http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Zhou Jing,Feng Ji,Wu Yong,Dai Hui-Qi,Zhu Guang-Zhi,Chen Pan-Hong,Wang Li-Ming,Lu Guang,Liao Xi-Wen,Lu Pei-Zhi,Su Wen-Jing,Hooi Shing Chuan,Ye Xin-Pin,Shen Han-Ming,Peng Tao,Lu Guo-Dong 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Transarterial chemoembolization (TACE) is the first-line treatment for unresectable intermediate-stage hepatocellular carcinoma (HCC). It is of high clinical significance to explore the synergistic effect of TACE with antiangiogenic inhibitors and the molecular mechanisms involved. This study determined that glucose, but not other analyzed nutrients, offered significant protection against cell death induced by sorafenib, as indicated by glucose deprivation sensitizing cells to sorafenib-induced cell death. Next, this synergistic effect was found to be specific to sorafenib, not to lenvatinib or the chemotherapeutic drugs cisplatin and doxorubicin. Mechanistically, sorafenib-induced mitophagy, as indicated by PINK1 accumulation, increased the phospho-poly-ubiquitination modification, accelerated mitochondrial membrane protein and mitochondrial DNA degradation, and increased the amount of mitochondrion-localized mKeima-Red engulfed by lysosomes. Among several E3 ubiquitin ligases tested, SIAH1 was found to be essential for inducing mitophagy; that is, SIAH1 silencing markedly repressed mitophagy and sensitized cells to sorafenib-induced death. Notably, the combined treatment of glucose restriction and sorafenib abolished ATP generation and mitophagy, which led to a high cell death rate. Oligomycin and antimycin, inhibitors of electron transport chain complexes, mimicked the synergistic effect of sorafenib with glucose restriction to promote cell death mediated via mitophagy inhibition. Finally, inhibition of the glucose transporter by canagliflozin (a clinically available drug used for type-II diabetes) effectively synergized with sorafenib to induce HCC cell death in vitro and to inhibit xenograft tumor growth in vivo. This study demonstrates that simultaneous treatment with sorafenib and glucose restriction is an effective approach to treat HCC, suggesting a promising combination strategy such as transarterial sorafenib-embolization (TASE) for the treatment of unresectable HCC.
The Effects of Multi-minerals on Susceptibility to Lead Toxicity in Rats
Lu, Jing,Zhang, Jun,Zhang, Lili,Cui, Tao,Xie, Guangyun,He, Xiwen The Korean Society of Toxicology Korea Environment 2001 Toxicological Research Vol.17 No.-
Female Wistar rats were randomly divided into 5 groups: Control, received distilled water; Low lead, received 0.5 g/ιlead (as acetate) in drinking water; High lead, received 2.0 g/ιlead; Low lead + Minerals, received 0.5 g/ιlead in drinking water and received minerals (Ca$^{2+}$, 25 mg/kg/day; Fe$^{3+}$, 0.47 mg/ kg/day; Zn$^{2+}$, 0.33 mg/kg/day; Se, 0.83 $\mu\textrm{g}$/kg/day) by gavage; High lead + Minerals, received 2.0 g/ιlead and received the same minerals. Animals exposure to lead was from 10 days before mating till postnatal day 21; and the minerals was administered from the first day of pregnancy and during lactation. No statistical difference was found either in body weights or in blood lead levels between the pups received minerals and those only exposed to lead at the same dose. The developmental and behavioral teratological effects of lead on pups, such as time-lag of eye opening, pinna detachment, fur developing, incisor eruption, ear unfolding, and surface righting were observed in this study; and the minerals decreased the toxicity of lead either in low or in high lead exposure pups. The numbers of step-down were significantly increased in lead exposed animals, and the effect of intervention by the minerals was appeared only in the pups exposed to low lead. The ChAT activity and levels of glutamate and aspartate in hippocampus decreased in treated animals compared to control animals, no effect of intervention by the minerals was found. The results of this study indicate that the applied multi-minerals can alter the outcome of develop-mental lead poisoning in rats.s.s.s.
