혈액투석실 간호사의 비판적 사고성향과 임상의사결정능력이 환자안전역량에 미치는 영향

서미란(Mi-ran Seo),정경희(Kyung-Hee Chung) 인문사회과학기술융합학회 2018 예술인문사회융합멀티미디어논문지 Vol.8 No.8

This descriptive research is to provide preliminary data for the development of a nursing service program that ensures the safety of hemodialysis patients by identifying the effects of nurses’ critical thinking disposition and clinical decision making ability on the patient safety competence. The research participants were recruited through convenience sampling. The survey was conducted on 202 nurses who had worked for three months or longer in a hemodialysis unit. Critical thinking disposition was measured using the instrument to measure critical thinking disposition developed by Yun Jin (2004), and clinical decision making ability was measured using the Korean version of the Clinical Decision Making in Nursing Scale (Jenkins, 1985), which was translated and revised by Baek Mi-kyung (2005). The instrument to measure patient safety competence in this study is the one developed by Lee Nam-ju (2012) and then revised and supplemented by Jang Hae-na (2012) for clinical nurses. In summary, Consequently, education programs tailored for nurses according to their years of experience and position need to be developed and implemented. In addition, policies related to patient safety accidents should be prepared and continuous education should be provided for nurses working at a hemodialysis unit. 본 연구는 서술적 조사연구로 혈액투석실에 근무하는 간호사의 비판적 사고성향과 임상의사결정능력이 환자안전에 미치는 영향을 확인하여 혈액투석환자의 안전간호를 위한 서비스 프로그램 개발의 기초자료를 제공하기 위해 수행되었다. 연구대상은 혈액투석실 근무경력 3개월 이상의 간호사 202명이며, 구조화된 설문지를 이용하여 자료를 수집하였다. 연구도구는 윤진(2004)이 개발한 비판적 사고성향 측정도구, Jenkins(1985)가 개발한 The Clinical Decision Making in Nursing Scale을 백미경이(2005)이 수정한 임상의사결정능력 측정도구, 이남주(2012)가 개발한 환자안전역량 측정도구를 장해나(2013)가 수정한 도구를 사용하였다. 연구결과 혈액투석환자의 안전간호 실현을 위해 간호사의 비판적 사고성향과 임상의사결정 능력이 주요한 영향요인임을 확인하였으므로 직급별 맞춤형 교육프로그램을 개발하여 적용하고, 환자안전을 위한 정책을 마련하여 지속적으로 환자, 보호자 및 간호사에 대한 교육이 필요할 것으로 사료되었다.

소아에서 성장호르몬 결핍증 진단을 위한 혈중 IGF-1과 IGFBP-3의 절단값

손미란,안영선,정우영,유병철 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Background : It is essential to have reference criteria for the diagnosis of growth hormone deficiency in children. The objective of study was to decide the cut-off value for Insulin-like Growth Factor-Ⅰ(IGF-Ⅰ) and Insulin-like Growth Factor Binding Protein-3(IGFBP-3) for diagnosis of growth hormone deficiency. Methods : We studied the serum level of IGF-Ⅰ and IGFBP-3 in 231 subjects(131 boys and 100 girls) with idiopathic short stature(ISS) and 37 subjects(23 boys and 14 girls) with complete or partial growth hormone deficiency(GHD). IGF-Ⅰ were measured by radioimmunoassay(RIA) method and IGFBP-3 were measured by immnoradiometric assay(IRMA) method. We conducted chi-square test, Fisher's exact test, student t-test, receiver operating characteristic(ROC) curve and discriminant anaylsis using MedCalc and SPSS Program. Results : The ROC curves showed that the best IGF-Ⅰ and IGFBP-3 cut-off value. Cut-off value of serum IGF-Ⅰ concentration was 346ng/mL(sensitivity 86.49%, specificity 85.71%) and of serum IGFBP-3 concentration was 3196ng/mL(sensitivity 81.82%, specificity 81.66%). If discriminant value (Z=0.442+0.661×IGF-Ⅰ+0.469×IGFBP-3) was below -1.47, the subject is discriminated GHD respectively. Conclusion : Our study results support that the measurement of serum IGF-Ⅰ and IGFBP-3 concentration might be an essential supplementary tools in the diagnostic evaluation of children with GHD.

