HPLC/FLD를 이용한 성별·연령별 혈장 homocysteine 정상치 조사

이경옥,류광석,이규범,이경옥,류광석,이규범 대한임상검사정도관리학회 1999 臨床檢査와 精度管理 Vol.21 No.1

정신분열병에 대한 Risperidone의 효과 및 안전성에 관하여

신석철,왕성근,지익성,이선우,이규광,이봉희,이진영,황선희,신용재,배경도,김정란 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.1

In order to evaluate the efficacy and safety of risperidone, 10 patients with chronic schizophrenia were examined for 8 weeks in a silgle-open study. After the wash-out period of 1 week, risperidone was administered. Efficacy was evaluated by means of Positive and Negative syndrome Scale for Schizophernia(PANSS) and Clinical Global Impression(CGI). Safety assessment included the Extrapyramidal Symptom Rating Scale(ESRS), vital signs, body weight, ECG, and laboratory tests. The results were as follows 1) On the PANSS total score, there was significant improvement of total score after 1 week (P<.05) of administratiom. 2) On the PANSS positive and negative subscal, there were significant improvement of posotive and negative scores after 2 weeks (P<.05) of administration. 3) On the PANSS general psychopatholgy subscals, there were significant improvement of general psychopathologyscores after 1 week (P<.05) of administratiom. 4) On the CGI, there was significant decreasement of clinical impression of severity of schizophrenia score after 2 week (P<.05) of administration. 5) A statistically significant increase in body weight (P<.05) was observed after 8 weeks of administration. 6) EPS reached the peak at the end of the 1st week of administration of risperidone (11.8± 24.25) but they were easily relieved by addition of benztropine and clonazepam. There was not significant change in laboratory tests, vital sign, ECG after 8 weeks of administration. These results suggest that Risperidone is an effective antipsychotics and clinically safe except for increased body weight in chronic schizophrenia.

화학적 요부 교감신경절 차단에서 한 분절 차단과 두 분절 차단의 비교

김종일,이규종,이상곤,민병우,반종석,문철준 대한마취과학회 2001 Korean Journal of Anesthesiology Vol.41 No.4

Chemical Lumbar Sympathetic Block: Comparison of One- Versus Two-needle Techniques Chul-Jun Mun, M.D., Kyu-Jong Lee, M.D., Sang-Gon Lee, M.D., Jong-Il Kim, M.D.^* Jong-Suk Ban, M.D., and Byung-Woo Min, M.D. Department of Anesthesiology, Fatima Hospital, Daegu, Korea ^*Kim Jong Il Pain Clinic, Daegu, Korea Background: It was frequently noticed in the course of performing a two-needle sympathectomy, that satisfactory spread of contrast solution could be produced by injection through only one of the needles. This led to a closer examination of the merits of single-needle technique. Methods: Forty patients were randomized into two groups. Patients in the single-needle group (n = 20) were injected at the second or third lumbar sympathetic ganglia, while patients in the two-needle group (n = 20) were injected at the second and thired lumbar sympathetic ganglia. Lumbar sympathetic blocks were performed using 3 ml of alcohol and the spread of injectate was verified with C-arm fluoroscopy. The indicators of a successful sympathetic block are increasing skin temperature, decreasing pain, and anhidrosis in the distal extremity. Results: The duration of anhidrosis was 12.2 ?? 2.6 months (mean ?? SD) in the single-needle group versus 13.6 ?? 3.6 months (mean << SD) in the two-needle group. Conclusions: As these results were not significantly different from those obtained in patients having considered to be effective for a neurolytic ;i,bar sympathectomy. (korean J Anesthesiol 2001; 41: 439~443)

