초등학교 학생에 있어서 환경 소음과 스트레스와의 관련성

강현경,황인철,옥치상,탁효정 고신대학교보건과학연구소 1999 보건과학연구소보 Vol.9 No.-

In order to understande the relationship the fourth grade students' stress and environmental noise, the authors surveyed 421 persons and the sound environment of eleven classrooms and their surroundings of five elementary schools in Pusan area. Both questionnaire and 1/3 octave band noise measuriment were administrated. Each sound level at class room (10-minute recess), corridor, classroom (lesson), playground, and gate was highest mostly at 800Hz, appeared to be 71.70.2 dB, 65.78.7dB, 57.57.9dB, 53.91.2 dB, and 53.52.6 dB respectively. Sound levels at frequencies less than 4,000 Hz were in range of 46.7 dB to 71.7dB, while those over 10,000 Hz were background level of 14.3 dB to 39.6 dB.Noise in corridor was higher than play ground and gate, this fact supports that school buildings seemed to bo little affected on environment sound but the sound proof of most classrooms wall was very poor. In order to grasp how sound affects on stress, multiple regression analysis using backward variable elimination method was conducted, and the resulting equation was as follows(R = 0.186, R2 = 0.035, adjusted R2 = 0.027); Stress = 2.221 + 0.459*(study disturbance due to home noise) + 0/607*(home noise) + 0.227*(sound in lesson).

Grade 2, 4 티타늄 마이크로 임플랜트의 식립 및 제거 토크와 식립 후 조직학적 반응의 비교

강승택,권오원,성재현,경희문,박효상 대한치과교정학회 2006 대한치과교정학회지 Vol.36 No.3

마이크로 임플랜트는 순티타늄과 티타늄 합금을 사용하고 있다. 순티타늄의 경우 grade가 낮을 수록 생체적합성은 증가하나 기계적 성질이 낮다. 이에 본 연구에서는 순티타늄 grade 2와 grade 4를 재료로 한 마이크로 임플랜트를 각각 토끼의 다리뼈에 식립한 후 2, 8, 12주의 시간경과에 따른 조직학적 소견의 차이와 식립, 제거 시의 최대토크의 측정으로 그 티타늄 종류에 따른 차이를 살펴보았다. 토끼의 경골에 식립한 티타늄의 종류에 따른 식립시 및 시간의 경과에 따른 제거시의 토크를 측정하여 다음과 같은 결론을 얻었다. 첫째, grade 2와 grade 4간의 식립 시 최대토크의 차이는 없었다. 둘째, 식립 후 2, 8, 12주 후의 제거 시 최대토크 측정에서 전체 마이크로 임플랜트의 그룹간 차이는 없었다. 셋째, 2주에서 8주로 시간이 경과함에 따라 제거 시 최대토크가 유의하게 증가하였으며 8주와 12주간에는 유의한 상관관계가 없었다. 따라서 유지력은 grade 2 티타늄과 비슷하지만 물리적 성질이 더 단단한 grade 4 티타늄을 마이크로 임플랜트 재료로 사용하는 것이 좋은 것으로 생각된다. The purpose of this study was to evaluate the light microscopic features and the maximum insertional and removal torque value of microimplants, made from titanium grade 2 or 4, in the tibia of 6 rabbits. First, the maximum torque values of microimplants at implantation were measured. After 2, 8, and 12 weeks of healing time, the microimplant-containing segments of tibia of 2 rabbits were removed and the maximum removal torque of each microimplant were measured. Comparisons of histologic examination and insertional and removal torque values were carried out for the two groups of microimplants. Removal torque values were significantly increased in both groups after 8 and 12 weeks as compared to 2 weeks after implantation. Other values measured did not show any statistically significant differences and there were no histological differences between grade 2 and 4 titanium. Based on these results, this study showed that there were no significant differences between grade 2 and 4 titanium. It seems better to use grade 4 titanium for making microimplants because grade 4 titanium is mechanically harder than grade 2 titanium and has similar retention.

柴胡가 Alloxan投與家兎 血淸中 Cholesterol 含量 및 Transaminase 活性度에 미치는 影響

李京燮,姜孝信,鄭址昌 中央醫學社 1975 中央醫學 Vol.29 No.1

The effects of root of the Bupleurum falcatum L. on the serum transaminase (SGP-T, SGO-T) activities and the content of total cholesterol in serum from normal and alloxan-diabetic rabbits were observed. The Bupleuri Radix were extracted with methanol, and the extracted samples were orally administrated to the normal and alloxan-diabetic rabbits. The blood sugar levels, the amount of total cholesterol in serum and the serum transaminase activities of normal rabbits were significantly increased by intravenous administration of the alloxan 80mg/kg. The increased serum transaminase activities of the alloxan-diabetic rabbits were significantly decreased after 96 hours by administration of the extracted sample compared to that of control group. The increased content of total cholesterol in serum of the alloxan-diabetic rabbits were gradually decreased by administration of the extracted samples and returned to the control levels ,after 12 days. According to the above results, it is concluded that the extract of Bupleuri Radix have influence to the recovery of the increased contents of total cholesterol and serum transaminase activities by alloxan.

