Aflatoxin B_1 투여가 急性 肝 病變에 미치는 영향에 對한 病理學的 硏究

장선문,이충식,강대영 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.1

In an attempt of elucidate the pathologic and histochemical changes of aflatoxin B_2-induced hepatie lesions, the present study in male Sprague-Dawley rats was undertaken to evalute the relation between pathologic change of the liver and histochemical changes of several enzymes : alkaline phosphatase, acid phosphatase and succinic dehydrogenase at 3. 9. 24. 48. 72, and 144 hours after single administration of aflatoxin B_1 by gastric tube. The aflatoxin B_1 was dissolved in peanut oil(0.5㎎ aflatoxin B_1 to 0.5ml peanut oil). Grouop of male rats received aflatoxin B_1 1㎎ per ㎏ of body weight, respectively. Control animals were given a similar volume of peanut oil alone. The results on morphologic and histochemical changes were as follows: 1. The necrotic change of liver was mainly periportal, and it became most severe at 24 hours and was more prominent in the large dose group than the small dose group. 2. Biliary ductular cell proliferation started to appear within 72 hours and after became regressed later in the small dose group, but it remained approximately 144 hours after exposure in the large dose group. 3. Electron microscopically, all three groups showed irregular nuclear membrane and nucleolar change characterized by segregation of granular and fibrillar elements. All the group showed cytoplasmie changes such as dilatation of rough endoplasmic reticulum with detached ribosome, hyperplasia of smooth endoplasmic reticulum, increased numbers of lipid droplets and mitochondrial alteration. The above change in the large dose group was more severe than those of the small dose group. 4. In the histochemical study of experimental animals, there was a decrease in the intensity of the staining reaction of alkaline phosphatase and succinic dehydrogenase within 24 hours and a progressive decrease in staining intensity was noted at 144 hours. And then the staining intensity of the acid phosphatase was similar to that shown by the control animal. In summary, the data obtained by present experiments indicate aflatoxin B_1 exerts periportal necrosis of hepatic lobules accompanied by bile ductular cell proliferation, and inhibition of protein synthesis, as jedged by elertron microscopic and histochemical changes.

건축 프로젝트 적정 설계변경 관리를 위한 사례조사

김성욱(Kim Sung-Wook),남혜원(Nam Hye-Won),이종식(Lee Jong-Sik),신창현(Shin Chang-Hyun),전재열(Chun Jae-Youl) 대한건축학회 2009 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.29 No.1(구조계)

Recent design changes in the existing research on the factors and issues of design changes and analysis, responsible for analyzing the relationship, procedural issues, and issues of research that can be active. However, changes in the design of problems are essentially designed to complement the book is for the procedure. Methodology for dealing with design changes in the characteristics of the country and to reflect more realistically, and various design changes and looked at trends in related research. the design Change of this study to examine the domestic status and problems, identify the status of the country about the design changes, and in suggesting the direction to the development of the design changes.

전통주 주박의 항혈전 활성 평가

김미선(Mi-Sun Kim),이예슬(Ye-Seul Lee),김종식(Jong Sik Kim),신우창(Woo-Chang Shin),손호용(Ho-Yong Sohn) 한국생명과학회 2014 생명과학회지 Vol.24 No.8

