Dimethylnitrosamine 유발 급성 간 손상 흰쥐에서 ^(99m)Tc-Lactosylated Serum Albumin을 이용한 간 기능의 평가

정신영,이재태,서명랑,유정아,배진호,안병철,황재석,정재민,하정희,이규보 대한핵의학회 2003 핵의학 분자영상 Vol.37 No.6

목적: ^(99m)Tc-lactosylated serum albumin (^(99m)Tc-LSA)은 간세포에 특이적으로 결합하는 간수용체 영상용 방사성의약품으로 새로이 합성되었다. 간섬유화를 유발하는 dimethylnitrosamine (DMN)을 투여한 간 손상 휜쥐 모델에서 ^(99m)Tc-LSa의 역동학적인 간섭취를 조사하고 간효소치의 변화와 조직학적 소견을 비교하여, LSA의 간섭취가 간기능의 변화를 반영하는지를 연구하였다. 대상 및 방법: SD계 흰쥐에 DMN를 27 mg/kg으로 복강 내 주사하여 급성 간손상을 유도하고 대조군과 비교하였다. DMN을 주사한 흰쥐를 3일(DMN-3), 8일(DMN-8), 21일(DMN-21)에 ^(99m)Tc=LSA (1,665 mg/kg) 29 MBq를 정맥 주사하여, 30분 동안 동적 영상을 획득하고 간과 신장부위에 관심영역을 설정하여 간과 심장부위의 시간방사능 곡선을 얻었다. 간기능 평가를 위해 시간방사능 곡선을 이용하여 간섭취지수와 혈중제거지수를 구하였고 곡선 최적화를 시행하였다. DMN 투여군과 대조군의 간효소치의 변화와 간조직의 광학현미경 소견을 비교하였다. 결과: 대조군에서는 ^(99m)Tc-LSA가 빠르게 간에 섭취되고 혈중에서 제거되었으나 DMN을 처리한 군에서는 간섭취가 낮았다. 간섭취지수의 비교에서 대조군에 비해 DMN 처리군에서 유의하게 간섭취지수가 낮았다(DMN-3: 0.842, DMN-8: 0.898, DMN-21: 0.91, 대조군: 0.96, p<0.05). 혈중제거지수의 비교에서도 대조군에 비해 DMN 처리군에서 혈중제거지수가 유의하게 높았다(DMN-3: 0.731, DMN-8: 0.654, DMN-21: 0.604, 대조군: 0.473, p<0.05). 비선형 회귀분석에서 R_(2) 값은 0.9이상으로 좋은 일치를 보였고, 대조군에ㅓ K값이 DMN처리군에 비해 크고(DMN-3: 0.28, DMN-8: 0.41, DMN-21: 0.46, 대조군: 0.97, p<0.05), T_(1/2)값은 작았다(DMN-3: 2.5, DMN-8: 1.7, DMN-21: 1.5, 대조군: 0.7, p<0.05). 간효소치의 변화는 DMN-3군에서는 대조군에 비해 상승하였으나 DMN-8, DMN-21군에서는 간효소치의 상승이 관찰되지 않았다. 간조직 소견의 경우 DMN-3군에서 중심정맥 주위에 괴사가 관찰되었으나 DMN-8군, DMN-21군에서는 미약한 정도의 염증세포 침윤만이 관찰되었다. 결론: ^(99m)Tc-LSA 간신티그래피의 간섭취 정도는 간손상과 반비례하였으며 간섭취의 변화는 조직학적 손상이 심한 정도와 간손상후 회복되는 과정을 반영하여 주었다. ^(99m)Tc-LSA 간신티그래피가 간손상을 평가하고 간손상후 회복되는 과정을 추적하는 간수용체 영상용 방사성 의약품으로 사용될 수 있을 것으로 생각된다. Objects: ^(99m)Tc-lactosylated human serum albumin(LSA) is a newly synthesized radiopharmaceutical that binds to asialoglycoprotein receptors, which are specifically presented on the hepatocyte membrane. Hepatic uptake and blood clearance of LSA were evaluated in rat with acute hepatic injury induced by dimethylnitrosamine(DMN) and results were compared with corresponding findings of liver enzyme profile and these of histologic changes. Materials and Methods: DMN (27 mg/kg) was injected intraperitoneally in Sprague-Dawley rat to induce acute hepatic injury. At 3(DMN-3), 8(DMN-8), and 21(DMN-21) days after injection of DMN, LSA injected intravenously, and dynamic images of the liver and heart were recorded for 30 minutes. Time-activity curves of the heart and liver were generated from regions of interest drawn over liver and heart area. Degree of hepatic uptake and blood clearance of LSA were evaluated with visual interpretation and semiquantitative analysis using parameters (receptor index : LHL3 and index of blood clearance : HH3), analysis of time-activity curve was also performed with curve fitting using Prism program. Results: Visual assessment of LSA images revealed decreased hepatic uptake in DMN treated rat, compared to control group. In semiquantitative analysis, LHL3 was significantly lower in DMN treated rat group than control rat group (DMN-3:0.842, DMN-8: 0.898, DMN-21: 0.91, Control: 0.96, p<0.05), whereas HH3 was significantly higher than control rat group (DMN-3: 0.731, DMN-8: 0.654, DMN-21: 0.604, Control: 0.473, p<0.05). AST and ALT were significantly higher in DMN-3 group than those of control group. Centrilobular necrosis and infiltration of inflammatory cells were most prominent in DMN-3 group, and were decreased over time. Conclusion: The degree of hepatic uptake of LSA was inversely correlated with liver transaminase and degree of histologic liver injury in rat with acute hepatic injury.