유리섬유강화 복합절연재료의 열화특성에 관한 연구

이규철,유근민,김경석,박홍태 울산대학교 1996 공학연구논문집 Vol.27 No.2

본 연구에서는 주위 환경 열화에 따른 복합절연재료의 절연특성과 수명을 향상시키기 위해 고온에서 흡습량을 변화시켰을 때와 탈습량을 변화시켰을 때 흡십시료와 탈습시료의 전기적 특성 및 기계적 특성을 조사하였다. 유리섬유 각층의 흡습상수는 각각 1층에서 0.0117, 2층에서 0.0123, 3층에서 0.0152를 나타냈다. 전기적 특성 및 기계적 특성은 복합재료의 흡습에 따라 크게 떨어졌다. 70℃에서 습기가 완전히 건조되어도 흡습전의 전기적 및 기계적 특성을 얻기가 어려운 것으로 나타났다. 수분에 의해 발생한 복합절연재료내에 존재하는 많은 결함들은 에폭시 메트릭스와 필라사이에 존재하였다. The electrical and mechanical properties of moisture absorbed and moisture desorbed specimens were investigated to improve the insulating characteristics and the reliability of composite materials against environment aging. Moisture absorption constants with the layers of glass fiber showed 0.0117 in 1 layer, 0,0123 in 2 layer and 0.0152 in 3 layer, respectively. Although moisture was removed at 70℃, it was impossible to obtain the initial electrical and mechanical properties. Many defects induced by moisture were observed at the interface between epoxy matrix and filler in composite materials.

양극성 정동장애 및 정신분열증 환자군에서 성별에 따른 TRH 자극검사

이규환,신석호,백인호 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.1

This study was designed to evaluate the hypothalamic-pituitary-thyroid axis abnormalities and the possible influence of gender on the TSH response to TRH in bipolar patients and schizophrenics by using TRH stimulation test. The subjects were consisted of 34 bipolar patients(male : 14, female : 20) and 24 schizophrenics(male : 11, female : 13). The results were as follows ; 1) There was a significant difference in the baseline TSH level of female subjects before TRH administration between bipolar patients and schizophrenics. 2) The TSH levels at 60 and 90 minutes after TRH administration in female bipolar patients were significantly higher from those of female schizophrenics(P〈0.05). 3) In female subjects, the response of TSH level after TRH administration was significantly different between the two groups(P〈0.005).

유사학과 조정 및 교양교과과정개편에 관한 연구

이종범,김규연,전지용,이춘의,홍석주 朝鮮大學校 1995 교과교육연구 Vol.17 No.-

CFRP 복합재 적층판의 파괴메카니즘에 관한 연구

이권범,박환규,홍석주,김기형 조선대학교 동력자원연구소 1996 動力資源硏究所誌 Vol.18 No.1

In this study, when CFRP lamimates are subjected to static loading by the indentation of steel ball to examine a failure mechanism of lamimates, the fracture surface of interlaminar delamination generated at interfaces is investigated by the scanning electron microscopy (SEM). When orthotropic CFRP laimates stacked with two interface are subjected to static loading, interlaminar delaminations extend from the loading side to delamination edge even at any interface, and the fracture surface fo interlaminar delamination generated at two interfaces is symmertrically formed. In the CFRP laminates, the fracture mechanism sppears mainly to be the mixed mode(modes Ⅰ+Ⅱ), and the ratio of mixed mode varies partially. After the fracture initiates at the interface near the loading side with mode Ⅰ, the mixed mode gradually developes, but the total surface at the opposite plane to the loading side fractures with the mixed mode(modes Ⅰ+Ⅱ). While transverse cracks are generated, the direction of shear stresses reverses itself ar the delaminated surface, clarified by the hackle direction of fracture surface.

엔지오텐신이 Norepinephrine의 신혈관 반응에 미치는 영향

이석호,김종규,양훈모,민영기,임한혁 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.2

To determine the effect of angiotensin Ⅱ(ANG Ⅱ)-induced hypertension on the renal hemodynamic response of norepinephrine(NE), mongrel dog instrumented for checking of renal blood flow(RBF) was followed as the step increases every 2 minutes in the rate of norepinephrine infusion into the renal artery during 5 conditions (C : control, C+PD : control+pressure decompression of aorta, ACEI : angiotensin converting enzyme inhibitor, ACEI+ANG Ⅱ : angiotensin converting enzyme inhibitor+ANG Ⅱ, ACEI+ANG Ⅱ+PD : angiotensin converting enzyme inhibitor+ANG Ⅱ+pressure decompression of aorta) Without relation of increase (C, C+PD) or decrease (ACEI+ANG Ⅱ, ACEI+ANG Ⅱ+PD) of the plasma ANG Ⅱ level when NE is infused into vessel, there were no differences in RBF response to NE infusion between C and C+PD and between ACEI+ANG Ⅱ and ACEI+ANG Ⅱ+PD, which implies that renal arterial pressure(RAP) does not play an important role in controling the renal hemodynamic response to NE. When renin angiotensin system was blocked by captopril without adding to ANG Ⅱ supply (ACEI), RBF can be severe decreased to approximately 90% at much lower rates of NE infusion than occurred when the sufficient concentration of ANG Ⅱ were present in the plasma. As the increased sensitivity of NE did not occur at lower renal arterial pressure, when ANGⅡ was present in the plasma in sufficient concentrations, it seems that protective effect on renal function is possible by ANGⅡ during renal sympathetic stimulation.