전통주 주박을 이용한 고부가가치 식품소재 개발을 위해, 상업적 시설에서 생산된 3종 약주(J-B, J-S, J-Y) 및 2종 탁주(J-H, J-W) 주박의 ethanol 추출물 및 열수 추출물을 조제하고 이들의 혈액응고 저해활성, 혈소판 응집저해 활성 및 인간 적혈구 용혈활성을 평가하였다. 5종 주박의 pH는 3.90~4.29로 유사하였으나, brix는 5.0~27.0으로 다양하게 나타났으며, 수분 및 알코올 함량에서도 시료에 따라 1.8배의 차이를 나타내었다. 주박의 색차와 성분은 첨가된 부재료 및 사용누룩에 좌우되었으며, J-W 주박의 경우 수분함량이 80.3%, brix 13, 알코올 함량 1.8%를 함유하여 다른 주박에 비해 다양한 식품제조에 용이하게 이용 가능하리라 판단되었다. Ethanol 추출효율은 J-H, J-W, J-B, J-S, J-Y의 순, 열수 추출효율은 J-S, J-B, J-W, J-H, J-Y의 순으로 높았으며, 총폴리페놀 및 총플라보노이드함량은 ethanol 추출물 중에서는 J-H, 열수 추출물 중에서는 J-Y 주박에서 가장 높았다. 5종 주박의 10종 추출물은 모두 5 mg/ml 농도까지 인간 적혈구에 대한 용혈활성이 나타나지 않았으며, J-B, J-S, J-Y의 약주 주박의 ethanol 추출물에서 유의적인 혈액응고저해 활성이 나타났으며, J-W 탁주 주박의 열수 추출물에서 thrombin 저해 활성과 J-B, J-S 및 J-H 주박 열수 추출물에서 혈액 응고인자 저해활성을 확인하였다. 혈소판 응집저해 활성평가의 경우 J-W 탁주 주박의 ethanol 및 열수 추출물에서만 아스피린에 필적하는 우수한 활성이 확인되었다. 본 연구결과는 다양한 약주 및 탁주 주박이 항혈전 활성을 가지고 있으며, 주박으로부터 항혈전제 개발이 가능함을 제시하고 있다. In this study, ethanol and hot water extracts of lees from Korean traditional wine (J-B, J-S, J-Y, J-H, and J-W) were prepared, and their effects on blood coagulation, platelet aggregation, and hemolysis of human red blood cells (hRBCs) were investigated to develop functional food ingredients from lees. The pH and brix of the lees ranged from 3.90 to 4.29 and 5.0 to 27.0o, respectively, and there was a huge difference in the water and ethanol content among the lees. The nuruk and additives used affected the color and physicochemical properties of lees. The J-W takju made from only rice and traditional nuruk, which has 13o brix and 1.8% of alcohol, has potential as functional food ingredient. With regard to the extraction yields of lees, higher yields were obtained from J-H, which contains different medicinal plants, in ethanol, followed by J-W, J-B, J-S, and J-Y. Higher extraction yields of lees were obtained from J-S in hot water, followed by J-B, J-W, J-H, and J-Y, respectively. The ethanol extract of J-H and the hot water extract of J-Y had the highest contents of total polyphenol and total flavonoids among the lees extracts. The 10 lees extracts did not show hemolysis activity against hRBCs up to 5 mg/ml. In an anticoagulation activity assay, the ethanol extracts of three yakju lees (J-B, J-S, and J-Y) and the hot water extract of J-W inhibited thrombin activity, whereas the hot water extract of J-B, J-S, and J-H inhibited blood coagulation factors. In an antiplatelet aggregation activity assay, only the J-W takju lees showed significant inhibition activity. Our results suggest that lees from traditional wine had high potential as a novel antithrombosis agent.

도장작업시 유해인자들의 노출수준과 작업환경관리실태

이세기,문덕환,이채관,황용식,선병관,손병철,김대환,이창희,김휘동,이채언 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.5

Objectives: For the purpose of preparing the fundamental data and assessing the status of exposure level of chemical substances in painting process. Methods and Materials: The author determined the concentration of organic solvents, lead(Pb), Chromium(Cr), and Toluene-2, 4-diisocyanate(TDI) in air of painting process to 90 industries classified by 15 types of manufacturing industry during a period from Jan. 1st 2001 to Dec. 31st 2001. Results: The results were as follows: 1. The geometric mean level of each chemical substance was 0.1706 ppm for exposure index in organic solvents, 0.0019㎎/㎥ for Pb, 0.0024 ㎎/㎥ for Cr, and 0.0004ppm for TDI, respectively. 2. The exposure level of each chemical substances by type of painting was the highest in dipping and brush painting for organic solvent, in spray-painting for TDI, and in spray gun-painting for Pb and Cr, respectively. 3. The exposure level of each chemical substances by type of local ventilation equipment was higher in enclosed and booth type for organic solvents. Cr, and TDI, and in exterior type for Pb, respectively than those of other types. 4. The exposure level of each chemical substances by type of hazardous material arresting media was higher in using water for organic substances, in using bag filter for Pb, TDI, respectively than those of other types. Conclusion: According to above results, this study suggests that the exposure level by type of industry exceeded the exposure level in wooden furniture and metal furniture manufacturing industry for organic solvents and Pb, respectively.

