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한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고
최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1
The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.
랫드에서 인체 재조합 적혈구 조혈인자, rHuEPO의 13주 정맥투여 아만성독성에 관한 연구
김형식,곽승준,천선아,박현선,한하수,임소영,안미영,김원배,김병문,안병옥,홍성렬,이병무 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1
A recombinant human erythropoietin (rHuEPO) was administered intravenously at dosage levels of 0, 100, 500, and 2500 IU/㎏/day for a period of 13 weeks. There were no observed clinical signs and deaths related to treatment in all groups tested. Decreases in body weight gain and food consumption were observed only in males of 2,500 IU/㎏ group after 2 weeks. In hematological parameters, erythrocyte content, hematocrit values and hemoglobin concentration were dose-dependently increased in rHuEPO treated groups. The ratio between kidney weight and whole body weight was significantly increased in females of 500 and 2,500 IU/㎏ groups. The spleen weight was also increased in both sexes of 500 and 2,500 IU/㎏ groups. However, the absolute weight change of other organs was not observed. In histopathological examinations, the renal tubular basophilia was observed only in males and females of 2,500 IU/㎏ groups. From these results, it is concluded that the no-observed adverse effect level(NOAEL) of rHuEPO is 100 IU/㎏ in rats in the present study.
Yun Kyeong Seon,Moon Bong-Goon,Park Miae,Kim Seong-Ju,Shin Yunmi,Cho Sun Mi,Noh Jai Sung,Lim Ki-Young,Chung Young-Ki,Son Sang Joon,Roh Hyun Woong,Hong Chang Hyung 대한신경정신의학회 2020 PSYCHIATRY INVESTIGATION Vol.17 No.5
Objective Early detection and proper management of mental illness can help to prevent severe deterioration. However, with limited financial and human resources of community mental health services, it is not practical to carry out all conventional screening tools simultaneously. In this study, we aimed to develop and validate a brief but comprehensive screening questionnaire for four common mental illnesses of the elderly. Methods The brief screening for four mental illnesses of elderly (BS4MI-elderly) is a 14-item binary response questionnaire that covers dementia, depressive disorder, sleep disorder, and hwa-byung. To test validity, we compared conventional scale scores for three groups of participants classified using the BS4MI-elderly. The sensitivity, specificity, predictive value of positive test, likelihood ratio of positive test and internal consistency of the BS4MI-elderly were assessed. Finally, a correlation analysis between the BS4MI-elderly and general mental health scales was conducted. Results A total of 254 participants aged over 65 years were recruited. The BS4MI-elderly showed moderate to high sensitivity for the test that distinguishes the normal group from the risk and disorder groups (dementia: 0.61, depressive disorder: 0.88, sleep disorder: 0.85, hwa-byung: 0.94) and high specificity for the test that distinguishes the disorder group from the normal and risk groups (dementia: 0.91, depressive disorder: 0.93, hwa-byung: 0.84, sleep disorder: 0.84). The BS4MI-elderly also exhibited good internal consistency and significant correlations with general mental health scales. Conclusion The BS4MI-elderly, a brief but comprehensive screening tool, could be a useful instrument for screening the elderly in community mental health services.
Lim, Hyun-Chang,Nam, Ok Hyung,Kim, Mi-joo,El-Fiqi, Ahmed,Yun, Hyung-Mun,Lee, Yoo-Mi,Jin, Guang-Zhen,Lee, Hae-Hyoung,Kim, Hae-Won,Kim, Eun-Cheol DOVE MEDICAL PRESS 2016 INTERNATIONAL JOURNAL OF NANOMEDICINE Vol.11 No.-
<P>Therapeutically relevant design of scaffolds is of special importance in the repair and regeneration of tissues including dentin and pulp. Here we exploit nanofiber matrices that incorporate bioactive glass nanoparticles (BGNs) and deliver the odontogenic drug dexamethasone (DEX) to stimulate the odontogenic differentiation of human dental pulp cells (HDPCs). DEX molecules were first loaded onto the BGN, and then the DEX-BGN complex was incorporated within the biopolymer nanofiber matrix through electrospinning. The release of DEX continued over a month, showing a slow releasing profile. HDPCs cultured on the DEX-releasing BGN matrices were viable, proliferating well up to 14 days. The odontogenic differentiation, as assessed by alkaline phosphatase activity, mRNA expression of genes, and mineralization, was significantly stimulated on the matrices incorporating BGN and further on those releasing DEX. The DEX-releasing BGN matrices highly upregulated the expression of the integrin subsets α1, α5, and β3 as well as integrin downstream signaling molecules, including focal adhesion kinase (FAK), Paxillin, and RhoA, and activated bone morphogenetic protein mRNA and phosphorylation of Smad1/5/8. Furthermore, the DEX-releasing BGN-matrices stimulated Akt and mammalian target of rapamycin (mTOR), which was proven by the inhibition study. Collectively, the designed therapeutic nanofiber matrices that incorporate BGN and deliver DEX were demonstrated to promote odontogenesis of HDPCs, and the integrins, bone morphogenetic protein, and mTOR signaling pathways are proposed to be the possible molecular mechanisms. While further in vivo studies are still needed, the DEX-releasing bioactive scaffolds are considered as a potential therapeutic nanomatrix for regenerative endodontics and tissue engineering.</P>