Jing Lu Liang,장영동,Hyo Chang Cha,이승호,손종근,장현욱,Ji-Eun Eom,권영주 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.3
A new procedure for the preparation of emodin carbaldehyde and citreorosein was described, in which, ω,ω’-dibromomethylemodin triacetate was prepared as a key intermediate by NBSmediated bromination of 1,3,8-triacetylemodin. Reduction of emodin and citreorosein with SnCl2 in a 1:1 mixture of HOAc and HCl afforded the corresponding anthrones in 90% and 92% yield, respectively, while the corresponding 10-desoxyemodin carbaldehyde was prepared by MnO2 oxidation of 10-desoxycitreorosein. 10-Desoxycitreorosein and emodin carbaldehyde showed feasible μ-calpain inhibitory activities with IC50 values of 20.15 and 25.77 M, respectively.
Synthesis of 6-deoxymollugins and their inhibitory activities on tyrosinase
Jing Lu Liang,Umair Javed,이승호,박재규,장영동 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.7
Aseries of 6-deoxymollugins were prepared fivesteps from benzaldehyde and its derivatives via phenylboronicacid-catalyzed chromenylation as a key step. Theirinhibitory activities against tyrosinase from mushroom wereevaluated to show that the parent, methyl 2,2-dimethyl-2Hbenzo[h]chromene-5-carboxylate (9a) showed best andpromising inhibitory activity at IC50 = 18.3 lM.
Jing-Guang Lu,Yingwei Wang,Ming-Rong Yang,Cai-Yun Wang,Jieru Meng,Jiazheng Liu,Zifeng Yang,Kongsong Wu,Li-Ping Bai,Guo-Yuan Zhu,Zhi-Hong Jiang 대한약학회 2022 Archives of Pharmacal Research Vol.45 No.9
(±)-Decumicorine A ( 1 ) and (±)- epi -decumicorine A ( 2 ), two pairs of enantiomeric isoquinoline alkaloids featuring a novel phenylpropanoid-conjugated protoberberine skeleton, were isolated and purifi ed from the rhizomes of Corydalis decumbens . The separation of (±)- 1 and (±)- 2 was achieved by chiral HPLC to produce four optically pure enantiomers. The structures and absolute confi gurations of compounds (−)- 1 , (+)- 1 , (−)- 2 , and (+)- 2 were elucidated by spectroscopic analysis, ECD calculations, and X-ray crystallographic analyses. The two racemates were generated from a Diels-Alder [4 + 2] cycloaddition between jatrorrhizine and ferulic acid in the proposed biosynthetic pathways, which were fully verifi ed by a biomimetic synthesis. Moreover, compound (+)- 1 exhibited an antiviral entry eff ect on SARS-CoV-2 pseudovirus by blocking spike binding to the ACE2 receptor on HEK-293T-ACE2 h host cells.
LU JING HUA,정성임 동북아시아문화학회 2018 동북아 문화연구 Vol.1 No.56
Although Chinese and Korean belong to different language families, Korea is one of the countries in the East Asian Chinese cultural circle, the development of language is deeply influenced by Chinese characters. In Korean vocabulary system, we know that Korean vocabulary is divided into three types: intrinsic words, Chinese characters, and foreign words, while 70% of the total Korean vocabulary are Chinese characters. This paper will focus on the meaning of comparison between Korean Chinese Characters and Chinese words. Furthermore, we will analyze the similarities and differences between Korean Chinese Characters and Chinese words. Finally, the problems in the teaching of Chinese vocabulary to Korean students will be summarized. This paper is divided into four sections. The first section is a comparative analysis of Korean Chinese Characters and Chinese vocabulary. It mainly expounds the similarities and differences between Chinese vocabulary and Korean Chinese Characters. In the second section, combining with the practical experience of the author's teaching work, the application and teaching methods of Chinese teaching to Korean students will be discussed through the methods of classification and comparison. The third section is the conclusion of this paper. Problems existing in the teaching of Korean Chinese words will be summarized. We hope to promote the teaching of Chinese characters, provide practical reference and some help for Chinese learners in Korean. Moreover, for the deep study, we will prepare the paper about Korean Chinese Characters and Chinese Words focusing on the grammar. We hope to promote the teaching of Chinese characters, and provide some help for Chinese learners in Korean.