Gene profile of fibroblasts identify relation of CCL8 with idiopathic pulmonary fibrosis

Lee, Jong-Uk,Cheong, Hyun Sub,Shim, Eun-Young,Bae, Da-Jeong,Chang, Hun Soo,Uh, Soo-Taek,Kim, Young Hoon,Park, Jong-Sook,Lee, Bora,Shin, Hyoung Doo,Park, Choon-Sik BioMed Central 2017 Respiratory research Vol.18 No.-

<P><B>Background</B></P><P>Idiopathic pulmonary fibrosis (IPF) is characterized by the complex interaction of cells involved in chronic inflammation and fibrosis. Global gene expression of a homogenous cell population will identify novel candidate genes.</P><P><B>Methods</B></P><P>Gene expression of fibroblasts derived from lung tissues (8 IPF and 4 controls) was profiled, and ontology and functional pathway were analyzed in the genes exhibiting >2 absolute fold changes with <I>p</I>-values < 0.05. <I>CCL8</I> mRNA and protein levels were quantified using real-time PCR and ELISA. <I>CCL8</I> localization was evaluated by immunofluorescence staining.</P><P><B>Results</B></P><P>One hundred seventy eight genes differentially expressed and 15 genes exhibited >10-fold change. Among them, 13 were novel in relation with IPF. <I>CCL8</I> expression was 22.8-fold higher in IPF fibroblasts. The levels of <I>CCL8</I> mRNA and protein were 3 and 9-fold higher in 14 IPF fibroblasts than those in 10 control fibroblasts by real-time PCR and ELISA (<I>p</I> = 0.022 and <I>p</I> = 0.026, respectively). The <I>CCL8</I> concentrations in BAL fluid was significantly higher in 86 patients with IPF than those in 41 controls, and other interstitial lung diseases including non-specific interstitial pneumonia (<I>n</I> = 22), hypersensitivity pneumonitis (<I>n</I> = 20) and sarcoidosis (<I>n</I> = 19) (<I>p</I> < 0.005, respectively). Cut-off values of 2.29 pg/mL and 0.43 pg/mL possessed 80.2 and 70.7% accuracy for the discrimination of IPF from NC and the other lung diseases, respectively. IPF subjects with <I>CCL8</I> levels >28.61 pg/mL showed shorter survival compared to those with lower levels (<I>p</I> = 0.012). <I>CCL8</I> was expressed by α-SMA-positive cells in the interstitium of IPF.</P><P><B>Conclusions</B></P><P>Transcriptome analysis identified several novel IPF-related genes. Among them, <I>CCL8</I> is a candidate molecule for the differential diagnosis and prediction of survival.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (doi:10.1186/s12931-016-0493-6) contains supplementary material, which is available to authorized users.</P>