만성 강박장애 환자의 정서처리 특성 : 정신분열병 환자 및 정상인과의 비교

석정호,김재진,전종희,이홍식,안석균,이은,김찬형 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.3

Objectives : Obsessive compulsive disorder (OCD) tends to take chronic course as schizophrenia. Researchers reported that OC patients had idiosyncratic sensitivity to threat-related information, while schizophrenic patients were reported to have affec-tive blunting. We hypothesized that there might be a difference in emotional response between OCD and SPR in cronic phase. Methods : Eight different emotional tasks were done by 25 healthy controls, 21 OCD patients and 25 SPR patients. Visual stimuli were made by pairing two words or pictures. Four kinds of emotional stimuli (positive, negative, combined and neutral)were presented to subjects through monitor and they were asked to report their subjective feelings by pushing mouse button, In the combined condition, a pair of positive words (or pictures) and negative words (or pictures) were presented simultaneously. The responses and response time were recorded and analyzed using SPSS 9.0 package. Results : In the negative condition, OCD group didn't show any deficit compared to healthy group. But SPR group showed significantly lower appropriate response rate than healthy group, In the combined condition, OCD and healthy control group Showed 'negativity bias' which SPR group didn't show. In the positive condition, however, OCD and SPR groups did show Significantly lower appropriate response rate than healthy controls. Conclusion : Our results suggested that OCD patients may not have deficits in the processing of negative emotion even in the chronic phase but to have a specific deficit in positive emotion. This result supports the 'threat-relatedness hypothesis' on attentional bias of OCD.

Clinical Comparison between the Traditional and Otic Capsule Classification Systems of Temporal Bone Fracture : Clinical Research

정희석 외 중앙대학교 의과대학 의과학연구소 2010 中央醫大誌 Vol.35 No.3/4

The traditional classification system (longitudinal vs. transverse) of temporal bone fractures has limited predictability of complications. Recently, some authors reported that the otic capsule classification system (otic capsule-violated vs. -spared) was better for predicting complications of temporal bone fractures. We made a comparison between the two systems. Between January 2002 and May 2008, 43 cases of temporal bone fracture were included in this study. Using the two classification systems we evaluated the incidence of complications such as conductive hearing loss (CHL), sensorineural hearing loss (SNHL), facial nerve (FN) palsy and cerebrospinal fluid (CSF) leakage, etc. With the traditional system, fractures were classified as longitudinal 19 (44%), transverse 12 (28%), and mixed 12 (28%). With the otic capsule system, 35 (81%) were otic capsule sparing and 8 (19%) were violating. With a comparison of the two systems, patients with otic capsule-violating fractures were 1.4 times more likely to have FN palsy, 2.3 times more likely to have CSF leakage. Especially, SNHL in otic capsule-violating fractures was 5.4 times more common than in otic capsule-sparing (p <0.01). Although the traditional system failed to demonstrate clinical predictability in this study, the otic capsule system demonstrated statistically significant predictive power only for SNHL. Thus, it would be better that both traditional and otic capsule classification systems are applied for predicting the complications of the temporal bone fracture.

