카르복시 폴리술폰 아이오노머의 기계적 성질

유지강,이용혁,김희석,김준섭,박기주,D. Nguyen,A. Eisenberg 조선대학교 생산기술연구소 1997 生産技術硏究 Vol.19 No.1

The dynamic mechanical properties of carboxylated polysulfone ionomers were studied by using DMTA. It was found that at 25 mol% of ions, the ionomer shows two glass transitions: one at ca. 200 ℃ and the other at ca. 235 ℃. It was also found that with increasing an ion content to ca. 37 mol%, a matrix T_(g) shifts to ca. 210 ℃, but a cluster T_(g) remains at the same temperature; however, the sizes of tan δ peaks for each transitions do not change with the ion content. This result means that even at those high ion contents, there is sufficient amount of a unclustered material in the samples, and the increase in the ion content does not increase the volume fraction of a cluster phase. In addition, the difference in two T_(g)s of this ionomer system was found to be ca. 40 ℃, which is smaller than that in poly(styrene-co-methacrylate) ionomer system. This finding implies that in the polysulfone ionomers weak ionic interactions in a multiplet resulting from steric hindrance due to the bulkiness of benzene ring to which the ionic group is attached and the tension on polymer chains surrounding the multiplet due to chain rigidity affect the size and stability of the multiplet significantly.

졸-겔법에 의해 합성한 실리카 졸의 GC 및 GC/MASS 분석

김선일,김준섭,유지강 조선대학교 생산기술연구소 1999 生産技術硏究 Vol.21 No.2

The optimal condition for reaction of silica sol at room temperature(25±1℃) was identified when the mole ratio of TEOS : EtOH : H₂0 : HCl was 0.345 : 0.390 : 0.612 : 1.21 x 10^(-3). The equilibrium state reached when the hydrolysis for TEOS was proceeded for 40~50 minutes at the room temperature, and the volume percent of ethanol which was detected from GC column reached to 61.6%. In order to identify the path for the molecular growth of intermediate, hydroxyl group of intermediate was change into TMS by the. TMCS, so that monomer and tetrasilicate were 92% based on the amount of TEOS by the GC/MASS.

자료포락분석(DEA)를 이용한 보건의료의 효율성 측정

김남송,박홍섭,김은진,김설화,김정숙,김현아,김경숙,신지혜,최은정,양은진,유선미,유수진 圓光大學校 醫科學硏究所 2007 圓光醫科學 Vol.22 No.1

11β-수산화효소 결핍에 의한 선천성 부신증식증 1예

류옥현,류혜진,박수연,권순범,박상수,김희영,이계원,서지아,오정헌,김신곤,김난희,최경묵,백세현,최동섭 대한내분비학회 2004 Endocrinology and metabolism Vol.19 No.1

저자들은 국내에서 처음으로 음핵 비대와 지속적인 질출혈을 주소로 내원한 19세 여성에서 고혈압이 동반되지 않으면서 11 -수산화효소 결핍으로 인한 선천성부신증식증을 경험하였기에 문헌 고찰과 함께 이를 보고하는 바이다. Congenital adrenal hyperplasia refers to a group of autosomal recessive disorders that is defective in the synthesis of cortisol. The enzymes most often affected are 21-hydroxylase and 11 - hydroxylase. The low levels of cortisol stimulate the pituitary gland to release ACTH. Chronic elevation of the ACTH level causes bilateral adrenal hyperplasia and a secondary increase in androgen formation. We examined a 19 year-old woman presented with clitoral hypertrophy and vaginal spotting. The subjects basal level of serum cortisol was low, but the serum levels of ACTH, 17a-hydroxyprogesterone, deoxy-corticosterone were elevated. The urinary excretions of 17-ketosteroids and 17-hydroxycorticosteroids were also increased. The karyotyping study and transrectal ultrasonography showed normal findings. The patient underwent clitoris reduction surgery and received hydrocortisone. To the best of our knowledge, this is the first case of 11 -hydroxylase deficiency in Korea (J Kor Soc Endocrinol 19:58∼63, 2004).

Styrene-co-lithium methacrylate ionomer의 기계적인 성질에 미치는 LiCl의 영향

나연화,김준섭,유지강,박기주 조선대학교 생산기술연구소 1999 生産技術硏究 Vol.21 No.2

The effect of LiCl salt added to styrene-co-lithium methacrylate ionomer on the mechanical properties of ionomers was studied dynamic rnschanically. When the LiCl salt was added to a 100% Li-neutralized ionomer, the amount of added salt. in the range of 100-300% to ionic groups of the ionomer, did not change the mechanical properties of the ionomers, This implies that the added salt may form isolated LiCl salt aggregates in the polymer matrix. However, when LiCl was added to a 200% neutralized ionomer, the cluster T_(g) shifted to a low temperature and then the sample started to flow. This result suggests that in this case the LiCl salts reside in and near the multiplets, resulting the weakening of ionic interactions between ionic groups in multiplets.

