In-line 마그네트론 스퍼터 장치를 사용하여 산소 분위기에서 제작한 Ag 박막의 특성

구대영,김원목,조상무,황만수,이인규,정병기,이택성,이경석,조성훈,Ku, Dae-Young,Kim, Won-Mok,Cho, Sang-Moo,Hwang, Man-Soo,Lee, In-Kyu,Cheong, Byung-Ki,Lee, Taek-Sung,Lee, Kyeong-Seok,Cho, Sung-Hun 한국재료학회 2002 한국재료학회지 Vol.12 No.8

A study was made to examine the electrical, compositional, structural and morphological properties of Ag thin films deposited by DC magnetron sputtering in $O_2$ atmosphere with deposition temperature from room temperature to 15$0^{\circ}C$ using in-line sputter system. The Ag films deposited at temperature above $100^{\circ}C$ in oxygen atmosphere gave a similar specific resistivity to and even lower oxygen content than those deposited using pure Ar sputter gas The Ag films deposited with pure Ar gas was mainly composed of crystallites with [111] preferred orientation, while, for those deposited in oxygen atmosphere, more than 50% of the volume was composed of crystallites with [100] orientation. The difference in the micro structure did not cause any difference in the specific resistivity of Ag films. The results showed that the transparent conducting oxide films and the Ag films could be processed sequentially in the same deposition chamber with careful control of deposition temperature, which might result in a cost reduction for constructing the large scale in-line deposition system.

Nelumbinis Semen Reverses a Decrease in $5-HT_{1A}$Receptor Binding Induced by Chronic Mild Stress, a Depression-like Symptom

Jang, Choon-Gon,Kang, Moon-Kyu,Cho, Jae-Han,Lee, Sun-Bok,Kim, Hyun-Taek,Park, Soon-Kwon,Lee, Jin-Woo,Park, Seong-Kyu,Hong, Moo-Chang,Shin, Min-Kyu,Shim, In-Sup,Bae , Hyun-Su The Pharmaceutical Society of Korea 2004 Archives of Pharmacal Research Vol.27 No.10

Depression is associated with a dysfunctional serotonin (5-hydroxytryptamine; 5-HT) system. More recently, several lines of evidence suggest that an important factor in the development of depression may be a deficit in the function and expression of $5-HT_{1A}$ receptors. The present study assessed if Nelumbinis Semen (N. s.) had an anti-depression effect through reversing a decrease in $5-HT_{1A}$receptor binding in rats with depression-like symptoms induced by chronic mild stress. Using a $5-HT_{1A}$ receptor binding assay, with a specific $5-HT_{1A}$receptor agonist, 8- OH-DPAT (8-hydroxy-2-(di-n-propylamino) tetralin), the mechanism of the anti-depression effect of N. s. on rats was investigated, and the effects compared with two well-known antidepressants, Hyperium Perforatum (St. Johns Wort) and fluoxetine (Prozac). Animals were divided into five groups: the normal (N) group without chronic mild stress (CMS), the control (C) group under CMS for 8 weeks, the Nelumbinis Semen (N. s.) treatment group under CMS for 8 weeks, the Hyperium Perforatum (H. p.) treatment group under CMS for 8 weeks and finally, the fluoxetine (F) treatment group under CMS for 8 weeks. Each treatment was administered to rats during the last 4 weeks of the 8-week CMS. A sucrose intake test was performed to test the anti-depression effect of N. s. The N. s. treatment significantly reversed the decreased sucrose intake under CMS (P<0.05 compared to control group under CMS). In the CA2 and CA3 regions of the hippocampus, both N. s. and H. p. reversed the CMS-induced decrease in $5-HT_{1A}$receptor binding. In the I to II regions of the frontal cortex, N. s. and H. p. also reversed the CMS-induced decrease in$5-HT_{1A}$receptor binding, and even showed a significant increase in $5-HT_{1A}$receptor binding compared to the F treatment group (N. s. vs. P, p<0.05, H. p. vs. P, p<0.05). However, in the hypothalamus, all treatments reversed the CMSinduced decrease in $5-HT_{1A}$receptor binding. This reversal effect of N. s. on the decrease in $5-HT_{1A}$receptor binding in the frontal cortex, hippocampus and hypothalamus of rat brains was very similar to that of H. p, but different from that of F. It is concluded that N. s. presents an anti-depression effect through enhancing $5-HT_{1A}$receptor binding.