자발성 뇌출혈 환자의 일상생활동작 수행에 영향을 미치는 인자

정호중,진기은,박희석 고신대학교 의학부 1996 高神大學校 醫學部 論文集 Vol.11 No.1-2

The Modified Barthel Index (MBI) and the Functional Independence Measure (FIM) have been used widely as evaluating tools for Activities of Daily Living (ADL) of the disabled. To obtain the guideline for the evaluation and planning of rehabilitative management, we performed this study by comparative analysis of MBI and FIM about the factors affecting ADL of the spontaneous intracerebral hemorrhage patients. The mean scores of MBI and FIM were 46.0 and 68.9 at the beginning of rehabilitation therapy, and 75.4 and 94.4 at discharge, respectively. Thus the average scores of improvement of MBI and FIM were 29.5and 25.5, respectively, each of which was statistically significant (p<0.05). The mean FIM score at discharge of the patient group with initial MBI score above 50 was significant higher than that of the group with initial MBI score equal to or below 50 (109.6 versus 85.9, p<0.05). According to the amount of initial intracerebral hemorrhage. MBI and FIM scores at discharge were found significantly different by 20cc (p<0.05). In conclusion. MBI and FIM scores are found to be useful to evaluate the factors affecting ADL in patients with spontaneous ICH.

자발성 뇌출혈 환자의 일상생활동작 수행에 영향을 미치는 인자

정호중,진기은,박희석 高神大學 醫學部 1996 高神大學醫學部 論文集 Vol.11 No.1-2

췌십이지장절제술 후 결과에 영향을 미치는 인자

정희석,정귀애,장정환,김권천,민영돈,김성환 조선대학교 2003 The Medical Journal of Chosun University Vol.28 No.1

`Background : Pancreatoduodenectomy is a widely used technique in the treatment of periampullary, duodenal and cephalic pancreatic disease. Although many improvements have been made in operative technique and posmiddleerative care, pancreatoduodenectomy remains a technically difficult procedure attended by relatively high morbidity and mortality rates. Materials and methods : The hospital records of 51 patients who underwent pancreatoduodenectomy at the Chosun University Hospital between 1994 and 2001 were reviewed. Clinical data and the following morbidity and mortality were recorded The risk factors were analyzed by a Chi-square test. Results : Fifth decade was the most prevalent ages (43.1%) The mean age was 59 years (ranging from 29 to 78) and the male to female ratio was 26 to 1. The periampullary cancer was the most reason to operation (86%) and injury due to trauma, adenocarcinoma of stomach, colon cancer, chronic pancreatitis in order Posmiddleerative complications were developed in seventeen patients and anastomotic leakage was the most common complication Death within a month after operation was 3 (5.8%) and the one of the cause of death was leakage in two patients, the other cause was intraadbominal bleeding in one patients. The cardiovascular disease, pulomnary problem, diabetes, level of bilirubin were checked preoperatively and showed no statistical difference in the posmiddleerative morbidity. The other factors such as amount of bleeding, operation time were not influencing posmiddleerative complications. The occurrence of leakage in eight cases of drainage tuve inserted into the pancreaticojejunostomy site was not different from no tuve insertion statistically Conclusion: old age of the patients, diabetes mellitus and massive intraoperative hemorrhage are the risk factors influencing the results after pancreatoduodenectomy. Morbidity and mortality after pancreatoduodenctomy can be devreased if a prudent selection of paients is made and the operation is performed by accomplushed surgeon.

플레이트를 이용한 냉간성형 각형강관 T형 접합부에 관한 실험적 연구

석희원,박금성,정상민,조성식,배규웅,문태섭 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2(구조계)

The purpose of this paper is to investigate experimentally the strength and deformation of T-joints to evaluate the structural behavior of truss connection consisted in square hollow steel section with plate. There are the branch plate type in T-joint shapes. Principal parameters are the ratio of the chord width to thickness(2ν=31.3, 22.2, 16.7) and the ratio of branch plate thickness to chord width(βp=0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.75, 0.85). The most important result obtained from this experiment is as follows; The ultimate strength of T-joints increase proportionally as the 2ν ratio decrease, and the βp ratio increase. The others, experimental results are summarized for ultimate strength to displacement, initial stiffness and failure mode of each T-joints.