Q 열에 의한 감염성 심내막염 2예

문수연,최영실,박미연,이정아,정미경,정혜숙,정두련,송재훈,백경란 대한감염학회 2009 감염과 화학요법 Vol.41 No.3

Q fever is a zoonosis caused by Coxiella burnetii, Presenting as acute and chronic illness and it has been reported worldwide. Acute Q fever is usually asymptomatic or mild and self-limiting, but infective endocarditis is one of the most serious complications of chronic Q fever and can be fatal. Known risk factors for Q fever endocarditis are valvular heart disease, immunocompromised hosts, and pregnancy. There have been some reports on Q fever in Korea but there exists no report on Q fever endocarditis. We have experienced 2 cases of Q fever with underlying valvular heart disease; both Patients came to the hospital for evaluation of prolonged fever. Although Q fever and Q fever endocarditis are rare in Korea, Q fever endocarditis should be considered in the differential diagnosis of patient with infective endocarditis when causative microorganism cannot be identified.

일부 부인과 양성 질환자의 지방조직 및 혈청의 PCBs와 DDE 농도

박성균,이강숙,노영만,구정완,민선영,한진구,고원경,김미란,정재근,이종승,김진홍 大韓産業醫學會 2000 대한직업환경의학회지 Vol.12 No.1

목적 : 본 연구는 지방조직과 혈청의 PCBs와 DDE 농도를 측정하고, 이에 영향을 미치는 것으로 알려진 요인들과의 관련성을 평가하고자 하였다. 방법 : 유방암, 자궁내막증 등 유기염소계 화합물의 영향이 있는 것으로 알려진 호르몬 관련 질병을 제외한 부인과 환자 52명을 대상으로 지방조직과 혈청을 분석하였으며, 설문조사를 통하여 연령, 교육수준, 직업, 비만도, 흡연과 음주, 출산력, 수유력등을 조사하였다. 지방조직과 혈청의 PCBs와 DDE 농도는 가스크로마토그래피를 사용하여 측정하였다. 결과 : 지방조직의 경우, 13개 PCBs congeners 농도의 합은 중앙값이 48.29 ng/g, 기하평균값이 56.78 ng/g이었고, DDE 농도는 중앙값이 142.89ng/g, 기하평균값이 117.06 ng/g이었으며, 혈청의 경우는 PCBs congeners 농도의 합은 중앙값이 4.67 ㎍/L, 기하평균값이 4.85 ㎍/L이었고, DDE 농도는 중앙값이 1.75 ㎍/L, 기하평균값이 2.09 ㎍/L로 나타났다. 지방조직과 혈청의 DDE 농도 사이는 높은 상관성을 보였으나(r²=0.310, p=0,0002), PCBs는 상관성이 약한 것으로 나타났다(r²=0.029, p=0.2582). 영향요인을 범주화한 후 로그변환 시킨 지방조직과 혈청의 PCBs, DDE 평균의 차이를 분석한 결과, 지방조직의 DDE만이 출산자녀수(p=0.015), 초산연령 (p=0.014), 비만지수(p=0.035)와 연관성이 발견되었다 다중회귀분석의 결과 지방조직의 DDE는 출산자녀수가 적을수록, 초산연령이 늦을수록 증가하는 경향을 보였다. 결론 : 출산자녀수와 초산연령, 비만도가 지방조직의 DDE와 관련성을 보였으며, 또한 유기염소계 화합물의 장기간의 노출에 의한 영향을 평가하는데 있어서 혈청보다 지방조직이 더 유용한 생물지표임을 알 수 있었다. Objectives : This study was purposed to determine the levels of PCBs and DDE in adipose tissue and serum and to evaluate the relations with factors affecting these levels. Methods : We analyzed adipose tissues and sera from 52 gynecologic benign disease patients aged 27-78 years, except hormonal diseases such as breast cancer and endometriosis. We also surveyed age, education, occupation, body mass index (BMI), smoking, drinking, number of children, and duration of breastfeeding by questionnaires. Tissue and serum levels of PCBs and DDE were measured using gas chromatography. Results : The median and geometric mean levels of PCBs were 48.29 ng/g, 56.78 ng/g for adipose tissue and 4.67 ㎍/L, 4.85 ㎍/L for serum, and those of DDE were 142.89 ng/g, 117.06 ng/g for adipose tissue and 1.75 ㎍/L, 2.09 ㎍/L for serum, respectively. Adipose tissue and serum levels for DDE showed high correlation (r²=0.310, p=0.0002), but those of PCBs didn't (r²=0.029, p=0.2582). In analyses of the differences of the means of log transformed adipose tissue and serum PCBs and DDE levels for groups of potential covariates, only adipose tissue DDE levels were significantly associated with number of children (p=0.015), age at first birth (p=0.074) and BMI (p=0.035). In multiple regression analysis, adipose tissue DDE levels were significantly increased with decreasing number of children and increasing age at first birth. Conclusions : This study suggested that parity and adiposity were associated with levels of DDE in adipose tissue, and adipose tissue is a better biomarker than serum for evaluating the long-term exposure of organochlorines.