家兎의 妊娠에 따른 生殖器官, 血中 性Hormone 및 代謝物質의 變化에 關한 硏究

李揆丞,韓成郁,朴昌植 충남대학교 농업과학연구소 1982 農業技術硏究報告 Vol.9 No.1

The study was conducted to find out the concentrations of sex hormones and the contents of metabolites in serum, and the changes of weights and tissues on ovary, thyroid gland and adrenal gland according to gestation period in rabbit. The results were summarized as follows: 1. The ovary weights were increased significantly with the time elapse after gestation and recovered normally at 5 days after parturition. In the histological changes of ovary, the lutein cells were hypertrophied and the secretory granules were increased actively until 3 weeks after gestation, and then atrophied thereafter. 2. The thyroid gland weights at all observation times were higher than those in control group, and the significance was recognized at 1, 3 and 4 weeks after gestation. The histological features of the secretory epithelium were the hypertrophic and columnar condition stimulating the functional state from 1 week after gestation. 3. The adrenal gland weights in experimental group were recognized significantly at 4 weeks after gestation, but showed higher than those in control group at all observation times. The zona fasciculata and zona reticularis of the gland showed the slight hypertrophic condition, but the zona glomeerulosa and adrenal medulla did not find out any particular changes. 4. The serum concentrations of progesterone and LH reached a peak level at 2 weeks and week after geestation respectively, and rapidly began to decline thereafter. 5. The serum concentrations of estradiol-17β and FSH were riot detected below 20.0 pg/ml and 1.3mIU/ml respectively. 6. The contents of total protein and non-protein nitrogen nitrogen were decreased gradually with the time elapse after gestation, but the significant differences were recognized from 3 weeks. 7. The total lipids were not changed markedly until 3 weeks, but increased significantly at 4 weeks after gestation and at 5 days after parturition. 8. The serum cholesterol tended to be decreased until 3 weeks, but increased at 4 weeks after gestation and at 5 days after parturition. 9. The serum calcium showed. a. continuous decrease during the gestation period, but the significant differences were recognized at 3 and 4 weeks. The serum phosphorus also had a significant decrease at 4 weeks after gestation.

Fluoxetine과 Haloperidol의 병합투여시 정신병리 및 추체외로 증상의 변화

이민수,한창수,김제원,원경식,곽동일,Lee, Min-Soo,Han, Chang-Su,Kim, Jae-Won,Won, Kyung-Sik,Kwak, Dong-Il 대한생물정신의학회 1997 생물정신의학 Vol.4 No.1

본 연구는 정신분열증 환자 38명을 대상으로 하여 haloperidol과 fluoxetine을 8주간 병합투여 하였고, PANSS, CGI, Simpson-Angus 척도를 투여전과 투여후 2, 4, 6, 8주에 시행하여 임상증상 및 추체외로 부작용을 평가하였다. 결과는 다음과 같다. 1) 8주간의 연구기간동안 양성, 음성증상의 유의한 변화가 없었다. 2) 8주의 연구기간동안 추체외로 부작용의 증가가 나타나지 않았다. 이는 기존 연구에서 fluoxetine에 의해 haloperidol의 혈중농도가 증가하여 효과 및 부작용이 증가한다는 연구보고와는 다르며, 이 결과는 haloperidol과 fluoxetine의 병합사용을 안전하게 할 수 있다는 것을 의미한다고 하겠다. Objectives : The authors have intended to know the drug interaction of fluoxetine and haloperidol when coadministering two drugs to the chronic schizophrenics by assessing the changes of positive, negative symptoms and extrapyramidal symptoms. Method : We selected 38 patients, the chronic schizophrenics with no physical problems. they are randomly assigned to placebo group and drug group. And then, placebo or fluoxetine 20mg were administered to the subjects of each group during 8 week period. We have assessed their psychopatholgy and extrapyramidal symptoms using Positive and Negative Syndrome Scale(PANSS), Clinical Global Impression(CGI), Simpson-Angus Scale at 0, 2, 4, 6, 8 week during the period. Results : 38 patients have completed the study during 8 weeks. 1) PANSS, CGI : no significant difference between groups and no significant change according to the times. 2) Simpson-Angus Scale : no significant changes. Conclusion : When co-administering fluoxetine and haloperidol, there were no significant changes of psychopathology and extrapyramidal symptoms. These results suggest that it is safe to coadminister fluoxetine to schizophrenic patients with haloperidol treatmemt.

급성 췌장염으로 발현된 낭성 변화를 이릉킨 종격동 부갑상선 선종 1예

이준호,최영식,박진홍,허갑도,윤설영,최소진,권태헌,이창렬,손성표,박영효 대한내분비학회 1998 Endocrinology and metabolism Vol.13 No.3