Jing Nan Lu,이원섭,Arulkumar Nagappan,장승환,최영현,김혜정,김곤섭,류충호,신성철,정진명,홍순찬 대한암예방학회 2015 Journal of cancer prevention Vol.20 No.1
Background:Cisplatin (cis-diaminedichloroplatinum, CDDP) is a widely used chemotherapeutic agent for the treatment of many cancers. However, initial resistance to CDDP is a serious problem in treating these cancers. Vitis coignetiae Pulliat (Meoru in Korea) have shown anti-nuclear factor kappa B and anti-epidermal growth factor receptor activities in cancer cells. Methods:In this study, in order to seeking an approach to increase the anti-cancer effects of CDDP with natural products. Here, we investigated anthocyanins isolated from Vitis coignetiae Pulliat (anthocyanidins isolated from meoru, AIMs) can enhance anti-cancer effects of cisplatin (CDDP) in stomach cancer cells. The cell viability of SNU-1 and SNU-16 cells after treated with AIMs and CDDP wereanalyzed by MTT assay. The expressions of Akt and X-linked inhibitor of apoptosis protein (XIAP) proteins were examined by western blot in AIMs- and CDDP-treated cells. Results:We found that AIMs enhanced anticancer effects of CDDP, which activity was additive but not synergistic. AIMs suppressed Akt activity of the cancer cells activated by CDDP. AIMs also suppressed in XIAP an anti-apoptotic protein. Conclusions:This study suggests that the anthocyanins isolated from fruits of Vitis coignetiae Pulliat enhanced anti-cancer effects of CDDP by inhibiting Akt activity activated by CDDP.
Lu, Jing Nan,Lee, Won Sup,Yun, Jeong Won,Kim, Min Jeong,Kim, Hye Jung,Kim, Dong Chul,Jeong, Jae-Hoon,Choi, Yung Hyun,Kim, Gon-Sup,Ryu, Chung Ho,Shin, Sung Chul Hindawi Publishing Corporation 2013 Evidence-based Complementary and Alternative Medic Vol.2013 No.-
<P>Recently we have demonstrated that anthocyanins from fruits of <I>Vitis coignetiae</I> Pulliat (AIMs) have anticancer effects. Here, we investigate the effects of AIMs on cell proliferation and invasion as well as epithelial-mesenchymal transition (EMT) which have been linked to cancer metastasis in human uterine cervical cancer HeLa cells. AIMs inhibited the invasion of HeLa cells in a dose-dependent manner. AIMs inhibited MMP-9 expression in a dose-dependent manner. AIMs inhibited the motility of HeLa cells in a wound healing test. AIMs still suppressed NF-<I><I>κ</I></I>B activation induced by TNF. AIMs also inhibited EMT in HeLa cells. AIMs suppressed vimentin, N-cadherin, and <I>β</I>-catenin expression and induced E-cadherin. AIMs also suppressed expression of <I>β</I>-catenin and Snail, which was regulated by GSK-3. These effects of AIMs were also limited in the HeLa cells treated with TNF. In conclusion, this study indicates that AIMs have anticancer effects by suppressing NF-<I><I>κ</I></I>B-regulated genes and EMT, which relates to suppression of I<I><I>κ</I></I>B<I><I>α</I></I> phosphorylation and GSK-3 activity, respectively. However, the effects of AIMs were attenuated in the TNF-high condition.</P>