,Ah Rha Wang,Jeong Sun Park,Heon Cheon Jeong,Iksoo Kim 한국응용곤충학회 2013 한국응용곤충학회 학술대회논문집 Vol.2013 No.04

Lepidoptera is one of the largest insect orders, but the phylogenetic relationships within this order, have yet to be completely described. One of the unresolved relationships includes the monophyly of Papilionoidea in relationship with the monotypic superfamily Hesperioidea. We newly sequenced five hesperid mitochondrial genomes (mitogenomes), representing four subfamilies: Pyrginae (Daimio tethys and Lobocla bifasciatus), Coeliadinae (Choaspes benjaminii), and Hesperiinae (Potanthus flavus), and Heteropterinae (Carterocephalus silvicola). Along with these newly sequenced hesperid genomes phylogenetic analysis was conducted with all available lepidopteran mitogenomes including three reported species of Hesperiidae that consisted of ~70 species in ten lepidopteran superfamilies. The test for the effect of optimization schemes, such as exclusion and inclusion of third codon position of 13 PCGs, other genes (22 tRNAs and two rRNAs), and with and without partitions also was performed. Majority of datasets consistently placed the monophyletic Hesperiidae the sister to ((Pieridae + Lycaenidae) + Nymphalidae), placing another true butterfly family Papilionidae as the basal lineage of this group, presenting the relationships (Papilionidae + (Hesperiidae + ((Pieridae + Lycaenidae) + Nymphalidae))). Consistent to previous result, Pyraloidea was placed as the sister to ((Bombycoidea + Geometroidea) + Noctuoidea), placing the Macrolepidoptera as non-monophyletic group.