폴리(스타이렌-b-아이소부틸렌-b-스타이렌) 삼블록 공중합체 아이오노머의 기계적인 성질

나연화,김희석,김준섭,유지강,박기주,이영관 조선대학교 생산기술연구소 1998 生産技術硏究 Vol.20 No.2

The dynamic mechanical properties of poly(styrene-b-isobutylene-b-styrene) and its sulfonated ionomers were investigated. The triblock copolymer showed a tan δ peak at ca. -25℃, which is ascribed to the T_(g) of polyisobutylene blocks. The copolymer also showed a shoulder on a tan δ curve at ca. 50℃, which is probably associated with crystallization and/or melting of the crystalline polyisobutylene blocks. Above 100℃, the copolymer started to flow. In the cases of ionomers, well developed rubbery plateaus, extended to ca. 150-160℃, were seen in modulus-temperature plots. A tan δ peak for the T_(g) of the polyisobutylene blocks and a shoulder peak were also observed for the tetramethylammonia neutralized sulfonated ionomer. However, the shoulder peak became smaller and shifted to low temperatures, which implies that the ionic interactions in this system reduces the ability of crystallization or/and melting of the polyisobutylene blocks. For the K neutralized ionomer sample, only a tanδ peak for the T_(g) of the isobutylene blocks was seen. This different result in these two ionomers is believed to be due to the difference in the strength of ionic interactions.

스타이렌 아이오노머의 기계적인 성질에 미치는 혼합 양이온의 영향

김희석,나연화,이용혁,이법원,유지강,박기주,김준섭 조선대학교 생산기술연구소 1998 生産技術硏究 Vol.20 No.1

The styrene-co-methacrylate ionomers neutralized with Na +, Ba2 +, and mixed cation of both were prepared. The dynamic mechanical properties of two cation-containing ionomers were measured and compared to those of the ionomers neutralized with only one type of cations. We found that in the ionomers with one type of cations the difference in the type of cation does not change the glass transition temperatures. It was found, however, that the cluster Tg of the mixed cation ionomer is lower than that of the single cation ionomers. Thus it was postulated that in the two-cation system the two cations in a solution have sufficient dynamics to form new type of multiplet containing both cations, which may be slightly bigger than that found in the single cation multiplet. The mechanical properties also imply that the strength of ion interactions in the multiplets of the two cation ionomer is thought to be weaker than that of the one cation ionomers. These two effects are believed to contribute the lower in the cluster glass transition of mixed cation system.

자연적으로 발생한 수정체 관련 포도막염 1예

김지혜(Ji Hye Kim),유웅선(Woong Sun Yoo),공민귀(Min Gui Kong),한용섭(Yong Seop Han),정인영(In Young Chung),서성욱(Seong Wook Seo),유지명(Ji Myong Yoo),김성재(Seong Jae Kim) 대한안과학회 2016 대한안과학회지 Vol.57 No.9

목적: 외상이나 수술의 과거력 없이 자연적으로 발생한 수정체 관련 포도막염을 진단하고 치료하였기에 보고하고자 한다. 증례요약: 77세 여성이 내원 4일 전부터 발생한 우안의 시력 저하 및 안통을 주소로 내원하였다. 환자는 우안에 외상이나 수술 등의 과거력은 없었으며, 내원 당시 교정시력은 우안 안전수동, 좌안 0.22였고 안압은 우안이 27 mmHg, 좌안은 15 mmHg로 측정되었다. 전안부 검사에서 우안에 각막 부종, 전방축농과 심한 염증으로 수정체는 관찰되지 않았으며 안구초음파 검사에서는 수정체 뒤쪽으로 유리체 혼탁이 보였다. 우안 안내염으로 진단하에 전방 천자를 통한 염색 및 배양검사, 전방세척술을 시행하였다. 전방세척술 후 전낭손상 없이 과숙백내장이 관찰되어 수정체낭외적출술을 시행하고 유리체내 항생제 주입술을 함께 시행하였다. 술 후 도말 검사 및 세균배양검사는 모두 음성이었으며, 광학현미경 검사에서 수정체단백을 포식한 대식세포가 관찰되어 과숙백내장으로 인해 발생한 수정체 관련 포도막염으로 진단하였다. 술 후 항생제와 스테로이드 안약을 점안하고 경구 스테로이드를 사용하였으며 염증의 재발없이 치료되었다. 결론: 안내염과 비슷한 양상으로 내원한 환자에서 과숙백내장에 의한 포도막염을 진단하고 치료하였기에 보고하고자 한다. Purpose: To report a case of phacoanaphylactic uveitis presenting as endophthalmitis. Case summary: A 77-year-old woman presented with sudden visual disturbance and painful red right eye. She did not have a history of trauma or surgery in her right eye. Her best corrected visual acuity was hand movement in the right eye and log MAR 0.22 in the left eye; intraocular pressure was 27 mm Hg in the right eye and 15 mm Hg in the left eye. Slit-lamp examination revealed corneal edema and prominent inflammation with hypopyon in the anterior chamber. B-scan showed vitreous opacity behind the lens. Based on the diagnosis of endophthalmitis, anterior chamber paracentesis and irrigation were performed. After irrigation, a hypermature cataract with intact anterior capsule was observed. Therefore, we performed extracapsular cataract extraction and intravitreal antibiotics injection. Gram staining of the aqueous humor revealed numerous macrophages filled with lens protein but no organisms. She was treated with hourly topical corticosteroid and an antibiotic agent. One month later, the anterior chamber is clear, and the cultures remained negative. Conclusions: We report a case of spontaneous phacoanaphylactic uveitis presenting as endophthalmitis in a patient with no history of eye trauma or surgery.

