C형 간염바이러스항체 검출을 위한3세대 효소면역측정 시약의 비교

이장혁,서순팔,기승정,송정원,신명근,신종희,양동욱,김세종 대한임상병리학회 1997 대한임상병리학회지 Vol.17 No.4

대학 운동부 지도자의 지도경험과 교육적 의미 탐색

김동기(Kim, Dong?Kee) 한국체육과학회 2018 한국체육과학회지 Vol.27 No.1

This study suggested the categorization of the notion, the factors and process of axial coding deducted through grounded approach as a research to verify the instruction experiences and educational significance of survey of university athletic club coaches. As a result of open coding, first, a total of 135 terms, 22 subcategories, and 11 upper categories were suggested. Second, as a result of axial coding, 6 paradigms were composed in the instruction experiences and education significance of university athletic club coaches. As for the casual conditions, university coach life, becoming a coach after retirement, and charm of the job were suggested, and as to the situational context, it was deducted as the relation formation with athletic students. Furthermore, as a central phenomenon, the professional instruction method was shown. In this connection, instruction contents and experiences are suggested as an interventional condition. As for the interaction, such as communications and successful instructors are found as a strategy of interaction. As a result of this process, it was found that athletic club coaches acquire the educational contents know-how and methods applicable for each level for themselves. Third, as selective coding, the outline of a story about the instruction method specialization process of athletic club coaches were performed, and the core categories were discovered in this process. It was understood that through not only improvement of educational contents but also instruction methods and various curricula about the specialization process, the individual “Know-how” of a coach, namely, empirical knowledge is naturally accumulated.

두개골의 3차원 영상 분석을 위한 전산화단층촬영 방법의 비교 : 상층 두께가 3차원 영상의 계측에 미치는 영향

정호걸,김기덕,박혁,김동욱,정해조,김희중,유선국,김용욱,박창서 대한구강악안면방사선학회 2004 Imaging Science in Dentistry Vol.34 No.3

Purpose : To evaluate the quantitative accuracy of three-dimensional (3D) images by means of comparing distance measurements on the 3D images with direct measurements of dry human skull according to slice thickness and scanning modes. Materials and Mathods : An observer directly measured the distance of 21 line items between 12 orthodontic landmarks on the skull surface using a digital vernier caliper and each was repeated five times. The dry human skull was scanned with a Helical CT with various slice thickness (3, 5, 7 mm) and acquisition modes (Conventional and Helical). The same observer measured corresponding distance of the same items on reconstructed 3D images with the internal program of V-works 4.0 (Cybermed Inc., Seoul, Korea). The quantitative accuracy of distance measurements were statistically evaluated with Wilcoxons’ two-sample test. Results : 11 line items in Conventional 3 mm, 8 in Helical 3mm, 11 in Conventional 5 mm, 10 in Helical 5 mm, 5 in Conventional 7 mm and 9 in Helical 7 mm showed no statistically significant difference. Average difference between direct measurements and measurements on 3D CT images was within 2 mm in 19 line items of Conventional 3 mm, 20 of Helical 3 mm, 15 of Conventional 5 mm, 18 of Helical 5 mm, 11 of Conventional 7mm and 16 of Helical 7 mm. Conclusion : Considering image quality and patient’s exposure time, scanning protocol of Helical 5 mm is recommended for 3D image analysis of the skull in CT.

두개외 경동맥 협착증에 대한 스텐트 삽입술의 추적 결과

윤영섭,홍범기,최동훈,김선호,김동익,김승민,장양수,심원흠 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.11

경동맥 스텐스의 조기결과

심원흠,홍범기,최동훈,김선호,김동익,김승민,이도연,장병철 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.1

자유형 수영 경기에서 유형별 킥 동작에 따른 출발구간 기록의 비교

김동기,홍관이 江原大學校 附設 體育科學硏究所 1998 江原大學校附設體育科學硏究所論文集 Vol.- No.22

The purpose of this study was to compare starting section records by kick action of different type on crawl swimming. The results were summarized as follows: (1) For elementary school. male swimmers had no difference of records both Dolphin Kick and Beat Kick. but female swimmers had a little superior on records with Dolphin Kick. It was showed that there was possibility to apply Dolphin Kick (2)For middle school. male swimmers had more superiority with Dolphin Kick than Beat Kick. The frequency of Dolphin Kick is three times enough. Statistically. Dolphin Kick was superiority more or less (3)For high school. male swimmers had more superiority with Dolphin Kick than Beat Kick. Dolphin Kick is five times enough. Female swimmers had also more superiority with Dolphin Kick than Beat Kick