甲狀腺製劑 投與中의 甲狀腺機能動態

李圭寶,孫惠卿,黃基錫 慶北大學校 醫科大學 1982 慶北醫大誌 Vol.23 No.2

1982年 1月부터 1982年 8月사이에 慶北醫大附屬病院 核醫學科에서 甲狀腺製劑(Comthyroid)를 投與받고 있는 患者中 3∼6個月사이에 甲狀腺機能檢査를 比較觀察할 수 있었던 35例를 檢査한 結果 다음과 같은 所見을 얻었다. RAIU檢査는 甲狀腺製劑 投與前에 比하여 6時間値나 24時間値가 모두 有意하게 正常以下로 低下되었으나, 血中 T_3와 T_4 値는 少數例에서 上昇되어있었으나 全體的으로 別 有意한 上昇은 없었다. 臨床的으로 腺腫의 約半數例에서 縮小效果가 있었으며 藥濟服用으로 因한 副作用은 없었다. 甲狀腺腫의 抑制法으로 投與하는 甲狀腺製劑의 效果는 臨床的으로 甲狀腺 hormone의 生體에 對한 影響이나 副作用은 없이 뇌하수체-甲狀腺軸에만 作用하여 甲狀腺機能抑制 또는 腺腫縮小를 招來할 수 있다고 思料된다. In order to evaluate the effects of thyroid hormone preparation upon the thyroid function, authors investigated comparative thyroid function tests including of RAIU, serum T_3, and T_4 before and after Comthyroid therapy from January to August 1982 in 35 cases of nontoxic goiter. RAIU both in 6 hrs and 24 hrs were significantly decreased during medication, whereas serum T_4 and T_3 showed no appreciable change. There was no case of side reaction from the regimen, however size of goiter seemed regressed more or less in more than half of the cases.