전북지방 젖소의 유방염 검색

조정곤,김종면,최민순,채효석,강명대,송희종 全北大學校 附設 畜産開發硏究所 1987 畜産開發硏究報告 Vol.1 No.-

A total of 444 quarters milk samples of 111 dairy cattle in Chonbuk area were examined for infection rete and causative agents of mastitis by "the laboratory procedures used in the Connecticut Mastitis Control Program (CMCP) and California mastitis Test (CMT)". The results obtained were as follows: 1. Of 444 samples, 39.2% had positive CMCP value and 24.4% positive CMT reaction. 2. One hendred and seventy four (39.2%) from 82 cattle (73.9%) were found to infected with mastitis. It was found that 8(1.8%0 of the infected quarters were clinical mastitis and all of the rest were subclinical mastitis. 3. The main causative agents were found to Staphylococcus aureus (63 quarters), Streptococcus agalactiae (56 quarters), non-Str. agalactiae streptococci (54 querters), Escherichia coli (19 quaters), the actual total number of quarters detected as mastitis would be 174, as 18 of these quarters showed multiple infection with two different organisms. 4. Having examined the number of infection quarter per head of mastitis in dairy cattle sampling, major finding were that the average number of infection quarters to total dairy cattle exemined was 1.57 quarters, and that of the infected cattle was 2.1 quarters. Infected quarters in cattle with 1, 2, 3 and 4 were noted 27(32.9%), 28(34.1%), 17(20.7%), and 10(12.3%), respectively.

중질유 탈황공정 폐촉매로부터 유가금속의 회수에 관한 연구

조정우,이정희,구덕모,김기석 嶺南大學校 工業技術硏究所 1995 工業技術硏究所論文集 Vol.23 No.1

In order to selectively recover by the extractive separation the value metals including V, Mo, Ni, Co, and Al from the spent catalysts removed from the resid desulfurization processes, we investigated the following: how to efficiently remove the nonmetallic impurities from the spent catalyst by roasting how to optimize the pore structure of roasted spent catalyst, how to select the suitable leachants and extractants, how to optimize the conditions of leaching/extraction, and how to determine the effective sequence of selectively recovering the value metals. With regard to roasting of spent catalyst, 550℃ was found to be the optimal roasting temperature in terms of sulfur removal and solubility of roasted catalyst in the sulfuric acid leaching solution as the specific surface area, porosity, and residual sulfur content were measured for the spent catalysts roasted at various temperatures in the tubular furnace. For the spent catalysts roasted at temperatures above 650℃, the efficiency of selectively recovering the value metals was diminished due to the decreased surface area and porosity, thereby the lowered solubility of roasted catalyst in the sulfuric acid leaching solution. In the case of roasting at 550℃, the ratio of (oxygen flow rate)/(volume of spent catalyst sample) equal to 30min?? was optimal for the efficient removal of sulfur from the spent catalyst. With regard to the selective recovery of value metals by leaching/extraction operations, two spent catalysts of different metal compositions as well as two model oxide mixtures simulating the metal compositions of those catalysts were experimented to determine the suited leachants/extractants and search for the effective sequences of selective recovery. The sequential recovery operation consisting of the solid-liquid separation via leaching and the liquid-liquid separation via extraction made it possible to selectively recover the value metals from both the model oxide mixtures and the spent catalysts. The differences in particle structure and component distribution between the model oxide mixture and the spent catalyst accounted for the differences in leaching, leaching conditions, and recovery sequences between the two. The sequences of selectively recovering the value metals which are relatively simple and of good potential to be applied in commercial scale were developed for the spent catalyst of two different metal compositions

도심지 터널형 방음벽의 환경적 요인 및 외관 디자인에 관한 연구

최정민,윤태호,박창섭,이경희,박진석 국립7개대학공동논문집간행위원회 2005 공업기술연구 Vol.5 No.-

This study is to obtain a basic data for a better environment and visual design improvement for the sound barrier tunnel located along the overpasses which passed through downtown areas. For this purpose, the traffic noise was measured in Daegu. In addition. using the sound analysis software, equivalent sounds were checked and analyzed. Finally, the alternatives of sound barrier tunnel were proposed.