월성원자력발전소 주변의 삼림식생 분석

이호준,김인택,정흥락,전영문,윤영진,임웅규 建國大學校基礎科學硏究所 1996 理學論集 Vol.21 No.-

월성원자력발전소 주변의 삼림식생을 분석하기 위하여 1994년 4월부터 1994년 10월까지 식물사회학적 조사를 실시하였다. 또한 상관에 의해 현존식생도 및 녹지자연도를 작성하였으며, 순 1차 생산력과 식물현존량도 추정하였다. 군집조성표에 의한 삼림군락은 소나무군락, 곰솔군락, 굴참나무군락, 상수리 나무군락의 4군락으로 구분되었다. 각 군락의 주요 구성종으로는 소나무군락에서 소나무, 졸참나무, 털진달래, 맑은대쑥, 산거울, 곰솔군락에서 곰솔, 소나무, 진달래, 청미래덩굴, 굴참나무군락에서 굴참나무, 조록싸리, 큰기름새, 맑은대쑥, 댕댕이덩굴, 상수리나무군락에서 상수리나무, 갈참나무, 큼기름새, 그늘사초, 맑은대쑥 등이다. 현존식생도에 의한 삼림군락의 분포율은 곰솔군락이 40.3%로 가장 높고, 녹지자연도는 7등급이 60.0%로 가장 넓은 분포율을 보였다. 삼림토양의 pH는 4.45∼5.32, 유기물함량은 5.61∼6.34%의 범위로 나타났다. Montreal model에 의한 순 1차 생산력은 1,555.2g/㎡/yr, 식물현존량은 14,963.32ton/㎢로 추정되었다 The forest vegetation, estimation of phytomass and net primary production on the vicinity of Wolsong Atomic Power Plant were analyzed on the basis of the phytosociological data. And depending on physiognomy, actual vegetation map and the degree of green naturality(DGN) was drawn in 1:50,000 scale. According to Z-M method, the forest vegetation was classified into 4 communities; A. Pinus densiflora community, B. Pinus thunbergii community, C. Quercus variabilis community, D. Quercus acutissima community. Generally, Pinus densiflora, Quercus variabilis, in tree-1 layer, Quercus acutissima, Quercus variabilis, in tree-2 layer, Rhodedendron mucronulatum, Quercus serrate, in shrub layer, Artemisia keiskeana, Carex humilis, in herb layer, showed high coverage index. The pH and contents of organic matter of the forest soil collected in each sites were shown range of 4.45 to 5.32 and 5.61% to 6.34% in mean of communities respectively. The distribution rate in actual vegetation map were the highest in Pinus thunbergii community. The average DGN showed to 5.1. Net primary production and phytomass per unit area which estimated by Montreal model were assumed in 1,555.2g/㎡/yr, 14,963.32ton/㎢, respectively.

Impact of the Metabolic Syndrome on the Clinical Outcome of Patients with Acute ST-Elevation Myocardial Infarction

Lee, Min Goo,Jeong, Myung Ho,Ahn, Youngkeun,Chae, Shung Chull,Hur, Seung Ho,Hong, Taek Jong,Kim, Young Jo,Seong, In Whan,Chae, Jei Keon,Rhew, Jay Young,Chae, In Ho,Cho, Myeong Chan,Bae, Jang Ho,Rha, S The Korean Academy of Medical Sciences 2010 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.25 No.10