Mito-Tempo Can Protect Against the Allergic Airway Inflammation through Reducing Mitochondrial ROS Generation

( So Ri Kim ),( Yong Chul Lee ),( Dong Im Kim ),( Yang Keun Rhee ),( Heung Bum Lee ),( Seoung Ju Park ),( Chi Ryang Chung ),( Seung Yong Park ),( Mi Ran Kang ) 대한결핵 및 호흡기학회 2012 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.114 No.-

Oxidative stress is well known to be implicated in the development of asthma. The mitochondrial respiratory chain is a major site of intracellular reactive oxygen species (ROS) generation and, at the same time, an important target for the damaging effects of ROS. Mito-Tempo is a specific mitochondrial ROS inhibitor and it is known to be associated with opening of mi-tochondrial permeability transition pore and inhibition of cell necroptosis or apoptosis. However, there is little information on the protective effects of Mito-Tempo on the inflammatory airway disorders including bronchial asthma and its acute exacerbation. We investigate the effects of Mito-tempo on the allergic airway inflammation and hyperresponsiveness using the mice sensitized with OVA and LPS and then challenged with OVA (OVALPS-OVA mice). The OVALPS-OVA mice showed the typical features of neutrophilic asthma; increased airway inflammatory cells, the pathologic changes, the increased levels of Th2 cytokines in lungs of OVALPS-OVA mice, increased mitochondrial ROS generation, and increased bronchial hyperresponsiveness. Interestingly, we found that in OVALPS-OVA mice, Mito-Tempo, a novel mitochondrial targeting agent significantly reduced the increases in inflammatory cytokines, mitochondrial ROS generation, airway inflammation, and bron-chial hyperresponsiveness. These findings indicate that mitochondrial dysfunction including oxidative damage may be im-plicated in the pathogenesis of bronchial asthma and provide the therapeutic potential of a mitochondrial targeting agent, Mito-Tempo, for bronchial asthma.

Bioactive Functional Water Determined on Cell Fate

Mi-Ran Ki,Eun-Joo Lee,Kyung-Ku Kang,Eun-Mi Lee,Myung-Jin Chung,Ji-Yoon Son,Sul-Gi Jeon,Sun Young Park,Kyu-Shik Jeong 대한지질학회 2018 대한지질학회 학술대회 Vol.2018 No.10

국화 꽃 휘발성 향기성분의 식중독균에 대한 항균 작용

장미란 ( Mi Ran Jang ),서지은 ( Ji Eun Seo ),이제혁 ( Je Hyuk Lee ),정미숙 ( Mi Sook Chung ),김건희 ( Gun Hee Kim ) 한국식품영양학회 2010 韓國食品營養學會誌 Vol.23 No.2

The aim of this study was to investigate antibacterial activities of essential oil from C. morifolium against four Gram-positive bacteria and six Gram-negative bacteria. The antibacterial activity of the oils was determined by agar-well diffusion assay, minimum inhibitory concentration(MIC), and minimum bactericidal concentration(MBC). Essential oil of C. morifolium had a large inhibition zones especially against Salmonella enterica(21 mm) and Bacillus cereus(l9 mm). Essential oil of C. morifolium generally show4 higher antibacterial activity against Gm-positive bacteria than Gram-negative bacteria. MIC of essential oil from C. morifolium was 5㎕/㎖ against ten food-borne pathogens. MBC values were determined to be from 5 to 20㎕㎖ against eight bacteria except Salmonella choleraesuis and Listeria monocytogenes. Therefore, the essential oil of C. morifolium and its components have a potent antibacterial activity against food-borne pathogens, and is expected to be used as a novel food preservative.