중금속 킬레이트 약의 만성 Cadmium 중독 흰쥐의 간장과 신장에서의 Cadmium 잔류량에 미치는 영향

이석호,서대규,신인철 漢陽大學校 環境科學硏究所 1993 環境科學論文集 Vol.14 No.-

중금속은 다른 물질과는 달리 체내에서는 생성되지도 파괴되지도 않으며 환경오염에 의해 공기, 물, 모양으로 침투되고 음식물에 혼입되기도 한다. 대부분의 중금속은 지질학적, 생물학적인 순환을 통해 자연적으로 재분포되며, 특히 납, 수은 및 cadmium(Cd)등은 과거에는 자연적인 순환이 생물학적인 순환을 능가해 왔지만 근대산업화 사회가 도래하면서 인간활동에 의한 생물학적인 순환이 급속도로 증가하면서 환경오염이 시작되었다. 본 실험은 Cd 투여로 유발되는 실험적 Cd 중독 Sprague-Dawley계 웅성흰쥐에서의 중금속 킬레이트 약 투여가 간장과 신장에서의 Cd 잔류량에 미치는 영향을 관찰하고자 시도하였다. 실험동물은 동일환경하에서 사육된 체중 200∼250mg의 Sprague-Dawley계 웅성흰쥐를 사용하였으며, 실험적 Cd 중독은 CdCl₂ (Signa사)의 1mg/ml의 생리식염수 용액을 사용하여 체중 kg당 1.5mg의 용량을 48시간 간격으로 3회 복강내 주사하여 유발시켰으며 1주일 후부터 72시간 간격으로 10회에 걸쳐 킬레이트 약을 복강내로 주사하였다. 적용한 킬레이트 약과 그 용량은 1,2-diaminocyclohexanetetraacetate(CDTA), disodium calcium ethylenediaminetetraacetate(EDTA), diethylenetriaminepentaacetate(DTPA), , triethylenetetraaminehexaacetate(TTHA), D-penicillamine(DPA), N-acetylpenicillamine(NAPA), 2,3-dimercaptopropanol(BAL), sodium 2,3-dimercaptopropanesulfonate(DMPS), sodium 2,3-dimercaptosuccinate(DMSA) 및 sodium diethyldithiocarbamate(DDTC) 등은 각각 0.1mmol/kg(BAL은 0.1mmol/kg)이다. CDTA, EDTA, DTPA 및 TTHA 등은 CaCl₂ 와 1 : 1 mole 비율이고 실험군은 적용한 킬레이트 약 별로 흰쥐 5마리씩을 배정하였고, 동량의 생리식염수를 주사한 군을 대조군으로 하였다. 킬레이트 약 주사 종료 3일 동물을 단두로 도살하여 개복한 후 간장과 신장을 적출하여 이들을 각각 0.1mg 씩 취하여 1.0ml의 질산과 1.0ml의 과염소산으로 전처리하여 조직추출액을 얻었고 이를 사용하여 polarized zeeman 원자분광흡광기(Atomic absorption spectrophotometer : Model Z-8100, Hitachi, Japan)로 조직내 중금속 잔류량을 flame 법으로 측정하였다. 간장에서의 Cd 잔류량을 DPA, EDTA, NAPA, DCTA, DDTC 및 DMSA 투여군에서 대조군보다 각각 32%, 23%, 19%, 17%, 16% 및 15%씩 감소하였고, 신장에서의 Cd잔류량은 DPA, DDTC, CDTA 및 EDTA 투여군에서 대조군보다 각각 33%, 21%, 18% 및 17% 씩 감소하였으며, 간장과 신장에서의 Cd 잔류량의 합계는 DPA, EDTA, DDTC 및 CDTA투여군 에서 대조군보다 각각 32%, 20%, 18% 및 17%씩 감소하였다. 이상의 결과로 여러가지 킬레이트 약 중 DPA, EDTA, CDTA 및 DDTC 등은 Cd 중독의 치료에 이용될 가능성이 많으나, DTPA, TTHA, BAL 및 DMPS 등은 Cd 중독에 치료에 큰 효과가 없는 것으로 사료된다. 그러나 기존의 실험들과 다른 결과가 나온 DTPA, TTHA, BAL 및 DMPS 등에 대해서는 더욱 깊은 연구가 필요하다고 사료된다. Sprague-Dawley albino male rats weighing 200 to 250gm were used. All animals were loaded with 3 intraperitoneal injections of cadmium chloride(1.5mg/kg) given at 48 hourly interval. Intraperitoneal injection of chelators commenced 1 week after the last loading injection and continued every 72 hour for a total of 10 injections. Chelators were given at a level of lmmol/kg(except, 0.01mmol/kg of BAL). The chelators used in present experiment are 1,2-diaminocyclohexanetetraacetate(DCTA), disodium calcium ethylenediaminetetraacetate(EDTA), diethylenetriaminepentaacetate(DTPA), triethylenetetramine hexaacetate(TTHA), D-penicillamine(DPA), N-acetylpenicilllamine(NAPA), 2,3-dimercaptopropanol(BAL), sodium 2,3-dimercaptopropanesulfonate(DMPS), sodium 2,3-dimercaptosuccinate(DMSA) , sodium diethyldithiocarbamate(DDTC). In order to establish the relative abilities of chelators to mobilized liver and kidney cadmium contents, at the end of the experiment the rats were sacrified and the livers and kidneys were immediately excised. A sample of approximately 0.1mg of tissue was digested in 1.0ml of nitric acid, followed by 1.0ml of perchloric acid, and the cadmium content of the samples was determined by atomic absorption spectrophotometer. The result obtained can be summarized as follow : 1. The residual liver cadmium content was reduced in rats administered DPA. EDTA, NAPA, CDTA, DDTC and DMSA(32%, 23%, 19%, 17%, 16% and 15% respectively)compared to control group. 2. The residual kidney cadmium content was reduced in rats administered DPA, DDTC, CDTA and EDTA(33%. 21%, 18% and 17% respectively) compared to control group. 3. The summation of residual cadmium content in liver and kidney was reduced in rats administered DPA, EDTA, DDTC and CDTA(33%, 20%, 18% and 17% respectively) compared to control group. These results suggested that DPA, EDTA, CDTA and DDTC might have protective role against the toxic effects of cadmium.