<P>We sought to determine the prevalence of metabolic syndrome (MS) in patients with acute myocardial infarction and its effect on clinical outcomes. Employing data from the Korea Acute Myocardial Infarction Registry, a total of 1,990 patients suffered from acute ST-elevation myocardial infarction (STEMI) between November 2005 and December 2006 were categorized according to the National Cholesterol Education Program-Adult Treatment Panel III criteria of MS. Primary study outcomes included major adverse cardiac events (MACE) during one-year follow-up. Patients were grouped based on existence of MS: group I: MS (n=1,182, 777 men, 62.8±12.3 yr); group II: Non-MS (n=808, 675 men, 64.2±13.1 yr). Group I showed lower left ventricular ejection fraction (LVEF) (<I>P</I>=0.005). There were no differences between two groups in the coronary angiographic findings except for multivessel involvement (<I>P</I>=0.01). The incidence of in-hospital death was higher in group I than in group II (<I>P</I>=0.047), but the rates of composite MACE during one-year clinical follow-up showed no significant differences. Multivariate analysis showed that low LVEF, old age, MS, low high density lipoprotein cholesterol and multivessel involvement were associated with high in-hospital death rate. In conclusion, MS is an important predictor for in-hospital death in patients with STEMI.</P>

잘못된 Stent 삽입 치료 후 슬와 동맥 포착 증후군에서 발생한 슬와 동맥의 완전 폐쇄 1예

이인선 ( In Sun Lee ),최동훈 ( Dong Hoon Choi ),김은혜 ( Eun Hye Kim ),신상훈 ( Sang Hun Shin ),이도연 ( Do Yun Lee ),김승환 ( Seong Hwan Kim ),이택연 ( Taek Yeon Lee ) 대한내과학회 2012 대한내과학회지 Vol.83 No.6

Entrapment of the popliteal artery is a rare cause of ischemia of the lower extremities in young males. The development of local occlusive or aneurysmal changes of the popliteal artery is caused by abnormal anatomical relationships between vascular and musculotendinous structures in the popliteal fossa. A 55-year-old male patient visited Yonsei University College of Medicine with the chief complaint of claudication in his right calf. He had undergone stent insertion in the right popliteal artery for peripheral artery occlusive disease 2 years earlier. Lower extremity CT angiography showed stent fracture and in-stent thrombosis. He underwent femoral-to-popliteal artery bypass surgery. Postoperative lower extremity CT angiography showed that the vein graft was compressed between the medial head of the gastrocnemius and the semimembranosus muscle. However, the blood flow was normal and his pain was relieved. (Korean J Med 2012;83:786-790)

Feasibility and Effects of a Postoperative Recovery Exercise Program Developed Specifically for Gastric Cancer Patients (PREP-GC) Undergoing Minimally Invasive Gastrectomy

Cho, In,Son, Younsun,Song, Sejong,Bae, Yoon Jung,Kim, Youn Nam,Kim, Hyoung-Il,Lee, Dae Taek,Hyung, Woo Jin The Korean Gastric Cancer Association 2018 Journal of gastric cancer Vol.18 No.2