Obstructive sleep apnea with excessive daytime sleepiness is associated with non-alcoholic fatty liver disease regardless of visceral fat

( Ji Hee Yu ),( Jae Hee Ahn ),( Hye Jin Yoo ),( Ji A Seo ),( Sin Gon Kim ),( Kyung Mook Choi ),( Sei Hyun Baik ),( Dong Seop Choi ),( Chol Shin ),( Nan Hee Kim ) 대한내과학회 2015 The Korean Journal of Internal Medicine Vol.30 No.6

Background/Aims: Obstructive sleep apnea (OSA) is associated with an increased risk of obesity and non-alcoholic fatty liver disease (NAFLD), but it remains unclear whether the risk of NAFLD is independently related to OSA regardless of visceral obesity. Thus, the aim of the present study was to examine whether OSA alone or in combination with excessive daytime sleepiness (EDS) or short sleep duration was associated with NAFLD independent of visceral fat in Korean adults. Methods: A total of 621 participants were selected from the Korean Genome and Epidemiology Study (KoGES). The abdominal visceral fat area (VFA) and hepatic fat components of the participants were assessed using computed tomography scans and they were then categorized into four groups depending on the presence of OSA and EDS. Results: The proportions of NAFLD were 21.1%, 18.5%, 32.4%, and 46.7% in participants without OSA/EDS, with only EDS, with only OSA, and with both OSA and EDS, respectively. A combination of OSA and EDS increased the odds ratio (OR) for developing NAFLD (OR, 2.75; 95% confidence interval [CI], 1.21 to 6.28) compared to those without OSA/EDS, and this association remained significant (OR, 2.38; 95% CI, 1.01 to 5.59) even after adjusting for VFA. In short sleepers (< 5 hours) with OSA, the adjusted OR for NAFLD was 2.50 (95% CI, 1.08 to 5.75) compared to those sleeping longer than 5 hours without OSA. Conclusions: In the present study, OSA was closely associated with NAFLD in Korean adults. This association was particularly strong in those with EDS or short sleep duration regardless of VFA.

Vascular Inflammation Stratified by C-Reactive Protein and Low-Density Lipoprotein Cholesterol Levels: Analysis with 18F-FDG PET.

Yoo, Hye Jin,Kim, Sungeun,Park, Man Sik,Yang, Sae Jeong,Kim, Tae Nyun,Seo, Ji A,Kim, Sin Gon,Kim, Nan Hee,Seo, Hong Seog,Baik, Sei Hyun,Choi, Dong Seop,Choi, Kyung Mook Society of Nuclear Medicine 2011 The Journal of nuclear medicine Vol.52 No.1

<P>We examined the severity of vascular inflammation in healthy individuals without hyperlipidemia but with elevated high-sensitivity C-reactive protein (hsCRP) using (18)F-FDG PET, which is a promising imaging technique for the assessment of vascular inflammation within atherosclerotic plaques. Methods: Vascular inflammation in the carotid arterial wall, represented as the target-to-background ratio (TBR), was measured using (18)F-FDG PET in 120 healthy subjects without a history of cardiovascular diseases. RESULTS: Subjects with high hsCRP (?? mg/L) and low low-density lipoprotein cholesterol (LDL-C) (<130 mg/dL) levels had a significantly higher maximum TBR than did those with low hsCRP (<2 mg/L) and low LDL-C levels (<130 mg/dL) or low hsCRP (<2 mg/L) and high LDL-C levels (??30 mg/dL) (1.29 ± 0.13, 1.12 ± 0.10, and 1.16 ± 0.05, respectively), even though there were no significant differences in the carotid intima-media thickness. The maximum TBR values had the strongest positive correlation with hsCRP level among the various cardiovascular risk factors (r = 0.68, P < 0.01). However, other emerging inflammatory markers such as lipoprotein-associated phospholipase A(2) or monocyte chemoattractant protein-1 were not coherently associated with TBR values. Multiple stepwise regression analyses showed that hsCRP and diastolic blood pressure were independent decisive factors for maximum TBR, whereas age, diastolic blood pressure, and LDL-C were factors that determined the maximum intima-media thickness. CONCLUSION: Vascular inflammation measured using (18)F-FDG PET was increased in healthy individuals without hyperlipidemia but with elevated hsCRP.</P>