Hypercalcemia due to hyperparathyroidism is rarely associated with acute pancreatitis. But, the relationship between hypercalcemia and pancreatitis still remains controvesial. Ectopic parathyroid adenoma with cystic change is one of the rare causes of hyperparathyroidism, and is usually located in neck and mediastinum. We report a case of mediastinal parathyroid adenoma with cystic change associated with acute pancreatitis. A 54-year-old male presented with epigastric pain for 3 days. The serum calcium, phosphate, elastase were 16.8mg/dL, 1.1 mg/dL, 2772.0 ng/mL respectively and his parathyroid hormone level in serum was 651.84 pg/mL. Chest CT showed a mediastinal mass with well defined inhomogenously enhanced density located between SVC and aorta. The patient was diagnosed to hyperparathyroidism with acute pancreatitis due to mediastinal parathyroid adenoma with cystic change, and was surgically removed. The surgical biopsy showed parathyroid adenoma with cystic change. After operation his general condition was improved and serum calcium, phosphate, amylase, lipase level were normalized (J Kor Soc Endocrinol 13:473-479, 1998).

기획논문1- 주제: <주제: 한국무형문화재와 공연문화> : 아리랑유산 가창자의 전승과 공연

이창식 ( Chang Sik Lee ) 한국공연문화학회(구 한국고전희곡학회) 2016 공연문화연구 Vol.0 No.32

구비민요의 여성구연자 곧 여성가창자는 향토적 요소를 의식하지 않지만 향토성을 구연하는 현장의 소리 사설에 자연스럽게 반영하고 있다. 태백아라레이 가창자는 태백방언 어투. 토리와 지역적 요소, 창곡 등을 살려 연행한다. 황지 화전마을 쪽의 여성가창자들이 전통 아라레이를 연행하였다. 철암과 장성 쪽은 탄광지역인 관계로 족보 있는 토박이 노래가 적으며, 경북 북부 봉화 등 외지에서 유입되어 변질된 소리 각편이 남아 있다. 사설이나 창곡에는 정선아라리와 삼척메나리의 요소가 많았다. 현장성으로 볼때 태백아라레이 각편들이 화전민들의 오래된 화전형 아리랑소리인데 강원도 구전민요 중 매우 고형임을 확인하였다. 태백아라레이 정체성을 전승하는 구연자집단은 생업 관련 소리 각편 부르기에 익숙하였다. 이러한 사정을 문화옥,김금수,김효정 3대의 여성가창자들은 아라레이의 과거와 현재, 미래를 통합하여 보여주고 있다. 이들 주도의 태백아라레이보존회는 가창자들의 시연적 공연활동과 전승 계보를 지속적으로 유지하고 있다. 문화옥 가창자는 평안남도 태천에서 출생하여 다섯 살 때 남한으로 내려와 삼척 하장에서 살다가 장성으로 들어와 재문곡에서 살았다고 한다. 6남매를 두고, 평생 농사일로 여생을 보내고 있다. 2015년에도 태백시 문곡동에 거주하며 마을잔치를 비롯해 동네 행사가 있는 날이면 아라레이를 즐겨불렀는데 옛날에는 태백일대 아라레이가 많이 불려졌기 때문에 자연스레배워서 부르게 되었다고 한다. 생업 밀착형의 전형적인 토종 아리랑구연자인 셈이다. 김금수 가창자는 문화옥 딸인데 현재 태백아라레이보존회를 이끌며 태백의 소리(태백아리랑)를 찾아 연구하고 전수, 보급해 오고 있다. 어머니 문화옥의 가창맥락을 잇고 보존회 회원들과 지역민에게 광부아리랑, 태백아라레이 등을 전수하고 있다.박효정 가창자는 문화옥 손녀로서 앞선 할머니,어머니 세대의 장점도 온전히 받아들이고 미래 아리랑콘텐츠도 적절히 대응하고 있어 아리랑공연 차원으로 보아 고무적이다. 3대여성가창자 사례는 아리랑유산의 창조적 계승 국면-원형 보존과 활용 재현국면-에서 전승론 시각에서 주목하였다. Female folk song singers do not necessarily recognize the indigenous elements, which are, however, naturally reflected in the narration in the context. Singers of Taebaek Ararei recognize the dialect, the tone and the song when performing. Traditional Ararei had been performed by singers in the village of slash-and-burn field in Hwangji. Cheolam and Jangseong do not have their own traditional songs sing they are mining regions but had adopted songs from other areas including Gyeonggbuk, which still remain as alternative versions. Many elements of Jeongseon Arari and Samcheok Menari are in the narration and the songs. In terms of the context, alternative versions of Ararei are old Arirang melodies from slash-and-burn fields and were confirmed to be a very old form of oral folk songs in Gangwondo. Female singers of 3 generations, Hwaok Mun, Geumsu Kim and Hyojeong Kim, who keep the tradition and identity of Taebaek Ararei, show the integration of the past, present and future of Ararei. The Ararei Preservation Society continuously organizes singers`` performances and maintains the tradition. The singer Hwaok Mun was born in Taecheon, Pyeongannamdo and moved to south at 5 and lived in Hajang, Samcheok and then moved to Jangseong and lived in Jaemungok. She is a mother of 6 children and has been a farmer for most of her life. She currently resides in Mungokdong and would sing Ararei at village feasts or events. She says she learned the song naturally because Ararei was sung very often in the past around Taebaek area. She is a typical native Arirang singer. The singer Geumsu Kim is a daughter of Hwaok Mun and leads the Taebaek Ararei Preservation Society to study, maintain and introduce the sound of Taebaek(Taebaek Arirang). She introduces Miner Arirang and Taebaek Ararei to the society members and the local residents. The singer Hyojeong Kim is a granddaughter of Hwaok Mun and follows the tradition of her grandmother and mother while adopting more modern Arirang contents.