Purpose: Exercise intervention after surgery has been found to improve physical fitness and quality of life (QOL). The purpose of this study was to investigate the feasibility and effects of a postoperative recovery exercise program developed specifically for gastric cancer patients (PREP-GC) undergoing minimally invasive gastrectomy. Materials and Methods: Twenty-four patients treated surgically for early gastric cancer were enrolled in the PREP-GC. The exercise program comprised sessions of In-hospital Exercise (1 week), Home Exercise (1 week), and Fitness Improvement Exercise (8 weeks). Adherence and compliance to PREP-GC were evaluated. In addition, body composition, physical fitness, and QOL were assessed during the preoperative period, after the postoperative recovery (2 weeks after surgery), and upon completing the PREP-GC (10 weeks after surgery). Results: Of the 24 enrolled patients, 20 completed the study without any adverse events related to the PREP-GC. Adherence and compliance rates to the Fitness Improvement Exercise were 79.4% and 99.4%, respectively. Upon completing the PREP-GC, patients also exhibited restored cardiopulmonary function and muscular strength, with improved muscular endurance and flexibility (P<0.05). Compared to those in the preoperative period, no differences were found in symptom scale scores measured using the European Organization for Research and Treatment of Cancer (EORTC) Core Quality of Life Questionnaire (QLQ-C30) and Quality of Life Questionnaire-Stomach Cancer-Specific Module (QLQ-STO22); however, higher scores for global health status and emotional functioning were observed after completing the PREP-GC (P<0.05). Conclusions: In gastric cancer patients undergoing minimally invasive gastrectomy, PREP-GC was found to be feasible and safe, with high adherence and compliance. Although randomized studies evaluating the benefits of exercise intervention during postoperative recovery are needed, surgeons should encourage patients to participate in systematic exercise intervention programs in the early postoperative period (Registered at the ClinicalTrials.gov, NCT01751880).

장기간 항경련제를 복용한 간질환자의 골대사 변화에 대한 연구 : DR-XRA(Quantitative Dual-Energy Radiography ; X-Ray Absorptiometry)법에 의한 측정 Measurement by DR-XRA(Quantitative Dual-Energy Radiography ; X-Ray Absorptiometry)

이호택,장호균,이상연,정인과 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.1

This study examined, among others, the relationship between the use of anticonvulsant and the bone mineral metabolism(measured via DR-XRA and biochemical study) in 46 adult epileptic outpatients who had been on anticonvulsant for more than one year at Seoul Red Cross Hospital. The study findings wel as follows. 1) There was statistically significant difference between index group(i.e. 46 adult epileptic outpatients) and control group(i.e. 46 healthy adults without previous exposure to anticonvulsant) in terms of bone mineral density. Specifically, the bone mineral density in the epileptic outpatients was significantly lower than that in the healthy adults. Although there was no statistically significant difference between male and female outpatients, their bone mineral density tended to decrease with the increase of age. 2) The bone mineral density in the epileptic outpatients was negatively correlated to both ⅰ) the age when the outpatients started anticonvulsant treatment and ⅱ) the period for which the outpatients were on anticonvulsant. 3) Index group was further classified into three subgroups(i.e. low, normal and high subgroup) based on the mean and standard deviation of the bone mineral density in healthy adults control group. 24 outpatients(5.2%) out of 46 fell into low subgroup, of which 10 were male. Overall, there was no statistically significant difference between male and female outpatients in terms of their bone mineral density. 4) Low subgroup's average age(38.6 with SD of 12.5) was significantly higher than those of the other two subgroups. Low subgroup started anticonvulsant treated when their average age was 24.8(SD 15.0) years, which was higher than those of the other two subgroups. Low subgroup was on anticonvulsant, on average, for 13.3(SD 7.6) years, which was also higher than those of the other two subgroups although there was no significant difference among the subgroups. 5) A series of comparison regarding the possible impact of various types of anticonvulsant(e.g. PHT, CBZ PB, SV) in terms of ⅰ) overall dosage and ⅱ) daily average dosage on bone mineral density showed no significant difference across the three subgroups. 6) There was no significant difference in terms of bone mineral density between the epileptic outpatients on only one type of anticonvulsant and those on two or more types of anticonvulsant. 7) A biochemical study showed that ⅰ) each subgroup fell into normal range in terms of blood serum Ca, P, and ALP with no significant difference among the subgroups, and ⅱ) in low subgroup, there were 6 outpatients(25%) with Ca decrease, 2(9.5%) with P decrease, and 5(20.8%) with ALP increase.