Hyung Mi Lim,Joonho Yun,Mikyung Hyun,Yeomyoung Yoon,Dong Jin Lee,Sang Ok Jeong,Seung-Ho Lee,Chin Myung Whang 한양대학교 세라믹연구소 2009 Journal of Ceramic Processing Research Vol.10 No.4
Magnesium hydroxide as a halogen-free flame retardant attracts increasing attention due to environmental regulations and its unique physical properties such as non-toxicity and smoke suppressant ability during combustion. Low-density polyethylene/ethylene vinyl acetate(LDPE/EVA) blends are one of the polyolefins of which the flame retardance is enhanced by compositions containing magnesium hydroxide. Natural magnesium hydroxide flame retardant is available from the mineral brucite by the adjusting size distribution and surface treatment. A synthetic magnesium hydroxide is usually prepared by precipitation and hydrothermal treatment from magnesium salts or hydrolysis of MgO mineral(periclase). Natural and synthetic magnesium hydroxide have been prepared and mixed with LDPE/EVA by melt compounding. The dependence of the particle size and purity of the magnesium hydroxide and various additives for the synergistic effect on the flame retardance of LDPE/EVA has been studied through combustion tests of the polymer composites. The combustion behavior has been tested by limited oxygen index tests and the vertical burning tests of UL-94. Magnesium hydroxide as a halogen-free flame retardant attracts increasing attention due to environmental regulations and its unique physical properties such as non-toxicity and smoke suppressant ability during combustion. Low-density polyethylene/ethylene vinyl acetate(LDPE/EVA) blends are one of the polyolefins of which the flame retardance is enhanced by compositions containing magnesium hydroxide. Natural magnesium hydroxide flame retardant is available from the mineral brucite by the adjusting size distribution and surface treatment. A synthetic magnesium hydroxide is usually prepared by precipitation and hydrothermal treatment from magnesium salts or hydrolysis of MgO mineral(periclase). Natural and synthetic magnesium hydroxide have been prepared and mixed with LDPE/EVA by melt compounding. The dependence of the particle size and purity of the magnesium hydroxide and various additives for the synergistic effect on the flame retardance of LDPE/EVA has been studied through combustion tests of the polymer composites. The combustion behavior has been tested by limited oxygen index tests and the vertical burning tests of UL-94.
공업용 물유리를 출발물질로 한 흡수용 제올라이트 제조 공정 연구
임형미 ( Hyung Mi Lim ),정상진 ( Sang Jin Jung ),안병길 ( Byeng Gil Ahn ),최병현 ( Byung Hyun Choi ),이명영 ( Myung Young Lee ) 한국공업화학회 2003 공업화학 Vol.14 No.1
본 연구는 공업용 물유리와 액상 알루민산나트룸을 출발물질로 하여, A형 제올라이트를 합성할 때 합성 변수에 따른 결정형과 그 특성에 대한 것으로, 출발물질의 몰비, 반응온도, 숙성 조건, 결정화 조건 및 가열 속도에 따른 생성물의 결정형, 결정화도, 입자 형성, 입도, 양이온 교환능, 흡습량의 변화를 관찰하였다. 일반적으로는 숙성한 조건에서 생성된 입자가 더 작고 균일한 크기의 입자를 얻었다. 숙성과정을 거치지 않은 경우, 가열속도가 빠르면 경쟁상으로 알려진 소달라이트상이 일부 관찰되기도 한였다. 합성된 제올라이트는 주사전자현미경, X선 분말 회절 및 FT-IR 분광기를 이용해 분석하였다. 실온 고습 조건에서 흡습량을 확인한 결과 A형 제올라이트의 경우 초기 흡습 속도는시간당 0.3~0.4wt%이나 소달라이트는 시간당 0.07wt% 정도로 작고 15일 방치 후 최대 흡습량은 A형 제올라이트의 경우 26wt% 소달라이트는 14wt% 정도이다. In the synthesis of zeolite with industrial water glass and sodium aluminate, the synthesis condition and water adsorption characteristics of zeolite were studied. It was found that type of zeolite, crystallinity, morphology, cation exchange capacity, water adsorption capacity depended on molar ratio of starting material, reaction temperature, aging condition, crystallization condition, and heating rate. In general, aging led to production of zeolite particles with smaller and more uniform in size. Without aging, simultaneous formation of sodalite phase was apparent when the heating rate was fast. The products were analyzed by scanning electron microscopy, X-ray powder diffractometry, and FT-IR spectrometry. The initial water adsorption rate was 0.3~0.4wt%/h and 0.07wt%/h and the maximum water adsorption capacity was 26wt% and 14wt% for NaA and sodalite, respectively, in the humid chamber at room temperature.