특집논문 : 아리랑 유산의 세계화와 스토리텔링

이창식 ( Chang Sik Lee ) 국제비교한국학회 2012 비교한국학 Comparative Korean Studies Vol.20 No.2

이 글은 아리랑 원형에 대해 정신소를 고려하여, 저항-상생-대동의 삼재론을 내세웠다. 저항성은 한민족의 천명적 신화론(天)과 관련이 있다. 상생성은 한민족의 숙명적 지역론(地)과 관련이 있다. 대동성은 한민족의 인본론(人)인데, 세계적 열린 마인드다. 이 셋은 아리랑의 잠재가치로 문화콘텐츠의 원형으로 값진 측면이 있다. 한류의 저항적 상상력, 지역기반 감성의 진행형, 치유의 융합원리는 아리랑 유산의 창조적 유전인자라고 정리해 보았다. 이는 현장경험론과 앞선 아리랑 인문론을 통해 얻어낸 결과이다. 스토리텔링의 사례와 창작 방향은 기존 글을 비판하여 아리랑 초장르론을 제기해 보았다. 팩션지향 상상력 스토리텔링, 놀이지향 재미 스토리텔링, 컨버전스지향 치유 스토리텔링이 그것이다. 세부 창작 사례는 아리랑피칭워크샵-생산, 유통, 소비 동시다발의 아리랑포럼-으로 수행되어야 한다고 강조하였다. 아리랑 유산의 세계화 방안을 위한 국책급 아리랑 문화 프로젝트가 수행되어야 한다. 아리랑 유산의 창조성 연구는 아리랑의 융합학문의 방법이 가장 적절하다. 아리랑 유산에 대한 인문융합의 학제적 연구가 먼저 수행되어야 한다. 아리랑 유산의 세계화 기반의 보편적 가치를 심화시켜 가는 방안을 연구해야 한다. 후속 인재로서 이 방면 아리랑 전문가-아리랑학당의 아리랑 유산 스토리텔러-를 집중 육성해야 한다. 체계적인 정책을 통해 아리랑의 활성화를 지속시켜 가야 한다. 아리랑 유산의 원형성을 짚으면서 세계화의 당위성과 현재성, 소통성 등을 강조하였다. 항목별 연구는 아리랑 원형과 아리랑 콘텐츠의 가치창조를 통한 인류문화의 걸작으로 학제간의 융합프로젝트가 시도되어야 한다. 아리랑 문화콘텐츠산업의 확산은 K-팝과 같은 한류의 K-아리랑의 경제력과 감성공유의 코드에 맞춰야 한다. 아리랑 원형은 한류 킬러콘텐츠의 문화상품으로 드러날 것이다. 아리랑 유산의 다양한 국면에 대한 검증과 해석을 바탕으로 생산, 유통, 소비 등 동시다발의 스토리텔링-스토리텔링마케팅을 구축해야 한다. 북한의 집체아리랑 공연 기획과 연출을 참고하되, K-아리랑과 아리랑굿 한류의 감성 스토리텔링 접합이 검토되어야 할 것이다. 자생적인 향토소스(지역의 아리랑자원 활용)와 디아스포라의 한인 향수소스(역사적 아리랑자원 활용)를 통해 이야기 가공과 세계인의 감성 자극 문제를 지속적으로 진단해 나가야 한다. 아울러 아리랑의 세계화 센터 설립을 거듭 제안한다. 한류에 부합하는 스토리텔링을 통해 전문적으로 한류의 성과를 비판하고 아리랑의 감성적 확산을 정립하면서 통섭의 세계화를 되짚어야 할 것이다. 중국에서 아리랑 유산을 국가급 비물질문화유산으로 등재했다고 해서 반대 급부로 감정적 대응으로 추진하는 것은 적절하지 않다. 오히려 아리랑 유산의 매력에 적절한 이야기의 감성DNA 찾기가 시의적절한 대응책이 필요하다고 주장한다. 아리랑 유산의 진정성은 OSMU(One source multi use)에서도 유지되어야 한다. 김구의 민족적 문화주의 실현론이 가능하다. 아리랑 스토리텔링의 창조적 진행형은 한류의 또다른 국면이다. 한류 K-아리랑의 가치창조론은 21세기 대세이다. 다만 보편적 가치 소통 문제는 앞으로의 과제다. 또 역기능의 우려에 대한 반론도 기대된다. 이 글을 통해 향후 아리랑의 문화적 다양한 국면을 쟁점화하여 명실상부한 문화강국으로의 진입을 기대한다. 필자의 관심은 과거의 아리랑 예찬에 있지 않고 오래된 미래 아리랑 활용, 곧 소통의 세계화 프로젝트에 있다. 앞서 제시한 스토리텔링 사례는 인문학자로서 창조 스토리텔러로서 제안에 머물러 있어 분명 한계가 있다. The cultural content of Arirang has been accumulated for many years which provides the base for creating Arirang values in the 21st century. Transformation of Arirang in the cultural content industries is unlimited. The area of Arirang as cultural products has infinite potentials. This study explores the identity and creativity of Arirang using the cluster-method as well as Arirang`s symbolic image and its perspective as fusion-learning. Attempts