Simvastatin 정제의 생물학적 동등성 연구

김형기,권준택,손동렬,염윤기 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

The bioequivalence of generic simvastatin tablet(Dongsung Pharmaceutical Co.) to the simvastatin tablet(Zocor^(®), MSD Korea Co.) as a reference drug. Single dose of 20 mg simvastatin was administered to 20 healthy male volunteers in a balanced, randomized crossover design with a washout between the two study periods. Blood samples were collected up to 12 hours and plasma concentration of simvastatin was measured by well validated LC-MS/MS. Pharmacokinetic parameters were analyzed by non-compartmental analysis and ANOVA test was used for the statistical analysis of parameters. No statistically significant formulation, period, or sequence effect was encountered. Ninety percent confidence intervals of log transformed C_(max) and AUC_(t) were comprised in the stipulated 0.80-1.25 range. These results suggest that test formulation of simvastatin is bioequivalent with the reference, both formulations in 20 mg tablet.

정신분열증환자에서 Haloperidol과 Reduced Haloperidol 사이의 상호변환에 있어 Haloperidol Reductase에 관한 연구

김민정,정은기,오동열,김이영,양병환 大韓神經精神醫學會 1994 신경정신의학 Vol.33 No.5

Haloperidol is metabolized through reductation by the enzyme haloperidol reductase at the benzylic ketone to form an alcohol metabolite, known as reduced haloperidol. The basic and clinical pharmacology of reduced haloperidol and also haloperidol reductase is the main subject of haloperidol study, as the reduced metabolite can be converted back to the parent drug which has some neuroleptic effect. This study was undertaken to investigate correlations between haloperiol reductase activity in RBC and reduced haloperidol formation, also the difference of haloperidol reductase activity between responding and nonresponding schizophrenic patient. The results were as follows : 1) The haloperidol reductase activity of schizophrenic patients in RBC at 2 weeks was 12.8±4.3ng/30 min/200ul RBC, 16.0±11.9 at 4 weeks and 22.3±71 in control group. There was statistically significant difference of haloperidol reductase activity in RBC between schizophrenic patient and control group at 2 weeks but no difference at 4 weeks. 2) We divided the patient into responding and nonresponding group by the percentage of improvement in total BPRS score as more or less than 31% respectively and there was no significant difference of haloperidol reductase activity in RBC among two groups. 3)) There was no significant relationship between haloperidol dose of administration and haloperidol reductase activity in RBC. Considering the above results, haloperidol reductase activity in schizophrenic patients showed different results according to the duration of drug administration, so the study which deal with the factors, influencing the activity of haloperidol reductase, should be undertaken in the future.

韓國 孝行說話의 硏究

金東箕 충남대학교 문리과대학 어문연구회 1979 語文硏究 Vol.10 No.-

1. Filial piety narratives are based on morality. They are, in the traditional sense, considered the elements of the tales of Confucianism, of Buddhism, and of local customs. In terms of their motifs and types, they are classified as follows: a) self-devotion type. b) self-sacrifice type. c) self-toil type. d) child-abandonment types. e) mourning-service type. f) revenge type. g) allegory type. h) disapproved-filial-piety type. i) aged-abandonment type. j) miscellanous type. 2. In the social context filial piety narratives inspired the people with the social standard of morality which were to preserve a large family under the patriarchy system as the safety device to the conventional society. In the literary context, they had a function to have the minds of tradition realized among the readers, who would participate 'the tree of tradition' and the colorful literary impressions deepened through the diversity of their literary shapes. Thenarratives are therefore, expected to contribute to the reestablishment of our national culture, especially with their literary mechanisms and the materials and principles of the recons ti-tute throughout all the fields of contemporary literature. 3. Most of the protagonists in filial piety narratives are not the characters who yielded to the fates they were faced with, but the really faithful human beings that approved no immorality at all. They had even the superhuman strength to control their desires and to do only goodness, the filial piety.