생합성 플라스틱 Poly-β-Hydroxybutyrate의 생분해와 토양온도의 관계

이효혜미,조강현,조경숙 이화여자대학교 환경문제연구소 1988 이화환경연구 Vol.2 No.-

생분해성 플라스틱인 poly-β-hydroxybutyrate(PHB)의 미생물에 의한 분해에 대하여 2, 10, 20, 30 및 40℃의 항온이 유지되는 토양에서 49일간 배양하면서 조사하였다. 무게 감소로 측정한 poly-β-hydroxybutyrate의 분해속도는 배양 온도가 높을 수록 증가하였다. 배양온도 40℃에서 poly-β-hydroxybutyrate는 하루당 3.5%의 무게감소 속도로 빠르게 분해되었다. 한편 토양에서 poly-β-hydroxybutyrate의 분해는 토양의 pH, 전기전도도와 같은 화학적 특성에는 큰 영향을 미치지 않았다. 그러나 탈수소효소 활성도로 나타낸 토양미생물의 활성도는poly-β-hydroxybutyrate의 분해에 따라서 증가하였다. The microbial degradation of poly-β-hydroxybutyrate(PHB) films was studied in soil microcosms incubated at a constant temperature of 2, 10, 20, 30 and 40℃ for up to 49 days. The degradation rate measured through loss of weight was enhanced by incubation at a higher temperature. At the soil temperature 40℃, poly-β-hydroxybutyrate was rapidly degraded at a decay rate of 3.5% weight loss per day. The degradation of poly-β-hydroxybutyrate did not affected significantly the chemical properties of soils such as pH and electric conductivity. However, microbial activity of soil in terms of dehydrogenase activity was increased by the degradation of poly-β-hydroxybutyrate.

청소년기 여성의 가족폭력 피해에 관한 연구

김경희,권혜진,최미혜,정연강 韓國學校保建學會 1996 韓國學校保健學會誌 Vol.9 No.2

This study is designed to contribute to the intervention of adolescent domestic violence by understanding the experience of the victims, better. The data were coiiected through a series of interviews with 3 subjects singled out at each stage of research. With the permission of the subjects, the interviews were recorded and transcribed. The interviews lasted from two and a half to 8 hours. The data were analyzed in the framework of grounded theory as mapped out by Strauss & Corbin (1990). The major findings of this research are as follows : The core category was found to be the adaptation of "Jitnulim" or "Being suppressed" . The sub-categories identified in the process of grounded data analysis were 'roughness', 'wildness', 'driving', 'challenging', 'being strapped', 'being pressed', 'erupting', 'being horrified', 'being hardened', 'being connected', 'being seen', 'being helpful', being led', 'sprouting', 'being off , 'being cast out', 'shaking off,' getting out', 'covering-up', 'waiting', 'ruling', 'common placeness', 'overcoming', 'getting united', 'fa11ing behind', 'falling in', 'being mixed up', 'ruthlessness', 'estrangement', 'difficulty', 'being overwhelmed', 'feeling regreful', 'being pressed','hesitating', and 'shying off'. These categories were again grouped into 11 categories including 'threatening', 'straightjacketing', 'alliance', 'phenomenon','pattern of support','system of support','challenging','calming-down','being relieved','being hardened and entangled','being entangled'. The following four theses were confirmed on the basis of the reifetitive relation: 1) If the episodes of violence are frequent and serious, with the resulting straightjacketing being stronger the victim's family relations are coherent and the subject's support pattern is highly mature. Concrete the responses to the straighjacketing regulted in a'calming-down' which gradually relieved. 2) If the episodes of violence were frequent and serious, with the resulting straightjacketing being strong the victim's family relations and incoherent and the suhjects supporter is immature but strong the support type is superficial and the responses to the straightjacketing result in a bouncing-off which gets entangled with the passage of time. 3) If the episodes of the violence are frequent and serious, the straighljacketing is strong, but the family relations are and the subject's support system is mature and strong the responses to the straightjacketing result in a calming-down which gets partly relieved but partly entangled. 4) If the episodes of the violence are frequent and serious with the resulting straightiacketing being strong, the victim's family relations are incoherent, the subject's support system is immature, and the support type is immature the responses to the straightjacketing result in a 'bouncing-off' which gets entangled and partly hardened with time.