to create storytelling of Arirang will continue. This requires innovative ideas and an interdisciplinary approach is necessary. In this study, the justifiability, the necessity and the futurity of Arirang`s cultural content were examined. Many cases about the actual procedure of creating stories that are closely related to Arirang`s images, events and factions are presented in depth. Arirang is a fountainhead for various genres such as poetry, fiction, drama, movies, music, dance and art. If this change can be viewed as creation of new genre, this can constitute not only an economic power but also symbolic power of the Korean Wave stemming from the energy of traditional culture. Arirang`s original story as a storytelling source may attract new changes. Arirang`s history has been studied and investigated carefully and the resource has been recycled continuously. However, in spite of Arirang`s wide acceptance, the value of Arirang as a creative genetic resource has not been examined seriously. A blended intellectual research for Arirang and developing new domain of intellectual creation should be accomplished to create values. It is more than finding and understanding the identity of traditional culture. It is actually finding an alternative that suits a trend in this era, where higher value-added business is so much important. The power of Arirang is that, Arirang has targeted responding demanders, and expressions and responses for it has continuously accomplished in every era. Arirang is more than a symbol of Korean culture. It should secure a prestige as a universal cultural heritage. The hunger for creating knowledges of Arirang is sincerely required. Arirang`s values such as multi-communications, principles of creation and laws of transmissions, both originality and universality of Korean culture will be shown in the world. Arirang harmonizes well with 21st century global trend. To raise experts in this area, a well-organized system and supports are required. This includes policies from the government, which cover universality. To Arirang there is heal cultural heritage. The mode of life strategy and commercialization plan with leadership from the Korean wave create harmonizing Arirang heritage. he Arirang research is necessary to achieve all of these potentials.