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Southern Blot Hybridization법을 이용한 악성 림프종의 면역유전형에 관한 연구
전호종,기근홍,김윤신,이미숙,이미자,장원재,장숙진,박영진,정춘해,정종훈,양성훈,이광민 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.2
Immunogenotyping using gene rearrangement analysis has emerged as a precise laboratory aid in the diagnosis and classification of malignant Iymphoid neoplasms. The lineage and clonality of the malignant Iymphoid neoplasms can be identified by the demonstration of rearrangements of antigen receptor genes of the immunoglobulin and T-cell receptor genes. The analysis of the gene rearrangements on the malignant Iymphoid neoplasms are also useful as a sensitive unique clonal markers to detect early recurrence in patients with malignant Iymphoid neoplasms after treatment. To analyze the sensitivity and specificity of gene rearrangements in the diagnosis of malignant Iymphoid neoplasms. 24 cases of malignat Iymphoma were examined by Southern blot hybridization using CTβ-T cell receptor β chain gene-DNA probe and JH-immunoglobulin heavy chain gene-DNA probe. The results of the immunogenotypings using Southern blot hybridization disclosed high correlation between the immunophenotyping using immunohistochemical stain with monoclonal antibodies (B-cell Iymphoma 84.2%. T-cell Iymphoma 75% ). The analysis of the gene rearrangement of the angioimmunoblastic lymphadenopathy(AILD) and unclassifiable Iymphoma using immunohistochemical stain could resolve the monoclonality and lineage . Rearranged bands to the CTβDNA probe were observed in one case out of 2 cases of AILD. One case of unclassifiable Iymphoma showed rearranged bands to the CTβ DNA probe. There were no rearrangements in reactive follicular Iymphoid hyperplasia and paracortical Iymphoid hyperplasia. In conclusion, DNA gene rearrangement study should be applied to differentiate the clonality and cell lineage in the malignant Iymphoma with indistinctive immunophenotype.
金洪淑,李鍾春,도병권 淸州敎育大學校 1971 論文集 Vol.7 No.-
The Regional Development Plan for the Mt. Sok-Lee Area emerged in 1970. In that year Mt. Sok-Lee was designated as a National Park by the Ministry of culture and public Information. The development for this region should function on the basis of concrete, scientific and collective academie research. We are trying to the show the best methods for developing this area thru basic research in the following areas: Part1 Geographical terms Part2 Buddist cultural assets Part3 Conclusions concerning necessities, resources, development methods and issues of the Regional Development Plan.
이장준,이현아,최종환,이형,임정근,이상도,박영춘 계명대학교 의과학연구소 2000 계명의대학술지 Vol.19 No.2
Cerebral small vessel disease is the most important cause of lacunar infarction (LI) and intracerebral hemorrhage (ICH). It is generally postulated that, in its early stages, the vascular lesion engenders vessel wall fragility and ICH. But if rupture dose not occur, segmental vessel occlusion evolves, producing LI. It may be a common aging phenomenon that is exacerbated by hypertension and diabetes mellitus. This study was performed to evaluate risk factors of LI and ICH. We reviewed retrospectively the medical records of 690 patients (254 LI, 436 ICH) with stroke who were admitted to Keimyung University Dongsan Medical Center from January 1995 to December 1998. The major risk factors including age, sex, hypertension, diabetes mellitus and several minor risk factors were analyzed in these patients. Older age (p<0.01), male sex(p<0.01), hypertension with treatment(p<0.01), hypertension with long duration(p<0.01) and hypertriglyceridemia(p<0.01), cigarette smoking(p<0.01) were significantly more frequent in LI. Younger age(p<0.01), female sex(p<0.01) and hypertension without treatment(p<0.01), hypertension with short duration(p<0.01) were more frequent in ICH. The prevalence, duration and treatment of diabetes mellitus were not different between these two groups. This study show that the age, sex, treatment of hypertension, duration of hypertension and cigarette smoking seem to be significant risk factors between LI and ICH.
이종춘 東國專門大學 1995 金龜論叢 Vol.2 No.1
여성에 대한 복지적인 측면을 별도로 하더라도 개발이 가져온 사회변화 가운데 여성이 왜 그리고 어떠한 영향을 받는가라는 것에 대한 논의가 일기 시작한 것은 80년대가 되면서 부터였다. 그리고 특정 사회에 있어서 남성과 여성과의 구별을 지탱하고 있는 각종의 사회구조를 해명하고 분석하는 장치로서 젠다라는 개념이 확립되기에 이르렀다. 더우기 최근에는 개발에 의해 생기는 사회변동이 사회구성원 가운데서도 여성복지적인 면을 고려해서 정책이나 프로젝트를 입안해야 한다는 단계로까지 진입해 가고 있으며 특히 지난 여름 북경에서의 제4차 세계여성대회에서 sex에서 gender로의 합의를 계기로 특히 이 분야에서 기대되는 바가 크다. 개발에 의해 여성이 당한 불리한 상황은 지금까지 수없이 지적되었으나 여성을 젠다로서 파악하고 남성과의 사회적 관계를 이해하는 것에 의해서 비로소 왜 여성이 그러한 노력에도 불구하고 불리한 상황에 빠져 있는가에 대한 분석이 가능할 것이다. 이러한 맥락에서 여러 다양한 지역과 문화에 속해 있는 여성에 대한 이러한 분석을 축적해가는 것이 앞으로의 과제이며 이는 여성복지 차원에서도 상당히 요망된다고 하겠다.
위장관을 침범한 Henoch-Sch o¨nlein purpura 1예
이승곤,김채규,서종옥,이호영,이호준,정회상,박유환,정춘해 朝鮮大學校 附設 醫學硏究所 1996 The Medical Journal of Chosun University Vol.21 No.2
Henoch-Scho¨nlein purpura(H-S purpura) is a systemic necrotizing vasculitis of small vessels that is characterized by nonthrombocytopenic palpable purpura on the buttocks and extremities, arthritis of knees and ankles, glomerulonephritis, and colicky abdominal pain, histologically characterized by leukocytoclastic vasculitis. Gastrointestinal involvement with colicky abdominal pain and GI bleeding, most frequently in jejunum and ileum, occurs in above a half of all patients, but common in children. We performed GI endoscopy in a case of H-S Purpura. Gastroduodenoscopic findings showed erythemas and erosions in gastric antrum, and mucosal edema and petechiae in duodenal 2nd portion. Colonoscopic findings showed 5-10㎜ sized multiple shallow hemorrhagic ulcers in transverse and descending colons We report a case of H-S purpura involving colon with literatural review.