실험적 부자 시신경병증에서 Methylprednisolone의 효능

신재필,이상희,서형덕,김인택 경북대학교 병원 1998 경북대학교병원의학연구소논문집 Vol.2 No.1

동물실험에서 aconite 또는 aconitine은 신경계통에 독성을 나타낸다고 이미 알려져 있다. 그러한 독성은 시유발전위와 병리조직에서 탈수초증으로 나타난다. 저자들은 실험적으로 aconite을 주입하여 탈수초신경증을 일으킨 후 고용량이 methylprednisolone(MP)투여가 효능이 있는지를 알아보고자 하였다. Aconite를 복강내 주입하고 곧 이어 가토의 이연정맥으로 MP를 주입한 군과 aconite만을 주입한 군으로 나누었고 이들을 서로 비교하였다. 그리고 이 두 군을 정상군과도 비교하였다. 시유발전위에서 aconite를 주입후 MP를 투여한 군에서 aconite만을 주입한 군에 비하여 onset latency와 peak latency 그리고 진폭 모두에서 2주째에 통계학적으로 의미있게 회복되었으나 (p<0.05) 정상군과 비교하여 의미있는 차이를 나타내지 아니하였다. 그러나 정상군과 비교하여 1개월과 2개월에서 onset latency은 의미있게 지연되었고 (p<0.05) peak latency와 진폭은 다소 회복되었으나 정상군의 평균값에는 미치지 못하였다. 병리조직에서 MP으로 치료한 군과 aconite만을 주입한 군 모두에서 수초의 탈수초변화가 관찰되었으나 MP으로 치료한 군은 상대적으로 탈수초변화가 현저하지 아니하였다. 본 연구에서 실험적으로 가토에 aconite를 전신에 투여하여 시신경병증을 일으킨 후 고용량의 MP를 즉시 투여한 경우에 시신경의 기능을 정상상태까지 회복시키는데는 한계가 있으나 부분적으로 시신경의 기능을 회복시키는데 도움이 될 것으로 생각된다(한안지 37:1730~1740, 1996). Studies in animals indicate that aconitine or aconite has toxic effects in the visual system of a rabbit model. Such a toxic effects causes myelo-optic neuropathy in the visually evoked cortical potential(VECP) and histopathologic studies. Whether the administration of intravenous high-does of methyprednisolone(MP) in the myelo-optic neuropathy caused by aconitine(1.5㎖/㎏, equivalent to 0.7㎎/㎏ of aconitine) is experimentally effective remains uncertain. The group treated with MP(daily 30㎎/㎏×2 for 3 days followed by 15㎎/㎏ for 3 days) in addition to aconite was compared with the aconite alone group and the normal control group. In the MP treated group, increased recovery of onset latency, peak latency, and amplitude in VECP in comparision with the aconite alone group was recorded at 2 weeks(p<0.05). The MP treated group in comparision with the normal control group showed a significant delay in onset latency at 1 month and 2 months(p<0.05). But, the amplitude in both the MP treated group and the aconite alone group increased at 2 months and did not show a significant difference in comparision with the normal group(p<0.05). In histopathologic study, pathologic findings of myelin sheath in the MP treated group were less severe than in the aconite alone group generally. The true benefit of high-does MP was at least clear within 2 weeks. The authors conclude that treatment with intravenous high-does MP immediate after aconite injection may have some beneficial effects in recovery of neurologic function although such a treatment do no have the definite recovery in aconite induced myelo-optic neuropathy(J Korean Ophthalmol Soc 37:1730~1740, 1996).