셀레콕시브 및 그 합성유도체들의 항암활성 스크리닝

박정란,강진형,구효정,노지영,류형철,박상욱,고동현,조일환,이주영,황다니엘,김인경 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.2

Selective COX (cyclooxygenase)-2 inhibitors including celecoxib have been shown to induce apoptosis and cell cycle changes in various tumor cells. New inhibitors are recently being developed as chemomodulating agents. We evaluated celecoxib and screened 150 synthetic compounds for anti-proliferative activities in vitro. Effects of celecoxib on COX activity, cell growth, cell cycle distribution, and apoptosis induction were determined in A549 COX-2 overexpressing human non-small cell lung cancer (NSCLC) cells. The COX inhibition of celecoxib increased with concentration up to 82% at 1μM after 24 hr exposure. Forty μM and 50μM of celecoxib induce G_1 arrest, and TUNEL-positive apoptotic cells, respectively. Among 150 compounds, several compounds were selected for having greater COX-2 inhibitory activity and higher selectivity than celecoxib with growth inhibitory activity. Celecoxib showed concentration-dependent COX inhibitory activity, and ability to induce cell cycle arrest and apoptosis in human NSCLC cells in vitro. Among synthetic analogues screened, several compounds showed promising in vitro activity as COX-2 inhibitory anticancer agents, which warrant further evaluation in vitro and in vivo.

유아 로타바이러스 설사증에 대한 IgY 난황 항체의 효과시험

정동혁, 박효선, 김경미, 정규항, 김강영, 정후길, 윤숭섭, 전호남, 강신영 충북대학교 동물의학연구소 2006 Journal of Biomedical and Translational Research Vol.7 No.2

본문참고

단일 기관에서 경험한 소아청소년기 Kikuchi-Fujimoto병의 임상적 고찰

강희원,김한울,이소영,유경하,김혜순,유은선,최희정,김경효 이화여자대학교 의과학연구소 2018 EMJ (Ewha medical journal) Vol.41 No.4

Objectives: Kikuchi-Fujimoto disease (KFD) is characterized by lymphadenopathy and fever, and is usually self-limited. This study analyzed the clinical characteristics of pediatric patients with KFD. Methods: This retrospective, observational, single-center study was conducted in South Korea from March 2008 to October 2015. KFD was diagnosed based on clinical, radiological or histological findings and excluded when there were any other causes of lymphadenopathy. Medical records were reviewed for clinical and laboratory manifestations. Results: A total of 35 cases were included. The mean patient age was 12.1±2.9 years (range, 5 to 17 years); the male-to-female ratio was 1:0.8. The main clinical manifestations were cervical lymphadenopathy and fever in 34 cases (97%). The mean duration of fever was 12.2±8.3 days (range, 2 to 37 days). We noted enlargement of lymph nodes in the cervical, mesenteric (n=5, 14%), axillary (n=2, 6%), and inguinal (n=1, 3%) regions. Hepatosplenomegaly, loss of appetite, and rash were observed. On laboratory examinations, elevation of ferritin, leukopenia, and positivity for anti-nuclear antibodies were frequently observed. Twelve patients underwent biopsy and 23 cases were diagnosed by radiological findings. The mean duration of hospitalization for all cases was 7.9±2.9 days (range, 3 to 13 days) and steroids were administered in 10 cases. KFD recurrence was observed in 2 cases (5.7%) with the time to relapse of 7 months and 4 years. There were no cases with systemic lupus erythematous or other autoimmune disease. Conclusion: KFD should be considered in pediatric patients with lymphadenopathy and prolonged fever. Patients with KFD should be monitored for recurrence and the development of autoimmune disease.

맹출장애가 있는 하악대구치의 임상적 관리

손우성,이해경,남형진,강상욱,송효경,김성식 부산대학교 병원 암연구소 2009 부산대병원학술지 Vol.- No.25

Inhibitory Effect of Cordycepin on Human Platelet Aggregation

박화진,--,--,--,--,--,-- THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 2004 Journal of biomedical laboratory sciences Vol.10 No.1

Cordycepin separated from Cordyceps militaris is a major physiologic active component in Cordyceps militaris. The platelet aggregation is stimulated by Ca^(2+), which is either mobilized from intracellular endoplasmic reticulum or transported from extracellular space. cGMP antagonizes the actions of Ca^(2+). Based on these facts, we have investigated the effects of cordycepin on the mobilization of Ca^(2+) and the production of cGMP on collagen (10 ㎍/ml)-induced human platelet aggregation. Cordycepin potently stimulated the human platelet aggregation induced by collagen (10 ㎍/ml) in a dose-dependent manner. Cordycepin (500 μM) inhibited also the collagen-induced human platelet aggregation in the presence both 1 mM and 2 mM of CaCl_(2). These are in accord with the results that cordycepin inhibited the Ca^(2+)-influx on collagen-induced human platelet aggregation. These results suggest that cordycepin decrease the intracellular Ca^(2+) concentration to inhibit collagen-induced human platelet aggregation. Besides, cordycepin increased the level of cGMP on collagen-induced human platelet aggregation. This result is related with the decrease of intracellular Ca^(2+) concentration, because cGMP inhibits the mobilization of Ca^(2+). In addition, cordycepin inhibited the human platelet aggregation induced by LY-83583, inhibitor of guanylate cyclase. This result suggested that cordycepin inhibit the platelet aggregation by stimulating the activity of guanylate cyclase. In conclusion, we demonstrated that cordycepin might have the antiplatelet function by inhibiting Ca^(2+)-mobilization via the stimulation of the production of cGMP.