딥러닝 기반 손글씨 인식에 대한 연구

한미란(Mi-ran Han),김세호(Se-ho Kim),이승인(Seung-in Lee),조광희(Kwang-Hee Cho),김근희(Keun-Heui Kim),김종배(Jong-Bae Kim) 한국IT서비스학회 2019 한국IT서비스학회 학술대회 논문집 Vol.2019 No.2

손글씨를 인식하기 위하여 여러 방면의 노력들이 존재하여왔다. 손글씨를 인식하기 위한 예로는 일어 영어 숫자 등등 다양한 방면의 논문들이 존재하고 있다. 다만 어린아이들과 같은 경우는 인식에 대한 어려움이 존재하기에 이러한 것을 극복하기 위하여 우리는 Deep learning 기술을 사용하였다 사용한 기술은 SLR, ANN, CNN 총 3가지 기법을 사용하여 정확도를 측정하였고 그 결과 SLR은 91% 두 개의 층을 더 넣어준 것은 93% CNN은 95%로 가장 높은 성능을 보였다.

Serotypes and antimicrobial susceptibility of Actinobacillus pleuropneumoniae isolated from pigs in Korea

Hyun Mi Kim(Hyun Mi Kim),Bun Seung Jo(Bun Seung Jo),Yu-Ran Lee(Yu-Ran Lee),Chung Hyun Kim(Chung Hyun Kim),Ha-Young Kim(Ha-Young Kim),ByungJae So(ByungJae So),Jong Wan Kim(Jong Wan Kim) 한국예방수의학회 2017 한국예방수의학회 학술대회자료집 Vol.2017 No.-

Genome-scale DNA methylation pattern profiling of human bone marrow mesenchymal stem cells in long-term culture

Choi, Mi Ran,In, Yong-Ho,Park, Jungsun,Park, Taesung,Jung, Kyoung Hwa,Chai, Jin Choul,Chung, Mi Kyung,Lee, Young Seek,Chai, Young Gyu Korean Society for Biochemistry and Molecular Bion 2012 Experimental and molecular medicine Vol.44 No.8

Human bone marrow mesenchymal stem cells (MSCs) expanded in vitro exhibit not only a tendency to lose their proliferative potential, homing ability and telomere length but also genetic or epigenetic modifications, resulting in senescence. We compared differential methylation patterns of genes and miRNAs between early-passage [passage 5 (P5)] and late-passage (P15) cells and estimated the relationship between senescence and DNA methylation patterns. When we examined hypermethylated genes (methylation peak ${\geq}$ 2) at P5 or P15, 2,739 genes, including those related to fructose and mannose metabolism and calcium signaling pathways, and 2,587 genes, including those related to DNA replication, cell cycle and the PPAR signaling pathway, were hypermethylated at P5 and P15, respectively. There was common hypermethylation of 1,205 genes at both P5 and P15. In addition, genes that were hypermethylated at P5 (CPEB1, GMPPA, CDKN1A, TBX2, SMAD9 and MCM2) showed lower mRNA expression than did those hypermethylated at P15, whereas genes that were hypermethylated at P15 (MAML2, FEN1 and CDK4) showed lower mRNA expression than did those that were hypermethylated at P5, demonstrating that hypermethylation at DNA promoter regions inhibited gene expression and that hypomethylation increased gene expression. In the case of hypermethylation on miRNA, 27 miRNAs were hypermethylated at P5, whereas 44 miRNAs were hypermethylated at P15. These results show that hypermethylation increases at genes related to DNA replication, cell cycle and adipogenic differentiation due to long-term culture, which may in part affect MSC senescence.