고리원자력발전소 주변의 식생과 식물현존량 추정

김성종,이호준,김인택,김창호,정홍락 建國大學校基礎科學硏究所 1995 理學論集 Vol.20 No.-

고리원자력발전소 주변의 식생에 대한 식물사회학적 조사를 실시하였으며, 순1차생산력과 식물현존량을 추정하였다. 또한 상관에 의한 현존식생도 및 녹지자연도를 작성하였다. 종조성표에 의한 식물군락은 소나무군락, 곰솔군락, 서어나무-굴참나무군락, 아까시나무군락으로 구분되었다. 소나무군락은 아교목층(평균식피율 35%)이 빈약하였으며, 서어나무-굴참나무군락은 비교적 안정된 계층구조를 이루고 있었다. 전체적으로 교목층에서 소나무, 곰솔, 아교목층에서 사방오리, 졸참나무, 저목층에서 졸참나무, 사스레피나무, 초본층에서 산거울, 주름조개풀 등의 피복지수가 높았다. 삼림토양의 pH는 4.30~4.85, 유기물함량은 6.04~9.40%의 범위였다. 현존식생도에 의한 분포비율은 곰솔군락(31.4%)이 가장 높았으며, 평균녹지자연도는 5.4였다. Montreal model에 의한 순1차생산력은 1555.2g/㎡/yr, 식물현존량은 단위면적당16,982,21ton/k㎡으로 추정되었다. The forest vegetation and estimation of phytomass and net primary production in the vicinity of Kori Atomic Power Plant was analyzed on the basis of the phytosociological data. Depending on physiognomy, actual vegetation map and the degree of green naturality(DGN) was also drawn in the of 1:50,000. According to Z-M method, the forest vegetation was classified into four communities, which include Pinus densiflora, Pinus thunbergii, Carpinus laxiflora-Quercus variabilis, and Robinia pseudo-acacia communities. The Pinus densiflora community was most poorly covered in tree-2 layer. The Carpinus laxiflora-Quercus variabilis community was relatively stable in the stratum structure. It was generally shown that Pinus densiflora and Pinus thunbergii in tree-1 layer, Alnus firma and Quercus serrata in tree-2 layer, Quercus serrata and Eurya japonica in shrub layer, and Carex humilis and Oplismenus undulatifolius in herb layer had high coverage index. The pHs and contents of organic matter of the forest soil collected in each sites was in the range of 4.30 to 4.85 and 6.04% to 9.40% in average in the communities. The Pinus thunbergii community showed the highest distribution rate(31.4%) in the actual vegetation map. The average DGN was approximately 5.4. Net primary production and phytomass per unit area obtained by Montreal model were estimated to be 1555.2g/㎡/yr and 16,982.21ton/k㎡, respectively.

장시간 불가피한 공복(fasting)후 인체의 내분비 변화 : 삼풍백화점 붕괴 사고후 구조된 3인의 증례 THREE CASES IN COLLAPSE OF SAMPOONG DEPARTMENT STORE

박규남,황주일,박조현,오동렬,이원재,오승택,김세경,김인철 대한응급의학회 1995 대한응급의학회지 Vol.6 No.2

The interactions between nutrition and the endocrine system are more intimate and complex that previously thought. Nutrition modulates secretion and activity of many hormones, as part of the stress adaptation process. Fasting, in particular, produces a number of important changes in the endocrine system, with teleological purpose of helping the body tolerate the lack of food ingestion. These changes are therefore beneficial and protective, although at times they may not appear to be that way. The endocrine changes of fasting mediate the metabolic response. We must emphasize that these changes are completely reversible when appropriate nutrition is established. These changes are as followes: 1) decreased insulin and increased glucagon levels, 2) decreased thyroid effect, 3) decreased sympathetic activity, 4) hypothalamic hypogonadism, 5) decreased growth, 6) altered glucocorticoid secretion and metabolism, 7) impaired mineralocorticoid response, 8) decreased ADH secretion and effect. We experienced three cases of involuntary prolonged fasting after collapse of Sampoong department store. They were released from collapsed field after 11(case Ⅰ), 13(case Ⅱ), 17days(case Ⅲ) respectively. In each case, the endocrine changes of plasma levels were as followes: decrease of cortisol in case Ⅰ, increase of GH in case Ⅱ, decrease of free T3, T3, cortisol and increase of reverse T3, insulin in case Ⅲ. Each one did not show the same endocrine changes of plasma levels. But we think these changes of fasting are beneficial in metabolic response of human.