cis-platin에 의한 급성구토예방의 Dexamethasone의 4가지 정주량의 비교

김원,강지은,서영선,이동민,서정균,신병철,정기영,박유환,정춘해 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.1

B5-hydroxytryptamine _3수용체(5-HT_3) 길항제와 dexamethasone의 동시투여가 cis-platin에 의한 급성 구토를 막는데 가장 효과적이다. 그러나 현재까지 가장 적절한 정주dexamethasone의 용량이 알려져 있지 않았다. 이에 dexamethasone의 4가지 다른 용량을 투여하여 그 효과를 비교하였다. 환자는 임의 추출되어 cis-platin 투여 45분전에 15분 동안 정주로 각각 dexamethasone 5, 10, 15, 20 mg을 투여 받았다. cis-platin 투여 30분전에는 ondansetron 8 mg이 부가하여 정주 되었다. 1999년 3월부터 2000년 2월까지 54명의 환자가 연구에 등록되어졌고 53명의 환자가 연구 대상으로 실험에 4군 (dexamethasone 5 mg 13명, 10 mg 14명, 15 mg 13명, 20 mg 13명)으로 나뉘어 평가 되어졌다. 급성구토와 구역질의 완전한 예방은 dexamethasone 5 mg을 투여 받은 환자에서 각각 69.2%, 60.9%, dexamethasone 10 mg을 투여 환자에서 69.1%, 61%, dexamethasone 15 mg 투여 환자에서 78.5%, 66.9%, dexamethasone 20 mg을 투여 환자에서 83.2%, 71.0%로 나타났다. 구토로부터 완전한 예방은 dexamethasone 20 mg을 투여 환자에서 5, 10 mg을 투여 환자와 비교하여 높았고, dexamethasone 15 mg을 투여 군에 비교하여서는 약간 우수한 효과만 있었다. 구역질으로부터의 완전한 예방도 월등한 것은 아닐지라도 20 mg을 받은 환자에서 높았다. 항 구토 치료는 특별한 불편 없이 조절되었고, 부작용의 발생에서 4가지그룹간에는 커다란 차이가 발견되지 않았다. Dexamethasone의 20 mg 정주양이 cis-platin으로 인한 급성구토를 예방하는데 가장 효과적인 예방량으로 사료되어진다. Background and objective: A 5-hydroxytryptamine _3(5-HT_3) receptor antagonist plus dexamethasone is the most efficacious antiemetic prophylactic treatment for the prevention of cis-platin induced acute emesis, but the optimal intraveous (Ⅳ) dose of dexamethasone is unknown. This prompted us to perform a randomized, double-blind, dose-finding study that compared four different doses of dexamethasone. Materials and Methods: Patients were randomized to receive dexamethasone, either 5, 10, 15, 20 mg, administered by 15-minute Ⅳ infusion 45 minutes before cis-platin. Ondansetron 8 mg was added to dexamethasone and was administered Ⅳ 30 minutes before cis-platin. From March 1999 to February 2000, 54 patients were enrolled onto the study and 53 were assessable according to the intention-to-treat principle (13 patients received 5 mg; 14 patients, 10 mg; 13 patients, 15 mg and 13 patients, 20 mg of dexamethasone). Results: Complete protection from acute vomiting and nausea was achieved by 69.2% and 60.9% of patients, respectively, who received 5 mg of dexamethasone, by 69.1% and 61.0% of those who received 10 mg, by 78.5% and 66.9% of those who received 15 mg, and by 83.2% and 71.0% of those who received 20 mg of dexamethasone. Complete protection from vomiting was significantly superior in patients who received 20 mg compared with those who received 5 and 10 mg of dexamethasone (P<05) and was superior, but not significantly, compared with those who received 15mg. Complete protection from nausea was superior, but not significantly, in patients who received 20 mg of dekamethasone. Multifactorial analysis confirmed these results. Antiemetic treatment was well tolerated, and no significant difference was found among the four groups in the incidence of adverse events. Conclusion: A 20mg single Ⅳ dose of dexamethasone should be considered the most efficacious prophylactic dose for the prevention of ois-platin induced acute amesis in treatment of cancer.